NO20030876L - Fremgangsmåte for racemisering av 1-benzyl-4-(4-fluorfenyl)-3- hydroksymetyl-1,2,3,6-tetrahydropyridin for bruk som mellomprodukt i syntese avparoxetin - Google Patents
Fremgangsmåte for racemisering av 1-benzyl-4-(4-fluorfenyl)-3- hydroksymetyl-1,2,3,6-tetrahydropyridin for bruk som mellomprodukt i syntese avparoxetinInfo
- Publication number
- NO20030876L NO20030876L NO20030876A NO20030876A NO20030876L NO 20030876 L NO20030876 L NO 20030876L NO 20030876 A NO20030876 A NO 20030876A NO 20030876 A NO20030876 A NO 20030876A NO 20030876 L NO20030876 L NO 20030876L
- Authority
- NO
- Norway
- Prior art keywords
- tetrahydropyridine
- paroxetine
- racemization
- fluorophenyl
- hydroxymethyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0021147.4A GB0021147D0 (en) | 2000-08-30 | 2000-08-30 | Chemical process |
| PCT/EP2001/009998 WO2002018338A1 (en) | 2000-08-30 | 2001-08-30 | Process for the racemisation of 1-benzyl-4-(4-fluorophenyl)-3-hydroxymethyl-1,2,3,6-tetrahydropyridine to be used as intermediate in the synthesis of paroxetine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20030876D0 NO20030876D0 (no) | 2003-02-25 |
| NO20030876L true NO20030876L (no) | 2003-02-25 |
| NO324944B1 NO324944B1 (no) | 2008-01-07 |
Family
ID=9898420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20030876A NO324944B1 (no) | 2000-08-30 | 2003-02-25 | Fremgangsmate for racemisering av 1-benzyl-4-(4-fluorfenyl)-3-hydroksymetyl-1,2,3,6-tetrahydropyridin for bruk som mellomprodukt i syntese av paroxetin samt slike mellomprodukter |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6949650B2 (no) |
| EP (1) | EP1315701B1 (no) |
| JP (1) | JP2004518620A (no) |
| AT (1) | ATE421953T1 (no) |
| AU (1) | AU2002213865A1 (no) |
| CA (1) | CA2420579C (no) |
| CZ (1) | CZ2003503A3 (no) |
| DE (1) | DE60137577D1 (no) |
| ES (1) | ES2320631T3 (no) |
| GB (1) | GB0021147D0 (no) |
| HR (1) | HRP20030227A2 (no) |
| HU (1) | HUP0302910A3 (no) |
| IL (2) | IL154302A0 (no) |
| NO (1) | NO324944B1 (no) |
| SK (1) | SK2342003A3 (no) |
| WO (1) | WO2002018338A1 (no) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2748140A (en) * | 1954-10-07 | 1956-05-29 | Rohm & Haas | 3-hydroxymethyl-4-phenyltetrahydro-pyridines and their esters |
| GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| WO1996036636A1 (en) * | 1995-05-17 | 1996-11-21 | Novo Nordisk A/S | Process for preparing 4-aryl-piperidine derivatives |
| GB9526645D0 (en) * | 1995-12-28 | 1996-02-28 | Chiroscience Ltd | Stereoselective synthesis |
| HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
| GB9710004D0 (en) | 1997-05-17 | 1997-07-09 | Knoll Ag | Chemical process |
| DE19900576A1 (de) * | 1999-01-09 | 2000-07-13 | Merck Patent Gmbh | Benzolderivate |
-
2000
- 2000-08-30 GB GBGB0021147.4A patent/GB0021147D0/en not_active Ceased
-
2001
- 2001-08-30 SK SK234-2003A patent/SK2342003A3/sk unknown
- 2001-08-30 ES ES01982224T patent/ES2320631T3/es not_active Expired - Lifetime
- 2001-08-30 HU HU0302910A patent/HUP0302910A3/hu unknown
- 2001-08-30 IL IL15430201A patent/IL154302A0/xx unknown
- 2001-08-30 CA CA002420579A patent/CA2420579C/en not_active Expired - Fee Related
- 2001-08-30 JP JP2002523456A patent/JP2004518620A/ja not_active Ceased
- 2001-08-30 WO PCT/EP2001/009998 patent/WO2002018338A1/en active Application Filing
- 2001-08-30 DE DE60137577T patent/DE60137577D1/de not_active Expired - Lifetime
- 2001-08-30 CZ CZ2003503A patent/CZ2003503A3/cs unknown
- 2001-08-30 EP EP01982224A patent/EP1315701B1/en not_active Expired - Lifetime
- 2001-08-30 US US10/362,531 patent/US6949650B2/en not_active Expired - Fee Related
- 2001-08-30 AT AT01982224T patent/ATE421953T1/de not_active IP Right Cessation
- 2001-08-30 AU AU2002213865A patent/AU2002213865A1/en not_active Abandoned
-
2003
- 2003-02-05 IL IL154302A patent/IL154302A/en not_active IP Right Cessation
- 2003-02-25 NO NO20030876A patent/NO324944B1/no not_active IP Right Cessation
- 2003-03-24 HR HR20030227A patent/HRP20030227A2/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ2003503A3 (cs) | 2003-08-13 |
| EP1315701A1 (en) | 2003-06-04 |
| HRP20030227A2 (en) | 2005-02-28 |
| US20040014786A1 (en) | 2004-01-22 |
| CA2420579A1 (en) | 2002-03-07 |
| JP2004518620A (ja) | 2004-06-24 |
| WO2002018338A1 (en) | 2002-03-07 |
| SK2342003A3 (en) | 2003-09-11 |
| AU2002213865A1 (en) | 2002-03-13 |
| HUP0302910A3 (en) | 2008-02-28 |
| IL154302A0 (en) | 2003-09-17 |
| GB0021147D0 (en) | 2000-10-11 |
| IL154302A (en) | 2008-11-03 |
| EP1315701B1 (en) | 2009-01-28 |
| DE60137577D1 (de) | 2009-03-19 |
| HUP0302910A2 (hu) | 2004-01-28 |
| US6949650B2 (en) | 2005-09-27 |
| CA2420579C (en) | 2009-11-03 |
| NO20030876D0 (no) | 2003-02-25 |
| ATE421953T1 (de) | 2009-02-15 |
| ES2320631T3 (es) | 2009-05-27 |
| NO324944B1 (no) | 2008-01-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |