IT1307934B1 - Processo per la preparazione di derivati alchimercaptometilergolinici. - Google Patents

Processo per la preparazione di derivati alchimercaptometilergolinici.

Info

Publication number
IT1307934B1
IT1307934B1 IT1999MI000146A ITMI990146A IT1307934B1 IT 1307934 B1 IT1307934 B1 IT 1307934B1 IT 1999MI000146 A IT1999MI000146 A IT 1999MI000146A IT MI990146 A ITMI990146 A IT MI990146A IT 1307934 B1 IT1307934 B1 IT 1307934B1
Authority
IT
Italy
Prior art keywords
preparation
alchemercaptomethylergolinic
derivatives
unsaturated
cyclic
Prior art date
Application number
IT1999MI000146A
Other languages
English (en)
Inventor
Alberto Mangia
Paride Grisenti
Original Assignee
Poli Ind Chimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1999MI000146A priority Critical patent/IT1307934B1/it
Application filed by Poli Ind Chimica Spa filed Critical Poli Ind Chimica Spa
Priority to IL141920??A priority patent/IL141920A0/xx
Priority to DE69938153T priority patent/DE69938153D1/de
Priority to SK1040-2001A priority patent/SK286599B6/sk
Priority to CZ20012640A priority patent/CZ300684B6/cs
Priority to JP2000596004A priority patent/JP4593789B2/ja
Priority to PCT/EP1999/010493 priority patent/WO2000044748A1/en
Priority to AT99968403T priority patent/ATE386032T1/de
Priority to EP99968403A priority patent/EP1147106B1/en
Publication of ITMI990146A1 publication Critical patent/ITMI990146A1/it
Priority to US09/787,934 priority patent/US6395901B1/en
Priority to IL141920A priority patent/IL141920A/en
Application granted granted Critical
Publication of IT1307934B1 publication Critical patent/IT1307934B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT1999MI000146A 1999-01-27 1999-01-27 Processo per la preparazione di derivati alchimercaptometilergolinici. IT1307934B1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT1999MI000146A IT1307934B1 (it) 1999-01-27 1999-01-27 Processo per la preparazione di derivati alchimercaptometilergolinici.
DE69938153T DE69938153D1 (de) 1999-01-27 1999-12-31 Verfahren zur herstellung von alkylmercaptomethylergolinderivaten
SK1040-2001A SK286599B6 (sk) 1999-01-27 1999-12-31 Spôsob prípravy alkylmerkaptometylergolínových derivátov, medziprodukty a ich použitie
CZ20012640A CZ300684B6 (cs) 1999-01-27 1999-12-31 Zpusob prípravy alkylmerkaptomethylergolinových derivátu
IL141920??A IL141920A0 (en) 1999-01-27 1999-12-31 Process for the preparation of alkyl mercapto methyl ergoline derivatives
JP2000596004A JP4593789B2 (ja) 1999-01-27 1999-12-31 アルキルメルカプトメチルエルゴリン誘導体の製造方法
PCT/EP1999/010493 WO2000044748A1 (en) 1999-01-27 1999-12-31 Process for the preparation of alkyl mercapto methyl ergoline derivatives
AT99968403T ATE386032T1 (de) 1999-01-27 1999-12-31 Verfahren zur herstellung von alkylmercaptomethylergolinderivaten
EP99968403A EP1147106B1 (en) 1999-01-27 1999-12-31 Process for the preparation of alkyl mercapto methyl ergoline derivatives
US09/787,934 US6395901B1 (en) 1999-01-27 2000-12-31 Process for the preparation of alkyl mercapto methyl ergoline derivatives
IL141920A IL141920A (en) 1999-01-27 2001-03-08 Process for the preparation of derivatives of alkyl mercapto methyl ergoline and a number of new intermediates obtained during it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI000146A IT1307934B1 (it) 1999-01-27 1999-01-27 Processo per la preparazione di derivati alchimercaptometilergolinici.

Publications (2)

Publication Number Publication Date
ITMI990146A1 ITMI990146A1 (it) 2000-07-27
IT1307934B1 true IT1307934B1 (it) 2001-11-29

Family

ID=11381633

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999MI000146A IT1307934B1 (it) 1999-01-27 1999-01-27 Processo per la preparazione di derivati alchimercaptometilergolinici.

Country Status (10)

Country Link
US (1) US6395901B1 (it)
EP (1) EP1147106B1 (it)
JP (1) JP4593789B2 (it)
AT (1) ATE386032T1 (it)
CZ (1) CZ300684B6 (it)
DE (1) DE69938153D1 (it)
IL (2) IL141920A0 (it)
IT (1) IT1307934B1 (it)
SK (1) SK286599B6 (it)
WO (1) WO2000044748A1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10053397A1 (de) 2000-10-20 2002-05-02 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
DE10043321B4 (de) * 2000-08-24 2005-07-28 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung der Parkinsonschen Krankheit, zur Behandlung und Prävention des prämenstruellen Syndroms und zur Lactationshemmung
DE10064453A1 (de) * 2000-12-16 2002-07-04 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
US7019140B2 (en) 2002-03-15 2006-03-28 Antibioticos S.P.A. Process for the synthesis of pergolide
ITMI20021755A1 (it) 2002-08-02 2002-11-01 Poli Ind Chimica Spa Processo e nuovi intermedi per la preparazione di steroidi ad attivita' progestinica.
GB0409785D0 (en) * 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
GB0505965D0 (en) * 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
US20070197576A1 (en) * 2006-02-08 2007-08-23 Resolution Chemicals Limited Production of Cabergoline and Novel Polymorphic Form Thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0240647B2 (ja) * 1978-02-08 1990-09-12 Lilly Co Eli Purorakuchinbunpyokuseizai
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
JPH0240044B2 (ja) * 1978-02-08 1990-09-10 Lilly Co Eli Paakinsonshokogunchiryozai
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate
US5463060A (en) * 1992-05-21 1995-10-31 Eli Lilly And Company One-pot process

Also Published As

Publication number Publication date
SK286599B6 (sk) 2009-02-05
EP1147106A1 (en) 2001-10-24
US6395901B1 (en) 2002-05-28
WO2000044748A1 (en) 2000-08-03
CZ20012640A3 (cs) 2002-02-13
JP4593789B2 (ja) 2010-12-08
CZ300684B6 (cs) 2009-07-15
ATE386032T1 (de) 2008-03-15
DE69938153D1 (de) 2008-03-27
ITMI990146A1 (it) 2000-07-27
IL141920A0 (en) 2002-03-10
EP1147106B1 (en) 2008-02-13
JP2002535403A (ja) 2002-10-22
IL141920A (en) 2008-11-26
SK10402001A3 (sk) 2002-04-04

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