YU60801A - Postupak za dobijanje paroksetina - Google Patents
Postupak za dobijanje paroksetinaInfo
- Publication number
- YU60801A YU60801A YU60801A YUP60801A YU60801A YU 60801 A YU60801 A YU 60801A YU 60801 A YU60801 A YU 60801A YU P60801 A YUP60801 A YU P60801A YU 60801 A YU60801 A YU 60801A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- paroxetine
- production
- paroxetin
- sesamol
- derivatisation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Opisan je postupak za dobijanje paroksetina, gde su N-supstituisani derivati 4-(p-fluorofenil)-3-hidroksi-1,2,3,6-tetrahidropiridina tretirani sledećom sekvencom reakcija: (a) hidrogenizacija katalizovana kompleksima prelaznih metala sa hiralnim difosfinskim ligandima; (b) derivatizacija -OH i nukleofilna supstitucija, supstituent je sezamol; (c) N-dealkilacija. Postupak je visoko stereospecifičan i omogućava nastanak obogaćenih intermedijera sa željenom izomernom komponentom, koja se prevodi u paroksetin u kvantitativnim prinosima.[A process for the production of paroxetin is described, wherein N-substituted derivatives of 4-(i(p)-fluorophenyl)-3-hydroxymethyl-1,2, 3,6-tetrahydropyridine are treated according to the following sequence of reactions: (a) hydrogenation catalysed by transition metal complexes with chiral diphosphinic ligands; (b) -OH derivatisation and nucleophilic substitution, the substitutent being sesamol; (c) N- dealkylation. The process is highly stereospecific and brings about the formation of intermediates enriched with the desired isomeric components, which are converted into paroxetine in quantitative yields.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000364A IT1308629B1 (it) | 1999-02-23 | 1999-02-23 | Processo per la produzione di paroxetina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| YU60801A true YU60801A (sh) | 2005-07-19 |
Family
ID=11382007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU60801A YU60801A (sh) | 1999-02-23 | 2000-02-22 | Postupak za dobijanje paroksetina |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6583287B1 (sh) |
| EP (1) | EP1153023B1 (sh) |
| JP (1) | JP2002537394A (sh) |
| KR (1) | KR20010102366A (sh) |
| CN (1) | CN1161353C (sh) |
| AT (1) | ATE238295T1 (sh) |
| AU (1) | AU759441B2 (sh) |
| BR (1) | BR0008220A (sh) |
| CA (1) | CA2361758A1 (sh) |
| CZ (1) | CZ20012997A3 (sh) |
| DE (1) | DE60002303T2 (sh) |
| DK (1) | DK1153023T3 (sh) |
| ES (1) | ES2195876T3 (sh) |
| HK (1) | HK1040516B (sh) |
| HR (1) | HRP20010608A2 (sh) |
| HU (1) | HUP0105482A3 (sh) |
| IL (1) | IL144883A (sh) |
| IT (1) | IT1308629B1 (sh) |
| MX (1) | MXPA01008502A (sh) |
| NO (1) | NO319724B1 (sh) |
| PL (1) | PL349358A1 (sh) |
| PT (1) | PT1153023E (sh) |
| RU (1) | RU2242473C2 (sh) |
| SK (1) | SK12042001A3 (sh) |
| TR (1) | TR200102441T2 (sh) |
| TW (1) | TWI221473B (sh) |
| WO (1) | WO2000050422A1 (sh) |
| YU (1) | YU60801A (sh) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE602005001873T2 (de) * | 2004-03-03 | 2008-04-24 | Chemi S.P.A., Cinisello Balsamo | Amorphe 3-Pyridyl-1-Hydroxyethyliden-1,1-Bisphosphonsäure Mononatriumsalz und Verfahren zu deren Herstellung |
| US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
| EP2810942B1 (en) * | 2012-01-31 | 2016-03-30 | Eisai R&D Management Co., Ltd. | Paroxetine derivative |
| CN106831736A (zh) * | 2017-02-15 | 2017-06-13 | 浙江华海药业股份有限公司 | 一种制备帕罗西汀杂质的方法 |
| CN112521377A (zh) * | 2020-11-26 | 2021-03-19 | 北京福元医药股份有限公司 | 一种盐酸帕罗西汀的连续化制备方法 |
| CN115260153B (zh) * | 2022-07-21 | 2023-10-27 | 威尚（上海）生物医药有限公司 | 一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0757758B2 (ja) | 1988-10-24 | 1995-06-21 | 高砂香料工業株式会社 | ルテニウム―ホスフィン錯体 |
| DK715988D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Etherifikation og dealkylering af piperidin-derivater samt intermediater |
| US5233084A (en) * | 1989-06-22 | 1993-08-03 | Monsanto Company | Method for preparing α-arylpropionic acids |
| FR2651152B1 (fr) * | 1989-08-23 | 1991-11-29 | Elf Aquitaine | Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore. |
| GB9209687D0 (en) * | 1992-05-06 | 1992-06-17 | Smithkline Beecham Plc | Novel process |
| DE4422672A1 (de) * | 1994-06-30 | 1996-01-04 | Hoechst Ag | Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung |
| AU721257B2 (en) * | 1995-05-17 | 2000-06-29 | Novo Nordisk A/S | Process for preparing 4-aryl-piperidine derivatives |
| HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
| HUP0003362A3 (en) * | 1997-05-06 | 2001-04-28 | Novo Nordisk As | Piperidine derivatives and pharmaceutical compositions containing them |
| EP0920354B1 (en) * | 1997-05-20 | 2003-12-03 | Firmenich Sa | Ruthenium catalysts and their use in the asymmetric hydrogenation of weakly coordinating substrates |
-
1999
- 1999-02-23 IT IT1999MI000364A patent/IT1308629B1/it active
-
2000
- 2000-02-18 TW TW089102997A patent/TWI221473B/zh not_active IP Right Cessation
- 2000-02-22 TR TR2001/02441T patent/TR200102441T2/xx unknown
- 2000-02-22 BR BR0008220-1A patent/BR0008220A/pt not_active IP Right Cessation
- 2000-02-22 PT PT00909228T patent/PT1153023E/pt unknown
- 2000-02-22 HU HU0105482A patent/HUP0105482A3/hu unknown
- 2000-02-22 US US09/890,414 patent/US6583287B1/en not_active Expired - Fee Related
- 2000-02-22 AU AU31583/00A patent/AU759441B2/en not_active Ceased
- 2000-02-22 ES ES00909228T patent/ES2195876T3/es not_active Expired - Lifetime
- 2000-02-22 KR KR1020017010760A patent/KR20010102366A/ko not_active Application Discontinuation
- 2000-02-22 PL PL00349358A patent/PL349358A1/xx not_active IP Right Cessation
- 2000-02-22 RU RU2001125933/04A patent/RU2242473C2/ru not_active IP Right Cessation
- 2000-02-22 DK DK00909228T patent/DK1153023T3/da active
- 2000-02-22 WO PCT/EP2000/001430 patent/WO2000050422A1/en not_active Application Discontinuation
- 2000-02-22 EP EP00909228A patent/EP1153023B1/en not_active Expired - Lifetime
- 2000-02-22 AT AT00909228T patent/ATE238295T1/de not_active IP Right Cessation
- 2000-02-22 SK SK1204-2001A patent/SK12042001A3/sk unknown
- 2000-02-22 CZ CZ20012997A patent/CZ20012997A3/cs unknown
- 2000-02-22 JP JP2000601002A patent/JP2002537394A/ja active Pending
- 2000-02-22 YU YU60801A patent/YU60801A/sh unknown
- 2000-02-22 CA CA002361758A patent/CA2361758A1/en not_active Abandoned
- 2000-02-22 CN CNB008041873A patent/CN1161353C/zh not_active Expired - Fee Related
- 2000-02-22 MX MXPA01008502A patent/MXPA01008502A/es active IP Right Grant
- 2000-02-22 DE DE60002303T patent/DE60002303T2/de not_active Expired - Fee Related
- 2000-02-22 IL IL14488300A patent/IL144883A/en not_active IP Right Cessation
-
2001
- 2001-08-17 HR HR20010608A patent/HRP20010608A2/hr not_active Application Discontinuation
- 2001-08-22 NO NO20014078A patent/NO319724B1/no unknown
-
2002
- 2002-03-14 HK HK02101971.9A patent/HK1040516B/zh not_active IP Right Cessation
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