YU60801A - Postupak za dobijanje paroksetina - Google Patents

Postupak za dobijanje paroksetina

Info

Publication number
YU60801A
YU60801A YU60801A YUP60801A YU60801A YU 60801 A YU60801 A YU 60801A YU 60801 A YU60801 A YU 60801A YU P60801 A YUP60801 A YU P60801A YU 60801 A YU60801 A YU 60801A
Authority
YU
Yugoslavia
Prior art keywords
paroxetine
production
paroxetin
sesamol
derivatisation
Prior art date
Application number
YU60801A
Other languages
English (en)
Inventor
Renzo Rossi
Stefano Turchetta
Maria Donnarumma
Original Assignee
Recordati S.A. Chemical And Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati S.A. Chemical And Pharmaceutical Company filed Critical Recordati S.A. Chemical And Pharmaceutical Company
Publication of YU60801A publication Critical patent/YU60801A/sh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Opisan je postupak za dobijanje paroksetina, gde su N-supstituisani derivati 4-(p-fluorofenil)-3-hidroksi-1,2,3,6-tetrahidropiridina tretirani sledećom sekvencom reakcija: (a) hidrogenizacija katalizovana kompleksima prelaznih metala sa hiralnim difosfinskim ligandima; (b) derivatizacija -OH i nukleofilna supstitucija, supstituent je sezamol; (c) N-dealkilacija. Postupak je visoko stereospecifičan i omogućava nastanak obogaćenih intermedijera sa željenom izomernom komponentom, koja se prevodi u paroksetin u kvantitativnim prinosima.[A process for the production of paroxetin is described, wherein N-substituted derivatives of 4-(i(p)-fluorophenyl)-3-hydroxymethyl-1,2, 3,6-tetrahydropyridine are treated according to the following sequence of reactions: (a) hydrogenation catalysed by transition metal complexes with chiral diphosphinic ligands; (b) -OH derivatisation and nucleophilic substitution, the substitutent being sesamol; (c) N- dealkylation. The process is highly stereospecific and brings about the formation of intermediates enriched with the desired isomeric components, which are converted into paroxetine in quantitative yields.
YU60801A 1999-02-23 2000-02-22 Postupak za dobijanje paroksetina YU60801A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI000364A IT1308629B1 (it) 1999-02-23 1999-02-23 Processo per la produzione di paroxetina.

Publications (1)

Publication Number Publication Date
YU60801A true YU60801A (sh) 2005-07-19

Family

ID=11382007

Family Applications (1)

Application Number Title Priority Date Filing Date
YU60801A YU60801A (sh) 1999-02-23 2000-02-22 Postupak za dobijanje paroksetina

Country Status (28)

Country Link
US (1) US6583287B1 (sh)
EP (1) EP1153023B1 (sh)
JP (1) JP2002537394A (sh)
KR (1) KR20010102366A (sh)
CN (1) CN1161353C (sh)
AT (1) ATE238295T1 (sh)
AU (1) AU759441B2 (sh)
BR (1) BR0008220A (sh)
CA (1) CA2361758A1 (sh)
CZ (1) CZ20012997A3 (sh)
DE (1) DE60002303T2 (sh)
DK (1) DK1153023T3 (sh)
ES (1) ES2195876T3 (sh)
HK (1) HK1040516B (sh)
HR (1) HRP20010608A2 (sh)
HU (1) HUP0105482A3 (sh)
IL (1) IL144883A (sh)
IT (1) IT1308629B1 (sh)
MX (1) MXPA01008502A (sh)
NO (1) NO319724B1 (sh)
PL (1) PL349358A1 (sh)
PT (1) PT1153023E (sh)
RU (1) RU2242473C2 (sh)
SK (1) SK12042001A3 (sh)
TR (1) TR200102441T2 (sh)
TW (1) TWI221473B (sh)
WO (1) WO2000050422A1 (sh)
YU (1) YU60801A (sh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005001873T2 (de) * 2004-03-03 2008-04-24 Chemi S.P.A., Cinisello Balsamo Amorphe 3-Pyridyl-1-Hydroxyethyliden-1,1-Bisphosphonsäure Mononatriumsalz und Verfahren zu deren Herstellung
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
EP2810942B1 (en) * 2012-01-31 2016-03-30 Eisai R&D Management Co., Ltd. Paroxetine derivative
CN106831736A (zh) * 2017-02-15 2017-06-13 浙江华海药业股份有限公司 一种制备帕罗西汀杂质的方法
CN112521377A (zh) * 2020-11-26 2021-03-19 北京福元医药股份有限公司 一种盐酸帕罗西汀的连续化制备方法
CN115260153B (zh) * 2022-07-21 2023-10-27 威尚(上海)生物医药有限公司 一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0757758B2 (ja) 1988-10-24 1995-06-21 高砂香料工業株式会社 ルテニウム―ホスフィン錯体
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
US5233084A (en) * 1989-06-22 1993-08-03 Monsanto Company Method for preparing α-arylpropionic acids
FR2651152B1 (fr) * 1989-08-23 1991-11-29 Elf Aquitaine Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore.
GB9209687D0 (en) * 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
DE4422672A1 (de) * 1994-06-30 1996-01-04 Hoechst Ag Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung
AU721257B2 (en) * 1995-05-17 2000-06-29 Novo Nordisk A/S Process for preparing 4-aryl-piperidine derivatives
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
HUP0003362A3 (en) * 1997-05-06 2001-04-28 Novo Nordisk As Piperidine derivatives and pharmaceutical compositions containing them
EP0920354B1 (en) * 1997-05-20 2003-12-03 Firmenich Sa Ruthenium catalysts and their use in the asymmetric hydrogenation of weakly coordinating substrates

Also Published As

Publication number Publication date
NO20014078L (no) 2001-10-18
IL144883A (en) 2004-12-15
SK12042001A3 (sk) 2001-12-03
HUP0105482A3 (en) 2002-11-28
DE60002303T2 (de) 2004-04-01
TR200102441T2 (tr) 2002-01-21
RU2242473C2 (ru) 2004-12-20
CA2361758A1 (en) 2000-08-31
MXPA01008502A (es) 2003-06-06
HK1040516B (zh) 2003-10-31
BR0008220A (pt) 2001-11-06
KR20010102366A (ko) 2001-11-15
CZ20012997A3 (cs) 2001-11-14
US6583287B1 (en) 2003-06-24
CN1161353C (zh) 2004-08-11
DE60002303D1 (de) 2003-05-28
JP2002537394A (ja) 2002-11-05
DK1153023T3 (da) 2003-08-11
HK1040516A1 (en) 2002-06-14
CN1341113A (zh) 2002-03-20
ITMI990364A1 (it) 2000-08-23
HRP20010608A2 (en) 2002-08-31
IT1308629B1 (it) 2002-01-09
NO319724B1 (no) 2005-09-05
PL349358A1 (en) 2002-07-15
EP1153023B1 (en) 2003-04-23
PT1153023E (pt) 2003-09-30
ATE238295T1 (de) 2003-05-15
HUP0105482A2 (en) 2002-08-28
AU759441B2 (en) 2003-04-17
ES2195876T3 (es) 2003-12-16
NO20014078D0 (no) 2001-08-22
WO2000050422A1 (en) 2000-08-31
IL144883A0 (en) 2002-06-30
EP1153023A1 (en) 2001-11-14
TWI221473B (en) 2004-10-01
AU3158300A (en) 2000-09-14

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