TW200420293A - Pharmaceutical compositions for the reduction of gastric acid concentration in blood - Google Patents

Pharmaceutical compositions for the reduction of gastric acid concentration in blood

Info

Publication number
TW200420293A
TW200420293A TW092126425A TW92126425A TW200420293A TW 200420293 A TW200420293 A TW 200420293A TW 092126425 A TW092126425 A TW 092126425A TW 92126425 A TW92126425 A TW 92126425A TW 200420293 A TW200420293 A TW 200420293A
Authority
TW
Taiwan
Prior art keywords
alkyl
pharmaceutical compositions
blood
reduction
pharmaceutical acceptable
Prior art date
Application number
TW092126425A
Other languages
Chinese (zh)
Inventor
Keiichi Ito
Atsuyuki Tomizawa
Masahiko Hagihara
Nobuhiko Shibakawa
Original Assignee
Sankyo Co
Ube Industries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co, Ube Industries filed Critical Sankyo Co
Publication of TW200420293A publication Critical patent/TW200420293A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to pyrrolopyridazine compounds of formula (I) and the pharmaceutical acceptable salt or pharmaceutical acceptable ester thereof, which is useful as medicines for the reduction of gastrin concentration in blood. In addition, the pharmaceutical compositions consisting of these pyrrolopyridazine compounds and the pharmaceutical acceptable salt or pharmaceutical acceptable ester thereof, as well as gastric acid secretion inhibitor having benzimidazole structure, are useful as pharmaceutical compositions for the treatment or prevention of ulcerous diseases with less side effects. The pyrrolopyridazine compounds of formula (I): wherein R1 is alkenyl, halogenoalkenyl, alkynyl, cycloalkyl, or optionally substituted cycloalkyl-alkyl; R2 is hydrogen or alkyl; R3 is hydrogen, alkyl, or hydroxyalkyl; R4 is hydrogen or alkyl; R5 is optionally substituted phenyl; A is alkylene; X is O or S.
TW092126425A 2002-09-25 2003-09-25 Pharmaceutical compositions for the reduction of gastric acid concentration in blood TW200420293A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002278551 2002-09-25

Publications (1)

Publication Number Publication Date
TW200420293A true TW200420293A (en) 2004-10-16

Family

ID=32040430

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092126425A TW200420293A (en) 2002-09-25 2003-09-25 Pharmaceutical compositions for the reduction of gastric acid concentration in blood

Country Status (3)

Country Link
AU (1) AU2003266622A1 (en)
TW (1) TW200420293A (en)
WO (1) WO2004029058A1 (en)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991017164A1 (en) * 1990-04-27 1991-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Novel pyridazines
ATE129522T1 (en) * 1990-11-26 1995-11-15 Procter & Gamble SHAPED SOLID MADE WITH A NEUTRALIZED CARBONIC ACID SOLID INTERLOCKING MESH.
JPH07500329A (en) * 1991-10-25 1995-01-12 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング Pyrrolo-pyridazine
ES2185693T3 (en) * 1994-01-19 2003-05-01 Sankyo Co DERIVED FROM PIRROLOPIRIDACINA.
SE9704404D0 (en) * 1997-11-28 1997-11-28 Astra Ab New compounds
TWI287014B (en) * 1999-06-15 2007-09-21 Sankyo Co Optically active pyrrolopyridazine compound
HUP0204579A3 (en) * 2000-02-10 2006-01-30 Ube Industries Pyrrolopyridazine derivatives, pharmaceutical compositions containing them and their use
JP2002068992A (en) * 2000-08-25 2002-03-08 Ito En Ltd Eradicating agent for helicobacter pylori, and food, beverage or food additive having this eradicating effect
JP3387066B2 (en) * 2000-12-14 2003-03-17 三共株式会社 Anti-ulcer agent containing pyrrolopyridazine compound
JP2003119140A (en) * 2001-08-08 2003-04-23 Sankyo Co Ltd Pharmaceutical agent containing pyrrolopyridazine compound

Also Published As

Publication number Publication date
WO2004029058A1 (en) 2004-04-08
AU2003266622A8 (en) 2004-04-19
AU2003266622A1 (en) 2004-04-19

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TW200420293A (en) Pharmaceutical compositions for the reduction of gastric acid concentration in blood