CN1531566A - 作为药物载体的带正电的两亲嵌段共聚物及其与带负电的药物的络合物 - Google Patents
作为药物载体的带正电的两亲嵌段共聚物及其与带负电的药物的络合物 Download PDFInfo
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- CN1531566A CN1531566A CNA028141652A CN02814165A CN1531566A CN 1531566 A CN1531566 A CN 1531566A CN A028141652 A CNA028141652 A CN A028141652A CN 02814165 A CN02814165 A CN 02814165A CN 1531566 A CN1531566 A CN 1531566A
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- methylpropyl
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- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
- C08G81/02—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
制备 | 嵌段共聚物 | 数均分子量(道尔顿) |
1 | mPEG-PLA-OH | 2000-1765 |
2 | mPEG-PLGA-OH | 5000-4500 |
3 | mPEG-PLDO-OH | 12000-5400 |
4 | mPEG-PCL-OH | 12000-5000 |
实施例 | 嵌段共聚物 | 数均分子量(道尔顿) | |
A | B | ||
1 | mPEG-PLA-O-C(=O)CH2-NH3 +·Cl- | 2000 | 1765 |
2 | mPEG-PLGA-O-C(=O)CHCH3-NH3 +·Cl- | 5000 | 4500 |
3 | mPEG-PLDO-O-C(=O)CH(CH2Ph)-NH3 +·Cl- | 12000 | 5400 |
4 | mPEG-PCL-O-C(=O)CH(CH2Ph)-NH3 +·Cl- | 12000 | 5000 |
实施例 | 嵌段共聚物 | 数均分子量(道尔顿) | |
A | B | ||
5 | mPEG-PLA-O-C(=O)(CH2)2C(=O)-O-CH2CH2N+H3·Cl- | 2000 | 1765 |
6 | mPEG-PLGA-O-C(=O)(CH2)3C(=O)-O-CH2CH2N+(CH3)H2·Cl- | 5000 | 4500 |
7 | mPEG-PCL-O-C(=O)(CH2)6C(=O)-O-CH2CH2N+(CH3)2H·Cl- | 12000 | 5000 |
8 | mPEG-PLDO-O-C(=O)(CH2)2C(=O)-O-CH2CH2N+(CH3)3·Cl- | 12000 | 5400 |
9 | mPEG-PLA-O-C(=O)(CH2)2C(=O)-O-CH2CH2N+(CH3)H2·Cl- | 2000 | 1765 |
10 | mPEG-PLA-O-C(=O)(CH2)2C(=O)-O-CH2CH2N+(CH3)2H·Cl- | 2000 | 1765 |
11 | mPEG-PLA-O-C(=O)(CH2)2C(=O)-O-CH2CH2N+(CH3)3·Cl- | 2000 | 1765 |
Claims (20)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR2001/42563 | 2001-07-14 | ||
KR20010042563 | 2001-07-14 |
Publications (2)
Publication Number | Publication Date |
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CN1531566A true CN1531566A (zh) | 2004-09-22 |
CN1220717C CN1220717C (zh) | 2005-09-28 |
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CNB028141652A Expired - Lifetime CN1220717C (zh) | 2001-07-14 | 2002-07-13 | 作为药物载体的带正电的两亲嵌段共聚物及其与带负电的药物的络合物 |
Country Status (13)
Country | Link |
---|---|
US (1) | US7226616B2 (zh) |
EP (1) | EP1406946B1 (zh) |
JP (1) | JP4015994B2 (zh) |
KR (1) | KR100527291B1 (zh) |
CN (1) | CN1220717C (zh) |
AT (1) | ATE365183T1 (zh) |
AU (1) | AU2002319922B2 (zh) |
CA (1) | CA2452827C (zh) |
DE (1) | DE60220796T2 (zh) |
ES (1) | ES2287297T3 (zh) |
MX (1) | MXPA04000317A (zh) |
NZ (1) | NZ530588A (zh) |
WO (1) | WO2003008480A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010121455A1 (zh) * | 2009-04-21 | 2010-10-28 | 财团法人工业技术研究院 | 使用包囊抗肿瘤药物的聚合胶束用于治疗肿瘤的药物组合物 |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004105799A1 (ja) * | 2003-05-29 | 2004-12-09 | Toudai Tlo, Ltd. | 安定化高分子ミセル |
ITMI20031872A1 (it) * | 2003-09-30 | 2005-04-01 | Mediolanum Farmaceutici Srl | Copolimeri di poliesteri e polivinilpirrolidone. |
AU2003272127A1 (en) * | 2003-10-24 | 2005-05-11 | Samyang Corporation | Polymeric composition for drug delivery |
ATE399625T1 (de) * | 2004-04-28 | 2008-07-15 | Plasbio Inc | Verfahren zum herstellen von abbaubaren polymeren |
US7576145B2 (en) | 2004-04-28 | 2009-08-18 | Plasbio, Inc. | Method for producing degradable polymers |
US8007775B2 (en) * | 2004-12-30 | 2011-08-30 | Advanced Cardiovascular Systems, Inc. | Polymers containing poly(hydroxyalkanoates) and agents for use with medical articles and methods of fabricating the same |
CN101137700B (zh) * | 2005-03-09 | 2012-07-18 | 东丽株式会社 | 微粒及医药组合物 |
KR100714458B1 (ko) * | 2005-11-24 | 2007-05-07 | 헤벨 주식회사 | 변전설비용 차단기 |
KR100918524B1 (ko) * | 2007-02-14 | 2009-09-21 | 성균관대학교산학협력단 | 온도 및 피에치 민감성 블록공중합체 고분자 하이드로겔을이용한 주사가능한 약물전달체 및 약물전달방법 |
US8652506B2 (en) * | 2008-06-05 | 2014-02-18 | Boston Scientific Scimed, Inc. | Bio-degradable block co-polymers for controlled release |
JP5814793B2 (ja) * | 2008-11-25 | 2015-11-17 | エコール ポリテクニク フェデラル ド ローザンヌ(エーペーエフエル) | ブロックコポリマーおよびその使用 |
MX2011010390A (es) * | 2009-03-30 | 2011-12-14 | Cerulean Pharma Inc | Conjugados, particulas, composiciones de agentes polimericos y metodos relacionados de uso. |
WO2010114770A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-agent conjugates, particles, compositions, and related methods of use |
WO2010114768A1 (en) * | 2009-03-30 | 2010-10-07 | Cerulean Pharma Inc. | Polymer-epothilone conjugates, particles, compositions, and related methods of use |
KR101249389B1 (ko) * | 2010-10-28 | 2013-04-03 | 재단법인대구경북과학기술원 | 자극반응성 수화젤 |
US10711106B2 (en) | 2013-07-25 | 2020-07-14 | The University Of Chicago | High aspect ratio nanofibril materials |
CN105362251B (zh) * | 2015-12-14 | 2019-02-26 | 四川大学 | DOTAP-mPEG-PLA纳米粒及其纳米粒溶液、载药复合物和制备方法和应用 |
WO2024009268A1 (en) * | 2022-07-07 | 2024-01-11 | Biorchestra Co., Ltd. | Micellar nanoparticles and uses thereof |
WO2024153108A1 (en) * | 2023-01-18 | 2024-07-25 | Original Biomedicals Co., Ltd. | Chelating complex micelle presenting antimicrobial activity against gram-negative bacteria and method for using thereof |
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EP0268705B1 (en) * | 1986-11-21 | 1991-01-16 | Agfa-Gevaert N.V. | Polymeric surfactant |
US5035972A (en) * | 1989-10-31 | 1991-07-30 | E. I. Du Pont De Nemours And Company | AB diblock copolymers as charge directors for negative electrostatic liquid developer |
US5783178A (en) * | 1994-11-18 | 1998-07-21 | Supratek Pharma. Inc. | Polymer linked biological agents |
JP2690276B2 (ja) | 1995-01-10 | 1997-12-10 | 科学技術振興事業団 | 静電結合型高分子ミセル薬物担体とその薬剤 |
US5569448A (en) * | 1995-01-24 | 1996-10-29 | Nano Systems L.L.C. | Sulfated nonionic block copolymer surfactants as stabilizer coatings for nanoparticle compositions |
JPH11510837A (ja) * | 1995-07-28 | 1999-09-21 | フォーカル,インコーポレイテッド | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
SI9620107A (sl) * | 1995-08-10 | 1998-10-31 | Kazunori Kataoka | Blok polimer, ki ima funkcionalne skupine na obeh svojih koncih |
KR0180334B1 (ko) | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
ES2239408T3 (es) | 1997-10-03 | 2005-09-16 | Macromed Inc. | Copolimeros tribloque de poli(lactido-co-glicolido) polietilenglicol de bajo peso molecular biodegradables con propiedades de gelificacion termica inversa. |
US6201072B1 (en) * | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US5939453A (en) * | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
JP2003520810A (ja) * | 2000-01-28 | 2003-07-08 | インファイムド セラピューティクス インコーポレイテッド | 徐放性タンパク質ポリマー |
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- 2002-07-13 ES ES02749399T patent/ES2287297T3/es not_active Expired - Lifetime
- 2002-07-13 WO PCT/KR2002/001328 patent/WO2003008480A1/en active IP Right Grant
- 2002-07-13 MX MXPA04000317A patent/MXPA04000317A/es active IP Right Grant
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- 2002-07-13 CA CA002452827A patent/CA2452827C/en not_active Expired - Fee Related
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010121455A1 (zh) * | 2009-04-21 | 2010-10-28 | 财团法人工业技术研究院 | 使用包囊抗肿瘤药物的聚合胶束用于治疗肿瘤的药物组合物 |
US8420119B2 (en) | 2009-04-21 | 2013-04-16 | Industrial Technology Research Institute | Drug composition for treating tumor with polymeric micelle encapsulating anti-neoplastic |
Also Published As
Publication number | Publication date |
---|---|
US20040234494A1 (en) | 2004-11-25 |
NZ530588A (en) | 2005-06-24 |
MXPA04000317A (es) | 2004-05-04 |
CN1220717C (zh) | 2005-09-28 |
ES2287297T3 (es) | 2007-12-16 |
ATE365183T1 (de) | 2007-07-15 |
AU2002319922B2 (en) | 2004-12-16 |
DE60220796T2 (de) | 2007-10-18 |
JP4015994B2 (ja) | 2007-11-28 |
KR20030007176A (ko) | 2003-01-23 |
JP2004536189A (ja) | 2004-12-02 |
DE60220796D1 (de) | 2007-08-02 |
EP1406946A1 (en) | 2004-04-14 |
WO2003008480A1 (en) | 2003-01-30 |
KR100527291B1 (ko) | 2005-11-09 |
EP1406946B1 (en) | 2007-06-20 |
CA2452827A1 (en) | 2003-01-30 |
CA2452827C (en) | 2009-12-08 |
US7226616B2 (en) | 2007-06-05 |
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