DE60123579D1 - Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one - Google Patents

Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one

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Publication number
DE60123579D1
DE60123579D1 DE60123579T DE60123579T DE60123579D1 DE 60123579 D1 DE60123579 D1 DE 60123579D1 DE 60123579 T DE60123579 T DE 60123579T DE 60123579 T DE60123579 T DE 60123579T DE 60123579 D1 DE60123579 D1 DE 60123579D1
Authority
DE
Germany
Prior art keywords
pyran
dialkyl
dihydro
hydroxy
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60123579T
Other languages
English (en)
Other versions
DE60123579T2 (de
Inventor
Paul Fleming
Yeun-Kwei Han
M Hodges
A Johnston
P Micheli
Kurt Puentener
R Roberts
Michelangelo Scalone
A Schwindt
J Topping
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE60123579D1 publication Critical patent/DE60123579D1/de
Application granted granted Critical
Publication of DE60123579T2 publication Critical patent/DE60123579T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60123579T 2000-02-04 2001-01-26 Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one Expired - Lifetime DE60123579T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18056000P 2000-02-04 2000-02-04
US180560P 2000-02-04
PCT/EP2001/000866 WO2001057014A2 (en) 2000-02-04 2001-01-26 Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one

Publications (2)

Publication Number Publication Date
DE60123579D1 true DE60123579D1 (de) 2006-11-16
DE60123579T2 DE60123579T2 (de) 2007-06-21

Family

ID=22660904

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60123579T Expired - Lifetime DE60123579T2 (de) 2000-02-04 2001-01-26 Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one

Country Status (14)

Country Link
US (4) US6545165B1 (de)
EP (1) EP1255747B1 (de)
JP (1) JP4097943B2 (de)
KR (1) KR100516242B1 (de)
CN (2) CN1239493C (de)
AT (1) ATE341541T1 (de)
AU (1) AU2001237347A1 (de)
CA (1) CA2397232C (de)
DE (1) DE60123579T2 (de)
DK (1) DK1255747T3 (de)
ES (1) ES2272446T3 (de)
JO (1) JO2243B1 (de)
MX (1) MXPA02007520A (de)
WO (1) WO2001057014A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1765771A4 (de) * 2004-07-08 2008-04-02 Merck & Co Inc Bildung von tetrasubstituierten enamiden und deren stereoselektive reduktion
ES2313672T3 (es) * 2005-05-24 2009-03-01 F. Hoffmann-La Roche Ag Praparacion de (s)-4-fluorometil-dihidro-furan-2-ona.
BRPI0709880A2 (pt) * 2006-04-03 2011-07-26 Hoffmann La Roche processo para preparaÇço e Ácidos carboxÍlicos cÍclicos beta-arÍlicos ou heteroarÍlicos e-nantiomericamente enriquecidos
CN101511830B (zh) * 2006-09-15 2013-07-24 霍夫曼-拉罗奇有限公司 通过烯胺的催化不对称氢化制备吡啶并[2,1-a]异喹啉衍生物的方法
KR101076680B1 (ko) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 (6ｒ)-3-헥실-4-히드록시-6-운데실-5,6-다이히드로피란-2-온의 제조방법 및 이에 사용되는 중간체
KR101126084B1 (ko) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 (3ｓ,4ｓ)-4-((ｒ)-2-(벤질옥시)트라이데실)-3-헥실-2-옥세타논의 제조방법 및 이에 사용되는 중간체
CN102245570A (zh) * 2008-12-16 2011-11-16 弗·哈夫曼-拉罗切有限公司 制备吡咯烷-3-甲酸类的方法
PL2379491T3 (pl) * 2008-12-18 2013-08-30 Hoffmann La Roche Sposób syntezy pochodnych aminometylotetraliny
US20110040091A1 (en) 2009-08-13 2011-02-17 Stephan Bachmann Process for the preparation of (r)-2-phenyl propionic acid derivatives
US20110054174A1 (en) 2009-08-28 2011-03-03 Stephan Bachmann Process for the preparation of a glucokinase activator compound
KR101106603B1 (ko) * 2009-11-24 2012-01-20 허성환 하이브리드형 낙뢰보호 장치
JP5915486B2 (ja) * 2012-09-28 2016-05-11 Jsr株式会社 フォトレジスト組成物、レジストパターン形成方法及び重合体
US9163202B2 (en) 2013-08-02 2015-10-20 Eastman Chemical Company Aqueous cleaning compositions including an alkyl 3-hydroxybutyrate
US9388114B2 (en) 2013-08-02 2016-07-12 Eastman Chemical Company Compositions including an alkyl 3-hydroxybutyrate
US9255059B2 (en) 2013-08-02 2016-02-09 Eastman Chemical Company Method for producing an alkyl 3-hydroxybutyrate
US9249378B2 (en) 2013-08-02 2016-02-02 Eastman Chemical Company Aqueous cleaning compositions having enhanced properties
PL3656764T3 (pl) 2013-11-15 2024-01-22 F. Hoffmann-La Roche Ag Sposoby przygotowania związków pirymidynylocyklopentanu
CN110734420A (zh) * 2019-12-04 2020-01-31 重庆植恩药业有限公司 一种奥利司他杂质f及其制备方法和用途
CN115974634B (zh) * 2023-02-15 2023-11-28 瑞博(苏州)制药有限公司 不对称催化氢化制备沙库巴曲化合物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4962242A (en) 1986-08-27 1990-10-09 Takasago Perfumery Co., Ltd. Process for producing optically active alcohols
DE3778857D1 (de) * 1986-11-14 1992-06-11 Takasago Perfumery Co Ltd Katalytische produktion von optisch aktiven carbonsaeuren.
JPH064544B2 (ja) 1987-06-19 1994-01-19 高砂香料工業株式会社 光学活性アルコ−ルの製造方法
CA2035972C (en) 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones
US5144057A (en) 1990-10-15 1992-09-01 Lonza Ltd. Process for the production of 3-oxocarboxylic acid esters
DE4116906A1 (de) 1991-05-23 1992-11-26 Wacker Chemie Gmbh Verfahren zur herstellung von (beta)-ketocarbonsaeureestern
US5274143A (en) 1991-07-23 1993-12-28 Hoffmann-La Roche Inc. Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
JP3251525B2 (ja) 1996-05-24 2002-01-28 高砂香料工業株式会社 ３−オキソカルボン酸エステルの製造方法

Also Published As

Publication number Publication date
MXPA02007520A (es) 2002-12-13
CA2397232A1 (en) 2001-08-09
US6858749B2 (en) 2005-02-22
JP4097943B2 (ja) 2008-06-11
WO2001057014A2 (en) 2001-08-09
US6743927B2 (en) 2004-06-01
EP1255747A2 (de) 2002-11-13
KR100516242B1 (ko) 2005-09-20
KR20030005180A (ko) 2003-01-17
US20030158423A1 (en) 2003-08-21
JP2003521546A (ja) 2003-07-15
AU2001237347A1 (en) 2001-08-14
CN1396919A (zh) 2003-02-12
US6818789B2 (en) 2004-11-16
CN1680347A (zh) 2005-10-12
US20030171602A1 (en) 2003-09-11
ATE341541T1 (de) 2006-10-15
US20030158422A1 (en) 2003-08-21
DE60123579T2 (de) 2007-06-21
CA2397232C (en) 2007-01-23
EP1255747B1 (de) 2006-10-04
ES2272446T3 (es) 2007-05-01
JO2243B1 (en) 2004-10-07
WO2001057014A3 (en) 2002-04-18
CN100355740C (zh) 2007-12-19
DK1255747T3 (da) 2007-02-12
US6545165B1 (en) 2003-04-08
CN1239493C (zh) 2006-02-01

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