ATE187958T1 - Verfahren zur herstellung von levobupivacain und analogue aus l-lysin - Google Patents

Verfahren zur herstellung von levobupivacain und analogue aus l-lysin

Info

Publication number
ATE187958T1
ATE187958T1 AT95933512T AT95933512T ATE187958T1 AT E187958 T1 ATE187958 T1 AT E187958T1 AT 95933512 T AT95933512 T AT 95933512T AT 95933512 T AT95933512 T AT 95933512T AT E187958 T1 ATE187958 T1 AT E187958T1
Authority
AT
Austria
Prior art keywords
pct
lysine
levobupivacain
analogue
producing
Prior art date
Application number
AT95933512T
Other languages
English (en)
Inventor
Gordon Eric Chiroscienc Hutton
Road Milton
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9420243A external-priority patent/GB9420243D0/en
Priority claimed from GBGB9504928.4A external-priority patent/GB9504928D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of ATE187958T1 publication Critical patent/ATE187958T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT95933512T 1994-10-07 1995-10-09 Verfahren zur herstellung von levobupivacain und analogue aus l-lysin ATE187958T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9420243A GB9420243D0 (en) 1994-10-07 1994-10-07 Complex and its use
GBGB9504928.4A GB9504928D0 (en) 1995-03-10 1995-03-10 Diazotisation and cyclisation
PCT/GB1995/002385 WO1996011181A1 (en) 1994-10-07 1995-10-09 The manufacture of levobupivacaine and analogues thereof from l-lysine

Publications (1)

Publication Number Publication Date
ATE187958T1 true ATE187958T1 (de) 2000-01-15

Family

ID=26305755

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95933512T ATE187958T1 (de) 1994-10-07 1995-10-09 Verfahren zur herstellung von levobupivacain und analogue aus l-lysin

Country Status (9)

Country Link
US (1) US5929242A (de)
EP (1) EP0784608B1 (de)
JP (1) JP3970925B2 (de)
AT (1) ATE187958T1 (de)
AU (1) AU695348B2 (de)
DE (1) DE69514115T2 (de)
ES (1) ES2141384T3 (de)
MX (1) MX9702486A (de)
WO (1) WO1996011181A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009089842A1 (en) 2008-01-15 2009-07-23 Pharmathen S.A. Process for producing pipecolic-2-acid-2 ',6'-xylidide useful as an intermediate for the preparation of local anesthetics
CN111548303A (zh) * 2020-06-28 2020-08-18 山东美泰医药有限公司 一种盐酸左布比卡因的杂质及其制备和分析方法

Also Published As

Publication number Publication date
AU695348B2 (en) 1998-08-13
WO1996011181A1 (en) 1996-04-18
EP0784608B1 (de) 1999-12-22
DE69514115T2 (de) 2000-04-20
EP0784608A1 (de) 1997-07-23
JPH10507173A (ja) 1998-07-14
AU3614295A (en) 1996-05-02
US5929242A (en) 1999-07-27
ES2141384T3 (es) 2000-03-16
DE69514115D1 (de) 2000-01-27
JP3970925B2 (ja) 2007-09-05
MX9702486A (es) 1998-04-30

Similar Documents

Publication Publication Date Title
DE59108707D1 (de) Verfahren zur Herstellung von Oxetanonen
DE59510533D1 (de) Verwendung von dioxomorpholinen zur bekämpfung von endoparasiten, neue dioxomorpholine und verfahren zu ihrer herstellung
ATE310630T1 (de) Generatives verfahren zur herstellung eines bauteils sowie vorrichtung zur durchführung des verfahrens
ATE410412T1 (de) Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen
ATE450523T1 (de) Verfahren zur herstellung von 3-halogen-4,5- dihydro-1 h-pyrazolen
ATE232854T1 (de) Verfahren zur herstellung von 9-desoxotaxanen
ATE198738T1 (de) 2-chloro-3,5-bis(trifluoromethyl)phenyl- benzoylharnstoff-derivate und verfahren zur herstellung derselben
DE69525950D1 (de) Racemisierungsverfahren bei der herstellung von levobupivacaine und analogen
ATE221533T1 (de) Verfahren zur racematspaltung von etodolac unter verwendung von glucamin-derivaten
DE69627166D1 (de) Verfahren zur herstellung von 2-chlor-5-chlomethyl-thiazol-derivaten
ATE159512T1 (de) Prozess zur herstellung von beta-phenylisoserin und analogen verbindungen
ATE187440T1 (de) Verfahren zur herstellung von substituierten 3- aminobenzonitrilen
DE69706382D1 (de) Verfahren zur herstellung von 2,2'-bipyrrolyl-pyrromethen-derivaten (prodigiosine)
ATE246515T1 (de) Verfahren zur herstellung von oralen dosierungsformulierungen enthaltend diclofenac
DE60105441D1 (de) Verfahren zur herstellung von pantoprazol und zwischenprodukte dieses verfahrens
DE60015563D1 (de) Verfahren zur herstellung von benzoperhydroisoindolen
ATE187958T1 (de) Verfahren zur herstellung von levobupivacain und analogue aus l-lysin
DE59908525D1 (de) Trockenextrakt aus der hennapflanze, verfahren zu dessen herstellung und dessen verwendung
ATE282594T1 (de) Verfahren zur herstellung von (+)-trans-4-p- fluorophenyl-3-hydroxymethyl-1-methylpiperidin
ATE299851T1 (de) Verfahren zur herstellung von zwischenprodukten
DE69414586D1 (de) Verfahren zur herstellung von indolizinderivaten
ATE121626T1 (de) Verwendung von 20(r)-22-oxa-vitamin d analoge zur herstellung eines medikaments für die behandlung des altershaut.
ATE250581T1 (de) Verfahren zur herstellung von 3-cyanopyridin aus 2-methyl-1,5-pentandiamin
DE50312447D1 (de) Verfahren zur herstellung von 4,6-dichlor-5-fluorpyrimidin
DE59501170D1 (de) Verfahren zur herstellung von 6-aryloxymethyl-1-hydroxy-4-methyl-2-pyridonen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties