BRPI0210335B8 - copolímero de blocos, e, composição - Google Patents

copolímero de blocos, e, composição

Info

Publication number
BRPI0210335B8
BRPI0210335B8 BRPI0210335A BR0210335A BRPI0210335B8 BR PI0210335 B8 BRPI0210335 B8 BR PI0210335B8 BR PI0210335 A BRPI0210335 A BR PI0210335A BR 0210335 A BR0210335 A BR 0210335A BR PI0210335 B8 BRPI0210335 B8 BR PI0210335B8
Authority
BR
Brazil
Prior art keywords
block copolymer
composition
drug
provides
biocompatible
Prior art date
Application number
BRPI0210335A
Other languages
English (en)
Other versions
BR0210335A (pt
BR0210335B1 (pt
Inventor
Kong Han-Uk
Choi In-Ja
Seo Min-Hyo
Original Assignee
Samyang Biopharmaceuticals
Samyang Corp
Samyang Holdings Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samyang Biopharmaceuticals, Samyang Corp, Samyang Holdings Corp filed Critical Samyang Biopharmaceuticals
Publication of BR0210335A publication Critical patent/BR0210335A/pt
Publication of BR0210335B1 publication Critical patent/BR0210335B1/pt
Publication of BRPI0210335B8 publication Critical patent/BRPI0210335B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"copolímero de blocos, e, composição". a presente invenção fornece um copolímero de blocos anfifílico contendo grupo aniônico, que é biocompatível e biodegradável e, quando usado como um carreador de medicamento para um medicamento catiônico, proporciona várias vantagens, tais como concentração sangüínea aumentada e estabilidade melhorada do medicamento.
BRPI0210335A 2001-06-25 2002-06-05 copolímero de blocos, e, composição BRPI0210335B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR2001/36203 2001-06-25
KR1020010036203A KR100566911B1 (ko) 2001-06-25 2001-06-25 약물 전달체용 음이온기-함유 양친성 블록 공중합체 및 그의 양이온성 약물과의 복합체
PCT/KR2002/001074 WO2003000778A1 (en) 2001-06-25 2002-06-05 Negatively charged amphiphilic block copolymer as drug carrier and complex thereof with positively charged drug

Publications (3)

Publication Number Publication Date
BR0210335A BR0210335A (pt) 2004-07-20
BR0210335B1 BR0210335B1 (pt) 2014-06-24
BRPI0210335B8 true BRPI0210335B8 (pt) 2021-05-25

Family

ID=36792807

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0210335A BRPI0210335B8 (pt) 2001-06-25 2002-06-05 copolímero de blocos, e, composição

Country Status (17)

Country Link
US (1) US6890560B2 (pt)
EP (1) EP1399501B1 (pt)
JP (1) JP4154328B2 (pt)
KR (1) KR100566911B1 (pt)
CN (1) CN1226332C (pt)
AT (1) ATE337357T1 (pt)
AU (1) AU2002303027C1 (pt)
BR (1) BRPI0210335B8 (pt)
CA (1) CA2449244C (pt)
DE (1) DE60214173T2 (pt)
ES (1) ES2269694T3 (pt)
HK (1) HK1067950A1 (pt)
IL (2) IL159166A0 (pt)
MX (1) MXPA03011619A (pt)
NZ (1) NZ530176A (pt)
WO (1) WO2003000778A1 (pt)
ZA (1) ZA200309357B (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523544A (ja) * 2000-02-17 2003-08-05 レックスマーク・インターナショナル・インコーポレーテツド 導電性駆動ハブを備えたトナーカートリッジ
US7763663B2 (en) * 2001-12-19 2010-07-27 University Of Massachusetts Polysaccharide-containing block copolymer particles and uses thereof
US7311901B2 (en) 2003-10-10 2007-12-25 Samyang Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
CA2541445A1 (en) * 2003-10-31 2005-05-12 Teva Pharmaceutical Industries Ltd. Nanoparticles for drug delivery
DK2256134T3 (en) 2003-11-13 2014-02-24 Hanmi Science Co Ltd IgG Fc fragment to a drug carrier and process for preparation thereof
US7179867B2 (en) * 2003-11-26 2007-02-20 Industrial Technology Research Institute Thermosensitive biodegradable copolymer
ES2311226T3 (es) * 2004-05-05 2009-02-01 Firmenich Sa Copolimeros injertados biodegradables.
WO2006096814A2 (en) * 2005-03-08 2006-09-14 Akrion, Inc. Method and system for processing substrates with sonic energy that reduces or eliminates damage to semiconductor devices
KR100773470B1 (ko) * 2005-04-25 2007-11-05 김태균 층간 소음 방지를 위한 방음판 구조
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
CN101400717B (zh) 2006-03-09 2011-08-31 科洛普拉斯特公司 具有用于软组织再生的改进生物相容性的可降解亲水嵌段共聚物
US20100150994A1 (en) 2006-12-01 2010-06-17 Anterios, Inc. Amphiphilic entity nanoparticles
JP5292304B2 (ja) * 2006-12-01 2013-09-18 アンテリオス， インコーポレイテッド ペプチドナノ粒子およびその使用
KR100918524B1 (ko) * 2007-02-14 2009-09-21 성균관대학교산학협력단 온도 및 피에치 민감성 블록공중합체 고분자 하이드로겔을이용한 주사가능한 약물전달체 및 약물전달방법
KR20100050443A (ko) 2007-05-31 2010-05-13 안테리오스, 인코퍼레이티드 핵산 나노입자 및 이의 용도
WO2009078756A1 (en) * 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
WO2009078755A1 (en) * 2007-12-19 2009-06-25 Ardenia Investments, Ltd. Drug delivery system for administration of a water soluble, cationic and amphiphilic pharmaceutically active substance
CA2724014C (en) * 2008-05-13 2016-09-13 University Of Washington Micellic assemblies
US8652506B2 (en) * 2008-06-05 2014-02-18 Boston Scientific Scimed, Inc. Bio-degradable block co-polymers for controlled release
US20110212157A1 (en) * 2008-06-26 2011-09-01 Anterios, Inc. Dermal delivery
JP5866117B2 (ja) 2009-04-06 2016-02-17 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 分子を送達するための方法および材料
KR101220162B1 (ko) * 2009-07-02 2013-01-14 한양대학교 산학협력단 아르기닌―기제 양친성 펩티드 마이셀
KR101249389B1 (ko) * 2010-10-28 2013-04-03 재단법인대구경북과학기술원 자극반응성 수화젤
KR101685646B1 (ko) * 2010-12-29 2016-12-13 한화케미칼 주식회사 홍합 접착단백질 모방을 통한 나노입자를 수계 매질에 분산시키는 생체적합성 분산 안정화제
KR101230598B1 (ko) 2011-02-28 2013-02-15 부산대학교 산학협력단 페하 응답성을 가지는 히스트딘이 공유결합된 덱스트란과 메톡시폴리에틸렌글리콜 블록공중합체
EP3027221A1 (en) 2013-07-30 2016-06-08 PhaseRx, Inc. Block copolymers and their conjugates or complexes with oligonucleotides
CN111732652A (zh) 2013-09-09 2020-10-02 卡尼姆盖德治疗学公司 免疫系统调节器
AU2016229309B2 (en) 2015-03-06 2021-12-02 Canimguide Therapeutics Ab Immune system modulators and compositions
CN105362251B (zh) * 2015-12-14 2019-02-26 四川大学 DOTAP-mPEG-PLA纳米粒及其纳米粒溶液、载药复合物和制备方法和应用
KR102487144B1 (ko) 2016-11-21 2023-01-12 에이리온 테라퓨틱스, 인코포레이티드 큰 물질의 경피 전달
US11684584B2 (en) 2016-12-30 2023-06-27 Genevant Sciences Gmbh Branched peg molecules and related compositions and methods
US11590080B2 (en) 2017-12-18 2023-02-28 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
JP2021506871A (ja) * 2017-12-18 2021-02-22 シー・アール・バード・インコーポレーテッドＣ Ｒ Ｂａｒｄ Ｉｎｃｏｒｐｏｒａｔｅｄ 薬物充填マイクロビーズ組成物、塞栓組成物および関連の方法
CN110742903B (zh) * 2019-11-22 2021-06-01 兰州大学 含铑(ⅰ)的聚合物胶束、其制备方法与应用
CN118159252A (zh) 2021-08-05 2024-06-07 美蒂森股份公司 药物组合物
WO2023076284A1 (en) * 2021-10-25 2023-05-04 The Secant Group, Llc Polymeric delivery systems

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3677019D1 (de) 1986-11-21 1991-02-21 Agfa Gevaert Nv Oberflaechenaktives polymer.
US5035972A (en) 1989-10-31 1991-07-30 E. I. Du Pont De Nemours And Company AB diblock copolymers as charge directors for negative electrostatic liquid developer
CA2029631A1 (en) * 1989-11-22 1991-05-23 Kathleen A. Hughes Graft polymers as biodegradable detergent additives
NL9100218A (nl) * 1991-02-07 1992-09-01 Philips Nv Encodeer/decodeer-schakeling, alsmede digitaal video-systeem voorzien van de schakeling.
US5567410A (en) * 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging
US5783178A (en) 1994-11-18 1998-07-21 Supratek Pharma. Inc. Polymer linked biological agents
JP2690276B2 (ja) 1995-01-10 1997-12-10 科学技術振興事業団 静電結合型高分子ミセル薬物担体とその薬剤
US5569448A (en) 1995-01-24 1996-10-29 Nano Systems L.L.C. Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions
US6201065B1 (en) 1995-07-28 2001-03-13 Focal, Inc. Multiblock biodegradable hydrogels for drug delivery and tissue treatment
WO1997006202A1 (fr) 1995-08-10 1997-02-20 Kazunori Kataoka Polymere sequence pourvu de groupes fonctionnels aux deux extremites
KR0180334B1 (ko) * 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
AU3585397A (en) * 1996-06-27 1998-01-14 G.D. Searle & Co. Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
WO1998056334A1 (en) * 1997-06-13 1998-12-17 University Of Nebraska Board Of Regents Compositions for delivery of biological agents and methods for the preparation thereof
US6004573A (en) * 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6201072B1 (en) * 1997-10-03 2001-03-13 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6117949A (en) * 1998-10-01 2000-09-12 Macromed, Inc. Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
AU1819499A (en) * 1997-12-12 1999-06-28 Samyang Corporation Positively-charged poly{alpha-(omega-aminoalkyl)glycolic acid} for the delivery of a bioactive agent via tissue and cellular uptake
DE69840175D1 (de) * 1997-12-12 2008-12-11 Samyang Corp Biologisch abbaubare gemischte polymerische mizellen zur genverabreichung
US5939453A (en) 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6715874B1 (en) * 1999-02-08 2004-04-06 Novartis Ag Organic polymers

Also Published As

Publication number Publication date
US20030017206A1 (en) 2003-01-23
DE60214173D1 (de) 2006-10-05
US6890560B2 (en) 2005-05-10
MXPA03011619A (es) 2004-04-05
ZA200309357B (en) 2005-05-25
KR100566911B1 (ko) 2006-04-03
EP1399501B1 (en) 2006-08-23
BR0210335A (pt) 2004-07-20
JP4154328B2 (ja) 2008-09-24
AU2002303027B2 (en) 2005-06-09
CN1520437A (zh) 2004-08-11
BR0210335B1 (pt) 2014-06-24
KR20030000433A (ko) 2003-01-06
ATE337357T1 (de) 2006-09-15
CN1226332C (zh) 2005-11-09
AU2002303027C1 (en) 2006-06-01
JP2004530768A (ja) 2004-10-07
DE60214173T2 (de) 2007-08-23
ES2269694T3 (es) 2007-04-01
CA2449244A1 (en) 2003-01-03
WO2003000778A1 (en) 2003-01-03
CA2449244C (en) 2007-10-02
HK1067950A1 (en) 2005-04-22
EP1399501A1 (en) 2004-03-24
NZ530176A (en) 2005-06-24
IL159166A (en) 2007-12-03
IL159166A0 (en) 2004-06-01
EP1399501A4 (en) 2005-02-16

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B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
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B25D Requested change of name of applicant approved

Owner name: SAMYANG HOLDINGS CORPORATION (KR)

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Owner name: SAMYANG BIOPHARMACEUTICALS CORPORATION (KR)

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