ATE421953T1 - Verfahren zur racemisierung von 1-benzyl-4-(4- fluorophenyl)-3-hydroxymethyl-1,2,3,6- tetrahydropyridin und dessen verwendung in der synthese von paroxetin - Google Patents

Verfahren zur racemisierung von 1-benzyl-4-(4- fluorophenyl)-3-hydroxymethyl-1,2,3,6- tetrahydropyridin und dessen verwendung in der synthese von paroxetin

Info

Publication number
ATE421953T1
ATE421953T1 AT01982224T AT01982224T ATE421953T1 AT E421953 T1 ATE421953 T1 AT E421953T1 AT 01982224 T AT01982224 T AT 01982224T AT 01982224 T AT01982224 T AT 01982224T AT E421953 T1 ATE421953 T1 AT E421953T1
Authority
AT
Austria
Prior art keywords
tetrahydropyridine
paroxetine
racemization
fluorophenyl
hydroxymethyl
Prior art date
Application number
AT01982224T
Other languages
English (en)
Inventor
Jayne Froggett
Dean Riley
Andrew Turner
Original Assignee
Aesica Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aesica Pharmaceuticals Ltd filed Critical Aesica Pharmaceuticals Ltd
Application granted granted Critical
Publication of ATE421953T1 publication Critical patent/ATE421953T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
AT01982224T 2000-08-30 2001-08-30 Verfahren zur racemisierung von 1-benzyl-4-(4- fluorophenyl)-3-hydroxymethyl-1,2,3,6- tetrahydropyridin und dessen verwendung in der synthese von paroxetin ATE421953T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0021147.4A GB0021147D0 (en) 2000-08-30 2000-08-30 Chemical process

Publications (1)

Publication Number Publication Date
ATE421953T1 true ATE421953T1 (de) 2009-02-15

Family

ID=9898420

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01982224T ATE421953T1 (de) 2000-08-30 2001-08-30 Verfahren zur racemisierung von 1-benzyl-4-(4- fluorophenyl)-3-hydroxymethyl-1,2,3,6- tetrahydropyridin und dessen verwendung in der synthese von paroxetin

Country Status (16)

Country Link
US (1) US6949650B2 (de)
EP (1) EP1315701B1 (de)
JP (1) JP2004518620A (de)
AT (1) ATE421953T1 (de)
AU (1) AU2002213865A1 (de)
CA (1) CA2420579C (de)
CZ (1) CZ2003503A3 (de)
DE (1) DE60137577D1 (de)
ES (1) ES2320631T3 (de)
GB (1) GB0021147D0 (de)
HR (1) HRP20030227A2 (de)
HU (1) HUP0302910A3 (de)
IL (2) IL154302A0 (de)
NO (1) NO324944B1 (de)
SK (1) SK2342003A3 (de)
WO (1) WO2002018338A1 (de)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2748140A (en) * 1954-10-07 1956-05-29 Rohm & Haas 3-hydroxymethyl-4-phenyltetrahydro-pyridines and their esters
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
AU721257B2 (en) 1995-05-17 2000-06-29 Novo Nordisk A/S Process for preparing 4-aryl-piperidine derivatives
GB9526645D0 (en) 1995-12-28 1996-02-28 Chiroscience Ltd Stereoselective synthesis
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
GB9710004D0 (en) 1997-05-17 1997-07-09 Knoll Ag Chemical process
DE19900576A1 (de) * 1999-01-09 2000-07-13 Merck Patent Gmbh Benzolderivate

Also Published As

Publication number Publication date
CZ2003503A3 (cs) 2003-08-13
HUP0302910A2 (hu) 2004-01-28
NO20030876L (no) 2003-02-25
WO2002018338A1 (en) 2002-03-07
EP1315701A1 (de) 2003-06-04
JP2004518620A (ja) 2004-06-24
DE60137577D1 (de) 2009-03-19
CA2420579C (en) 2009-11-03
HUP0302910A3 (en) 2008-02-28
HRP20030227A2 (en) 2005-02-28
NO20030876D0 (no) 2003-02-25
CA2420579A1 (en) 2002-03-07
AU2002213865A1 (en) 2002-03-13
US6949650B2 (en) 2005-09-27
GB0021147D0 (en) 2000-10-11
ES2320631T3 (es) 2009-05-27
IL154302A0 (en) 2003-09-17
NO324944B1 (no) 2008-01-07
EP1315701B1 (de) 2009-01-28
IL154302A (en) 2008-11-03
SK2342003A3 (en) 2003-09-11
US20040014786A1 (en) 2004-01-22

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