EP1848410A4 - Compositions d'administration particulaires, polymeriques, et leurs methodes d'utilisation - Google Patents
Compositions d'administration particulaires, polymeriques, et leurs methodes d'utilisationInfo
- Publication number
- EP1848410A4 EP1848410A4 EP06734169A EP06734169A EP1848410A4 EP 1848410 A4 EP1848410 A4 EP 1848410A4 EP 06734169 A EP06734169 A EP 06734169A EP 06734169 A EP06734169 A EP 06734169A EP 1848410 A4 EP1848410 A4 EP 1848410A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- methods
- polymer particle
- particle delivery
- delivery compositions
- compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 229920000642 polymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/595—Polyamides, e.g. nylon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
- C08L77/12—Polyester-amides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65471505P | 2005-02-17 | 2005-02-17 | |
US68467005P | 2005-05-25 | 2005-05-25 | |
US68757005P | 2005-06-03 | 2005-06-03 | |
US71995005P | 2005-09-22 | 2005-09-22 | |
US73740105P | 2005-11-14 | 2005-11-14 | |
US75917906P | 2006-01-13 | 2006-01-13 | |
PCT/US2006/003575 WO2006088647A1 (fr) | 2005-02-17 | 2006-01-31 | Compositions d'administration particulaires, polymeriques, et leurs methodes d'utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1848410A1 EP1848410A1 (fr) | 2007-10-31 |
EP1848410A4 true EP1848410A4 (fr) | 2011-11-09 |
Family
ID=36916776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP06734169A Withdrawn EP1848410A4 (fr) | 2005-02-17 | 2006-01-31 | Compositions d'administration particulaires, polymeriques, et leurs methodes d'utilisation |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1848410A4 (fr) |
JP (1) | JP2008530206A (fr) |
CN (1) | CN101115471B (fr) |
AU (1) | AU2006214655A1 (fr) |
CA (1) | CA2596011C (fr) |
WO (1) | WO2006088647A1 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060177416A1 (en) | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
JP5178520B2 (ja) | 2005-09-22 | 2013-04-10 | メディバス エルエルシー | 固体ポリマー送達組成物およびその使用法 |
JP5192384B2 (ja) * | 2005-09-22 | 2013-05-08 | メディバス エルエルシー | ビス−(α−アミノ)−ジオール−ジエステル含有ポリ(エステルアミド)およびポリ(エステルウレタン)組成物および使用の方法 |
US8445627B2 (en) * | 2006-03-24 | 2013-05-21 | Medivas, Llc | Alkylene-dicarboxylate-containing biodegradable poly(ester-amides) and methods of use |
US8658210B2 (en) | 2006-04-17 | 2014-02-25 | Advanced Cardiovascular Systems, Inc. | Polyesteramide platform for site specific drug delivery |
EP2021141A4 (fr) * | 2006-05-09 | 2013-07-03 | Medivas Llc | Polymères hydrosolubles biodégradables |
EP2068937A2 (fr) * | 2006-09-05 | 2009-06-17 | Medivas, LLC | Compositions liposomales stabilisées par des polymères et leurs méthodes d'utilisation |
JP2010536884A (ja) * | 2007-08-23 | 2010-12-02 | メディバス エルエルシー | カチオン性アルファアミノ酸を含有する生分解性ポリマー遺伝子導入組成物 |
JP5575116B2 (ja) | 2008-05-15 | 2014-08-20 | ビオコムパトイブルエス ユーケー リミテド | 細胞内抗体送達 |
WO2010045241A1 (fr) * | 2008-10-15 | 2010-04-22 | Medivas, Llc | Polymères biodégradables à base de proline |
US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
CA2839526A1 (fr) | 2011-06-23 | 2012-12-27 | Dsm Ip Assets B.V. | Microparticules ou nanoparticules comprenant un copolymere biodegradable de polyesteramide destinees a une utilisation dans l'administration d'agents bioactifs |
CA2969171C (fr) | 2014-12-18 | 2023-12-12 | Dsm Ip Assets B.V. | Systeme d'administration de medicament pour administration de medicaments sensibles aux acides |
CN107922565B (zh) * | 2015-06-23 | 2022-01-04 | 菲吉乐科(加拿大)有限公司 | 包含氨基酸聚合物和生物活性剂的组合物及其制备方法 |
US11090273B2 (en) * | 2016-09-20 | 2021-08-17 | Cornell University | Tagged poly(ester amide urethane)s, nanoparticles formed from same, and uses thereof |
CN112321822B (zh) * | 2020-12-02 | 2021-12-10 | 中山大学 | 一种具有ros响应性的蛋氨酸-聚酯酰胺高分子聚合物及其应用 |
CN114920869B (zh) * | 2022-05-24 | 2023-07-14 | 太原工业学院 | 两亲性精氨酸嵌段环丙沙星共聚物、纳米颗粒及其制备方法和应用 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5449513A (en) * | 1992-08-14 | 1995-09-12 | Research Development Corporation Of Japan | Physical trapping type polymeric micelle drug preparation |
US5861387A (en) * | 1991-06-28 | 1999-01-19 | Endorecherche Inc. | Controlled release systems and low dose androgens |
US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US20020015720A1 (en) * | 2000-01-11 | 2002-02-07 | Ramaz Katsarava | Polymer blends as biodegradable matrices for preparing biocomposites |
WO2003062298A1 (fr) * | 2002-01-17 | 2003-07-31 | Polyrava Llc | Co-poly(ester amide) et co-poly(ester urethane) compositions presentant une biodegradabilite, procedes de production et utilisation associes |
WO2004039944A2 (fr) * | 2002-05-15 | 2004-05-13 | Rutgers, The State University | Polymeres triblocs pour administration de gene ou de medicament a base de nanospheres |
EP1945682A2 (fr) * | 2005-10-21 | 2008-07-23 | Medivas, LLC | Polymeres de poly(ester-uree) et leurs procedes d'utilisation |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020164374A1 (en) * | 1997-10-29 | 2002-11-07 | John Jackson | Polymeric systems for drug delivery and uses thereof |
ATE412403T1 (de) * | 1997-12-12 | 2008-11-15 | Samyang Corp | Biologisch abbaubare gemischte polymerische mizellen zur genverabreichung |
JP2002537415A (ja) * | 1999-02-19 | 2002-11-05 | バイオサルフ アーゲー | マイクロカプセルの製造のための生物分解性複合材料 |
KR20030009338A (ko) * | 2000-01-11 | 2003-01-29 | 인트랄리틱스, 인크. | 생복합체를 제조하기 위해 생분해성 매트릭스로 사용되는중합체 블렌드 |
DE60141680D1 (de) * | 2000-01-14 | 2010-05-12 | Univ Brown Res Found | Verfahren zur herstellung von mikronisierte gefriergetrocknete partikeln |
FR2811227A1 (fr) * | 2000-07-07 | 2002-01-11 | Philippe Maincent | Vecteurs particulaires destines a ameliorer l'absorption orale de principes actifs |
US6503538B1 (en) * | 2000-08-30 | 2003-01-07 | Cornell Research Foundation, Inc. | Elastomeric functional biodegradable copolyester amides and copolyester urethanes |
CN1119172C (zh) * | 2000-12-12 | 2003-08-27 | 天津大学 | 脂肪族聚酯表面的壳聚糖/明胶网络修饰方法 |
JP4679822B2 (ja) * | 2002-03-13 | 2011-05-11 | ノバルティス アーゲー | 医薬微粒子 |
US20060083778A1 (en) * | 2002-05-03 | 2006-04-20 | Dean Allison | Controlled release compositions of estradiol metabolites |
JP4850070B2 (ja) * | 2004-10-18 | 2012-01-11 | 義臣 近藤 | ペルチェ素子又はゼーベック素子の製造方法 |
-
2006
- 2006-01-31 CN CN200680004221XA patent/CN101115471B/zh active Active
- 2006-01-31 CA CA2596011A patent/CA2596011C/fr active Active
- 2006-01-31 JP JP2007556163A patent/JP2008530206A/ja active Pending
- 2006-01-31 WO PCT/US2006/003575 patent/WO2006088647A1/fr active Application Filing
- 2006-01-31 EP EP06734169A patent/EP1848410A4/fr not_active Withdrawn
- 2006-01-31 AU AU2006214655A patent/AU2006214655A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5861387A (en) * | 1991-06-28 | 1999-01-19 | Endorecherche Inc. | Controlled release systems and low dose androgens |
US5449513A (en) * | 1992-08-14 | 1995-09-12 | Research Development Corporation Of Japan | Physical trapping type polymeric micelle drug preparation |
US5874064A (en) * | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
US20020015720A1 (en) * | 2000-01-11 | 2002-02-07 | Ramaz Katsarava | Polymer blends as biodegradable matrices for preparing biocomposites |
WO2003062298A1 (fr) * | 2002-01-17 | 2003-07-31 | Polyrava Llc | Co-poly(ester amide) et co-poly(ester urethane) compositions presentant une biodegradabilite, procedes de production et utilisation associes |
WO2004039944A2 (fr) * | 2002-05-15 | 2004-05-13 | Rutgers, The State University | Polymeres triblocs pour administration de gene ou de medicament a base de nanospheres |
EP1945682A2 (fr) * | 2005-10-21 | 2008-07-23 | Medivas, LLC | Polymeres de poly(ester-uree) et leurs procedes d'utilisation |
Non-Patent Citations (2)
Title |
---|
ARABULI N ET AL: "HETEROCHAIN POLYMERS BASED ON NATURAL AMINO ACIDS. SYNTHESIS AND ENZYMATIC HYDROLYSIS OF REGULAR POL(ESTER AMIDE)S BASED ON BIS(L-PHENYLALANINE)ALPHA,OMEGA-ALKYLENE DIESTERS AND ADIPIC ACID", MACROMOLECULAR CHEMISTRY AND PHYSICS, WILEY-VCH VERLAG, WEINHEIM, DE, vol. 195, no. 6, 1 January 1994 (1994-01-01), pages 2279 - 2289, XP002171341, ISSN: 1022-1352, DOI: 10.1002/MACP.1994.021950633 * |
See also references of WO2006088647A1 * |
Also Published As
Publication number | Publication date |
---|---|
CN101115471B (zh) | 2011-02-09 |
EP1848410A1 (fr) | 2007-10-31 |
WO2006088647A1 (fr) | 2006-08-24 |
JP2008530206A (ja) | 2008-08-07 |
AU2006214655A1 (en) | 2006-08-24 |
CA2596011C (fr) | 2013-05-14 |
CA2596011A1 (fr) | 2006-08-24 |
CN101115471A (zh) | 2008-01-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1848410A4 (fr) | Compositions d'administration particulaires, polymeriques, et leurs methodes d'utilisation | |
EP1933881A4 (fr) | Compositions polymères solides pour administration et méthodes d'utilisation de celles-ci | |
EP1957113A4 (fr) | Particules polymeriques pour administration de macromolecules et procedes d'utilisation | |
EP2024476A4 (fr) | Compositions contenant des tensioactifs polymerises a faible degre de polymerisation et procedes d'utilisation de ceux-ci | |
HK1112427A1 (en) | Drug delivery compositions and related methods | |
EP2370455A4 (fr) | Compositions de particule de type viral et procédés d'utilisation | |
IL195161A0 (en) | Pharmaceutical compositions of ropinirole and methods of use thereof | |
EP2032156A4 (fr) | Compositions et procédés pour administrer de l'oxygène | |
EP1973986A4 (fr) | Compositions bioactives complexes et leurs méthodes d'utilisation | |
IL200990A0 (en) | 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same | |
EP2128196A4 (fr) | Composition de polymère et son utilisation | |
IL196761A0 (en) | Masterbatch and polymer composition | |
IL202684A0 (en) | Anti-cd20 therapeutic compositions and methods of use thereof | |
GB0911139D0 (en) | Directly photodefinable polymer compositions and methods thereof | |
EP2012803A4 (fr) | Compositions polymères et procédés de production et d'utilisation de ces compositions | |
EP1986685A4 (fr) | Compositions des modes d'administration d'un vaccin et procédés d'utilisation | |
EP1796537A4 (fr) | Compositions a base de dendrimeres et procedes d'utilisation de celles-ci | |
EP2152293A4 (fr) | Compositions de livraison de protéines et procédés d'utilisation de ces dernières | |
EP2233511A4 (fr) | Nouvelle particule de polymère et son utilisation | |
EP2056835A4 (fr) | Compositions pharmaceutiques et leurs utilisations | |
EP2064550A4 (fr) | Compositions associees a prrg4 et procedes d'utilisation de celles-ci dans des procedes de diagnostic de tumeur | |
EP1735456A4 (fr) | Compositions poylmeres et procedes associes d'utilisation | |
EP1966246A4 (fr) | Procédés et compositions servant à l'apport, sans aiguille, d'anticorps | |
EP2142216A4 (fr) | Formulations de particule et utilisations de celles-ci | |
EP1890677A4 (fr) | Compositions pharmaceutiques et leur utilisation |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20070817 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20111011 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C08L 75/02 20060101ALI20111005BHEP Ipc: C08L 75/04 20060101ALI20111005BHEP Ipc: A61K 9/16 20060101ALI20111005BHEP Ipc: A61K 47/48 20060101ALI20111005BHEP Ipc: A61K 9/51 20060101ALI20111005BHEP Ipc: C08L 75/06 20060101ALI20111005BHEP Ipc: A61L 31/00 20060101ALI20111005BHEP Ipc: A61F 2/00 20060101ALI20111005BHEP Ipc: C12N 15/88 20060101ALI20111005BHEP Ipc: C08L 77/12 20060101ALI20111005BHEP Ipc: C07K 16/28 20060101ALI20111005BHEP Ipc: A61K 9/107 20060101ALI20111005BHEP Ipc: A61K 47/34 20060101ALI20111005BHEP Ipc: A61K 9/50 20060101ALI20111005BHEP Ipc: C08L 77/00 20060101AFI20111005BHEP Ipc: C08G 18/10 20060101ALI20111005BHEP Ipc: C08G 69/44 20060101ALI20111005BHEP |
|
17Q | First examination report despatched |
Effective date: 20121022 |
|
GRAP | Despatch of communication of intention to grant a patent |
Free format text: ORIGINAL CODE: EPIDOSNIGR1 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: GRANT OF PATENT IS INTENDED |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: C08L 75/04 20060101ALI20170202BHEP Ipc: C08G 69/44 20060101ALI20170202BHEP Ipc: A61K 9/51 20060101ALI20170202BHEP Ipc: A61K 9/16 20060101ALI20170202BHEP Ipc: C07K 16/28 20060101ALI20170202BHEP Ipc: A61K 9/50 20060101ALI20170202BHEP Ipc: C12N 15/88 20060101ALI20170202BHEP Ipc: C08G 18/10 20060101ALI20170202BHEP Ipc: A61F 2/00 20060101ALI20170202BHEP Ipc: C08L 77/00 20060101AFI20170202BHEP Ipc: C08L 75/02 20060101ALI20170202BHEP Ipc: C08L 77/12 20060101ALI20170202BHEP Ipc: A61L 31/00 20060101ALI20170202BHEP Ipc: A61K 9/107 20060101ALI20170202BHEP Ipc: A61K 47/34 20170101ALI20170202BHEP Ipc: C08L 75/06 20060101ALI20170202BHEP |
|
INTG | Intention to grant announced |
Effective date: 20170220 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20170704 |