EP1848410A4 - Polymer particle delivery compositions and methods of use - Google Patents

Polymer particle delivery compositions and methods of use

Info

Publication number
EP1848410A4
EP1848410A4 EP06734169A EP06734169A EP1848410A4 EP 1848410 A4 EP1848410 A4 EP 1848410A4 EP 06734169 A EP06734169 A EP 06734169A EP 06734169 A EP06734169 A EP 06734169A EP 1848410 A4 EP1848410 A4 EP 1848410A4
Authority
EP
European Patent Office
Prior art keywords
methods
polymer particle
particle delivery
delivery compositions
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06734169A
Other languages
German (de)
French (fr)
Other versions
EP1848410A1 (en
Inventor
William G Turnell
Hong Li
Zaza D Gomurashvili
Jonathan Macferran Hughes
Jie Da
Huashi Zhang
Ramaz Katsarava
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivas LLC
Original Assignee
Medivas LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivas LLC filed Critical Medivas LLC
Publication of EP1848410A1 publication Critical patent/EP1848410A1/en
Publication of EP1848410A4 publication Critical patent/EP1848410A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/12—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP06734169A 2005-02-17 2006-01-31 Polymer particle delivery compositions and methods of use Withdrawn EP1848410A4 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US65471505P 2005-02-17 2005-02-17
US68467005P 2005-05-25 2005-05-25
US68757005P 2005-06-03 2005-06-03
US71995005P 2005-09-22 2005-09-22
US73740105P 2005-11-14 2005-11-14
US75917906P 2006-01-13 2006-01-13
PCT/US2006/003575 WO2006088647A1 (en) 2005-02-17 2006-01-31 Polymer particle delivery compositions and methods of use

Publications (2)

Publication Number Publication Date
EP1848410A1 EP1848410A1 (en) 2007-10-31
EP1848410A4 true EP1848410A4 (en) 2011-11-09

Family

ID=36916776

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06734169A Withdrawn EP1848410A4 (en) 2005-02-17 2006-01-31 Polymer particle delivery compositions and methods of use

Country Status (6)

Country Link
EP (1) EP1848410A4 (en)
JP (1) JP2008530206A (en)
CN (1) CN101115471B (en)
AU (1) AU2006214655A1 (en)
CA (1) CA2596011C (en)
WO (1) WO2006088647A1 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
JP5192384B2 (en) 2005-09-22 2013-05-08 メディバス エルエルシー Bis- (α-amino) -diol-diester-containing poly (ester amide) and poly (ester urethane) compositions and methods of use
CA2623239C (en) 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
EP2004145A4 (en) * 2006-03-24 2013-07-03 Medivas Llc Alkylene-dicarboxylate-containing biodegradable poly(ester amides) and methods of use
US8658210B2 (en) 2006-04-17 2014-02-25 Advanced Cardiovascular Systems, Inc. Polyesteramide platform for site specific drug delivery
EP2021141A4 (en) * 2006-05-09 2013-07-03 Medivas Llc Biodegradable water soluble polymers
EP2068937A2 (en) * 2006-09-05 2009-06-17 Medivas, LLC Polymer-stabilized liposomal compositions and methods of use
CA2713185A1 (en) * 2007-08-23 2009-02-26 Medivas, Llc Cationic alpha-amino acid-containing biodegradable polymer gene transfer compositions
EP2282720B1 (en) 2008-05-15 2013-09-11 Biocompatibles Uk Ltd. Intracellular antibody delivery
US20120027859A1 (en) * 2008-10-15 2012-02-02 Turnell William G Biodegradable Proline-Based Polymers
WO2012175748A1 (en) 2011-06-23 2012-12-27 Dsm Ip Assets B.V. Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
CA2969171C (en) 2014-12-18 2023-12-12 Dsm Ip Assets B.V. Drug delivery system for delivery of acid sensitive drugs
US10772964B2 (en) * 2015-06-23 2020-09-15 Phagelux (Canada), Inc. Composition comprising a polymer and a bioactive agent and method of preparing thereof
US11090273B2 (en) * 2016-09-20 2021-08-17 Cornell University Tagged poly(ester amide urethane)s, nanoparticles formed from same, and uses thereof
CA3133175A1 (en) * 2019-03-14 2020-09-17 Engene, Inc. Reversible coating of chitosan-nucleic acid nanoparticles and methods of their use
CN112321822B (en) * 2020-12-02 2021-12-10 中山大学 Methionine-polyesteramide high-molecular polymer with ROS responsiveness and application thereof
CN114920869B (en) * 2022-05-24 2023-07-14 太原工业学院 Amphiphilic arginine block ciprofloxacin copolymer, nanoparticle, preparation method and application thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449513A (en) * 1992-08-14 1995-09-12 Research Development Corporation Of Japan Physical trapping type polymeric micelle drug preparation
US5861387A (en) * 1991-06-28 1999-01-19 Endorecherche Inc. Controlled release systems and low dose androgens
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020015720A1 (en) * 2000-01-11 2002-02-07 Ramaz Katsarava Polymer blends as biodegradable matrices for preparing biocomposites
WO2003062298A1 (en) * 2002-01-17 2003-07-31 Polyrava Llc Co-poly(ester amide) and co-poly(ester urethane) compositions which exhibit biodegradability, methods for making same and uses for same
WO2004039944A2 (en) * 2002-05-15 2004-05-13 Rutgers, The State University Tri-block polymers for nanosphere-based drug or gene delivery
EP1945682A2 (en) * 2005-10-21 2008-07-23 Medivas, LLC Poly(ester urea) polymers and methods of use

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
AR018528A1 (en) * 1997-12-12 2001-11-28 Expression Genetics Inc BIODEGRADABLE POLYMER MIXTURE OF MICELS FOR GENETIC TRANSFER
AU4390200A (en) * 1999-02-19 2000-09-04 Bioserv Ag Biodegradable composite material for the production of microcapsules
CN1230206C (en) * 2000-01-11 2005-12-07 内立蒂克斯股份有限公司 Polymer blends as biodegradable matrices for preparing biocomposites
ATE462413T1 (en) * 2000-01-14 2010-04-15 Univ Brown Res Found METHOD FOR PRODUCING MICRONIZED FREEZE-DRIED PARTICLES
FR2811227A1 (en) * 2000-07-07 2002-01-11 Philippe Maincent PARTICULATE VECTORS FOR IMPROVING ORAL ABSORPTION OF ACTIVE PRINCIPLES
US6503538B1 (en) * 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
CN1119172C (en) * 2000-12-12 2003-08-27 天津大学 Chitosan/gelatin network modification on surface of aliphatic polyester
WO2003075892A1 (en) * 2002-03-13 2003-09-18 Novartis Ag Pharmaceutical microparticles
EP1507514B1 (en) * 2002-05-03 2007-02-14 PR Pharmaceuticals, Inc. Controlled release compositions of estradiol metabolites
WO2006043514A1 (en) * 2004-10-18 2006-04-27 Meidensha Corporation Structure of peltier element or seebeck element and its manufacturing method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861387A (en) * 1991-06-28 1999-01-19 Endorecherche Inc. Controlled release systems and low dose androgens
US5449513A (en) * 1992-08-14 1995-09-12 Research Development Corporation Of Japan Physical trapping type polymeric micelle drug preparation
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020015720A1 (en) * 2000-01-11 2002-02-07 Ramaz Katsarava Polymer blends as biodegradable matrices for preparing biocomposites
WO2003062298A1 (en) * 2002-01-17 2003-07-31 Polyrava Llc Co-poly(ester amide) and co-poly(ester urethane) compositions which exhibit biodegradability, methods for making same and uses for same
WO2004039944A2 (en) * 2002-05-15 2004-05-13 Rutgers, The State University Tri-block polymers for nanosphere-based drug or gene delivery
EP1945682A2 (en) * 2005-10-21 2008-07-23 Medivas, LLC Poly(ester urea) polymers and methods of use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARABULI N ET AL: "HETEROCHAIN POLYMERS BASED ON NATURAL AMINO ACIDS. SYNTHESIS AND ENZYMATIC HYDROLYSIS OF REGULAR POL(ESTER AMIDE)S BASED ON BIS(L-PHENYLALANINE)ALPHA,OMEGA-ALKYLENE DIESTERS AND ADIPIC ACID", MACROMOLECULAR CHEMISTRY AND PHYSICS, WILEY-VCH VERLAG, WEINHEIM, DE, vol. 195, no. 6, 1 January 1994 (1994-01-01), pages 2279 - 2289, XP002171341, ISSN: 1022-1352, DOI: 10.1002/MACP.1994.021950633 *
See also references of WO2006088647A1 *

Also Published As

Publication number Publication date
CA2596011A1 (en) 2006-08-24
WO2006088647A1 (en) 2006-08-24
CN101115471A (en) 2008-01-30
CA2596011C (en) 2013-05-14
AU2006214655A1 (en) 2006-08-24
EP1848410A1 (en) 2007-10-31
JP2008530206A (en) 2008-08-07
CN101115471B (en) 2011-02-09

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