DE60002303D1 - Verfahren zur herstellung von paroxetin - Google Patents

Verfahren zur herstellung von paroxetin

Info

Publication number
DE60002303D1
DE60002303D1 DE60002303T DE60002303T DE60002303D1 DE 60002303 D1 DE60002303 D1 DE 60002303D1 DE 60002303 T DE60002303 T DE 60002303T DE 60002303 T DE60002303 T DE 60002303T DE 60002303 D1 DE60002303 D1 DE 60002303D1
Authority
DE
Germany
Prior art keywords
paroxetine
sesamol
derivatisation
dealkylation
tetrahydropyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60002303T
Other languages
English (en)
Other versions
DE60002303T2 (de
Inventor
Renzo Rossi
Stefano Turchetta
Maria Donnarumma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
APOTECNIA, S.A., LLANERA-ASTURIAS, ES
Original Assignee
Recordati SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati SA filed Critical Recordati SA
Publication of DE60002303D1 publication Critical patent/DE60002303D1/de
Application granted granted Critical
Publication of DE60002303T2 publication Critical patent/DE60002303T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60002303T 1999-02-23 2000-02-22 Verfahren zur herstellung von paroxetin Expired - Fee Related DE60002303T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI990364 1999-02-23
IT1999MI000364A IT1308629B1 (it) 1999-02-23 1999-02-23 Processo per la produzione di paroxetina.
PCT/EP2000/001430 WO2000050422A1 (en) 1999-02-23 2000-02-22 Process for the production of paroxetine

Publications (2)

Publication Number Publication Date
DE60002303D1 true DE60002303D1 (de) 2003-05-28
DE60002303T2 DE60002303T2 (de) 2004-04-01

Family

ID=11382007

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60002303T Expired - Fee Related DE60002303T2 (de) 1999-02-23 2000-02-22 Verfahren zur herstellung von paroxetin

Country Status (28)

Country Link
US (1) US6583287B1 (de)
EP (1) EP1153023B1 (de)
JP (1) JP2002537394A (de)
KR (1) KR20010102366A (de)
CN (1) CN1161353C (de)
AT (1) ATE238295T1 (de)
AU (1) AU759441B2 (de)
BR (1) BR0008220A (de)
CA (1) CA2361758A1 (de)
CZ (1) CZ20012997A3 (de)
DE (1) DE60002303T2 (de)
DK (1) DK1153023T3 (de)
ES (1) ES2195876T3 (de)
HK (1) HK1040516B (de)
HR (1) HRP20010608A2 (de)
HU (1) HUP0105482A3 (de)
IL (1) IL144883A (de)
IT (1) IT1308629B1 (de)
MX (1) MXPA01008502A (de)
NO (1) NO319724B1 (de)
PL (1) PL349358A1 (de)
PT (1) PT1153023E (de)
RU (1) RU2242473C2 (de)
SK (1) SK12042001A3 (de)
TR (1) TR200102441T2 (de)
TW (1) TWI221473B (de)
WO (1) WO2000050422A1 (de)
YU (1) YU60801A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1571152B1 (de) * 2004-03-03 2007-08-08 CHEMI S.p.A. Amorphe 3-Pyridyl-1-Hydroxyethyliden-1,1-Bisphosphonsäure Mononatriumsalz und Verfahren zu deren Herstellung
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
CN104039777B (zh) * 2012-01-31 2016-03-02 卫材R&D管理有限公司 帕罗西汀衍生物
CN106831736A (zh) * 2017-02-15 2017-06-13 浙江华海药业股份有限公司 一种制备帕罗西汀杂质的方法
CN112521377A (zh) * 2020-11-26 2021-03-19 北京福元医药股份有限公司 一种盐酸帕罗西汀的连续化制备方法
CN115260153B (zh) * 2022-07-21 2023-10-27 威尚（上海）生物医药有限公司 一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0757758B2 (ja) 1988-10-24 1995-06-21 高砂香料工業株式会社 ルテニウム―ホスフィン錯体
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
US5233084A (en) 1989-06-22 1993-08-03 Monsanto Company Method for preparing α-arylpropionic acids
FR2651152B1 (fr) * 1989-08-23 1991-11-29 Elf Aquitaine Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore.
GB9209687D0 (en) 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
DE4422672A1 (de) * 1994-06-30 1996-01-04 Hoechst Ag Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung
BR9608471A (pt) * 1995-05-17 1998-12-29 Novo Nordisk As Processo para a preparação de um composto
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
HUP0003362A3 (en) * 1997-05-06 2001-04-28 Novo Nordisk As Piperidine derivatives and pharmaceutical compositions containing them
ES2212287T3 (es) * 1997-05-20 2004-07-16 Firmenich Sa Catalizadores de rutenio y su uso en la hidrogenacion asimetrica de sustratos debilmente coordinantes.

Also Published As

Publication number Publication date
YU60801A (sh) 2005-07-19
HUP0105482A3 (en) 2002-11-28
SK12042001A3 (sk) 2001-12-03
DK1153023T3 (da) 2003-08-11
HK1040516B (zh) 2003-10-31
IL144883A (en) 2004-12-15
AU759441B2 (en) 2003-04-17
CN1341113A (zh) 2002-03-20
AU3158300A (en) 2000-09-14
BR0008220A (pt) 2001-11-06
DE60002303T2 (de) 2004-04-01
TR200102441T2 (tr) 2002-01-21
RU2242473C2 (ru) 2004-12-20
NO20014078D0 (no) 2001-08-22
PL349358A1 (en) 2002-07-15
ES2195876T3 (es) 2003-12-16
US6583287B1 (en) 2003-06-24
ITMI990364A1 (it) 2000-08-23
HRP20010608A2 (en) 2002-08-31
EP1153023A1 (de) 2001-11-14
ATE238295T1 (de) 2003-05-15
NO319724B1 (no) 2005-09-05
MXPA01008502A (es) 2003-06-06
IL144883A0 (en) 2002-06-30
KR20010102366A (ko) 2001-11-15
JP2002537394A (ja) 2002-11-05
CN1161353C (zh) 2004-08-11
NO20014078L (no) 2001-10-18
PT1153023E (pt) 2003-09-30
HK1040516A1 (en) 2002-06-14
CZ20012997A3 (cs) 2001-11-14
CA2361758A1 (en) 2000-08-31
TWI221473B (en) 2004-10-01
EP1153023B1 (de) 2003-04-23
IT1308629B1 (it) 2002-01-09
WO2000050422A1 (en) 2000-08-31
HUP0105482A2 (en) 2002-08-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: HANSMANN & VOGESER, 81369 MUENCHEN

8327 Change in the person/name/address of the patent owner

Owner name: APOTECNIA, S.A., LLANERA-ASTURIAS, ES

8339 Ceased/non-payment of the annual fee