YU49003A - Novi postupak za sintezu fenilamida 5-(4-fluorofenil) -1-(2-((2r,4r)-4-hidroksi-6-okso-tetrahidro-piran-2-il)- etil)-2-izopropil-4-fenil-1h-pirol-3-karboksilne kiseline - Google Patents

Novi postupak za sintezu fenilamida 5-(4-fluorofenil) -1-(2-((2r,4r)-4-hidroksi-6-okso-tetrahidro-piran-2-il)- etil)-2-izopropil-4-fenil-1h-pirol-3-karboksilne kiseline

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Publication number
YU49003A
YU49003A YU49003A YUP49003A YU49003A YU 49003 A YU49003 A YU 49003A YU 49003 A YU49003 A YU 49003A YU P49003 A YUP49003 A YU P49003A YU 49003 A YU49003 A YU 49003A
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YU
Yugoslavia
Prior art keywords
pyran
fluorophenyl
pyrrole
tetrahydro
oxo
Prior art date
Application number
YU49003A
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English (en)
Inventor
Ronald Eugene Butler
Randall Lee Dejong
Jade Douglas Nelson
Michael Gerard Pamment
Timothy Lee Stuk
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Warner-Lambert Company
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Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of YU49003A publication Critical patent/YU49003A/sh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Catalysts (AREA)

Abstract

Opisan je poboljšani postupak za dobijanje fenilamida 5-(4-fluorofenil)-1-[2-((2R,4R)-4-hidroksi-6-okso-tetrahidro-piran-2-il)-etil]-2-izopropil-4-fenil-1H-pirol-3-karboksilne kiseline, novom sintezom, u kojoj se metilcijanoacetat u osam ili manje operacija konvertuje u željeni proizvod, kao i drugi vredni intermedijari koji se koriste u ovom postupku.[An improved process for the preparation of 5-(4-fluorophenyl)-1-[2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl]-2-isopropyl- 4-phenyl-1H-pyrrole-3-carboxylic acid phenylamide by a novel synthesis is described where methyl cyanoacetate is converted in eight operations or fewer to the desired product, as well as other valuable intermediates used in the process.
YU49003A 2001-01-09 2001-12-27 Novi postupak za sintezu fenilamida 5-(4-fluorofenil) -1-(2-((2r,4r)-4-hidroksi-6-okso-tetrahidro-piran-2-il)- etil)-2-izopropil-4-fenil-1h-pirol-3-karboksilne kiseline YU49003A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26050501P 2001-01-09 2001-01-09

Publications (1)

Publication Number Publication Date
YU49003A true YU49003A (sh) 2006-05-25

Family

ID=22989433

Family Applications (1)

Application Number Title Priority Date Filing Date
YU49003A YU49003A (sh) 2001-01-09 2001-12-27 Novi postupak za sintezu fenilamida 5-(4-fluorofenil) -1-(2-((2r,4r)-4-hidroksi-6-okso-tetrahidro-piran-2-il)- etil)-2-izopropil-4-fenil-1h-pirol-3-karboksilne kiseline

Country Status (25)

Country Link
US (7) US6476235B2 (sh)
EP (1) EP1353917B1 (sh)
JP (2) JP4190285B2 (sh)
KR (3) KR100677008B1 (sh)
CN (4) CN100351252C (sh)
AR (1) AR035680A1 (sh)
AT (1) ATE358126T1 (sh)
BR (1) BR0116739A (sh)
CA (1) CA2432064C (sh)
CY (1) CY1106590T1 (sh)
CZ (1) CZ20031893A3 (sh)
DE (1) DE60127583T2 (sh)
DK (1) DK1353917T3 (sh)
ES (1) ES2282200T3 (sh)
HK (2) HK1060572A1 (sh)
HU (1) HUP0302647A3 (sh)
IL (4) IL156461A0 (sh)
MX (1) MXPA03005284A (sh)
PL (1) PL365283A1 (sh)
PT (1) PT1353917E (sh)
RU (1) RU2244714C1 (sh)
TW (1) TWI293073B (sh)
WO (1) WO2002055519A2 (sh)
YU (1) YU49003A (sh)
ZA (1) ZA200304684B (sh)

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CY1106590T1 (el) 2012-01-25
US20070032664A1 (en) 2007-02-08
US6545153B1 (en) 2003-04-08
US7361771B2 (en) 2008-04-22
IL189358A0 (en) 2008-06-05
WO2002055519A2 (en) 2002-07-18
US20050239869A1 (en) 2005-10-27
CA2432064A1 (en) 2002-07-18
CA2432064C (en) 2007-09-11
CN1907984A (zh) 2007-02-07
US20070032663A1 (en) 2007-02-08
KR100677008B1 (ko) 2007-02-01
US7183408B2 (en) 2007-02-27
AR035680A1 (es) 2004-06-23
CN101024626A (zh) 2007-08-29
HK1084114A1 (en) 2006-07-21
TWI293073B (en) 2008-02-01
US20030195353A1 (en) 2003-10-16
ES2282200T3 (es) 2007-10-16
JP2004520351A (ja) 2004-07-08
DE60127583D1 (de) 2007-05-10
DE60127583T2 (de) 2007-12-06
ZA200304684B (en) 2004-06-28
CN1222521C (zh) 2005-10-12
JP4190285B2 (ja) 2008-12-03
US6933393B2 (en) 2005-08-23
CN1696129A (zh) 2005-11-16
US20070032662A1 (en) 2007-02-08
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