CN1161353C - 帕罗西汀的制备方法 - Google Patents

帕罗西汀的制备方法 Download PDF

Info

Publication number
CN1161353C
CN1161353C CNB008041873A CN00804187A CN1161353C CN 1161353 C CN1161353 C CN 1161353C CN B008041873 A CNB008041873 A CN B008041873A CN 00804187 A CN00804187 A CN 00804187A CN 1161353 C CN1161353 C CN 1161353C
Authority
CN
China
Prior art keywords
binap
paroxetine
mixture
compound
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB008041873A
Other languages
English (en)
Chinese (zh)
Other versions
CN1341113A (zh
Inventor
R����ϣ
R·罗希
S·特查塔
3
M·唐纳鲁玛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RECKORDATY CHEMICALS CORP
Original Assignee
RECKORDATY CHEMICALS CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RECKORDATY CHEMICALS CORP filed Critical RECKORDATY CHEMICALS CORP
Publication of CN1341113A publication Critical patent/CN1341113A/zh
Application granted granted Critical
Publication of CN1161353C publication Critical patent/CN1161353C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB008041873A 1999-02-23 2000-02-22 帕罗西汀的制备方法 Expired - Fee Related CN1161353C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000364A IT1308629B1 (it) 1999-02-23 1999-02-23 Processo per la produzione di paroxetina.
ITMI99A0000364 1999-02-23

Publications (2)

Publication Number Publication Date
CN1341113A CN1341113A (zh) 2002-03-20
CN1161353C true CN1161353C (zh) 2004-08-11

Family

ID=11382007

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB008041873A Expired - Fee Related CN1161353C (zh) 1999-02-23 2000-02-22 帕罗西汀的制备方法

Country Status (28)

Country Link
US (1) US6583287B1 (https=)
EP (1) EP1153023B1 (https=)
JP (1) JP2002537394A (https=)
KR (1) KR20010102366A (https=)
CN (1) CN1161353C (https=)
AT (1) ATE238295T1 (https=)
AU (1) AU759441B2 (https=)
BR (1) BR0008220A (https=)
CA (1) CA2361758A1 (https=)
CZ (1) CZ20012997A3 (https=)
DE (1) DE60002303T2 (https=)
DK (1) DK1153023T3 (https=)
ES (1) ES2195876T3 (https=)
HK (1) HK1040516B (https=)
HR (1) HRP20010608A2 (https=)
HU (1) HUP0105482A3 (https=)
IL (1) IL144883A (https=)
IT (1) IT1308629B1 (https=)
MX (1) MXPA01008502A (https=)
NO (1) NO319724B1 (https=)
PL (1) PL349358A1 (https=)
PT (1) PT1153023E (https=)
RU (1) RU2242473C2 (https=)
SK (1) SK12042001A3 (https=)
TR (1) TR200102441T2 (https=)
TW (1) TWI221473B (https=)
WO (1) WO2000050422A1 (https=)
YU (1) YU60801A (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1571152B1 (en) * 2004-03-03 2007-08-08 CHEMI S.p.A. Amorphous 3-Pyridil-1-Hydroxyethyliden-1,1-Biphosphonic acid monosodium salt and process for the preparation thereof .
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
WO2013115163A1 (ja) * 2012-01-31 2013-08-08 エーザイ・アール・アンド・ディー・マネジメント株式会社 パロキセチン誘導体
CN106831736A (zh) * 2017-02-15 2017-06-13 浙江华海药业股份有限公司 一种制备帕罗西汀杂质的方法
CN112521377A (zh) * 2020-11-26 2021-03-19 北京福元医药股份有限公司 一种盐酸帕罗西汀的连续化制备方法
CN115260153B (zh) * 2022-07-21 2023-10-27 威尚（上海）生物医药有限公司 一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0757758B2 (ja) 1988-10-24 1995-06-21 高砂香料工業株式会社 ルテニウム―ホスフィン錯体
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
US5233084A (en) * 1989-06-22 1993-08-03 Monsanto Company Method for preparing α-arylpropionic acids
FR2651152B1 (fr) * 1989-08-23 1991-11-29 Elf Aquitaine Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore.
GB9209687D0 (en) * 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
DE4422672A1 (de) * 1994-06-30 1996-01-04 Hoechst Ag Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung
AR001982A1 (es) * 1995-02-06 1998-01-07 Smithkline Beecham Plc Clorhidrato de paroxetina anhidratado, y procedimiento para su preparacion
CN1068597C (zh) 1995-05-17 2001-07-18 诺沃挪第克公司 制备4－芳基－哌啶衍生物的方法
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
WO1998050359A1 (en) * 1997-05-06 1998-11-12 Novo Nordisk A/S Novel heterocyclic compounds
ES2212287T3 (es) * 1997-05-20 2004-07-16 Firmenich Sa Catalizadores de rutenio y su uso en la hidrogenacion asimetrica de sustratos debilmente coordinantes.

Also Published As

Publication number Publication date
ATE238295T1 (de) 2003-05-15
CZ20012997A3 (cs) 2001-11-14
DK1153023T3 (da) 2003-08-11
HK1040516B (en) 2003-10-31
DE60002303T2 (de) 2004-04-01
HUP0105482A3 (en) 2002-11-28
SK12042001A3 (sk) 2001-12-03
MXPA01008502A (es) 2003-06-06
HK1040516A1 (en) 2002-06-14
EP1153023B1 (en) 2003-04-23
ITMI990364A1 (it) 2000-08-23
WO2000050422A1 (en) 2000-08-31
YU60801A (sh) 2005-07-19
NO20014078D0 (no) 2001-08-22
CN1341113A (zh) 2002-03-20
HRP20010608A2 (en) 2002-08-31
KR20010102366A (ko) 2001-11-15
BR0008220A (pt) 2001-11-06
AU3158300A (en) 2000-09-14
CA2361758A1 (en) 2000-08-31
NO319724B1 (no) 2005-09-05
HUP0105482A2 (en) 2002-08-28
TWI221473B (en) 2004-10-01
ES2195876T3 (es) 2003-12-16
IL144883A (en) 2004-12-15
DE60002303D1 (de) 2003-05-28
US6583287B1 (en) 2003-06-24
TR200102441T2 (tr) 2002-01-21
JP2002537394A (ja) 2002-11-05
RU2242473C2 (ru) 2004-12-20
PL349358A1 (en) 2002-07-15
IT1308629B1 (it) 2002-01-09
IL144883A0 (en) 2002-06-30
AU759441B2 (en) 2003-04-17
PT1153023E (pt) 2003-09-30
EP1153023A1 (en) 2001-11-14
NO20014078L (no) 2001-10-18

Similar Documents

Publication Publication Date Title
CN1234679C (zh) 3,3－二芳基丙基胺衍生物的简化合成法
CN1108239A (zh) 杀虫(菌)剂及其中间体的制备方法
CN1625550A (zh) 制备有机化合物的方法
CN1161353C (zh) 帕罗西汀的制备方法
CN1148382A (zh) 用于光学拆分外消旋α-[4-(1，1-二甲基乙基)苯基]-4-(羟基二苯基甲基)-1-哌啶丁醇和其衍生化合物的方法和非对映体盐
CN1268889A (zh) 新方法
EP3350173B1 (en) Stereoselective process
CN1047167C (zh) 用于制备毒扁豆碱的中间体的对映选择性合成方法
CN1160350C (zh) 制备手性内酯的方法
JP2002537394A5 (https=)
CN1360574A (zh) 制备三环氨基醇衍生物的方法
CN1212327C (zh) N－保护的－3－吡咯烷－内酰胺取代的鏻盐的制备
JP2008506746A (ja) ジアステレオマーに富んだ化合物の調製方法
JPH09208558A (ja) 光学活性４−ヒドロキシ−２−ピロリドンの製造方法
CN1622932A (zh) 使用氨基环戊二烯合钌催化剂拆分手性化合物
CN1735588A (zh) 由d－和l－天冬氨酸合成(r)和(s)－氨基肉碱及其衍生物
CN1216054C (zh) 1,4－二氢吡啶－3,5－二羧酸衍生物及其制备方法
CN1946711A (zh) 制备咪唑化合物的非对映选择性合成方法
CN1930116A (zh) 手性叔氨基烷基萘酚
CN1946710A (zh) 用6－溴－4－(3－氯苯基)－2－甲氧基喹啉进行的非对映选择性合成方法
JP4931379B2 (ja) 光学活性アゼチジン−２−カルボン酸エステル類の製造方法
US20010053862A1 (en) Process for preparing arylpiperidine carbinol intermediates and derivatives
CN1258529C (zh) 制备二芳基－4－氨基－哌啶基化合物的方法
KR20080095476A (ko) 베타-메틸아제티디논의 제조방법
KR20040050942A (ko) 파록세틴의 제조방법

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee