WO1995003356A1 - Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers - Google Patents
Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers Download PDFInfo
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- WO1995003356A1 WO1995003356A1 PCT/US1994/008287 US9408287W WO9503356A1 WO 1995003356 A1 WO1995003356 A1 WO 1995003356A1 US 9408287 W US9408287 W US 9408287W WO 9503356 A1 WO9503356 A1 WO 9503356A1
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- A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
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- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
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- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
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- A61K51/1251—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles micro- or nanospheres, micro- or nanobeads, micro- or nanocapsules
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/582,993 US6007845A (en) | 1994-07-22 | 1994-07-22 | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
EP94925102A EP0712421A1 (en) | 1993-07-23 | 1994-07-22 | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
JP7505337A JPH09504308A (en) | 1993-07-23 | 1994-07-22 | Non-linear hydrophilic-hydrophobic multiblock copolymer nanoparticles and microparticles |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/096,370 US5543158A (en) | 1993-07-23 | 1993-07-23 | Biodegradable injectable nanoparticles |
US096,370 | 1994-03-18 | ||
US08/210,677 US5565215A (en) | 1993-07-23 | 1994-03-18 | Biodegradable injectable particles for imaging |
US210,677 | 1994-03-18 | ||
US08/265,440 US5578325A (en) | 1993-07-23 | 1994-06-24 | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
US265,440 | 1994-06-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1995003356A1 true WO1995003356A1 (en) | 1995-02-02 |
Family
ID=27378175
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/008287 WO1995003356A1 (en) | 1993-07-23 | 1994-07-22 | Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0712421A1 (en) |
JP (1) | JPH09504308A (en) |
CA (1) | CA2167920A1 (en) |
WO (1) | WO1995003356A1 (en) |
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WO1998018498A2 (en) * | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
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FR2766195A1 (en) * | 1997-07-21 | 1999-01-22 | Transgene Sa | CATIONIC POLYMERS, COMPLEXES ASSOCIATING THE SAID CATIONIC POLYMERS AND THERAPEUTICALLY ACTIVE SUBSTANCES INCLUDING AT LEAST ONE NEGATIVE CHARGES, ESPECIALLY NUCLEIC ACIDS, AND THEIR USE IN GENE THERAPY |
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WO1999005183A1 (en) * | 1997-07-21 | 1999-02-04 | Transgene S.A. | Cationic polymers, complexes associating said cationic polymers with therapeutically active substances comprising at least a negative charge, in particular nucleic acids, and their use in gene therapy |
FR2766195A1 (en) * | 1997-07-21 | 1999-01-22 | Transgene Sa | CATIONIC POLYMERS, COMPLEXES ASSOCIATING THE SAID CATIONIC POLYMERS AND THERAPEUTICALLY ACTIVE SUBSTANCES INCLUDING AT LEAST ONE NEGATIVE CHARGES, ESPECIALLY NUCLEIC ACIDS, AND THEIR USE IN GENE THERAPY |
US6407178B1 (en) | 1997-07-21 | 2002-06-18 | Transgene S.A. | Cationic polymers, complexes associating said cationic polymers with therapeutically active substances comprising at least a negative charge, in particular nucleic acids, and their use in gene therapy |
US6828357B1 (en) | 1997-07-31 | 2004-12-07 | Metabolix, Inc. | Polyhydroxyalkanoate compositions having controlled degradation rates |
EP2258742A1 (en) | 1997-12-22 | 2010-12-08 | Metabolix, Inc. | Polyhydroxyalkanoate compositons having controlled degradation rates |
WO1999038535A1 (en) * | 1998-01-29 | 1999-08-05 | Kinerton Limited | Process for making absorbable microparticles |
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US6555156B1 (en) * | 1998-01-29 | 2003-04-29 | Kinerton Limited | Process for making absorbable microparticles |
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JPH09504308A (en) | 1997-04-28 |
CA2167920A1 (en) | 1995-02-02 |
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