IT1308629B1 - Processo per la produzione di paroxetina. - Google Patents
Processo per la produzione di paroxetina.Info
- Publication number
- IT1308629B1 IT1308629B1 IT1999MI000364A ITMI990364A IT1308629B1 IT 1308629 B1 IT1308629 B1 IT 1308629B1 IT 1999MI000364 A IT1999MI000364 A IT 1999MI000364A IT MI990364 A ITMI990364 A IT MI990364A IT 1308629 B1 IT1308629 B1 IT 1308629B1
- Authority
- IT
- Italy
- Prior art keywords
- paroxetine
- production
- paroxetin
- sesamol
- derivatisation
- Prior art date
Links
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 abstract 2
- 229960002296 paroxetine Drugs 0.000 abstract 2
- UIOFUWFRIANQPC-JKIFEVAISA-N Floxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl UIOFUWFRIANQPC-JKIFEVAISA-N 0.000 abstract 1
- LUSZGTFNYDARNI-UHFFFAOYSA-N Sesamol Natural products OC1=CC=C2OCOC2=C1 LUSZGTFNYDARNI-UHFFFAOYSA-N 0.000 abstract 1
- ZSYVGBLSRONTAI-UHFFFAOYSA-N [4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridin-3-yl]methanol Chemical class OCC1CNCC=C1C1=CC=C(F)C=C1 ZSYVGBLSRONTAI-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000006900 dealkylation reaction Methods 0.000 abstract 1
- 238000001212 derivatisation Methods 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (29)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000364A IT1308629B1 (it) | 1999-02-23 | 1999-02-23 | Processo per la produzione di paroxetina. |
| TW089102997A TWI221473B (en) | 1999-02-23 | 2000-02-18 | Process for the production of paroxetine |
| IL14488300A IL144883A (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
| BR0008220-1A BR0008220A (pt) | 1999-02-23 | 2000-02-22 | Processo para produção de paroxetina |
| TR2001/02441T TR200102441T2 (tr) | 1999-02-23 | 2000-02-22 | Paroksetin üretme süreci |
| PT00909228T PT1153023E (pt) | 1999-02-23 | 2000-02-22 | Processo de producao de paroxetine |
| DE60002303T DE60002303T2 (de) | 1999-02-23 | 2000-02-22 | Verfahren zur herstellung von paroxetin |
| HK02101971.9A HK1040516B (en) | 1999-02-23 | 2000-02-22 | The preparation method of paroxetine |
| HU0105482A HUP0105482A3 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
| AT00909228T ATE238295T1 (de) | 1999-02-23 | 2000-02-22 | Verfahren zur herstellung von paroxetin |
| DK00909228T DK1153023T3 (da) | 1999-02-23 | 2000-02-22 | Fremgangsmåde til fremstilling af paroxetin |
| PCT/EP2000/001430 WO2000050422A1 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
| PL00349358A PL349358A1 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
| CZ20012997A CZ20012997A3 (cs) | 1999-02-23 | 2000-02-22 | Způsob přípravy paroxetinu |
| CNB008041873A CN1161353C (zh) | 1999-02-23 | 2000-02-22 | 帕罗西汀的制备方法 |
| YU60801A YU60801A (sh) | 1999-02-23 | 2000-02-22 | Postupak za dobijanje paroksetina |
| HR20010608A HRP20010608A2 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
| ES00909228T ES2195876T3 (es) | 1999-02-23 | 2000-02-22 | Procedimiento para la produccion de paroxetina. |
| CA002361758A CA2361758A1 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
| JP2000601002A JP2002537394A (ja) | 1999-02-23 | 2000-02-22 | パロキセチンの製造方法 |
| AU31583/00A AU759441B2 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
| KR1020017010760A KR20010102366A (ko) | 1999-02-23 | 2000-02-22 | 파록세틴의 제조방법 |
| US09/890,414 US6583287B1 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
| EP00909228A EP1153023B1 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
| RU2001125933/04A RU2242473C2 (ru) | 1999-02-23 | 2000-02-22 | Способ получения пароксетина |
| SK1204-2001A SK12042001A3 (sk) | 1999-02-23 | 2000-02-22 | Spôsob prípravy paroxetínu |
| SI200030133T SI1153023T1 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
| MXPA01008502A MXPA01008502A (es) | 1999-02-23 | 2000-02-22 | Proceso para la produccion de paroxetina. |
| NO20014078A NO319724B1 (no) | 1999-02-23 | 2001-08-22 | Fremgangsmate for fremstilling av paroksetin |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000364A IT1308629B1 (it) | 1999-02-23 | 1999-02-23 | Processo per la produzione di paroxetina. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITMI990364A1 ITMI990364A1 (it) | 2000-08-23 |
| IT1308629B1 true IT1308629B1 (it) | 2002-01-09 |
Family
ID=11382007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1999MI000364A IT1308629B1 (it) | 1999-02-23 | 1999-02-23 | Processo per la produzione di paroxetina. |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6583287B1 (it) |
| EP (1) | EP1153023B1 (it) |
| JP (1) | JP2002537394A (it) |
| KR (1) | KR20010102366A (it) |
| CN (1) | CN1161353C (it) |
| AT (1) | ATE238295T1 (it) |
| AU (1) | AU759441B2 (it) |
| BR (1) | BR0008220A (it) |
| CA (1) | CA2361758A1 (it) |
| CZ (1) | CZ20012997A3 (it) |
| DE (1) | DE60002303T2 (it) |
| DK (1) | DK1153023T3 (it) |
| ES (1) | ES2195876T3 (it) |
| HK (1) | HK1040516B (it) |
| HR (1) | HRP20010608A2 (it) |
| HU (1) | HUP0105482A3 (it) |
| IL (1) | IL144883A (it) |
| IT (1) | IT1308629B1 (it) |
| MX (1) | MXPA01008502A (it) |
| NO (1) | NO319724B1 (it) |
| PL (1) | PL349358A1 (it) |
| PT (1) | PT1153023E (it) |
| RU (1) | RU2242473C2 (it) |
| SK (1) | SK12042001A3 (it) |
| TR (1) | TR200102441T2 (it) |
| TW (1) | TWI221473B (it) |
| WO (1) | WO2000050422A1 (it) |
| YU (1) | YU60801A (it) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005001873T2 (de) * | 2004-03-03 | 2008-04-24 | Chemi S.P.A., Cinisello Balsamo | Amorphe 3-Pyridyl-1-Hydroxyethyliden-1,1-Bisphosphonsäure Mononatriumsalz und Verfahren zu deren Herstellung |
| US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
| CN104039777B (zh) * | 2012-01-31 | 2016-03-02 | 卫材R&D管理有限公司 | 帕罗西汀衍生物 |
| CN106831736A (zh) * | 2017-02-15 | 2017-06-13 | 浙江华海药业股份有限公司 | 一种制备帕罗西汀杂质的方法 |
| CN112521377A (zh) * | 2020-11-26 | 2021-03-19 | 北京福元医药股份有限公司 | 一种盐酸帕罗西汀的连续化制备方法 |
| CN115260153B (zh) * | 2022-07-21 | 2023-10-27 | 威尚（上海）生物医药有限公司 | 一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0757758B2 (ja) | 1988-10-24 | 1995-06-21 | 高砂香料工業株式会社 | ルテニウム―ホスフィン錯体 |
| DK715988D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Etherifikation og dealkylering af piperidin-derivater samt intermediater |
| US5233084A (en) | 1989-06-22 | 1993-08-03 | Monsanto Company | Method for preparing α-arylpropionic acids |
| FR2651152B1 (fr) * | 1989-08-23 | 1991-11-29 | Elf Aquitaine | Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore. |
| GB9209687D0 (en) | 1992-05-06 | 1992-06-17 | Smithkline Beecham Plc | Novel process |
| DE4422672A1 (de) * | 1994-06-30 | 1996-01-04 | Hoechst Ag | Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung |
| SK283608B6 (sk) * | 1995-02-06 | 2003-10-07 | Smithkline Beecham Plc | Bezvodý hydrochlorid paroxetínu, spôsob jeho výroby a použitie |
| NZ307479A (en) * | 1995-05-17 | 1999-08-30 | Novo Nordisk As | A process for preparing 4-(4-halo substituted phenyl)-3-(3,4-methylenedioxy phenoxy methyl)piperidine derivatives |
| HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
| HUP0003362A3 (en) * | 1997-05-06 | 2001-04-28 | Novo Nordisk As | Piperidine derivatives and pharmaceutical compositions containing them |
| DE69820205T2 (de) * | 1997-05-20 | 2004-09-30 | Firmenich S.A. | Ruthenium-katalysatoren und ihre verwendung zur asymmetrischen hydrierung von substraten mit schwacher koordination |
-
1999
- 1999-02-23 IT IT1999MI000364A patent/IT1308629B1/it active
-
2000
- 2000-02-18 TW TW089102997A patent/TWI221473B/zh not_active IP Right Cessation
- 2000-02-22 PL PL00349358A patent/PL349358A1/xx not_active IP Right Cessation
- 2000-02-22 SK SK1204-2001A patent/SK12042001A3/sk unknown
- 2000-02-22 HR HR20010608A patent/HRP20010608A2/hr not_active Application Discontinuation
- 2000-02-22 KR KR1020017010760A patent/KR20010102366A/ko not_active Ceased
- 2000-02-22 US US09/890,414 patent/US6583287B1/en not_active Expired - Fee Related
- 2000-02-22 HK HK02101971.9A patent/HK1040516B/en not_active IP Right Cessation
- 2000-02-22 CN CNB008041873A patent/CN1161353C/zh not_active Expired - Fee Related
- 2000-02-22 IL IL14488300A patent/IL144883A/en not_active IP Right Cessation
- 2000-02-22 MX MXPA01008502A patent/MXPA01008502A/es active IP Right Grant
- 2000-02-22 BR BR0008220-1A patent/BR0008220A/pt not_active IP Right Cessation
- 2000-02-22 PT PT00909228T patent/PT1153023E/pt unknown
- 2000-02-22 EP EP00909228A patent/EP1153023B1/en not_active Expired - Lifetime
- 2000-02-22 ES ES00909228T patent/ES2195876T3/es not_active Expired - Lifetime
- 2000-02-22 JP JP2000601002A patent/JP2002537394A/ja active Pending
- 2000-02-22 YU YU60801A patent/YU60801A/sh unknown
- 2000-02-22 AU AU31583/00A patent/AU759441B2/en not_active Ceased
- 2000-02-22 RU RU2001125933/04A patent/RU2242473C2/ru not_active IP Right Cessation
- 2000-02-22 DE DE60002303T patent/DE60002303T2/de not_active Expired - Fee Related
- 2000-02-22 AT AT00909228T patent/ATE238295T1/de not_active IP Right Cessation
- 2000-02-22 CA CA002361758A patent/CA2361758A1/en not_active Abandoned
- 2000-02-22 HU HU0105482A patent/HUP0105482A3/hu unknown
- 2000-02-22 TR TR2001/02441T patent/TR200102441T2/xx unknown
- 2000-02-22 CZ CZ20012997A patent/CZ20012997A3/cs unknown
- 2000-02-22 WO PCT/EP2000/001430 patent/WO2000050422A1/en not_active Ceased
- 2000-02-22 DK DK00909228T patent/DK1153023T3/da active
-
2001
- 2001-08-22 NO NO20014078A patent/NO319724B1/no unknown
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