DE60324776D1 - Verfahren zur synthese von pergolid - Google Patents
Verfahren zur synthese von pergolidInfo
- Publication number
- DE60324776D1 DE60324776D1 DE60324776T DE60324776T DE60324776D1 DE 60324776 D1 DE60324776 D1 DE 60324776D1 DE 60324776 T DE60324776 T DE 60324776T DE 60324776 T DE60324776 T DE 60324776T DE 60324776 D1 DE60324776 D1 DE 60324776D1
- Authority
- DE
- Germany
- Prior art keywords
- synthesis
- pergolide
- pergolid
- dihydrolysergic
- intermediates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 229960004851 pergolide Drugs 0.000 abstract 2
- YEHCICAEULNIGD-MZMPZRCHSA-N pergolide Chemical compound C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 YEHCICAEULNIGD-MZMPZRCHSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229960001511 pergolide mesylate Drugs 0.000 abstract 1
- UWCVGPLTGZWHGS-ZORIOUSZSA-N pergolide mesylate Chemical compound CS(O)(=O)=O.C1=CC([C@H]2C[C@@H](CSC)CN([C@@H]2C2)CCC)=C3C2=CNC3=C1 UWCVGPLTGZWHGS-ZORIOUSZSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2002MI000555A ITMI20020555A1 (it) | 2002-03-15 | 2002-03-15 | Processo per la sintesi del pergolide |
| ITMI20022133 ITMI20022133A1 (it) | 2002-10-08 | 2002-10-08 | Procedimento per la preparazione del pergolide. |
| PCT/EP2003/002423 WO2003078432A2 (en) | 2002-03-15 | 2003-03-10 | Process for the synthesis of pergolide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60324776D1 true DE60324776D1 (de) | 2009-01-02 |
Family
ID=28043508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60324776T Expired - Fee Related DE60324776D1 (de) | 2002-03-15 | 2003-03-10 | Verfahren zur synthese von pergolid |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7019140B2 (de) |
| EP (1) | EP1485382B1 (de) |
| JP (1) | JP2005520833A (de) |
| AT (1) | ATE414704T1 (de) |
| AU (1) | AU2003221494A1 (de) |
| DE (1) | DE60324776D1 (de) |
| WO (1) | WO2003078432A2 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010118889A1 (en) * | 2009-04-17 | 2010-10-21 | Merz Pharma Gmbh & Co. Kgaa | Synthesis of 1-amino-1,3,3,5,5-pentamethylcyclohexane mesylate |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3901894A (en) * | 1974-06-06 | 1975-08-26 | Lilly Co Eli | 8-thiomethylergolines |
| US4166182A (en) * | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| US4246265A (en) | 1979-10-01 | 1981-01-20 | Eli Lilly And Company | 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds |
| US5463060A (en) * | 1992-05-21 | 1995-10-31 | Eli Lilly And Company | One-pot process |
| IT1307934B1 (it) | 1999-01-27 | 2001-11-29 | Poli Ind Chimica Spa | Processo per la preparazione di derivati alchimercaptometilergolinici. |
| CZ287962B6 (cs) | 1999-06-15 | 2001-03-14 | Galena A. S. | Způsob přípravy 8ß-methylthiomethyl derivátů ergolinu |
-
2003
- 2003-03-10 AT AT03717204T patent/ATE414704T1/de not_active IP Right Cessation
- 2003-03-10 JP JP2003576437A patent/JP2005520833A/ja active Pending
- 2003-03-10 US US10/507,620 patent/US7019140B2/en not_active Expired - Fee Related
- 2003-03-10 DE DE60324776T patent/DE60324776D1/de not_active Expired - Fee Related
- 2003-03-10 AU AU2003221494A patent/AU2003221494A1/en not_active Abandoned
- 2003-03-10 EP EP03717204A patent/EP1485382B1/de not_active Expired - Lifetime
- 2003-03-10 WO PCT/EP2003/002423 patent/WO2003078432A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| EP1485382B1 (de) | 2008-11-19 |
| US7019140B2 (en) | 2006-03-28 |
| JP2005520833A (ja) | 2005-07-14 |
| WO2003078432A3 (en) | 2004-01-15 |
| US20050124812A1 (en) | 2005-06-09 |
| EP1485382A2 (de) | 2004-12-15 |
| WO2003078432A2 (en) | 2003-09-25 |
| AU2003221494A1 (en) | 2003-09-29 |
| ATE414704T1 (de) | 2008-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |