ATE341541T1 - Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy- pyran-2-one - Google Patents

Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy- pyran-2-one

Info

Publication number
ATE341541T1
ATE341541T1 AT01909697T AT01909697T ATE341541T1 AT E341541 T1 ATE341541 T1 AT E341541T1 AT 01909697 T AT01909697 T AT 01909697T AT 01909697 T AT01909697 T AT 01909697T AT E341541 T1 ATE341541 T1 AT E341541T1
Authority
AT
Austria
Prior art keywords
pyran
dialkyl
dihydro
hydroxy
synthesis
Prior art date
Application number
AT01909697T
Other languages
English (en)
Inventor
Michael Paul Fleming
Yeun-Kwei Han
Lewis M Hodges
David A Johnston
Roger P Micheli
Kurt Puentener
Christopher R Roberts
Michelangelo Scalone
Mark A Schwindt
Robert J Topping
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE341541T1 publication Critical patent/ATE341541T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02Magnesium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12Beta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT01909697T 2000-02-04 2001-01-26 Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy- pyran-2-one ATE341541T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18056000P 2000-02-04 2000-02-04

Publications (1)

Publication Number Publication Date
ATE341541T1 true ATE341541T1 (de) 2006-10-15

Family

ID=22660904

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01909697T ATE341541T1 (de) 2000-02-04 2001-01-26 Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy- pyran-2-one

Country Status (14)

Country Link
US (4) US6545165B1 (de)
EP (1) EP1255747B1 (de)
JP (1) JP4097943B2 (de)
KR (1) KR100516242B1 (de)
CN (2) CN1239493C (de)
AT (1) ATE341541T1 (de)
AU (1) AU2001237347A1 (de)
CA (1) CA2397232C (de)
DE (1) DE60123579T2 (de)
DK (1) DK1255747T3 (de)
ES (1) ES2272446T3 (de)
JO (1) JO2243B1 (de)
MX (1) MXPA02007520A (de)
WO (1) WO2001057014A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006017045A2 (en) * 2004-07-08 2006-02-16 Merck & Co., Inc. Formation of tetra-substituted enamides and stereoselective reduction thereof
CN101180282B (zh) * 2005-05-24 2011-09-21 霍夫曼-拉罗奇有限公司 (s)-4-氟甲基-二氢-呋喃-2-酮的制备
CN101460461B (zh) * 2006-04-03 2012-10-03 弗·哈夫曼-拉罗切有限公司 对映体富集的环β-芳基或杂芳基羧酸的制备方法
CN101511830B (zh) * 2006-09-15 2013-07-24 霍夫曼-拉罗奇有限公司 通过烯胺的催化不对称氢化制备吡啶并[2,1-a]异喹啉衍生物的方法
KR101076680B1 (ko) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 (6r)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체
KR101126084B1 (ko) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 (3s,4s)-4-((r)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
CA2744511A1 (en) * 2008-12-16 2010-06-24 F.Hoffmann-La Roche Ag Process for the preparation of pyrollidine-3-carboxylic acids
DK2379491T3 (da) * 2008-12-18 2013-04-08 Hoffmann La Roche Fremgangsmåde til syntese af amino-methyl-tetralinderivater
US20110040091A1 (en) 2009-08-13 2011-02-17 Stephan Bachmann Process for the preparation of (r)-2-phenyl propionic acid derivatives
US20110054174A1 (en) 2009-08-28 2011-03-03 Stephan Bachmann Process for the preparation of a glucokinase activator compound
KR101106603B1 (ko) * 2009-11-24 2012-01-20 허성환 하이브리드형 낙뢰보호 장치
JP5915486B2 (ja) * 2012-09-28 2016-05-11 Jsr株式会社 フォトレジスト組成物、レジストパターン形成方法及び重合体
US9163202B2 (en) 2013-08-02 2015-10-20 Eastman Chemical Company Aqueous cleaning compositions including an alkyl 3-hydroxybutyrate
US9255059B2 (en) 2013-08-02 2016-02-09 Eastman Chemical Company Method for producing an alkyl 3-hydroxybutyrate
US9249378B2 (en) 2013-08-02 2016-02-02 Eastman Chemical Company Aqueous cleaning compositions having enhanced properties
US9388114B2 (en) 2013-08-02 2016-07-12 Eastman Chemical Company Compositions including an alkyl 3-hydroxybutyrate
CN110590606B (zh) 2013-11-15 2023-02-17 豪夫迈·罗氏有限公司 用于制备嘧啶基环戊烷化合物的方法
CN110734420A (zh) * 2019-12-04 2020-01-31 重庆植恩药业有限公司 一种奥利司他杂质f及其制备方法和用途
CN115974634B (zh) * 2023-02-15 2023-11-28 瑞博(苏州)制药有限公司 不对称催化氢化制备沙库巴曲化合物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962242A (en) 1986-08-27 1990-10-09 Takasago Perfumery Co., Ltd. Process for producing optically active alcohols
EP0272787B1 (de) * 1986-11-14 1992-05-06 Takasago International Corporation Katalytische Produktion von optisch aktiven Carbonsäuren
JPH064544B2 (ja) 1987-06-19 1994-01-19 高砂香料工業株式会社 光学活性アルコ−ルの製造方法
CA2035972C (en) 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones
JPH04264054A (ja) 1990-10-15 1992-09-18 Lonza Ag 3−オキソカルボン酸エステルの製造方法
DE4116906A1 (de) 1991-05-23 1992-11-26 Wacker Chemie Gmbh Verfahren zur herstellung von (beta)-ketocarbonsaeureestern
US5274143A (en) 1991-07-23 1993-12-28 Hoffmann-La Roche Inc. Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
JP3251525B2 (ja) 1996-05-24 2002-01-28 高砂香料工業株式会社 3−オキソカルボン酸エステルの製造方法

Also Published As

Publication number Publication date
AU2001237347A1 (en) 2001-08-14
US6818789B2 (en) 2004-11-16
KR20030005180A (ko) 2003-01-17
EP1255747B1 (de) 2006-10-04
US6545165B1 (en) 2003-04-08
CN1239493C (zh) 2006-02-01
JO2243B1 (en) 2004-10-07
DE60123579D1 (de) 2006-11-16
CN100355740C (zh) 2007-12-19
US20030158423A1 (en) 2003-08-21
JP2003521546A (ja) 2003-07-15
US6743927B2 (en) 2004-06-01
WO2001057014A2 (en) 2001-08-09
CA2397232A1 (en) 2001-08-09
DE60123579T2 (de) 2007-06-21
CN1680347A (zh) 2005-10-12
WO2001057014A3 (en) 2002-04-18
ES2272446T3 (es) 2007-05-01
CA2397232C (en) 2007-01-23
US6858749B2 (en) 2005-02-22
US20030158422A1 (en) 2003-08-21
KR100516242B1 (ko) 2005-09-20
EP1255747A2 (de) 2002-11-13
US20030171602A1 (en) 2003-09-11
DK1255747T3 (da) 2007-02-12
JP4097943B2 (ja) 2008-06-11
MXPA02007520A (es) 2002-12-13
CN1396919A (zh) 2003-02-12

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