HK1040516B - 帕羅西汀的製備方法 - Google Patents
帕羅西汀的製備方法Info
- Publication number
- HK1040516B HK1040516B HK02101971.9A HK02101971A HK1040516B HK 1040516 B HK1040516 B HK 1040516B HK 02101971 A HK02101971 A HK 02101971A HK 1040516 B HK1040516 B HK 1040516B
- Authority
- HK
- Hong Kong
- Prior art keywords
- paroxetine
- production
- sesamol
- derivatisation
- dealkylation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI000364A IT1308629B1 (it) | 1999-02-23 | 1999-02-23 | Processo per la produzione di paroxetina. |
PCT/EP2000/001430 WO2000050422A1 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
Publications (2)
Publication Number | Publication Date |
---|---|
HK1040516A1 HK1040516A1 (en) | 2002-06-14 |
HK1040516B true HK1040516B (zh) | 2003-10-31 |
Family
ID=11382007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK02101971.9A HK1040516B (zh) | 1999-02-23 | 2002-03-14 | 帕羅西汀的製備方法 |
Country Status (28)
Country | Link |
---|---|
US (1) | US6583287B1 (zh) |
EP (1) | EP1153023B1 (zh) |
JP (1) | JP2002537394A (zh) |
KR (1) | KR20010102366A (zh) |
CN (1) | CN1161353C (zh) |
AT (1) | ATE238295T1 (zh) |
AU (1) | AU759441B2 (zh) |
BR (1) | BR0008220A (zh) |
CA (1) | CA2361758A1 (zh) |
CZ (1) | CZ20012997A3 (zh) |
DE (1) | DE60002303T2 (zh) |
DK (1) | DK1153023T3 (zh) |
ES (1) | ES2195876T3 (zh) |
HK (1) | HK1040516B (zh) |
HR (1) | HRP20010608A2 (zh) |
HU (1) | HUP0105482A3 (zh) |
IL (1) | IL144883A (zh) |
IT (1) | IT1308629B1 (zh) |
MX (1) | MXPA01008502A (zh) |
NO (1) | NO319724B1 (zh) |
PL (1) | PL349358A1 (zh) |
PT (1) | PT1153023E (zh) |
RU (1) | RU2242473C2 (zh) |
SK (1) | SK12042001A3 (zh) |
TR (1) | TR200102441T2 (zh) |
TW (1) | TWI221473B (zh) |
WO (1) | WO2000050422A1 (zh) |
YU (1) | YU60801A (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE602005001873T2 (de) * | 2004-03-03 | 2008-04-24 | Chemi S.P.A., Cinisello Balsamo | Amorphe 3-Pyridyl-1-Hydroxyethyliden-1,1-Bisphosphonsäure Mononatriumsalz und Verfahren zu deren Herstellung |
US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
RU2616610C2 (ru) * | 2012-01-31 | 2017-04-18 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Производное пароксетина |
CN106831736A (zh) * | 2017-02-15 | 2017-06-13 | 浙江华海药业股份有限公司 | 一种制备帕罗西汀杂质的方法 |
CN112521377A (zh) * | 2020-11-26 | 2021-03-19 | 北京福元医药股份有限公司 | 一种盐酸帕罗西汀的连续化制备方法 |
CN115260153B (zh) * | 2022-07-21 | 2023-10-27 | 威尚(上海)生物医药有限公司 | 一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0757758B2 (ja) | 1988-10-24 | 1995-06-21 | 高砂香料工業株式会社 | ルテニウム―ホスフィン錯体 |
DK715988D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Etherifikation og dealkylering af piperidin-derivater samt intermediater |
US5233084A (en) | 1989-06-22 | 1993-08-03 | Monsanto Company | Method for preparing α-arylpropionic acids |
FR2651152B1 (fr) * | 1989-08-23 | 1991-11-29 | Elf Aquitaine | Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore. |
GB9209687D0 (en) | 1992-05-06 | 1992-06-17 | Smithkline Beecham Plc | Novel process |
DE4422672A1 (de) * | 1994-06-30 | 1996-01-04 | Hoechst Ag | Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung |
JPH11505229A (ja) * | 1995-05-17 | 1999-05-18 | ノボ ノルディスク アクティーゼルスカブ | 4−アリール−ピペリジン誘導体を製造する方法 |
HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
EP0983239A1 (en) * | 1997-05-06 | 2000-03-08 | Novo Nordisk A/S | Novel heterocyclic compounds |
DE69820205T2 (de) * | 1997-05-20 | 2004-09-30 | Firmenich S.A. | Ruthenium-katalysatoren und ihre verwendung zur asymmetrischen hydrierung von substraten mit schwacher koordination |
-
1999
- 1999-02-23 IT IT1999MI000364A patent/IT1308629B1/it active
-
2000
- 2000-02-18 TW TW089102997A patent/TWI221473B/zh not_active IP Right Cessation
- 2000-02-22 EP EP00909228A patent/EP1153023B1/en not_active Expired - Lifetime
- 2000-02-22 PT PT00909228T patent/PT1153023E/pt unknown
- 2000-02-22 HU HU0105482A patent/HUP0105482A3/hu unknown
- 2000-02-22 KR KR1020017010760A patent/KR20010102366A/ko not_active Application Discontinuation
- 2000-02-22 PL PL00349358A patent/PL349358A1/xx not_active IP Right Cessation
- 2000-02-22 AU AU31583/00A patent/AU759441B2/en not_active Ceased
- 2000-02-22 ES ES00909228T patent/ES2195876T3/es not_active Expired - Lifetime
- 2000-02-22 SK SK1204-2001A patent/SK12042001A3/sk unknown
- 2000-02-22 IL IL14488300A patent/IL144883A/en not_active IP Right Cessation
- 2000-02-22 JP JP2000601002A patent/JP2002537394A/ja active Pending
- 2000-02-22 WO PCT/EP2000/001430 patent/WO2000050422A1/en not_active Application Discontinuation
- 2000-02-22 US US09/890,414 patent/US6583287B1/en not_active Expired - Fee Related
- 2000-02-22 BR BR0008220-1A patent/BR0008220A/pt not_active IP Right Cessation
- 2000-02-22 AT AT00909228T patent/ATE238295T1/de not_active IP Right Cessation
- 2000-02-22 CZ CZ20012997A patent/CZ20012997A3/cs unknown
- 2000-02-22 RU RU2001125933/04A patent/RU2242473C2/ru not_active IP Right Cessation
- 2000-02-22 DE DE60002303T patent/DE60002303T2/de not_active Expired - Fee Related
- 2000-02-22 DK DK00909228T patent/DK1153023T3/da active
- 2000-02-22 CA CA002361758A patent/CA2361758A1/en not_active Abandoned
- 2000-02-22 MX MXPA01008502A patent/MXPA01008502A/es active IP Right Grant
- 2000-02-22 YU YU60801A patent/YU60801A/sh unknown
- 2000-02-22 CN CNB008041873A patent/CN1161353C/zh not_active Expired - Fee Related
- 2000-02-22 TR TR2001/02441T patent/TR200102441T2/xx unknown
-
2001
- 2001-08-17 HR HR20010608A patent/HRP20010608A2/hr not_active Application Discontinuation
- 2001-08-22 NO NO20014078A patent/NO319724B1/no unknown
-
2002
- 2002-03-14 HK HK02101971.9A patent/HK1040516B/zh not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PL378168A1 (pl) | Dihydropterydynony, sposoby ich wytwarzania i ich zastosowanie w postaci leków | |
HK1055118A1 (en) | Novel intermediates and process for the manufacture of camptothecin derivatives (cpt-11) and related compounds | |
UA49796C2 (uk) | Ангідрат пароксетин гідрохлориду, спосіб його одержання, сольвати пароксетин гідрохлориду, спосіб їх одержання, спосіб лікування та/або профілактики та фармацевтична композиція | |
ATE440087T1 (de) | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen | |
HU9601857D0 (en) | New benzyl-piperidine- or -tetrahydro-pyridine derivatives and processes for producing them | |
BG105177A (en) | Novel substituted pyrazole derivatives | |
AU4437896A (en) | Piperidine derivatives having tachykinin antagonist activity | |
RS20050173A (en) | Novel carboxamide compounds having an mch-antagonistic effect,medicaments containing said compounds,and methods for the production thereof | |
IL157552A0 (en) | Enantioselective synthesis of azetidinone intermediate compounds | |
ATE381559T1 (de) | Adamantan- und azabicyclooctan- und - nonanderivate, verfahren zu deren herstellung und deren verwendung als dpp-iv-inhibitoren | |
MXPA05012362A (es) | Yodopirazolilcarboxanilidas. | |
TW200500368A (en) | Process to tetrahydrotriazolopyrazines and intermediates | |
IL144883A0 (en) | Process for the production of paroxetine | |
DE60321452D1 (de) | Als modulatoren der chemokinrezeptoraktivität geeignete piperidinderivate | |
UA85428C2 (ru) | Способ получения с-2, с-3 замещенных n-алкилированных индолов, а также промежуточные соединения и способы их получения | |
AU5493198A (en) | Process for preparing a naphtalenamine derivative | |
MXPA03010960A (es) | Proceso para la produccion de fexofenadina derivado de piperidina. | |
MX2008000821A (es) | Nuevos derivados de piperidina. | |
MX2007004483A (es) | Metodo y productos intermediarios para la preparacion de derivados de n-(1-benzhidril-azetidin-3-il)-n- fenilmetilsulfonamida. | |
WO2003078420A3 (en) | Process for making chiral 1,4-disubstituted piperazines | |
DE60324776D1 (de) | Verfahren zur synthese von pergolid | |
MXPA05009153A (es) | Proceso para preparar 2-metilpirrolidina y enantiomeros especificos de la misma. | |
SU1563187A1 (ru) | 1-(2-этоксиэтил)-4-оксипиперидин в качестве промежуточного соединения в синтезе гидрохлоридов 1-(2-этоксиэтил)-4-ацилоксипиперидинов, обладающих местно-анестезирующей активностью | |
EA200600255A1 (ru) | Способ получения иминного промежуточного соединения | |
ES2117934A1 (es) | Tetrahidropiridinas (0 4-hidroxipiperidinas) alquilazoles. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20070222 |