CN1142933C - 抑制胃酸分泌的杂环化合物、其制备方法及其药物组合物 - Google Patents

抑制胃酸分泌的杂环化合物、其制备方法及其药物组合物 Download PDF

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Publication number
CN1142933C
CN1142933C CNB98813344XA CN98813344A CN1142933C CN 1142933 C CN1142933 C CN 1142933C CN B98813344X A CNB98813344X A CN B98813344XA CN 98813344 A CN98813344 A CN 98813344A CN 1142933 C CN1142933 C CN 1142933C
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China
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compound
preparation
acid
alkyl
acceptable salt
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Expired - Fee Related
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CNB98813344XA
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English (en)
Chinese (zh)
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CN1284078A (zh
Inventor
K
K·阿明
M·达尔斯特伦
P·诺尔贝里
I·斯塔克
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AstraZeneca AB
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNB98813344XA 1997-11-28 1998-11-18 抑制胃酸分泌的杂环化合物、其制备方法及其药物组合物 Expired - Fee Related CN1142933C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE97044044 1997-11-28
SE9704404A SE9704404D0 (sv) 1997-11-28 1997-11-28 New compounds

Publications (2)

Publication Number Publication Date
CN1284078A CN1284078A (zh) 2001-02-14
CN1142933C true CN1142933C (zh) 2004-03-24

Family

ID=20409181

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB98813344XA Expired - Fee Related CN1142933C (zh) 1997-11-28 1998-11-18 抑制胃酸分泌的杂环化合物、其制备方法及其药物组合物

Country Status (32)

Country Link
US (1) US6518270B1 (https=)
EP (1) EP1042324B1 (https=)
JP (1) JP2001525322A (https=)
KR (1) KR20010032559A (https=)
CN (1) CN1142933C (https=)
AR (1) AR016972A1 (https=)
AT (1) ATE233263T1 (https=)
AU (1) AU752187C (https=)
BR (1) BR9814755A (https=)
CA (1) CA2311798A1 (https=)
CZ (1) CZ292349B6 (https=)
DE (1) DE69811735T2 (https=)
DK (1) DK1042324T3 (https=)
EE (1) EE04060B1 (https=)
ES (1) ES2191356T3 (https=)
HU (1) HUP0100601A3 (https=)
ID (1) ID24730A (https=)
IL (1) IL136145A0 (https=)
IS (1) IS5486A (https=)
MY (1) MY121032A (https=)
NO (1) NO315704B1 (https=)
NZ (1) NZ504355A (https=)
PL (1) PL340920A1 (https=)
PT (1) PT1042324E (https=)
RU (1) RU2241000C2 (https=)
SE (1) SE9704404D0 (https=)
SK (1) SK283904B6 (https=)
TR (1) TR200001530T2 (https=)
TW (1) TW515798B (https=)
UA (1) UA70932C2 (https=)
WO (1) WO1999028322A1 (https=)
ZA (1) ZA9810468B (https=)

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AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
DE602004016831D1 (de) * 2003-03-17 2008-11-13 Affinium Pharm Inc Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
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US20070287726A1 (en) * 2004-08-02 2007-12-13 Altana Pharma Ag 5-Substituted 1H-Pyrrolo [3,2-B] Pyridines
KR100958828B1 (ko) * 2004-09-03 2010-05-24 주식회사유한양행 피롤로[3,2-ｂ]피리딘 유도체 및 그의 제조방법
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ATE466013T1 (de) * 2004-09-03 2010-05-15 Yuhan Corp Pyrroloä3,2-cüpyridinderivate und verfahren zu deren herstellung
WO2007024294A2 (en) 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
US7709468B2 (en) 2005-09-02 2010-05-04 Abbott Laboratories Imidazo based heterocycles
EP1973902A2 (en) * 2005-12-05 2008-10-01 Affinium Pharmaceuticals, Inc. 3-heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
AR061229A1 (es) * 2006-06-06 2008-08-13 Schering Corp Imidazopirazinas como inhibidores de la proteina quinasa
EP2687533B1 (en) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
WO2008098374A1 (en) 2007-02-16 2008-08-21 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab i inhibitors
JP5496915B2 (ja) 2008-02-13 2014-05-21 シージーアイ ファーマシューティカルズ，インコーポレーテッド ６−アリール−イミダゾ［１，２−ａ］ピラジン誘導体、その製造方法、及びその使用方法
EA021293B1 (ru) 2008-12-08 2015-05-29 Джилид Коннектикут, Инк. ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
CN102307474B (zh) 2008-12-08 2015-04-01 吉利德康涅狄格股份有限公司 咪唑并吡嗪syk抑制剂
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
CN103168039B (zh) 2010-03-11 2016-08-03 吉利德康涅狄格公司 咪唑并吡啶类syk抑制剂
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EA029281B1 (ru) 2013-07-30 2018-03-30 Джилид Коннектикут, Инк. Полиморф ингибиторов syk
CA2919522C (en) 2013-07-30 2019-02-26 Gilead Connecticut, Inc. Formulation of syk inhibitors
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US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
BR112016028641A2 (pt) 2014-07-14 2017-08-22 Gilead Sciences Inc ?método para tratar câncer?
BR122023021456A2 (pt) 2016-02-26 2024-02-20 Debiopharm International S.A. Uso de di-hidrogeno fosfato de {6- [(e)-3-{metil[(3-metil-1-benfofuran-2- iol)metil]amino)-3- oxopro-1-en-1-il]-2-oxo-3,4-di-hidro-1,8-naftiridin-1(2h)- il}metila para tratamento de osteomielite do pé diabético e composição farmacêutica
CA3073871A1 (en) 2017-08-25 2019-02-28 Gilead Sciences, Inc. Polymorphs of syk inhibitors
LT3923914T (lt) 2019-02-14 2023-07-25 Debiopharm International S.A. Afabicino kompozicija, jos gamybos būdas
CN113950479A (zh) 2019-02-22 2022-01-18 克洛诺斯生物股份有限公司 作为syk抑制剂的缩合吡嗪的固体形式
CN113939306B (zh) 2019-06-14 2024-07-19 德彪药业国际股份公司 用于治疗涉及生物膜的细菌感染的药物及其用途

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Also Published As

Publication number Publication date
CZ292349B6 (cs) 2003-09-17
CN1284078A (zh) 2001-02-14
HK1030216A1 (en) 2001-04-27
HUP0100601A3 (en) 2002-10-28
US6518270B1 (en) 2003-02-11
TW515798B (en) 2003-01-01
NO20002721L (no) 2000-07-28
AR016972A1 (es) 2001-08-01
HUP0100601A2 (hu) 2001-09-28
TR200001530T2 (tr) 2000-11-21
PL340920A1 (en) 2001-03-12
JP2001525322A (ja) 2001-12-11
ID24730A (id) 2000-08-03
BR9814755A (pt) 2000-10-03
PT1042324E (pt) 2003-06-30
SE9704404D0 (sv) 1997-11-28
ES2191356T3 (es) 2003-09-01
CA2311798A1 (en) 1999-06-10
SK6742000A3 (en) 2001-03-12
EE200000315A (et) 2001-10-15
EP1042324A1 (en) 2000-10-11
RU2241000C2 (ru) 2004-11-27
NO20002721D0 (no) 2000-05-26
AU752187C (en) 2003-09-18
ZA9810468B (en) 1999-05-21
IS5486A (is) 2000-05-10
IL136145A0 (en) 2001-05-20
MY121032A (en) 2005-12-30
EE04060B1 (et) 2003-06-16
NO315704B1 (no) 2003-10-13
AU752187B2 (en) 2002-09-12
WO1999028322A1 (en) 1999-06-10
ATE233263T1 (de) 2003-03-15
DE69811735T2 (de) 2003-12-18
CZ20001947A3 (cs) 2000-11-15
SK283904B6 (sk) 2004-04-06
EP1042324B1 (en) 2003-02-26
UA70932C2 (uk) 2004-11-15
KR20010032559A (ko) 2001-04-25
AU1356599A (en) 1999-06-16
DK1042324T3 (da) 2003-05-05
NZ504355A (en) 2001-12-21
DE69811735D1 (de) 2003-04-03

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