CN115105162A - 具有滑动保持架夹紧机构的血管栓塞取回装置 - Google Patents

具有滑动保持架夹紧机构的血管栓塞取回装置 Download PDF

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CN115105162A
CN115105162A CN202210268876.9A CN202210268876A CN115105162A CN 115105162 A CN115105162 A CN 115105162A CN 202210268876 A CN202210268876 A CN 202210268876A CN 115105162 A CN115105162 A CN 115105162A
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T·奥马利
S·惠兰
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Abstract

本发明题为“具有滑动保持架夹紧机构的血管栓塞取回装置”。所公开技术包括凝块取回装置，该凝块取回装置被构造成从血管中取回凝块并且具有约束递送构型和凝块接合构型。该装置可包括：第一可膨胀框架，该第一可膨胀框架具有形成第一主体的第一多个撑条；以及第二可膨胀框架，该第二可膨胀框架具有在凝块取回装置从约束递送构型转变为凝块接合构型时形成第二主体的第二多个撑条。在凝块接合构型中，第一主体可被构造成相对于第二主体从第一位置移动到第二位置。在从第一位置移动到第二位置时，凝块取回装置可以在第一主体与第二主体之间夹紧凝块。

Description

具有滑动保持架夹紧机构的血管栓塞取回装置
技术领域
本公开整体涉及用于在血管内医学治疗期间从血管移除堵塞物的装置和方法。
背景技术
在患者患有诸如急性缺血性中风(AIS)、心肌梗塞(MI)和肺栓塞(PE)等病症的情况下，在针对血管内干预的机械血栓切除术中经常使用凝块取回装置。急性栓塞可包括凝块、错位装置、迁移装置、大栓塞物等。当部分或全部血栓从血管壁脱离时，发生血栓栓塞。这种凝块(现在称为栓塞)随后沿血流方向运送。如果凝块滞留在大脑脉管系统中，则可能导致缺血性脑卒中。如果凝块起源于静脉系统或心脏的右侧并滞留在肺动脉或其分支中，则可能导致肺栓塞。凝块也可不以栓塞的形式释放，而是在局部形成并堵塞血管，这种机制在形成冠状动脉堵塞中较为常见。
设计可提供高水平性能的凝块取回装置存在重大挑战。首先，存在使得难以递送装置的许多进入挑战。在进入涉及导航主动脉弓(诸如冠状动脉或脑堵塞)的情况下，一些患者的弓构型使得难以定位引导导管。这些困难的弓构型被分类为2型或3型主动脉弓，其中3型弓呈现最大的困难。
在接近大脑的动脉中，曲折性挑战甚至更严重。例如，在颈内动脉的远侧端部处，装置将不得不在几厘米的血管中快速连续地导航具有180°弯曲、90°弯曲和360°弯曲的血管段，这种情况并不罕见。在肺栓塞的情况下，通过静脉系统并然后通过心脏的右心房和心室获得进入。右心室流出道和肺动脉是脆弱的血管，其很容易被不灵活或高轮廓的装置损坏。出于这些原因，期望凝块取回装置与尽可能低的轮廓和柔性的引导导管兼容。
其次，凝块可能滞留在的区域中的脉管系统通常是脆弱且纤弱的。例如，神经血管可比身体其他部位的类似尺寸的血管更脆弱并且可位于软组织床中。施加在这些血管上的过大拉力可能导致穿孔和出血。肺血管可大于大脑脉管系统的血管，但其性质也很纤弱，特别是更远侧血管。
另外，凝块可以具有一系列形态和一致性中的任何一种。例如，凝块可能难以夹持，并且不恰当的夹持可导致碎片化，这可能导致栓塞。较软凝块材料的长线束还可能倾向于在分叉或三分叉处滞留，从而导致多个血管同时在显著长度上被闭塞。更成熟且有组织的凝块材料可能比较软的较新鲜凝块更难以压缩，并且在血压作用下，其可能会使容纳该材料的顺应性血管扩张。此外，凝块的性质可以通过与其相互作用的装置的作用而显著改变。具体地，血液凝块的压缩可以导致凝块脱水并且可以导致凝块硬度和摩擦系数两者的显著增加。
最后，采用夹紧机构来捕获凝块的传统凝块取回装置可能需要递送微导管在部署凝块取回装置后正向，以便使用装置有效地夹紧凝块。然而，这可以在规程中添加附加的步骤，从而导致潜在的繁琐和非最佳规程。由于此类规程的关键性质，以及时且有效的方式捕获凝块可能是至关重要的。
对于装置需要克服上述挑战以便在移除凝块和恢复血流方面提供高水平的成功。
发明内容
期望凝块取回装置从患有AIS的患者的脑动脉、患有MI的患者的冠状天生或移植血管和患有PE的患者的肺动脉以及凝块造成至少部分闭塞的其他外周动脉和静脉血管中移除凝块。本文呈现的示例性装置和方法可以适用于此类规程和/或类似规程中的至少一些规程。
示例性凝块取回装置可具有约束递送构型和凝块接合构型，并且可被构造成从血管移除凝块。该装置可包括：第一可膨胀框架，该第一可膨胀框架具有形成第一主体的第一多个撑条；以及第二可膨胀框架，该第二可膨胀框架具有形成第二主体的第二多个撑条。在凝块接合构型中，第一主体可被构造成相对于第二主体从第一位置移动到第二位置。
第一主体可具有第一内径，并且第二主体可具有第二内径。第一内径和第二内径可以基本上相等。
当第一主体处于第一位置时，第一多个撑条和第二多个撑条可以脱离接合，使得形成多个凝块接纳空间。
当第一主体处于第二位置时，第一多个撑条和第二多个撑条可以接合，使得多个凝块接纳空间的平均横截面面积在第一主体从第一位置移动到第二位置时减小。
第一多个撑条可包括径向延伸的撑条，并且第二多个撑条可包括径向延伸的撑条径向延伸穿过的孔眼。孔眼和径向延伸的撑条可被构造成使得当第一主体从第一位置移动到第二位置时，径向延伸的撑条接合孔眼以抑制第一多个撑条相对于第二多个撑条移动超过第二位置。每个孔眼可以是锥形的。
凝块取回装置可包括聚合物涂层以接合第一多个撑条和第二多个撑条。聚合物涂层可被构造成失效，从而允许第一主体从第一位置移动到第二位置。
至少一个聚合物膜可以附连到第一多个撑条和第二多个撑条，使得聚合物膜设置在第一主体与第二主体之间。
当第一主体处于第一位置时，至少一个聚合物膜可以处于折叠构型，并且当第一主体朝近侧移动到第二位置时，至少一个聚合物膜可以转变为拉伸构型。
凝块取回装置可包括具有形成第三主体的第三撑条框架的第三可膨胀框架。在凝块接合构型中，第一主体和第二主体可以至少部分地围绕第三主体。
凝块取回装置的近侧端部可包括形成套环的多个膨胀撑条。
第三撑条框架可包括至少一个断开的撑条。
第三主体可包括多个凝块接纳空间。多个凝块接纳空间可被构造成接合凝块。
另一个示例性凝块取回装置可以具有约束递送构型和凝块接合构型，并且可被构造成从血管移除凝块。该装置可包括内部可膨胀框架、外部可膨胀框架和弹簧。内部可膨胀框架可以附连到拉线，并且可包括形成内部主体的第一多个撑条。外部可膨胀框架可以附连到拉线，并且可包括形成至少部分地围绕内部主体的外部主体的第二多个撑条。弹簧可以附连到拉线的远侧端部，并且可具有压缩构型和细长构型。在凝块接合构型中，内部主体可被构造成相对于外部主体从第一位置移动到第二位置，使得弹簧从压缩构型转变为细长构型。
外部可膨胀框架可包括多个凝块接纳空间，该多个凝块接纳空间被构造成当内部主体从第一位置移动到第二位置时将凝块夹紧在内部主体与外部主体之间。
用于捕获凝块的示例性方法可包括在凝块近侧部署凝块取回装置，其中凝块取回装置包括形成第一主体的第一可膨胀框架和形成至少部分地围绕第一主体的第二主体的第二可膨胀框架。该方法还可包括使第一主体相对于第二主体移动以将凝块的至少一部分夹紧在第一主体与第二主体之间并捕获凝块的一个或多个碎片。
使第一主体相对于第二主体移动以将凝块的至少一部分夹紧在第一主体与第二主体之间可包括向拉线施加张力，其中拉线与第一主体机械连通。
该方法还可包括同时缩回第一主体和第二主体。
凝块取回装置还可包括具有形成第三主体的第三多个撑条的第三可膨胀框架。第一主体和第二主体可以至少部分地围绕第三主体。在此类构型中，该方法还可包括在近侧方向上缩回第三主体以接合第一主体和第三主体。
技术方案1.一种凝块取回装置，所述凝块取回装置包括约束递送构型和凝块接合构型并且被构造成从血管中移除凝块，所述装置包括：
第一可膨胀框架，所述第一可膨胀框架包括形成第一主体的第一多个撑条；以及
第二可膨胀框架，所述第二可膨胀框架包括形成至少部分地围绕所述第一主体的第二主体的第二多个撑条，
其中在所述凝块接合构型中，所述第一主体被构造成相对于所述第二主体从第一位置移动到第二位置。
技术方案2.根据技术方案1所述的凝块取回装置，其中所述第一主体具有第一内径，并且所述第二主体具有第二内径，所述第一内径和所述第二内径基本上相等。
技术方案3.根据技术方案1所述的凝块取回装置，其中当所述第一主体处于所述第一位置时，所述第一多个撑条和所述第二多个撑条脱离接合，使得形成多个凝块接纳空间。
技术方案4.根据技术方案3所述的凝块取回装置，其中当所述第一主体处于所述第二位置时，所述第一多个撑条和所述第二多个撑条接合，使得所述多个凝块接纳空间的平均横截面面积在所述第一主体从所述第一位置移动到所述第二位置时减小。
技术方案5.根据技术方案1所述的凝块取回装置，其中所述第一多个撑条包括至少一个径向延伸的撑条，并且所述第二多个撑条包括至少一个孔眼，所述至少一个径向延伸的撑条径向延伸穿过所述至少一个孔眼，所述至少一个孔眼和所述至少一个径向延伸的撑条被构造成使得当所述第一主体从所述第一位置移动到所述第二位置时，所述至少一个径向延伸的撑条接合所述至少一个孔眼以抑制所述第一多个撑条相对于所述第二多个撑条移动超出所述第二位置。
技术方案6.根据技术方案5所述的凝块取回装置，其中每个孔眼是锥形的。
技术方案7.根据技术方案1所述的凝块取回装置，所述凝块取回装置还包括聚合物涂层以接合所述第一多个撑条和所述第二多个撑条，所述聚合物涂层被构造成失效以允许所述第一主体从所述第一位置移动到所述第二位置。
技术方案8.根据技术方案1所述的凝块取回装置，所述凝块取回装置还包括附连到所述第一多个撑条和所述第二多个撑条的至少一个聚合物膜，使得所述聚合物膜设置在所述第一主体与所述第二主体之间。
技术方案9.根据技术方案8所述的凝块取回装置，其中当所述第一主体处于所述第一位置时，所述至少一个聚合物膜处于折叠构型，并且当所述第一主体朝近侧移动到所述第二位置时，所述至少一个聚合物膜转变为拉伸构型。
技术方案10.根据技术方案1所述的凝块取回装置，所述凝块取回装置还包括第三可膨胀框架，所述第三可膨胀框架包括形成第三主体的第三多个撑条，在所述凝块接合构型中，所述第一主体和所述第二主体至少部分地围绕所述第三主体。
技术方案11.根据技术方案10所述的凝块取回装置，其中所述第三主体被构造成相对于所述第一主体和所述第二主体移动。
技术方案12.根据技术方案10所述的凝块取回装置，其中所述凝块取回装置的近侧端部包括形成套环的多个膨胀撑条。
技术方案13.根据技术方案10所述的凝块取回装置，其中所述第三多个撑条包括至少一个断开的撑条。
技术方案14.根据技术方案10所述的凝块取回装置，其中所述第三主体包括多个凝块接纳空间，所述多个凝块接纳空间被构造成接合所述凝块。
技术方案15.一种凝块取回装置，所述凝块取回装置包括约束递送构型和凝块接合构型并且被构造成从血管中移除凝块，所述装置包括：
内部可膨胀框架，所述内部可膨胀框架附连到拉线并且包括形成内部主体的内部多个撑条；
外部可膨胀框架，所述外部可膨胀框架附连到所述拉线并且包括外部多个撑条，所述外部多个撑条形成至少部分地围绕所述内部主体的外部主体；以及
弹簧，所述弹簧附连到所述拉线的远侧端部近侧，所述弹簧具有压缩构型和细长构型，
其中在所述凝块接合构型中，所述内部主体被构造成相对于所述外部主体从第一位置移动到第二位置，使得所述弹簧从所述压缩构型转变为所述细长构型。
技术方案16.根据技术方案15所述的凝块取回装置，其中所述外部可膨胀框架包括多个凝块接纳空间，所述多个凝块接纳空间被构造成当所述内部主体从所述第一位置移动到所述第二位置时将所述凝块夹紧在所述内部主体与所述外部主体之间。
技术方案17.一种捕获凝块的方法，所述方法包括：
在所述凝块近侧部署凝块取回装置，所述凝块取回装置包括形成第一主体的第一可膨胀框架和形成至少部分地围绕所述第一主体的第二主体的第二可膨胀框架；
使所述第一主体相对于所述第二主体移动以将所述凝块的至少一部分夹紧在所述第一主体与所述第二主体之间；以及
捕获所述凝块的一个或多个碎片。
技术方案18.根据技术方案17所述的方法，其中使所述第一主体相对于所述第二主体移动以将所述凝块的至少一部分夹紧在所述第一主体与所述第二主体之间包括向拉线施加张力，所述拉线与所述第一主体机械连通。
技术方案19.根据技术方案17所述的方法，所述方法还包括同时缩回所述第一主体和所述第二主体。
技术方案20.根据技术方案17所述的方法，其中所述凝块取回装置还包括第三可膨胀框架，所述第三可膨胀框架包括形成第三主体的第三多个撑条，所述第一主体和所述第二主体至少部分地围绕所述第三主体，所述方法还包括：
在近侧方向上缩回所述第三主体以接合所述第一主体和所述第三主体。
附图说明
图1A是根据本公开的处于凝块接合构型的示例性凝块取回装置的侧视图。
图1B是根据本公开的图1A的凝块取回装置的不同视角的附加侧视图。
图1C是根据本公开的图1A和图1B的凝块取回装置的轴的横截面视图。
图1D是根据本公开的接合到图1A和图1B的凝块取回装置的第一多个撑条的拉线的放大视图。
图1E是根据本公开的图1A和图1B的凝块取回装置的径向延伸的撑条和孔眼的放大视图。
图1F是根据本公开的在转变为凝块夹紧构型时图1A和图1B的凝块取回装置的侧视图。
图1G是根据本公开的图1F所示的处于凝块夹紧构型的凝块取回装置的附加侧视图。
图2A是根据本公开的处于凝块接合构型的附加示例性凝块取回装置的侧视图。
图2B是根据本公开的图2A的凝块取回装置的近侧部分的横截面视图。
图2C至图2E示出了根据本公开的图2A的凝块移除装置的第三主体的示例。
图2F是根据本公开的图2A的凝块取回装置的附加侧视图。
图2G示出了根据本公开的图2A的凝块移除装置的示例性第三套环。
图3A示出了根据本公开的具有处于压缩构型的弹簧的附加示例性凝块取回装置。
图3B示出了根据本公开的其中弹簧处于细长构型的图3A的凝块取回装置。
图4是概述使用图1A至图1G的凝块取回装置捕获凝块的方法的流程图。
图5是概述使用图2A至图2G的凝块取回装置捕获凝块的方法的流程图。
具体实施方式
本专利申请中描述的设计和功能本质上旨在是示例性的，并且并不旨在以任何方式限制本公开。相关领域的技术人员将理解，本公开的教导可以以各种合适的形式来实现，包括本文公开的那些形式以及相关领域的技术人员已知的附加形式。
根据以上描述将显而易见的是，虽然已经图示并描述了本公开的具体实施方案，但是可在不脱离本公开的实质和范围的情况下进行各种修改。例如，虽然本文描述的实施方案涉及具体特征结构，但是本公开包括具有不同特征结构的组合的实施方案。本公开还包括不包括所描述的所有特定特征结构的实施方案。现在参考附图详细描述本公开的具体实施方案，其中相同的参考标号表示相同或功能性相似的元件。
术语“远侧”或“近侧”用于下文有关相对于治疗医师的位置或方向的描述。“远侧”或“朝远侧”为远离医师的位置或在远离医师方向上。“近侧”或“朝近侧”或“在近侧”为靠近医师的位置或在朝向医师方向上。
在以下描述中，阐述了许多具体细节。但是应理解，可以在没有这些具体细节的情况下实践所公开技术的示例。在其他情况下，未详细示出熟知的方法、结构和技术，以免模糊对本说明书的理解。对“一个实施方案”、“实施方案”、“示例性实施方案”、“一些实施方案”、“某些实施方案”、“各种实施方案”、“一个示例”、“一些示例”、“某些示例”、“各种示例”等的引用指示所描述的所公开技术的实施方案和/或示例可以包括特定特征、结构或特性，但不包括特定特征、结构或特性。此外，短语“在一个实施方案中”等的重复使用不一定是指相同的实施方案、示例或实施方式，尽管其可以。
“包含”或“含有”或“包括”或“具有”是指至少命名的化合物、元素、颗粒、构型或方法步骤存在于组合物或装置或方法中，但不排除存在其他化合物、材料、颗粒、方法步骤或构型，即使其他此类化合物、材料、颗粒、方法步骤或构型具有与命名的那些相同的功能。
在整个说明书和权利要求书中，除非上下文另有明确规定，否则以下术语采用至少本文明确相关的含义。术语“或”旨在表示包含性的“或”。此外，除非另有说明或从上下文中明确指定为单数形式，否则术语“一(a)”、“一个(an)”和“该(the)”旨在表示一个或多个。
除非另有说明，否则使用序数形容词“第一”、“第二”、“第三”等来描述公共对象仅指示相似对象的不同实例被提及，并且不旨在暗示如此描述的对象应按给定的顺序排列，无论是在时间上、空间上、排名上还是以任何其他方式。
如本文所用，针对任何数值或范围的术语“约”或“大约”指示允许部件或元件的集合实现如本文所述的其预期要达到的目的的合适的尺寸公差。更具体地，“约”或“大约”可指列举值的值±20％的范围，例如“约90％”可指71％至99％的值范围。
如本文所讨论的，“患者”或“个体”可以是人或任何动物。应当理解，动物可以是各种任何适用的类型，包括但不限于哺乳动物、兽医动物、家畜动物或宠物类动物等。例如，动物可以是专门选择具有与人类相似的某些特性的实验动物(例如，大鼠、狗、猪、猴等)。
接近血管内的各种血管(无论是冠状血管、肺血管还是脑血管)涉及熟知的手术步骤和许多常规的可商购获得的附件产品的使用。这些产品诸如血管造影材料和导丝广泛用于实验室和医学规程中。当这些产品与以下描述中的本公开的系统和方法结合使用时，其功能和确切构造未被详细描述。
所公开技术通常可包括凝块移除装置，该凝块移除装置具有滑动保持架(例如，第一主体)和径向围绕滑动保持架的外部保持架(例如，第二主体)。拉线可以附连到滑动保持架，使得在张力施加到拉线时，滑动保持架可以朝近侧且独立于外部保持架移位。在滑动保持架朝近侧移位时，滑动保持架和外部保持架可以夹紧凝块。在一些情况下，凝块移除装置还可包括内部通道(例如，第三主体)。外部保持架和滑动保持架可以径向围绕内部通道。在施加张力后，内部通道可以朝近侧且独立于外部保持架和滑动保持架移动。随后，滑动保持架可以相对于外部保持架且独立于外部保持架朝近侧移动。在此类构型中，滑动保持架和外部保持架可以进一步夹紧凝块，并且因此凝块可以进一步整合在凝块移除装置内。因此，可以执行对血管凝块的高效且有效的移除。
现在参考附图，图1A和图1B示出了处于凝块接合构型的示例性凝块取回装置100的侧视图。凝块取回装置100可包括第一可膨胀框架102和第二可膨胀框架104。第一可膨胀框架102可包括第一多个撑条106，并且第二可膨胀框架104可包括第二多个撑条108。
第一可膨胀框架102和第二可膨胀框架104可以塌缩成约束护套(例如，微导管)，该约束护套的尺寸被设定成横穿凝块或其他栓塞。凝块取回装置100可以定位在血管中的凝块近侧。任选地，凝块取回装置100可以横穿凝块，使得凝块移除装置100的一部分相对于凝块正向。第一可膨胀框架102和第二可膨胀框架104可各自被构造成在从约束护套释放时自膨胀。在释放时，凝块取回装置100可以从约束递送构型转变为凝块接合构型，使得凝块取回装置100随后可以用于促进凝块移除、血流恢复和/或碎片化保护。
在转变为凝块接合构型后，第一可膨胀框架102的第一多个撑条106可膨胀以形成第一主体110。类似地，第二可膨胀框架104的第二多个撑条108可膨胀以形成第二主体112。第二主体112可至少部分地径向围绕第一主体110。任选地，第二主体112可以完全地径向围绕第一主体110。
包括第一多个撑条106的第一可膨胀框架102和包括第二多个撑条108的第二可膨胀框架104两者可以优选地由一旦从约束递送构型释放就能够自动恢复其形状的材料制成。超弹性材料或拟弹性材料诸如镍钛诺或类似性质的合金是特别合适的。该材料可具有足以如本文所述弹性塌缩和膨胀的高可恢复应变。该材料可为多种形式，诸如线状或条状或片状或管状。特别合适的制造工艺是激光切割镍钛诺管，然后对所得结构进行热定形和电抛光，以形成撑条和连接元件的框架。例如，第一可膨胀框架102和第二可膨胀框架104可以各自由具有大约0.40毫米的外径的镍钛诺管激光切割而成。根据本文所公开的教导内容，如相关领域的技术人员所理解的，第一可膨胀框架102和第二可膨胀框架104可以是一系列形状中的任一种。可通过添加合金元素或通过多种其他涂层或标记带使第一可膨胀框架102和第二可膨胀框架104在荧光镜透视检查下可见。例如，第一可膨胀框架102和第二可膨胀框架104可包括具有不透射线材料的材料和/或标记物，包括但不限于硫酸钡、次碳酸铋、氯氧化钡、金、钨、铂、铱、钽以及它们的合金。具体地讲，在一些示例中，第一可膨胀框架102和第二可膨胀框架104可包括具有铱合金，并且更具体地具有铂-铱合金的不透射线标记物。
如图1A和图1B所示，在凝块接合构型中，第一主体110和第二主体112可各自具有基本上圆柱形的形状。此外，第一主体110可具有第一内径134，并且第二主体112可具有第二内径136。第一内径134可以与第二内径136大致相同，使得第一主体110和第二主体112可以基本上彼此对准。举例来说，第一主体的第一内径134可以是大约4.75毫米，并且第二内径136可以是大约5毫米。因为第一主体110和第二主体112具有基本上相等的内径132、134，所以第一主体110可以在凝块接合构型中对第二主体112施加向外的力。
图1A和图1B示出了处于第一位置的第一主体110和第二主体112。第一多个撑条106可以形成具有闭孔的第一多个支架段138a，并且第二主体112的第二多个撑条108可以形成也具有闭孔的第二多个支架段138b。第一多个支架段138a和第二多个支架段138b可以基本上彼此对准。可以在第一多个支架段138a和第二多个支架段138b的每个支架段之间形成间隙。此类间隙可以是被构造成接纳凝块的凝块接纳空间120。在第一主体110相对于第二主体112从第一位置移动到第二位置时，凝块的部分可以进入此类凝块接纳空间120，由此被凝块取回装置100捕获，如本文进一步讨论的。
第一主体110和第二主体112的远侧端部可以形成远侧篮122。远侧篮122可具有基本上圆锥形形状并且可以减轻和/或防止凝块的捕获的碎片迁移出凝块取回装置100。
如图1C和图1D进一步所示，凝块取回装置100的近侧端部可包括轴132，该轴包括被外部护套116围绕的拉线114。第一多个撑条106中的近侧撑条可以附连到拉线114，如图1D所示。拉线114可以由不锈钢、MP35N、镍钛诺或具有适当高模量和拉伸强度的其他材料制成。拉线114可以优选地具有实芯，但也可以具有中空芯。第一主体110的第一多个撑条106可以经由焊接、粘结、通过从连续管切割下来或其他附接方式在接头130处附连到拉线114。接头130可以在第一多个撑条106中的近侧撑条和拉线114的附接的大致位置处形成。当第一主体110相对于第二主体112移动时，此类接头130可以抑制超出期望位置的非预期移动，如本文进一步讨论的。第二主体112的第二多个撑条108可以经由焊接、粘结接合到外部护套116，或者第二主体112可以使用与外部护套116相同的镍钛诺或其他材料管材形成。因为第一主体110和第二主体112附连到轴132的独立部分(例如，分别为拉线114和外部护套116)，所以第一主体110和第二主体112可以在施加到拉线114上时彼此独立地移动，如本文进一步讨论的。
图1E示出了基本上对准的第一主体110和第二主体112的放大视图，并且包括任选的径向延伸的撑条126和孔眼124，以抑制第一主体110与第二主体112之间的滑动移动范围。如图所示，第二主体112可径向围绕第一主体110，使得第二多个撑条108位于第一多个撑条106的外部。第二多个撑条108还可包括一个或多个孔眼124，并且第一多个撑条106可包括一个或多个径向延伸的“连接器”撑条，每个撑条延伸穿过相应的孔眼124。每个孔眼124可具有细长或替代形状的开口。举例来说，孔眼124可以基本上是卵圆形、圆形、矩形等。在一些示例中，孔眼124可以是基本上锥形的。
图1F和图1G示出了凝块取回装置100处于凝块夹紧构型的侧视图，其中第一主体110相对于第二主体112从如图1A和图1B所示的第一位置移动(例如，滑动)到第二位置。可以在近侧方向上拉动拉线114以施加张力。张力可使第一主体110相对于第二主体112从第一位置(图1A和图1B)移动到的第二位置(图1F和图1G)。因此，第一主体110可以相对于第二主体112从第一位置滑动到第二位置，使得第一主体110和第二主体112彼此接合。例如，第一主体110可以相对于第二主体112滑动小于大约5毫米。任选地，第一主体110可以相对于第二主体112滑动小于约4毫米。任选地，第一主体110可以相对于第二主体112滑动小于大约2毫米。任选地，第一主体110可以相对于第二主体112滑动小于大约0.5毫米。当第一主体110从第一位置移动到第二位置并且装置100包括一个或多个穿过相应的孔眼124的径向延伸的撑条126时，如图1E所示，径向延伸的撑条126可以与孔眼124接合，从而允许第一主体110和第二主体112彼此接合。此外，孔眼124可以抑制第一主体110相对于第二主体112移动超过第二位置，因为孔眼124可以限制径向延伸的撑条126在近侧方向上移动太远。
附加地或另选地，第一可膨胀框架102和第二可膨胀框架104可以涂覆有聚合物涂层(例如，聚对二甲苯)，以将第一主体110相对于第二主体112临时保持在第一位置。在拉线114沿近侧方向拉动时，聚合物涂层可能失效，使得第一主体110可以相对于第二主体112从第一位置移动到第二位置。可以施加抽吸以便从失效的聚合物涂层中移除颗粒。
附加地或另选地，第一主体110和第二主体112的形状记忆效应可以用于在已经经过预定时间段之后使第一主体110自动位移。例如，第二可膨胀框架104的第二多个撑条108可以局部热处理，以将奥氏体化终了温度(austenite finish temperature)提高到大于卒中或其他关键身体发生期间的典型体温的范围。第二多个撑条108可以在重新装护套时膨胀，然后通过电流加热到奥氏体化终了温度。在达到奥氏体化终了温度后，第一主体110可以相对于第二主体112从第一位置自动移动(例如，滑动)到第二位置，使得凝块可以被夹紧在第一主体110与第二主体112之间。
拉线114可以在近侧方向上拉动，使得第一主体110在近侧方向上移动(例如，滑动)，直到第一多个撑条106的近侧撑条遇到定位在轴132近侧的接头130。因此，接头130可以充当防止不期望的移动超出第二位置的机构。当第一主体110从第一位置移动到第二位置时，多个凝块接纳空间120的平均横截面面积可以减小(例如，至少部分地关闭)。例如，当第一多个支架段138a相对于第二多个支架段138b滑动时，多个凝块接纳空间120可以至少部分地关闭，使得第一多个支架段138a被设置在凝块接纳空间120上。由此，凝块可以被夹紧在第一主体110与第二主体112之间。凝块的夹紧可以防止凝块迁移出凝块取回装置100，特别是在凝块取回装置100缩回时，因为与其他凝块取回装置相比，夹紧可以增加凝块取回装置100的抓握力，特别是富含纤维蛋白的凝块。因此，凝块取回装置100可以确保对患者的凝块的有效且高效的移除。
如图1F和图1G所示，凝块取回装置100可包括设置在第一主体110与第二主体112之间的聚合物膜128。聚合物膜128(例如，弹性膜)可被构造成当第一主体110处于第一位置时从折叠构型转变，使得在第一主体110从第一位置移动到第二位置时第一主体110和第二主体112脱离接合到拉伸构型。聚合物膜128由此可以起到限制第一主体110相对于第二主体112的横向移动的作用，作为图1E所示的径向延伸的撑条126和孔眼124的补充或替代。聚合物膜128可以通过将微纤维穿过第二主体112的孔眼124来形成，并且/或者聚合物膜128可以通过将聚合物膜128钩到孔眼124中来形成。一旦凝块已经被夹紧在第一主体110与第二主体112之间，聚合物膜128就可以防止凝块迁移出凝块取回装置100。尽管图1F和图1G示出了在一个位置中的聚合物膜128，但是预期凝块取回装置100可以在多个位置包括附加的聚合物膜128。例如，凝块取回装置100可包括位于远侧篮122近侧的第一聚合物膜和位于轴132近侧的第二聚合物膜。
图2A示出了附加的示例性凝块取回装置200。如上文参考图1A至图1G所示的凝块取回装置100所讨论的，凝块取回装置200可类似地包括第一可膨胀框架102和第二可膨胀框架104，该第一可膨胀框架包括第一多个撑条106，该第二可膨胀框架包括第二多个撑条108。在凝块取回装置200从约束护套(例如，微导管)部署并从约束递送构型转变到凝块接合构型时，第一可膨胀框架102的第一多个撑条106可自膨胀以形成第一主体110，并且第二可膨胀框架104的第二多个撑条108可自膨胀以形成第二主体112。第一主体110和第二主体112可为基本上圆柱形的。另外，第一主体110和第二主体112可具有基本上相等的内径134、136。如此，并且如上所述，第一主体110和第二主体112的多个支架区段138a、138b可以基本上彼此对准。
与图1A至图1G所示的凝块取回装置100相比，凝块取回装置200还可包括具有第三多个撑条204的第三可膨胀框架202。在从约束护套部署凝块取回装置200后，第三可膨胀框架202的第三多个撑条204可以自膨胀以形成第三主体206。第三主体206可以是基本上多孔的。此外，第三主体206可以类似地是基本上圆柱形的，并且可以具有小于第一主体110的内径134和第二主体112的内径136的内径238。由此，第一主体110和第二主体112可以径向围绕第三主体206。任选地，第三主体206可具有大约为第一主体110的内径134和第二主体112的内径136的大小的一半(1/2)的内径238。任选地，第三主体206可具有大约为第一主体110的内径134和第二主体112的内径136的大小的四分之三(3/4)的内径238。第三可膨胀框架202可以优选地由这样的材料制成，该材料一旦从收缩递送构型释放后就能够自动恢复其形状。超弹性材料或拟弹性材料诸如镍钛诺或类似性质的合金是特别合适的。该材料可具有足以如本文所述弹性塌缩和膨胀的高可恢复应变。该材料可为多种形式，诸如线状或条状或片状或管状。特别合适的制造工艺是激光切割镍钛诺管，然后对所得结构进行热定形和电抛光，以形成撑条和连接元件的框架。任选地，第三可膨胀框架202可以由镍钛诺管激光切割而成。
如上文参考凝块取回装置100所讨论的，第一主体110可包括第一多个支架段138a，并且第二主体112可包括第二多个支架段138b。第一多个支架段138a和第二多个支架段138b可以基本上彼此对准。可以在第一多个支架段138a和第二多个支架段138b中的每个支架段之间形成间隙。此类间隙可以是凝块接纳空间120，该凝块接纳空间被构造成在凝块取回装置200转变为凝块夹紧构型时接纳凝块的至少一部分，如本文进一步描述。第三主体206的构型可以类似地产生附加的凝块接纳空间230，如本文进一步讨论的。
凝块取回装置200的远侧端部可包括远侧篮122。远侧篮122可具有基本上圆锥形形状并且可以减轻凝块的捕获的碎片迁移出凝块取回装置200。
如图2B进一步所示，多个膨胀撑条208a、208b可以由第一主体110的轴216形成。例如，第一主体110的轴216可以是管(例如，镍钛诺管)，并且两个膨胀撑条208a、208b可以由此类管形成(例如，激光切割)。第一主体110的轴216可以是尺寸被设定成接纳拉线114的中空管。因此，拉线114可以延伸穿过第一主体110的轴216。当凝块取回装置200转变为凝块夹紧构型时，多个膨胀撑条208a、208b可以促进改进的夹紧。任选地，如果在凝块取回装置200转变为凝块夹紧构造时未形成有效的夹紧，则多个膨胀撑条208a、208b可以用于允许第三主体206的再膨胀以稳定凝块。第二主体112的轴222可以围绕第一主体110的轴216和拉线114。第二主体112的轴222可以是管(例如，镍钛诺管)。第二主体112的近侧撑条224可以从第二主体112的轴222的远侧端部延伸。近侧撑条224可以是第二可膨胀框架104的最近侧撑条。第三主体206的轴218的近侧端部可以附连到拉线114的远侧端部。第三主体206的轴218可以是实芯管。可以形成接头220(例如，焊接接头)，其中第三主体206的轴218附连到拉线114，并且其中第一主体110的轴216形成膨胀撑条208a、208b。第三主体206的近侧撑条226可以从第三主体206的轴218的远侧端部延伸。近侧撑条226可以是第三可膨胀框架202的最近侧撑条。
图2C至图2E示出了第三主体206的各种构型。在图2C至图2E中，第三多个撑条204可被构造成形成互连撑条的基本上圆柱形主体。第三多个撑条204可以彼此互连，使得第三多个撑条形成大部分闭孔。第三多个撑条204可被构造成形成不同尺寸的闭孔。任选地，可以根据待捕获的凝块的含量(例如，基于待捕获的凝块有多柔软和/或富含多少纤维蛋白)来设定闭孔的大小。如图2C至图2E所示，第三主体206还可包括多个凝块接纳空间230。每个凝块接纳空间230的大小可以基于第三多个撑条204的构型。任选地，如图2C和图2E所示，第三多个撑条204可包括至少一个断开的撑条204a。断开的撑条可以形成开孔。此类开孔可以形成较大的凝块接纳空间230，并且由此促进凝块迁移到第三主体206中。任选地，第三多个撑条204可包括多个断开的撑条204a，使得大部分孔是开孔。第三主体206可用于两个主要功能。例如，第三主体206可以促进允许血液通过，使得当凝块取回装置200捕获和抽出凝块时，至少部分血液流过血管。另外，在部署凝块取回装置200时，凝块可以部分地整合到第一主体110和第二主体112的凝块接纳空间120中。在第三主体206相对于第一主体110和第二主体112移动(例如，滑动)时，第三主体206可以与凝块相互作用，从而在形成夹紧之前促进凝块在第一主体110与第二主体112之间进一步整合。
图2F示出了凝块取回装置200的附加侧视图。如图2F所示，第一主体110可包括第一套环210，第二主体112可包括第二套环212，并且第三主体206可包括第三套环214。每个套环210、212、214可有助于相对于第一主体110和第二主体112移动(例如，滑动)第三主体206，并且随后相对于第二主体112移动(例如，滑动)第一主体110以夹紧凝块的至少一部分。拉线114可以附连到第三主体206，并且可以穿过每个套环210、212、214，使得在拉线114沿近侧方向拉动时，凝块取回装置200可以从第一位置移动(例如，滑动)到第二位置并且随后从第二位置移动到第三位置。
图2G示出了示例性第三套环214。第三套环214可以设置在膨胀撑条208a、208b结合的位置处。第三套环214可以以特定的设计进行激光切割，以便于在凝块取回装置200从第一位置移动到第二位置并随后从第二位置移动到第三位置时夹紧凝块。
为了使用凝块取回装置200夹紧凝块，可以在近侧方向上拉动拉线114。此类张力可使第三主体206相对于第一主体110和第二主体112移动(例如，滑动)，从而使凝块取回装置200从第一位置转变到第二位置，如第一箭头232所示。例如，第三主体206可以相对于第一主体110和第二主体112滑动小于大约5毫米。任选地，第三主体206可以相对于第一主体110和第二主体112滑动小于大约4毫米。任选地，第三主体206可以相对于第一主体110和第二主体112滑动小于大约2毫米。任选地，第三主体206可以相对于第一主体和第二主体112滑动小于大约0.5毫米。
在第三主体206相对于第一主体110和第二主体112移动时，凝块的至少一部分可以被夹紧在第三主体206与第一主体110和第二主体112之间，以使凝块的部分在第一主体110和第二主体112内部迁移。另外，在第三主体206从第一位置移动到第二位置时，当第三套环214与第一套环210接合时，第三主体206可以与第一主体110接合。当第三套环214和第一套环210接合时，拉力可以传递到第一主体110，从而允许进一步的位移。
随后，第一主体110可以相对于第二主体112移动(例如，滑动)，使得凝块取回装置200从第二位置转变到第三位置，如第二箭头234所示。例如，第一主体110可以相对于第二主体112滑动小于大约5毫米。任选地，第一主体110可以相对于第二主体112滑动小于约4毫米。任选地，第一主体110可以相对于第二主体112滑动小于大约2毫米。任选地，第一主体110可以相对于第二主体112滑动小于大约0.5毫米。
在第一主体110从第二位置移动到第三位置时，与第三主体206接合的第一主体110可以与第二主体112接合，从而使多个凝块接纳空间120的平均横截面面积减小(例如，至少部分地关闭)。由此，可以进一步夹紧凝块的至少一部分。凝块的部分可以被夹紧在第一主体110与第二主体112之间，并且另外地夹紧在第三主体206之间。因此，凝块的部分可以进一步在第三主体206内部迁移。因此，凝块的部分可以进一步迁移到第三主体206的凝块接纳空间230中。在转变到第三位置后，当第一套环210与第二套环212接合时，膨胀撑条208a、208b可以重新装护套。当第一套环210与第二套环212接合时，拉力可以传递到第二主体112。因此，可以从患者的脉管系统同时移除第一主体110、第二主体112和第三主体206，包括捕获的凝块或其部分。
任选地，凝块取回装置200可包括即使医生停止施加张力也允许凝块取回装置200维持夹紧的密封件。例如，凝块取回装置200可包括在焊接接头220近侧设置的密封件。密封件可以使用摩擦将凝块取回装置200维持在适当位置。因此，密封件可以产生足够的静态摩擦，使得当医师停止施加张力时，凝块移除装置200不会移位，同时还确保静态摩擦不会太高以致用户在取回凝块和从患者体内移除凝块取回装置200期间操作凝块取回装置200时无法克服此类静态摩擦。
图3A和图3B示出了附加的示例性凝块取回装置300。凝块取回装置300可具有约束递送构型和凝块接合构型，并且可被构造成从血管移除凝块(例如，血栓)T。当凝块移除装置300定位在约束护套(例如，微导管)内时，凝块移除装置300可以处于约束递送构型。在约束护套缩回时，凝块移除装置300可以转变为凝块接合构型。凝块取回装置300可包括内部可膨胀框架302和外部可膨胀框架304。内部可膨胀框架302可包括内部多个撑条306，该内部多个撑条自膨胀以在凝块取回装置300从约束递送构型转变为凝块接合构型时形成内部主体310。类似地，外部可膨胀框架304可包括外部多个撑条308，该外部多个撑条自膨胀以在凝块取回装置300从约束递送构型转变为凝块接合构型时形成外部主体312。内部可膨胀框架302和外部可膨胀框架304可以优选地由这样的材料制成，该材料一旦从收缩递送构型释放后就能够自动恢复其形状，并且该内部可膨胀框架和外部可膨胀框架还包括如上文参考第一可膨胀框架102和第二可膨胀框架104所描述的附加特性。
内部主体310和外部主体312可具有不同的内径330、332和/或构型。例如，内部主体310可具有比外部主体312的内径332小的内径330，因为外部主体312可以径向围绕内部主体310。任选地，内部主体310的内径330可以为外部主体312的内径332的大小的大约一半。任选地，内部主体310的内径330可以约为外部主体312的内径332的大小的3/4。如图3A所示，内部主体310和外部主体312的不同直径330、332和形状构型可以形成多个凝块接纳空间320，该多个凝块结构空间被构造成与凝块T接合。例如，外部主体312可包括多个支架区段。凝块接纳空间320可以形成在多个支架区段中的每个支架区段338之间。另外，内部主体310可具有基本上“S”波形状。此类“S”波形状可以促进在内部主体310相对于外部主体312移动时夹紧和捕获凝块，并在捕获凝块时防止捕获的凝块迁移出凝块取回装置300。
内部主体310和外部主体312可以各自附连到拉线314。拉线314可包括位于拉线的近侧端部326处的第一挡块322和第二挡块324。第一挡块322可相对于第二挡块324设置在远侧。
弹簧316可以附连到拉线314的远侧端部318。弹簧316可被构造成在致动时从压缩构型和细长构型转变。弹簧316可被构造成维持内部主体310在外部主体312内的中心位置。在先前示出的凝块取回装置100、200中，因为第一主体110具有与第二主体112大致相等的内径134，所以第一主体110因从第一主体110到第二主体112上的向外力而居中驻留在第二主体112内。当内部主体310具有比外部主体312基本上更小的内径330时，如图3A和图3B所示，内部主体310的远侧部分可以相对于外部主体312径向偏转，但是对于弹簧316，这阻止了远侧部分偏转。当拉线314不处于张力下时，弹簧316可以进一步用于将装置300保持在第一位置。
如图3A所示，凝块取回装置300可以定位在凝块T近侧。凝块取回装置300的至少一部分可以横穿凝块T，使得凝块取回装置300的远侧端部可以相对于凝块T正向。拉线314可以在近侧方向上拉动，从而使内部主体310相对于外部主体312从第一位置移动(例如，滑动)到第二位置。
图3B示出了在内部主体310从第一位置移动到第二位置时转变为凝块夹紧构型的凝块取回装置300。拉线314可以在近侧方向上拉动，直到第一挡块322接近和/或接合(例如，接触或在第二挡块324的预定距离内)第二挡块324，如此第二挡块324可以用作何时停止向拉线314施加张力和/或逐渐弱化施加到拉线314的张力的量的指示器。当拉线314在近侧方向上拉动时，弹簧316可被致动，从而导致弹簧316从压缩构型转变为细长构型。当弹簧316转变为细长构型时，内部主体310可以从第一位置移动到第二位置。从第一位置到第二位置的此类移动可以使凝块接纳空间320的平均横截面面积减小(例如，至少部分地闭合)，从而在内部主体310与外部主体312之间夹紧凝块T。在将凝块T夹紧在内部主体310与外部主体312之间时，内部主体310和外部主体312，包括凝块T，可以缩回到约束护套(例如，微导管)中，并且随后可以从患者体内移除凝块取回装置300。
图4示出了概述使用图1A至图1G所示的凝块取回装置100捕获凝块的方法400的流程图。方法400可包括在凝块近侧部署402凝块取回装置100。如本文所讨论的，凝块取回装置100可包括第一可膨胀框架102和第二可膨胀框架104。在部署凝块取回装置100时，凝块取回装置100可以从约束递送构型转变为凝块接合构型，并且第一可膨胀框架102可膨胀以形成第一主体110，而第二可膨胀框架104可膨胀以形成径向围绕第一主体110的第二主体112。第一主体110和第二主体112可具有基本上相同的内径134、136，使得第一主体110和第二主体112基本上彼此径向对准。
方法400还可包括使第一主体110相对于第二主体112朝近侧移动404(例如，滑动)以将凝块的至少一部分夹紧在第一主体110与第二主体112之间，使得凝块移除装置100转变为凝块夹紧构型。举例来说，可以将张力施加到拉线114，直到第一主体110遇到接头130为止。当拉线114在近侧方向上拉动时，第一主体110可以相对于第二主体112在近侧方向上移动，从而将凝块的至少一部分夹紧在第一主体110与第二主体112之间。
方法400还可包括捕获406凝块的一个或多个碎片。
另外，方法400可包括当第一主体110和第二主体112在第一主体110相对于第二主体112移动时接合时，同时缩回第一主体110和第二主体112。类似地，在第一主体110和第二主体112缩回到约束护套中时，可以从患者的脉管系统中移除约束护套。
图5示出了概述使用图2A至图2F所示的凝块取回装置200捕获凝块的方法500的流程图。方法500可包括在凝块近侧部署502凝块取回装置200。如本文所讨论的，凝块取回装置100可包括第一可膨胀框架102、第二可膨胀框架104和第三可膨胀框架202。在部署凝块取回装置200时，凝块取回装置200可以从约束递送构型转变为凝块接合构型，并且第一可膨胀框架102可膨胀以形成第一主体110，而第二可膨胀框架104可膨胀以形成径向围绕第一主体110的第二主体112。第一主体110和第二主体112可具有基本上相同的内径134、136，使得第一主体110和第二主体112可以基本上彼此对准。类似地，第三可膨胀框架202可膨胀以形成第三主体206。第一主体110和第二主体112可以径向围绕第三主体206，因为与第一主体110和第二主体112相比，第三主体206可以具有较小的内径238。
方法500还可包括使第三主体206相对于第一主体110和第二主体112移动(例如，滑动)504，以将凝块的至少一部分夹紧在第三主体206与第一主体110和第二主体112之间，使得凝块移除装置200转变为凝块夹紧构型。因此，凝块的至少一部分可以迁移到第一主体110和第二主体112中。在使第三主体206相对于第一主体110和第二主体112移动时，第三主体206可以与第一主体110接合。
方法500还可包括使第一主体110相对于第二主体112朝近侧移动506(例如，滑动)，以进一步将凝块的至少一部分夹紧在第三主体206与第一主体110和第二主体112之间。当第一主体110相对于第二主体112移动时，凝块接纳空间120的平均横截面面积可以减小，从而夹紧凝块的至少一部分并防止和/或减轻凝块的捕获的部分从凝块取回装置200中迁移出。在夹紧凝块时，凝块的至少一部分可以在第三主体206内部迁移。当凝块的至少一部分在第三主体206内时，捕获的凝块的部分从凝块取回装置200迁移回来的可能性会降低。
方法500还可包括捕获508凝块的一个或多个碎片。
另外，方法500可包括同时缩回第一主体110、第二主体112和第三主体206。在缩回到递送微导管中时，可以从患者的脉管系统中移除递送微导管，并且因此，可以从患者的脉管系统有效且高效地移除凝块。
上文参考根据所公开技术的示例的框图和流程图描述所公开技术的某些示例和实施方案。应当理解，分别为框图和流程图的一个或多个框，以及框图和流程图中的框的组合。同样，根据所公开技术的一些实施例和实施方式，框图和流程图的一些框不一定需要按所呈现的顺序执行、可以重复或者根本不需要执行。还应当理解，提到一个或多个方法步骤不排除存在附加的方法步骤或在那些明确标识的步骤之间的中间方法步骤。另外，来自一个过程流程图或框图的方法步骤可以与来自另一过程图或框图的方法步骤组合。本文考虑了这些组合和/或修改。

Claims (10)

1.一种凝块取回装置，所述凝块取回装置包括约束递送构型和凝块接合构型并且被构造成从血管中移除凝块，所述装置包括：
第一可膨胀框架，所述第一可膨胀框架包括形成第一主体的第一多个撑条；以及
第二可膨胀框架，所述第二可膨胀框架包括形成至少部分地围绕所述第一主体的第二主体的第二多个撑条，
其中在所述凝块接合构型中，所述第一主体被构造成相对于所述第二主体从第一位置移动到第二位置。
2.根据权利要求1所述的凝块取回装置，其中所述第一主体具有第一内径，并且所述第二主体具有第二内径，所述第一内径和所述第二内径基本上相等。
3.根据权利要求1所述的凝块取回装置，其中当所述第一主体处于所述第一位置时，所述第一多个撑条和所述第二多个撑条脱离接合，使得形成多个凝块接纳空间。
4.根据权利要求3所述的凝块取回装置，其中当所述第一主体处于所述第二位置时，所述第一多个撑条和所述第二多个撑条接合，使得所述多个凝块接纳空间的平均横截面面积在所述第一主体从所述第一位置移动到所述第二位置时减小。
5.根据权利要求1所述的凝块取回装置，其中所述第一多个撑条包括至少一个径向延伸的撑条，并且所述第二多个撑条包括至少一个孔眼，所述至少一个径向延伸的撑条径向延伸穿过所述至少一个孔眼，所述至少一个孔眼和所述至少一个径向延伸的撑条被构造成使得当所述第一主体从所述第一位置移动到所述第二位置时，所述至少一个径向延伸的撑条接合所述至少一个孔眼以抑制所述第一多个撑条相对于所述第二多个撑条移动超出所述第二位置。
6.根据权利要求5所述的凝块取回装置，其中每个孔眼是锥形的。
7.根据权利要求1所述的凝块取回装置，所述凝块取回装置还包括聚合物涂层以接合所述第一多个撑条和所述第二多个撑条，所述聚合物涂层被构造成失效以允许所述第一主体从所述第一位置移动到所述第二位置。
8.根据权利要求1所述的凝块取回装置，所述凝块取回装置还包括附连到所述第一多个撑条和所述第二多个撑条的至少一个聚合物膜，使得所述聚合物膜设置在所述第一主体与所述第二主体之间。
9.根据权利要求8所述的凝块取回装置，其中当所述第一主体处于所述第一位置时，所述至少一个聚合物膜处于折叠构型，并且当所述第一主体朝近侧移动到所述第二位置时，所述至少一个聚合物膜转变为拉伸构型。
10.根据权利要求1所述的凝块取回装置，所述凝块取回装置还包括第三可膨胀框架，所述第三可膨胀框架包括形成第三主体的第三多个撑条，在所述凝块接合构型中，所述第一主体和所述第二主体至少部分地围绕所述第三主体。
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