EP1848410A4 - Zusammensetzungen zur ausgabe von polymerteilchen und anwendungsverfahren dafür - Google Patents

Zusammensetzungen zur ausgabe von polymerteilchen und anwendungsverfahren dafür

Info

Publication number
EP1848410A4
EP1848410A4 EP06734169A EP06734169A EP1848410A4 EP 1848410 A4 EP1848410 A4 EP 1848410A4 EP 06734169 A EP06734169 A EP 06734169A EP 06734169 A EP06734169 A EP 06734169A EP 1848410 A4 EP1848410 A4 EP 1848410A4
Authority
EP
European Patent Office
Prior art keywords
methods
polymer particle
particle delivery
delivery compositions
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP06734169A
Other languages
English (en)
French (fr)
Other versions
EP1848410A1 (de
Inventor
William G Turnell
Hong Li
Zaza D Gomurashvili
Jonathan Macferran Hughes
Jie Da
Huashi Zhang
Ramaz Katsarava
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medivas LLC
Original Assignee
Medivas LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivas LLC filed Critical Medivas LLC
Publication of EP1848410A1 publication Critical patent/EP1848410A1/de
Publication of EP1848410A4 publication Critical patent/EP1848410A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/593—Polyesters, e.g. PLGA or polylactide-co-glycolide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers
    • C08L77/12—Polyester-amides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
EP06734169A 2005-02-17 2006-01-31 Zusammensetzungen zur ausgabe von polymerteilchen und anwendungsverfahren dafür Withdrawn EP1848410A4 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US65471505P 2005-02-17 2005-02-17
US68467005P 2005-05-25 2005-05-25
US68757005P 2005-06-03 2005-06-03
US71995005P 2005-09-22 2005-09-22
US73740105P 2005-11-14 2005-11-14
US75917906P 2006-01-13 2006-01-13
PCT/US2006/003575 WO2006088647A1 (en) 2005-02-17 2006-01-31 Polymer particle delivery compositions and methods of use

Publications (2)

Publication Number Publication Date
EP1848410A1 EP1848410A1 (de) 2007-10-31
EP1848410A4 true EP1848410A4 (de) 2011-11-09

Family

ID=36916776

Family Applications (1)

Application Number Title Priority Date Filing Date
EP06734169A Withdrawn EP1848410A4 (de) 2005-02-17 2006-01-31 Zusammensetzungen zur ausgabe von polymerteilchen und anwendungsverfahren dafür

Country Status (6)

Country Link
EP (1) EP1848410A4 (de)
JP (1) JP2008530206A (de)
CN (1) CN101115471B (de)
AU (1) AU2006214655A1 (de)
CA (1) CA2596011C (de)
WO (1) WO2006088647A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
WO2007035938A2 (en) 2005-09-22 2007-03-29 Medivas, Llc BIS-(α-AMINO)-DIOL-DIESTER-CONTAINING POLY(ESTER AMIDE) AND POLY(ESTER URETHANE) COMPOSITIONS AND METHODS OF USE
WO2007038246A2 (en) 2005-09-22 2007-04-05 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
JP2009530484A (ja) * 2006-03-24 2009-08-27 メディバス エルエルシー アルキレン−ジカルボキシラート含有の生分解性ポリ（エステル−アミド）および使用法
US8658210B2 (en) * 2006-04-17 2014-02-25 Advanced Cardiovascular Systems, Inc. Polyesteramide platform for site specific drug delivery
EP2021141A4 (de) * 2006-05-09 2013-07-03 Medivas Llc Biologisch abbaubare wasserlösliche polymere
EP2068937A2 (de) * 2006-09-05 2009-06-17 Medivas, LLC Polymer-stabilisierte liposomale zusammensetzungen und anwendungsverfahren dafür
CA2713185A1 (en) * 2007-08-23 2009-02-26 Medivas, Llc Cationic alpha-amino acid-containing biodegradable polymer gene transfer compositions
EP2282720B1 (de) * 2008-05-15 2013-09-11 Biocompatibles Uk Ltd. Intrazelluläre antikörper-abgabe
WO2010045241A1 (en) * 2008-10-15 2010-04-22 Medivas, Llc Biodegradable proline-based polymers
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
ES2558357T3 (es) 2011-06-23 2016-02-03 Dsm Ip Assets B.V. Micro- o nanopartículas que comprenden un copolímero de poliesteramida biodegradable para uso en el suministro de agentes bioactivos
WO2016097297A1 (en) 2014-12-18 2016-06-23 Dsm Ip Assets B.V. Drug delivery system for delivery of acid sensitive drugs
WO2016207725A1 (en) * 2015-06-23 2016-12-29 Phagelux (Canada), Inc. Composition comprising amino acid polymers and a bioactive agent and method of preparing thereof
CN110023407B (zh) * 2016-09-20 2021-10-29 康奈尔大学 标记的聚(酯酰胺氨基甲酸酯)、由其形成的纳米粒子和其用途
CN112321822B (zh) * 2020-12-02 2021-12-10 中山大学 一种具有ros响应性的蛋氨酸-聚酯酰胺高分子聚合物及其应用
CN114920869B (zh) * 2022-05-24 2023-07-14 太原工业学院 两亲性精氨酸嵌段环丙沙星共聚物、纳米颗粒及其制备方法和应用

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5449513A (en) * 1992-08-14 1995-09-12 Research Development Corporation Of Japan Physical trapping type polymeric micelle drug preparation
US5861387A (en) * 1991-06-28 1999-01-19 Endorecherche Inc. Controlled release systems and low dose androgens
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020015720A1 (en) * 2000-01-11 2002-02-07 Ramaz Katsarava Polymer blends as biodegradable matrices for preparing biocomposites
WO2003062298A1 (en) * 2002-01-17 2003-07-31 Polyrava Llc Co-poly(ester amide) and co-poly(ester urethane) compositions which exhibit biodegradability, methods for making same and uses for same
WO2004039944A2 (en) * 2002-05-15 2004-05-13 Rutgers, The State University Tri-block polymers for nanosphere-based drug or gene delivery
EP1945682A2 (de) * 2005-10-21 2008-07-23 Medivas, LLC Poly(esterharnstoff)-polymere und verwendungsverfahren

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020164374A1 (en) * 1997-10-29 2002-11-07 John Jackson Polymeric systems for drug delivery and uses thereof
EP1037611B1 (de) * 1997-12-12 2008-10-29 Samyang Corporation Biologisch abbaubare gemischte polymerische mizellen zur genverabreichung
WO2000048573A1 (de) * 1999-02-19 2000-08-24 Bioserv Ag Bioabbaubare komposite zur herstellung von mikrokapseln
EP1250050B1 (de) * 2000-01-11 2004-10-27 Intralytix Inc. Verfahren und vorrichtung zur reinigung mit bakteriophagen
AU773735B2 (en) * 2000-01-14 2004-06-03 Brown University Research Foundation Micronized freeze-dried particles
FR2811227A1 (fr) * 2000-07-07 2002-01-11 Philippe Maincent Vecteurs particulaires destines a ameliorer l'absorption orale de principes actifs
US6503538B1 (en) * 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
CN1119172C (zh) * 2000-12-12 2003-08-27 天津大学 脂肪族聚酯表面的壳聚糖／明胶网络修饰方法
WO2003075892A1 (en) * 2002-03-13 2003-09-18 Novartis Ag Pharmaceutical microparticles
ATE353632T1 (de) * 2002-05-03 2007-03-15 Pr Pharmaceuticals Inc Zusammensetzungen aus östradiol-metaboliten mit kontrollierter freisetzung
US20090007952A1 (en) * 2004-10-18 2009-01-08 Yoshiomi Kondoh Structure of Peltier Element or Seebeck Element and Its Manufacturing Method

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5861387A (en) * 1991-06-28 1999-01-19 Endorecherche Inc. Controlled release systems and low dose androgens
US5449513A (en) * 1992-08-14 1995-09-12 Research Development Corporation Of Japan Physical trapping type polymeric micelle drug preparation
US5874064A (en) * 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20020015720A1 (en) * 2000-01-11 2002-02-07 Ramaz Katsarava Polymer blends as biodegradable matrices for preparing biocomposites
WO2003062298A1 (en) * 2002-01-17 2003-07-31 Polyrava Llc Co-poly(ester amide) and co-poly(ester urethane) compositions which exhibit biodegradability, methods for making same and uses for same
WO2004039944A2 (en) * 2002-05-15 2004-05-13 Rutgers, The State University Tri-block polymers for nanosphere-based drug or gene delivery
EP1945682A2 (de) * 2005-10-21 2008-07-23 Medivas, LLC Poly(esterharnstoff)-polymere und verwendungsverfahren

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARABULI N ET AL: "HETEROCHAIN POLYMERS BASED ON NATURAL AMINO ACIDS. SYNTHESIS AND ENZYMATIC HYDROLYSIS OF REGULAR POL(ESTER AMIDE)S BASED ON BIS(L-PHENYLALANINE)ALPHA,OMEGA-ALKYLENE DIESTERS AND ADIPIC ACID", MACROMOLECULAR CHEMISTRY AND PHYSICS, WILEY-VCH VERLAG, WEINHEIM, DE, vol. 195, no. 6, 1 January 1994 (1994-01-01), pages 2279 - 2289, XP002171341, ISSN: 1022-1352, DOI: 10.1002/MACP.1994.021950633 *
See also references of WO2006088647A1 *

Also Published As

Publication number Publication date
CN101115471A (zh) 2008-01-30
AU2006214655A1 (en) 2006-08-24
CA2596011C (en) 2013-05-14
JP2008530206A (ja) 2008-08-07
EP1848410A1 (de) 2007-10-31
WO2006088647A1 (en) 2006-08-24
CA2596011A1 (en) 2006-08-24
CN101115471B (zh) 2011-02-09

Similar Documents

Publication Publication Date Title
EP1848410A4 (de) Zusammensetzungen zur ausgabe von polymerteilchen und anwendungsverfahren dafür
EP1933881A4 (de) Feste polymer-abgabezusammensetzungen und anwendungsverfahren dafür
EP1957113A4 (de) Polymerteilchen zur ausgabe von makromolekülen und anwendungsverfahren dafür
EP2024476A4 (de) Zusammensetzungen mit nieder-dp-polymerisierten tensiden und anwendungsverfahren
HK1112427A1 (en) Drug delivery compositions and related methods
EP2370455A4 (de) Virusähnliche partikelzusammensetzungen und anwendungsverfahren
IL195161A0 (en) Pharmaceutical compositions of ropinirole and methods of use thereof
EP2032156A4 (de) Zusammensetzungen und verfahren zur abgabe von sauerstoff
EP1973986A4 (de) Zusammensetzungen bioaktiver komplexe und verfahren zu ihrer verwendung
ZA200906497B (en) 4'-o-substituted isoindoline derivatives and compositions comprising and methods of using the same
EP2128196A4 (de) Polymerzusammensetzung und anwendung davon
ZA200901386B (en) Masterbatch and polymer composition
IL202684A0 (en) Anti-cd20 therapeutic compositions and methods of use thereof
GB0911139D0 (en) Directly photodefinable polymer compositions and methods thereof
EP2012803A4 (de) Polymerzusammensetzungen sowie verfahren zu ihrer herstellung und verwendung
EP1986685A4 (de) Zusammensetzungen zur ausgabe eines impfstoffs und anwendungsverfahren dafür
EP1796537A4 (de) Dendrimer-basierte zusammensetzungen und verfahren zu ihrer verwendung
EP2152293A4 (de) Zusammensetzungen zur proteinabgabe und verfahren zu deren verwendung
EP2233511A4 (de) Neue polymerpartikel und ihre anwendung
EP2056835A4 (de) Pharmazeutische zusammensetzungen und ihre verwendungen
EP2064550A4 (de) Prrg4-assoziierte zusammensetzungen und verfahren zu ihrer verwendung für tumordiagnoseverfahren
EP1735456A4 (de) Polymerische zusammensetzung und damit verbundenes verwendungsverfahren
EP1966246A4 (de) Verfahren und zusammensetzungen zur nadellosen verabreichung von antikörpern
EP2142216A4 (de) Partikelformulierungen und ihre verwendungen
EP1890677A4 (de) Pharmazeutische zusammensetzungen und ihre verwendung

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20070817

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC NL PL PT RO SE SI SK TR

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20111011

RIC1 Information provided on ipc code assigned before grant

Ipc: C08L 75/02 20060101ALI20111005BHEP

Ipc: C08L 75/04 20060101ALI20111005BHEP

Ipc: A61K 9/16 20060101ALI20111005BHEP

Ipc: A61K 47/48 20060101ALI20111005BHEP

Ipc: A61K 9/51 20060101ALI20111005BHEP

Ipc: C08L 75/06 20060101ALI20111005BHEP

Ipc: A61L 31/00 20060101ALI20111005BHEP

Ipc: A61F 2/00 20060101ALI20111005BHEP

Ipc: C12N 15/88 20060101ALI20111005BHEP

Ipc: C08L 77/12 20060101ALI20111005BHEP

Ipc: C07K 16/28 20060101ALI20111005BHEP

Ipc: A61K 9/107 20060101ALI20111005BHEP

Ipc: A61K 47/34 20060101ALI20111005BHEP

Ipc: A61K 9/50 20060101ALI20111005BHEP

Ipc: C08L 77/00 20060101AFI20111005BHEP

Ipc: C08G 18/10 20060101ALI20111005BHEP

Ipc: C08G 69/44 20060101ALI20111005BHEP

17Q First examination report despatched

Effective date: 20121022

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

RIC1 Information provided on ipc code assigned before grant

Ipc: C08L 75/04 20060101ALI20170202BHEP

Ipc: C08G 69/44 20060101ALI20170202BHEP

Ipc: A61K 9/51 20060101ALI20170202BHEP

Ipc: A61K 9/16 20060101ALI20170202BHEP

Ipc: C07K 16/28 20060101ALI20170202BHEP

Ipc: A61K 9/50 20060101ALI20170202BHEP

Ipc: C12N 15/88 20060101ALI20170202BHEP

Ipc: C08G 18/10 20060101ALI20170202BHEP

Ipc: A61F 2/00 20060101ALI20170202BHEP

Ipc: C08L 77/00 20060101AFI20170202BHEP

Ipc: C08L 75/02 20060101ALI20170202BHEP

Ipc: C08L 77/12 20060101ALI20170202BHEP

Ipc: A61L 31/00 20060101ALI20170202BHEP

Ipc: A61K 9/107 20060101ALI20170202BHEP

Ipc: A61K 47/34 20170101ALI20170202BHEP

Ipc: C08L 75/06 20060101ALI20170202BHEP

INTG Intention to grant announced

Effective date: 20170220

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20170704