DE60214173D1 - Negativ geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit postitiv geladenem arzneistoff - Google Patents

Negativ geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit postitiv geladenem arzneistoff

Info

Publication number
DE60214173D1
DE60214173D1 DE60214173T DE60214173T DE60214173D1 DE 60214173 D1 DE60214173 D1 DE 60214173D1 DE 60214173 T DE60214173 T DE 60214173T DE 60214173 T DE60214173 T DE 60214173T DE 60214173 D1 DE60214173 D1 DE 60214173D1
Authority
DE
Germany
Prior art keywords
loaded
block copolymer
amphiphiles
negatively
complex
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60214173T
Other languages
English (en)
Other versions
DE60214173T2 (de
Inventor
Min-Hyo Seo
In-Ja Choi
Han-Uk Kong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Samyang Biopharmaceuticals Corp
Original Assignee
Samyang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Corp filed Critical Samyang Corp
Publication of DE60214173D1 publication Critical patent/DE60214173D1/de
Application granted granted Critical
Publication of DE60214173T2 publication Critical patent/DE60214173T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
DE60214173T 2001-06-25 2002-06-05 Negativ geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit postitiv geladenem arzneistoff Expired - Lifetime DE60214173T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020010036203A KR100566911B1 (ko) 2001-06-25 2001-06-25 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체
KR2001036203 2001-06-25
PCT/KR2002/001074 WO2003000778A1 (en) 2001-06-25 2002-06-05 Negatively charged amphiphilic block copolymer as drug carrier and complex thereof with positively charged drug

Publications (2)

Publication Number Publication Date
DE60214173D1 true DE60214173D1 (de) 2006-10-05
DE60214173T2 DE60214173T2 (de) 2007-08-23

Family

ID=36792807

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60214173T Expired - Lifetime DE60214173T2 (de) 2001-06-25 2002-06-05 Negativ geladenes amphiphiles blockcopolymer als arzneistoffträger und komplex davon mit postitiv geladenem arzneistoff

Country Status (17)

Country Link
US (1) US6890560B2 (de)
EP (1) EP1399501B1 (de)
JP (1) JP4154328B2 (de)
KR (1) KR100566911B1 (de)
CN (1) CN1226332C (de)
AT (1) ATE337357T1 (de)
AU (1) AU2002303027C1 (de)
BR (1) BRPI0210335B8 (de)
CA (1) CA2449244C (de)
DE (1) DE60214173T2 (de)
ES (1) ES2269694T3 (de)
HK (1) HK1067950A1 (de)
IL (2) IL159166A0 (de)
MX (1) MXPA03011619A (de)
NZ (1) NZ530176A (de)
WO (1) WO2003000778A1 (de)
ZA (1) ZA200309357B (de)

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US7763663B2 (en) * 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
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US20050170004A1 (en) * 2003-10-31 2005-08-04 Vered Rosenberger Nanoparticles for drug delivery
KR100775343B1 (ko) 2003-11-13 2007-11-08 한미약품 주식회사 면역글로불린 Ｆｃ 영역을 캐리어로 포함하는 약제학적조성물
US7179867B2 (en) * 2003-11-26 2007-02-20 Industrial Technology Research Institute Thermosensitive biodegradable copolymer
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KR100773470B1 (ko) * 2005-04-25 2007-11-05 김태균 층간 소음 방지를 위한 방음판 구조
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
ES2338820T3 (es) 2006-03-09 2010-05-12 Coloplast A/S Copolimeros en bloque hidrofilos degradables con biocompatibilidad mejorada para la regeneracion de tejidos blandos.
EP2494958A1 (de) 2006-12-01 2012-09-05 Anterios, Inc. Nanopartikel aus amphiphilen Einheiten
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CN103961315A (zh) 2007-05-31 2014-08-06 安特里奥公司 核酸纳米粒子和其用途
WO2009078755A1 (en) * 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
WO2009078756A1 (en) * 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
EP2285853B1 (de) * 2008-05-13 2013-02-27 University of Washington Micellenanordnungen
US8652506B2 (en) * 2008-06-05 2014-02-18 Boston Scientific Scimed, Inc. Bio-degradable block co-polymers for controlled release
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KR101249389B1 (ko) * 2010-10-28 2013-04-03 재단법인대구경북과학기술원 자극반응성 수화젤
KR101685646B1 (ko) * 2010-12-29 2016-12-13 한화케미칼 주식회사 홍합 접착단백질 모방을 통한 나노입자를 수계 매질에 분산시키는 생체적합성 분산 안정화제
KR101230598B1 (ko) 2011-02-28 2013-02-15 부산대학교 산학협력단 페하 응답성을 가지는 히스트딘이 공유결합된 덱스트란과 메톡시폴리에틸렌글리콜 블록공중합체
EP3027221A1 (de) 2013-07-30 2016-06-08 PhaseRx, Inc. Blockcopolymere und deren konjugate oder komplexe mit oligonukleotiden
US9657059B2 (en) 2013-09-09 2017-05-23 Canimguide Therapeutics Ab Immune system modulators
US10881709B2 (en) 2015-03-06 2021-01-05 Canimguide Therapeutics Ab Immune system modulators and compositions
CN105362251B (zh) * 2015-12-14 2019-02-26 四川大学 DOTAP-mPEG-PLA纳米粒及其纳米粒溶液、载药复合物和制备方法和应用
BR112019010131A2 (pt) 2016-11-21 2019-10-08 Eirion Therapeutics Inc entrega transdérmica de agentes grandes
US11684584B2 (en) 2016-12-30 2023-06-27 Genevant Sciences Gmbh Branched peg molecules and related compositions and methods
US11590080B2 (en) 2017-12-18 2023-02-28 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
EP4000604B1 (de) * 2017-12-18 2023-08-23 C. R. Bard, Inc. Arzneimittelbeladene mikrokügelchenzusammensetzungen, embolisationszusammensetzungen und zugehörige verfahren
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Also Published As

Publication number Publication date
CA2449244A1 (en) 2003-01-03
BRPI0210335B8 (pt) 2021-05-25
US20030017206A1 (en) 2003-01-23
CN1226332C (zh) 2005-11-09
IL159166A (en) 2007-12-03
EP1399501A4 (de) 2005-02-16
US6890560B2 (en) 2005-05-10
MXPA03011619A (es) 2004-04-05
CA2449244C (en) 2007-10-02
JP2004530768A (ja) 2004-10-07
AU2002303027C1 (en) 2006-06-01
CN1520437A (zh) 2004-08-11
ATE337357T1 (de) 2006-09-15
NZ530176A (en) 2005-06-24
ES2269694T3 (es) 2007-04-01
HK1067950A1 (en) 2005-04-22
WO2003000778A1 (en) 2003-01-03
JP4154328B2 (ja) 2008-09-24
BR0210335B1 (pt) 2014-06-24
KR100566911B1 (ko) 2006-04-03
EP1399501A1 (de) 2004-03-24
BR0210335A (pt) 2004-07-20
KR20030000433A (ko) 2003-01-06
DE60214173T2 (de) 2007-08-23
EP1399501B1 (de) 2006-08-23
ZA200309357B (en) 2005-05-25
IL159166A0 (en) 2004-06-01
AU2002303027B2 (en) 2005-06-09

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