EE200000315A - Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised - Google Patents

Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised

Info

Publication number
EE200000315A
EE200000315A EEP200000315A EEP200000315A EE200000315A EE 200000315 A EE200000315 A EE 200000315A EE P200000315 A EEP200000315 A EE P200000315A EE P200000315 A EEP200000315 A EE P200000315A EE 200000315 A EE200000315 A EE 200000315A
Authority
EE
Estonia
Prior art keywords
preparation
pharmaceutical compositions
heterocyclic compounds
gastric acid
acid secretion
Prior art date
Application number
EEP200000315A
Other languages
English (en)
Inventor
Amin Kosrat
Dahlstr�m Mikael
Nordberg Peter
Starke Ingemar
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of EE200000315A publication Critical patent/EE200000315A/et
Publication of EE04060B1 publication Critical patent/EE04060B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
EEP200000315A 1997-11-28 1998-11-18 Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised EE04060B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704404A SE9704404D0 (sv) 1997-11-28 1997-11-28 New compounds
PCT/SE1998/002091 WO1999028322A1 (en) 1997-11-28 1998-11-18 Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof

Publications (2)

Publication Number Publication Date
EE200000315A true EE200000315A (et) 2001-10-15
EE04060B1 EE04060B1 (et) 2003-06-16

Family

ID=20409181

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000315A EE04060B1 (et) 1997-11-28 1998-11-18 Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised

Country Status (33)

Country Link
US (1) US6518270B1 (et)
EP (1) EP1042324B1 (et)
JP (1) JP2001525322A (et)
KR (1) KR20010032559A (et)
CN (1) CN1142933C (et)
AR (1) AR016972A1 (et)
AT (1) ATE233263T1 (et)
AU (1) AU752187C (et)
BR (1) BR9814755A (et)
CA (1) CA2311798A1 (et)
CZ (1) CZ292349B6 (et)
DE (1) DE69811735T2 (et)
DK (1) DK1042324T3 (et)
EE (1) EE04060B1 (et)
ES (1) ES2191356T3 (et)
HK (1) HK1030216A1 (et)
HU (1) HUP0100601A3 (et)
ID (1) ID24730A (et)
IL (1) IL136145A0 (et)
IS (1) IS5486A (et)
MY (1) MY121032A (et)
NO (1) NO315704B1 (et)
NZ (1) NZ504355A (et)
PL (1) PL340920A1 (et)
PT (1) PT1042324E (et)
RU (1) RU2241000C2 (et)
SE (1) SE9704404D0 (et)
SK (1) SK283904B6 (et)
TR (1) TR200001530T2 (et)
TW (1) TW515798B (et)
UA (1) UA70932C2 (et)
WO (1) WO1999028322A1 (et)
ZA (1) ZA9810468B (et)

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SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds
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JP2003119140A (ja) * 2001-08-08 2003-04-23 Sankyo Co Ltd ピロロピリダジン化合物を含有する医薬
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US7312341B2 (en) 2002-09-09 2007-12-25 Cgi Pharmaceuticals, Inc. 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof
TW200418479A (en) * 2002-09-25 2004-10-01 Sankyo Co Pharmaceutical compositions for the treatment or prevention of visceral pains
TW200420293A (en) * 2002-09-25 2004-10-16 Sankyo Co Pharmaceutical compositions for the reduction of gastric acid concentration in blood
ES2518316T3 (es) * 2002-12-06 2014-11-05 Debiopharm International Sa Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia
WO2004072080A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity
AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
DE602004016831D1 (de) * 2003-03-17 2008-11-13 Affinium Pharm Inc Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
WO2005014599A1 (en) 2003-06-04 2005-02-17 Cellular Genomics, Inc. Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds
WO2005005429A1 (en) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
AU2004285394B2 (en) 2003-11-03 2009-01-08 Astrazeneca Ab Imidazo (1,2-A) pyridine derivatives for the treatment of silent gastro-esophageal reflux
CA2568914C (en) * 2004-06-04 2013-09-24 Affinium Pharmaceuticals, Inc. Therapeutic agents, and methods of making and using the same
US20070293532A1 (en) * 2004-07-28 2007-12-20 Takeda Pharmaceutical Compan6Y Limited Pyrrolo [2,3-C] Pyridine Compound, Process for Producing the Same, and Use
JP2008508347A (ja) * 2004-08-02 2008-03-21 ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング ５置換された１Ｈ−ピロロ［３，２−ｂ］ピリジン
MX2007002219A (es) * 2004-09-03 2007-05-04 Yuhan Corp Derivados de pirrolo [3,2-b ] piridina y procesos para su preparacion.
DK1784402T3 (da) * 2004-09-03 2011-11-14 Yuhan Corp Pyrrolo[3,2-c]pyridinderivater samt fremgangsmåder til deres fremstilling
CN101018789B (zh) 2004-09-03 2010-09-08 株式会社柳韩洋行 吡咯并[2,3-c]吡啶衍生物及其制备方法
JP4989477B2 (ja) * 2004-09-03 2012-08-01 ユーハン・コーポレイション ピロロ［３，２−ｃ］ピリジン誘導体及びその製造方法
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
CA2620223A1 (en) 2005-09-02 2007-03-08 Abbott Laboratories Novel imidazo based heterocycles
US20090156578A1 (en) * 2005-12-05 2009-06-18 PAULS Henry 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents
US7557104B2 (en) 2006-06-06 2009-07-07 Schering Corporation Imidazopyrazines as protein kinase inhibitors
EP2687533B1 (en) 2006-07-20 2017-07-19 Debiopharm International SA Acrylamide derivatives as FAB I inhibitors
EP2125802A4 (en) 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
AU2009215191A1 (en) 2008-02-13 2009-08-20 Gilead Connecticut, Inc. 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
KR20170013414A (ko) 2008-12-08 2017-02-06 질레드 코네티컷 인코포레이티드 이미다조피라진 ｓｙｋ 억제제
CA2745871C (en) 2008-12-08 2018-02-20 Gilead Connecticut, Inc. Imidazopyrazine syk inhibitors
US9562056B2 (en) 2010-03-11 2017-02-07 Gilead Connecticut, Inc. Imidazopyridines Syk inhibitors
PL2861608T3 (pl) 2012-06-19 2019-09-30 Debiopharm International Sa Pochodne prolekowe (e)-n-metylo-n-((3-metylobenzofuran-2-ylo)metylo)-3-(7-okso-5,6,7,8-tetrahydro-1,8-naftyrydyn-3-ylo)akryloamidu
MD4684B1 (ro) 2013-07-30 2020-03-31 Gilead Connecticut INc. Formulări pe bază de imidazopirazine în calitate de inhibitori SYK
US9657023B2 (en) 2013-07-30 2017-05-23 Gilead Connecticut, Inc. Polymorph of Syk inhibitors
EA201690608A1 (ru) 2013-12-04 2016-12-30 Джилид Сайэнс, Инк. Способы лечения раковых заболеваний
GB201321738D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
TWI662037B (zh) 2013-12-23 2019-06-11 美商基利科學股份有限公司 脾酪胺酸激酶抑制劑
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
NZ726365A (en) 2014-07-14 2018-06-29 Gilead Sciences Inc Combinations for treating cancers
US10751351B2 (en) 2016-02-26 2020-08-25 Debiopharm International S.A. Medicament for treatment of diabetic foot infections
KR102399996B1 (ko) 2017-08-25 2022-05-20 길리애드 사이언시즈, 인코포레이티드 Syk 억제제의 다형체
WO2020172431A1 (en) 2019-02-22 2020-08-27 Gilead Sciences, Inc. Solid forms of condensed pyrazines as syk inhibitors

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US4507294A (en) * 1982-03-08 1985-03-26 Schering Corp. Imidazo[1,2-a]pyrazines
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
US4725601A (en) 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
AU7754691A (en) 1990-04-27 1991-11-27 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel pyridazines
US5041442A (en) * 1990-07-31 1991-08-20 Syntex (U.S.A.) Inc. Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion
WO1992006979A1 (de) * 1990-10-15 1992-04-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue diazine
EP0609328B1 (de) 1991-10-25 1999-04-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Pyrrolo-pyridazine mit magen- und darmschutzwirkungen
AU680998B2 (en) 1994-01-19 1997-08-14 Sankyo Company Limited Pyrrolopyridazine derivative
SE9602286D0 (sv) 1996-06-10 1996-06-10 Astra Ab New compounds
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds

Also Published As

Publication number Publication date
IS5486A (is) 2000-05-10
KR20010032559A (ko) 2001-04-25
WO1999028322A1 (en) 1999-06-10
BR9814755A (pt) 2000-10-03
RU2241000C2 (ru) 2004-11-27
DE69811735T2 (de) 2003-12-18
UA70932C2 (uk) 2004-11-15
ATE233263T1 (de) 2003-03-15
CN1142933C (zh) 2004-03-24
DE69811735D1 (de) 2003-04-03
AU752187C (en) 2003-09-18
EP1042324B1 (en) 2003-02-26
CZ20001947A3 (cs) 2000-11-15
EE04060B1 (et) 2003-06-16
TW515798B (en) 2003-01-01
SE9704404D0 (sv) 1997-11-28
PL340920A1 (en) 2001-03-12
AU1356599A (en) 1999-06-16
CN1284078A (zh) 2001-02-14
IL136145A0 (en) 2001-05-20
DK1042324T3 (da) 2003-05-05
EP1042324A1 (en) 2000-10-11
ES2191356T3 (es) 2003-09-01
SK6742000A3 (en) 2001-03-12
ID24730A (id) 2000-08-03
CZ292349B6 (cs) 2003-09-17
HK1030216A1 (en) 2001-04-27
AU752187B2 (en) 2002-09-12
PT1042324E (pt) 2003-06-30
NO20002721L (no) 2000-07-28
TR200001530T2 (tr) 2000-11-21
SK283904B6 (sk) 2004-04-06
ZA9810468B (en) 1999-05-21
NO315704B1 (no) 2003-10-13
NO20002721D0 (no) 2000-05-26
JP2001525322A (ja) 2001-12-11
MY121032A (en) 2005-12-30
HUP0100601A2 (hu) 2001-09-28
HUP0100601A3 (en) 2002-10-28
AR016972A1 (es) 2001-08-01
NZ504355A (en) 2001-12-21
US6518270B1 (en) 2003-02-11
CA2311798A1 (en) 1999-06-10

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Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20031231

KB4A Valid patent at the end of a year

Effective date: 20041231

KB4A Valid patent at the end of a year

Effective date: 20051231

KB4A Valid patent at the end of a year

Effective date: 20061231

MM4A Lapsed by not paying the annual fees

Effective date: 20061118