AU2001237347A1 - Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one - Google Patents

Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one

Info

Publication number
AU2001237347A1
AU2001237347A1 AU2001237347A AU3734701A AU2001237347A1 AU 2001237347 A1 AU2001237347 A1 AU 2001237347A1 AU 2001237347 A AU2001237347 A AU 2001237347A AU 3734701 A AU3734701 A AU 3734701A AU 2001237347 A1 AU2001237347 A1 AU 2001237347A1
Authority
AU
Australia
Prior art keywords
pyran
dialkyl
dihydro
hydroxy
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001237347A
Inventor
Michael Paul Fleming
Yeun-Kwei Han
Lewis M. Hodges
David A. Johnston
Roger P. Micheli
Kurt Puentener
Christopher R. Roberts
Michelangelo Scalone
Mark A. Schwindt
Robert J. Topping
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of AU2001237347A1 publication Critical patent/AU2001237347A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention relates to a novel process for producing a delta-lactone of the formula:using an acyl halide of the formula:wherein R<1>, R<2 >R<3 >and X are described herein, as well as novel intermediates. In particular, the present invention relates to a process for enantioselectively producing the (R)-delta-lactone.
AU2001237347A 2000-02-04 2001-01-26 Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one Abandoned AU2001237347A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18056000P 2000-02-04 2000-02-04
US60180560 2000-02-04
PCT/EP2001/000866 WO2001057014A2 (en) 2000-02-04 2001-01-26 Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one

Publications (1)

Publication Number Publication Date
AU2001237347A1 true AU2001237347A1 (en) 2001-08-14

Family

ID=22660904

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001237347A Abandoned AU2001237347A1 (en) 2000-02-04 2001-01-26 Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one

Country Status (14)

Country Link
US (4) US6545165B1 (en)
EP (1) EP1255747B1 (en)
JP (1) JP4097943B2 (en)
KR (1) KR100516242B1 (en)
CN (2) CN100355740C (en)
AT (1) ATE341541T1 (en)
AU (1) AU2001237347A1 (en)
CA (1) CA2397232C (en)
DE (1) DE60123579T2 (en)
DK (1) DK1255747T3 (en)
ES (1) ES2272446T3 (en)
JO (1) JO2243B1 (en)
MX (1) MXPA02007520A (en)
WO (1) WO2001057014A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008505903A (en) * 2004-07-08 2008-02-28 メルク　エンド　カムパニー　インコーポレーテッド Formation of tetrasubstituted enamides and this stereoselective reduction.
DE602006002612D1 (en) * 2005-05-24 2008-10-16 Hoffmann La Roche PREPARATION OF (S) -4-FLUOROMETHYL-DIHYDRO-FURAN-2-ON
ATE453622T1 (en) * 2006-04-03 2010-01-15 Hoffmann La Roche METHOD FOR PRODUCING ENANTIOMERIC ENRICHED CYCLIC BETA-ARYL OR HETEROARYL CARBOXYLIC ACIDS
CN101511830B (en) * 2006-09-15 2013-07-24 霍夫曼-拉罗奇有限公司 Process for the preparation of pyrido[2,1-a]isoquinoline derivatives by catalytic asymmetric hydrogenation of an enamine
KR101076680B1 (en) * 2007-11-01 2011-10-26 한미홀딩스 주식회사 Method of preparing (6r)-3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one and intermediate used in the method
KR101126084B1 (en) * 2008-11-04 2012-03-29 한미홀딩스 주식회사 Method for preparing 3s,4s-4-r-2-benzyloxytridecyl-3-hexyl-2-oxetanone and intermediates used therefor
EP2379500A1 (en) * 2008-12-16 2011-10-26 F. Hoffmann-La Roche AG Process for the preparation of pyrollidine-3-carboxylic acids
DK2379491T3 (en) * 2008-12-18 2013-04-08 Hoffmann La Roche Process for the synthesis of amino-methyl-tetraline derivatives
US20110040091A1 (en) * 2009-08-13 2011-02-17 Stephan Bachmann Process for the preparation of (r)-2-phenyl propionic acid derivatives
US20110054174A1 (en) 2009-08-28 2011-03-03 Stephan Bachmann Process for the preparation of a glucokinase activator compound
KR101106603B1 (en) * 2009-11-24 2012-01-20 허성환 Hybrid lightning protection device
JP5915486B2 (en) * 2012-09-28 2016-05-11 Jsr株式会社 Photoresist composition, resist pattern forming method and polymer
US9249378B2 (en) 2013-08-02 2016-02-02 Eastman Chemical Company Aqueous cleaning compositions having enhanced properties
US9255059B2 (en) 2013-08-02 2016-02-09 Eastman Chemical Company Method for producing an alkyl 3-hydroxybutyrate
US9388114B2 (en) 2013-08-02 2016-07-12 Eastman Chemical Company Compositions including an alkyl 3-hydroxybutyrate
US9163202B2 (en) 2013-08-02 2015-10-20 Eastman Chemical Company Aqueous cleaning compositions including an alkyl 3-hydroxybutyrate
SG10201901578UA (en) 2013-11-15 2019-03-28 Hoffmann La Roche Processes for the preparation of pyrimidinylcyclopentane compounds
CN110734420A (en) * 2019-12-04 2020-01-31 重庆植恩药业有限公司 orlistat impurity F, preparation method and application thereof
CN115974634B (en) * 2023-02-15 2023-11-28 瑞博(苏州)制药有限公司 Method for preparing Sha Kuba curved compound by asymmetric catalytic hydrogenation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3781749T3 (en) 1986-08-27 1997-02-06 Takasago Perfumery Co Ltd Manufacturing process of optically active alcohols.
DE3778857D1 (en) 1986-11-14 1992-06-11 Takasago Perfumery Co Ltd CATALYTIC PRODUCTION OF OPTICALLY ACTIVE CARBONIC ACIDS.
JPH064544B2 (en) 1987-06-19 1994-01-19 高砂香料工業株式会社 Method for producing optically active alcohol
CA2035972C (en) 1990-02-23 2006-07-11 Martin Karpf Process for the preparation of oxetanones
JPH04264054A (en) 1990-10-15 1992-09-18 Lonza Ag Preparation of 3-oxocarboxylic acid ester
DE4116906A1 (en) 1991-05-23 1992-11-26 Wacker Chemie Gmbh METHOD FOR PRODUCING (BETA) KETOCARBONIC ACID ESTERS
US5274143A (en) 1991-07-23 1993-12-28 Hoffmann-La Roche Inc. Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione
JP3251525B2 (en) 1996-05-24 2002-01-28 高砂香料工業株式会社 Method for producing 3-oxocarboxylic acid ester

Also Published As

Publication number Publication date
US20030158422A1 (en) 2003-08-21
JP2003521546A (en) 2003-07-15
DK1255747T3 (en) 2007-02-12
US6743927B2 (en) 2004-06-01
KR100516242B1 (en) 2005-09-20
ES2272446T3 (en) 2007-05-01
JO2243B1 (en) 2004-10-07
KR20030005180A (en) 2003-01-17
US20030158423A1 (en) 2003-08-21
DE60123579T2 (en) 2007-06-21
DE60123579D1 (en) 2006-11-16
CA2397232C (en) 2007-01-23
US6858749B2 (en) 2005-02-22
JP4097943B2 (en) 2008-06-11
EP1255747A2 (en) 2002-11-13
EP1255747B1 (en) 2006-10-04
CN100355740C (en) 2007-12-19
CN1396919A (en) 2003-02-12
WO2001057014A3 (en) 2002-04-18
US6818789B2 (en) 2004-11-16
US6545165B1 (en) 2003-04-08
MXPA02007520A (en) 2002-12-13
CA2397232A1 (en) 2001-08-09
WO2001057014A2 (en) 2001-08-09
CN1239493C (en) 2006-02-01
US20030171602A1 (en) 2003-09-11
CN1680347A (en) 2005-10-12
ATE341541T1 (en) 2006-10-15

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