DE69938153D1 - Verfahren zur herstellung von alkylmercaptomethylergolinderivaten - Google Patents

Verfahren zur herstellung von alkylmercaptomethylergolinderivaten

Info

Publication number
DE69938153D1
DE69938153D1 DE69938153T DE69938153T DE69938153D1 DE 69938153 D1 DE69938153 D1 DE 69938153D1 DE 69938153 T DE69938153 T DE 69938153T DE 69938153 T DE69938153 T DE 69938153T DE 69938153 D1 DE69938153 D1 DE 69938153D1
Authority
DE
Germany
Prior art keywords
alkylmercaptomethylergoline
derivatives
producing
unsaturated
cyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69938153T
Other languages
English (en)
Inventor
Alberto Mangia
Paride Grisenti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Poli Industria Chimica SpA
Original Assignee
Poli Industria Chimica SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poli Industria Chimica SpA filed Critical Poli Industria Chimica SpA
Application granted granted Critical
Publication of DE69938153D1 publication Critical patent/DE69938153D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69938153T 1999-01-27 1999-12-31 Verfahren zur herstellung von alkylmercaptomethylergolinderivaten Expired - Lifetime DE69938153D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999MI000146A IT1307934B1 (it) 1999-01-27 1999-01-27 Processo per la preparazione di derivati alchimercaptometilergolinici.
PCT/EP1999/010493 WO2000044748A1 (en) 1999-01-27 1999-12-31 Process for the preparation of alkyl mercapto methyl ergoline derivatives

Publications (1)

Publication Number Publication Date
DE69938153D1 true DE69938153D1 (de) 2008-03-27

Family

ID=11381633

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69938153T Expired - Lifetime DE69938153D1 (de) 1999-01-27 1999-12-31 Verfahren zur herstellung von alkylmercaptomethylergolinderivaten

Country Status (10)

Country Link
US (1) US6395901B1 (de)
EP (1) EP1147106B1 (de)
JP (1) JP4593789B2 (de)
AT (1) ATE386032T1 (de)
CZ (1) CZ300684B6 (de)
DE (1) DE69938153D1 (de)
IL (2) IL141920A0 (de)
IT (1) IT1307934B1 (de)
SK (1) SK286599B6 (de)
WO (1) WO2000044748A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10066158B4 (de) * 2000-08-24 2007-08-09 Neurobiotec Gmbh Verwendung eines transdermalen therapeutischen Systems zur Behandlung des Restless-Legs-Syndroms
DE10053397A1 (de) * 2000-10-20 2002-05-02 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
DE10064453A1 (de) * 2000-12-16 2002-07-04 Schering Ag Verwendung eines dopaminergen Wirkstoffes zur Behandlung von dopaminerg behandelbaren Erkrankungen
ATE414704T1 (de) * 2002-03-15 2008-12-15 Antibioticos Spa Verfahren zur synthese von pergolid
ITMI20021755A1 (it) 2002-08-02 2002-11-01 Poli Ind Chimica Spa Processo e nuovi intermedi per la preparazione di steroidi ad attivita' progestinica.
GB0409785D0 (en) * 2004-04-30 2004-06-09 Resolution Chemicals Ltd Preparation of cabergoline
US7339060B2 (en) 2005-03-23 2008-03-04 Resolution Chemicals, Ltd. Preparation of cabergoline
GB0505965D0 (en) * 2005-03-23 2005-04-27 Resolution Chemicals Ltd Preparation of cabergoline
US20070197576A1 (en) * 2006-02-08 2007-08-23 Resolution Chemicals Limited Production of Cabergoline and Novel Polymorphic Form Thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0240044B2 (ja) * 1978-02-08 1990-09-10 Lilly Co Eli Paakinsonshokogunchiryozai
JPH0240647B2 (ja) * 1978-02-08 1990-09-12 Lilly Co Eli Purorakuchinbunpyokuseizai
US4166182A (en) * 1978-02-08 1979-08-28 Eli Lilly And Company 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
US4782152A (en) * 1985-08-16 1988-11-01 Eli Lilly And Company Decyanation of pergolide intermediate
US5463060A (en) * 1992-05-21 1995-10-31 Eli Lilly And Company One-pot process

Also Published As

Publication number Publication date
IL141920A (en) 2008-11-26
SK286599B6 (sk) 2009-02-05
CZ20012640A3 (cs) 2002-02-13
IT1307934B1 (it) 2001-11-29
JP4593789B2 (ja) 2010-12-08
EP1147106A1 (de) 2001-10-24
EP1147106B1 (de) 2008-02-13
IL141920A0 (en) 2002-03-10
ATE386032T1 (de) 2008-03-15
ITMI990146A1 (it) 2000-07-27
CZ300684B6 (cs) 2009-07-15
JP2002535403A (ja) 2002-10-22
SK10402001A3 (sk) 2002-04-04
US6395901B1 (en) 2002-05-28
WO2000044748A1 (en) 2000-08-03

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Legal Events

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