AU758475B2 - Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties - Google Patents
Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties Download PDFInfo
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- AU758475B2 AU758475B2 AU10983/00A AU1098300A AU758475B2 AU 758475 B2 AU758475 B2 AU 758475B2 AU 10983/00 A AU10983/00 A AU 10983/00A AU 1098300 A AU1098300 A AU 1098300A AU 758475 B2 AU758475 B2 AU 758475B2
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- Prior art keywords
- drug
- polymer
- lactide
- block
- biodegradable
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- 239000002202 Polyethylene glycol Substances 0.000 title claims abstract description 41
- 230000002441 reversible effect Effects 0.000 title claims abstract description 36
- 238000001248 thermal gelation Methods 0.000 title claims abstract description 30
- 229920000728 polyester Polymers 0.000 title description 8
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- 229940079593 drug Drugs 0.000 claims abstract description 98
- 239000000203 mixture Substances 0.000 claims abstract description 49
- 230000002209 hydrophobic effect Effects 0.000 claims abstract description 36
- 238000012377 drug delivery Methods 0.000 claims abstract description 21
- 229920000229 biodegradable polyester Polymers 0.000 claims abstract description 17
- 239000004622 biodegradable polyester Substances 0.000 claims abstract description 17
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/91—Polymers modified by chemical after-treatment
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
Landscapes
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Neurosurgery (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyesters Or Polycarbonates (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/164,865 US6117949A (en) | 1998-10-01 | 1998-10-01 | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US09/164865 | 1998-10-01 | ||
| US09/396,589 US6201072B1 (en) | 1997-10-03 | 1999-09-15 | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US09/396589 | 1999-09-15 | ||
| PCT/US1999/022755 WO2000018821A1 (en) | 1998-10-01 | 1999-09-30 | Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU1098300A AU1098300A (en) | 2000-04-17 |
| AU758475B2 true AU758475B2 (en) | 2003-03-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU10983/00A Ceased AU758475B2 (en) | 1998-10-01 | 1999-09-30 | Biodegradable low molecular weight triblock polyester polyethylene glycol copolymers having reverse thermal gelation properties |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6201072B1 (enExample) |
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