ATE233263T1 - Heterocyclische verbindungen zur hemmung der magensäureproduktion, verfahren zu ihrer herstellung und pharmazeutische zubereitungen davon - Google Patents

Heterocyclische verbindungen zur hemmung der magensäureproduktion, verfahren zu ihrer herstellung und pharmazeutische zubereitungen davon

Info

Publication number
ATE233263T1
ATE233263T1 AT98957270T AT98957270T ATE233263T1 AT E233263 T1 ATE233263 T1 AT E233263T1 AT 98957270 T AT98957270 T AT 98957270T AT 98957270 T AT98957270 T AT 98957270T AT E233263 T1 ATE233263 T1 AT E233263T1
Authority
AT
Austria
Prior art keywords
production
stomachic
inhibiting
pharmaceutical preparations
heterocyclic compounds
Prior art date
Application number
AT98957270T
Other languages
English (en)
Inventor
Kosrat Amin
Mikael Dahlstroem
Peter Nordberg
Ingemar Starke
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE233263T1 publication Critical patent/ATE233263T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98957270T 1997-11-28 1998-11-18 Heterocyclische verbindungen zur hemmung der magensäureproduktion, verfahren zu ihrer herstellung und pharmazeutische zubereitungen davon ATE233263T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704404A SE9704404D0 (sv) 1997-11-28 1997-11-28 New compounds
PCT/SE1998/002091 WO1999028322A1 (en) 1997-11-28 1998-11-18 Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
ATE233263T1 true ATE233263T1 (de) 2003-03-15

Family

ID=20409181

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98957270T ATE233263T1 (de) 1997-11-28 1998-11-18 Heterocyclische verbindungen zur hemmung der magensäureproduktion, verfahren zu ihrer herstellung und pharmazeutische zubereitungen davon

Country Status (32)

Country Link
US (1) US6518270B1 (de)
EP (1) EP1042324B1 (de)
JP (1) JP2001525322A (de)
KR (1) KR20010032559A (de)
CN (1) CN1142933C (de)
AR (1) AR016972A1 (de)
AT (1) ATE233263T1 (de)
AU (1) AU752187C (de)
BR (1) BR9814755A (de)
CA (1) CA2311798A1 (de)
CZ (1) CZ292349B6 (de)
DE (1) DE69811735T2 (de)
DK (1) DK1042324T3 (de)
EE (1) EE04060B1 (de)
ES (1) ES2191356T3 (de)
HU (1) HUP0100601A3 (de)
ID (1) ID24730A (de)
IL (1) IL136145A0 (de)
IS (1) IS5486A (de)
MY (1) MY121032A (de)
NO (1) NO315704B1 (de)
NZ (1) NZ504355A (de)
PL (1) PL340920A1 (de)
PT (1) PT1042324E (de)
RU (1) RU2241000C2 (de)
SE (1) SE9704404D0 (de)
SK (1) SK283904B6 (de)
TR (1) TR200001530T2 (de)
TW (1) TW515798B (de)
UA (1) UA70932C2 (de)
WO (1) WO1999028322A1 (de)
ZA (1) ZA9810468B (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2324093A (en) 1996-01-04 1998-10-14 Rican Limited Helicobacter pylori bacterioferritin
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds
BRPI0014470B1 (pt) * 1999-10-08 2016-08-23 Affinium Pharm Inc compostos inibidores de fab i, composição farmacêutica, processo de preparação dos compostos e uso dos compostos para a produção de medicamento para tratamento de infecções bacterianas
WO2003088897A2 (en) * 2001-04-06 2003-10-30 Affinium Pharmaceuticals, Inc. Fab i inhibitors
JP2003119140A (ja) * 2001-08-08 2003-04-23 Sankyo Co Ltd ピロロピリダジン化合物を含有する医薬
CA2482991A1 (en) * 2002-04-19 2003-10-30 Cellular Genomics, Inc. Imidazo[1,2-a]pyrazin-8-ylamines method of making and method of use thereof
AU2003270489A1 (en) 2002-09-09 2004-03-29 Cellular Genomics, Inc. 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
WO2004029057A1 (ja) * 2002-09-25 2004-04-08 Sankyo Company, Limited 内臓痛の治療または予防のための医薬組成物
TW200420293A (en) * 2002-09-25 2004-10-16 Sankyo Co Pharmaceutical compositions for the reduction of gastric acid concentration in blood
US7790709B2 (en) 2002-12-06 2010-09-07 Affinium Pharmaceuticals, Inc. Heterocyclic compounds, methods of making them and their use in therapy
US7160885B2 (en) 2003-02-10 2007-01-09 Cgi Pharmaceuticals, Inc. Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity
AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
ATE409485T1 (de) * 2003-03-17 2008-10-15 Affinium Pharm Inc Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
AU2004285394B2 (en) 2003-11-03 2009-01-08 Astrazeneca Ab Imidazo (1,2-A) pyridine derivatives for the treatment of silent gastro-esophageal reflux
EP2848614A3 (de) * 2004-06-04 2015-07-29 Debiopharm International SA Acrylamidderivate und ihre Verwendung als Antibiotika
KR20120132582A (ko) * 2004-07-28 2012-12-05 다케다 야쿠힌 고교 가부시키가이샤 피롤로〔2,3-ｃ〕피리딘 화합물, 그 제조 방법 및 용도
US20070287726A1 (en) * 2004-08-02 2007-12-13 Altana Pharma Ag 5-Substituted 1H-Pyrrolo [3,2-B] Pyridines
WO2006025715A1 (en) * 2004-09-03 2006-03-09 Yuhan Corporation Pyrrolo[3,2-c]pyridine derivatives and processes for the preparation thereof
EP1784403B1 (de) * 2004-09-03 2013-07-17 Yuhan Corporation Pyrrolo[3,2-b]pyridinderivate und verfahren für deren herstellung
JP5126830B2 (ja) * 2004-09-03 2013-01-23 ユーハン・コーポレイション ピロロ［３，２−ｃ］ピリジン誘導体及びその製造方法
RU2385320C2 (ru) * 2004-09-03 2010-03-27 Юхан Корпорейшн ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-c] ПИРИДИНА И СПОСОБЫ ИХ ПОЛУЧЕНИЯ
US7777040B2 (en) 2005-05-03 2010-08-17 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
US7709468B2 (en) 2005-09-02 2010-05-04 Abbott Laboratories Imidazo based heterocycles
WO2007067416A2 (en) * 2005-12-05 2007-06-14 Affinium Pharmaceuticals, Inc. Heterocyclylacrylamide compounds as fabi inhibitors and antibacterial agents
TW200808802A (en) 2006-06-06 2008-02-16 Schering Corp Imidazopyrazines as protein kinase inhibitors
CA2658506C (en) 2006-07-20 2016-01-26 Affinium Pharmaceuticals, Inc. Acrylamide derivatives as fab 1 inhibitors
US8263613B2 (en) * 2007-02-16 2012-09-11 Affinium Pharmaceuticals, Inc. Salts, prodrugs and polymorphs of fab I inhibitors
EP2252617A1 (de) 2008-02-13 2010-11-24 CGI Pharmaceuticals, Inc. 6-arylimidazo[1,2-a]pyrazinderivate, herstellungsverfahren und verfahren zu deren anwendung
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
MX2011006094A (es) 2008-12-08 2011-11-29 Gilead Connecticut Inc Inhibidores de imidazopirazina syk.
MX2011006091A (es) 2008-12-08 2011-11-29 Gilead Connecticut Inc Inhibidores de imidazopirazina syk.
AU2011226689B2 (en) 2010-03-11 2016-09-01 Kronos Bio, Inc. Imidazopyridines Syk inhibitors
SG11201408100YA (en) 2012-06-19 2015-01-29 Debiopharm Int Sa Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
US9918939B2 (en) 2013-07-30 2018-03-20 Gilead Connecticut, Inc. Formulation of Syk inhibitors
AU2014296308C1 (en) 2013-07-30 2018-09-13 Kronos Bio, Inc. Polymorph of Syk inhibitors
EA201690608A1 (ru) 2013-12-04 2016-12-30 Джилид Сайэнс, Инк. Способы лечения раковых заболеваний
GB201321738D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
UY35898A (es) 2013-12-23 2015-07-31 Gilead Sciences Inc ?compuestos inhibidores de syk y composiciones que los comprenden?.
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
KR20170029580A (ko) 2014-07-14 2017-03-15 길리애드 사이언시즈, 인코포레이티드 암을 치료하기 위한 조합물
LT3419628T (lt) 2016-02-26 2021-01-25 Debiopharm International Sa Medikamentas diabetinėms pėdų infekcijoms gydyti
CA3073871A1 (en) 2017-08-25 2019-02-28 Gilead Sciences, Inc. Polymorphs of syk inhibitors
LT3923914T (lt) 2019-02-14 2023-07-25 Debiopharm International S.A. Afabicino kompozicija, jos gamybos būdas
CA3130848A1 (en) 2019-02-22 2020-08-27 Kronos Bio, Inc. Solid forms of condensed pyrazines as syk inhibitors
PH12021553086A1 (en) 2019-06-14 2023-08-14 Debiopharm Int Sa Medicament and use thereof for treating bacterial infections involving biofilm

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507294A (en) 1982-03-08 1985-03-26 Schering Corp. Imidazo[1,2-a]pyrazines
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
US4725601A (en) * 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
PT97467A (pt) * 1990-04-27 1992-01-31 Byk Gulden Lomberg Chem Fab Processo para preparacao de novas piridazinas e de composicoes farmaceuticas que as contem
US5041442A (en) * 1990-07-31 1991-08-20 Syntex (U.S.A.) Inc. Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion
WO1992006979A1 (de) * 1990-10-15 1992-04-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue diazine
JPH07500329A (ja) 1991-10-25 1995-01-12 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング ピロロ−ピリダジン
HU225920B1 (en) * 1994-01-19 2008-01-28 Sankyo Co Pyrrolo[2,3-d]pyridazine derivatives, process for their preparation and pharmaceutical compositions containing them
SE9602286D0 (sv) 1996-06-10 1996-06-10 Astra Ab New compounds
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds

Also Published As

Publication number Publication date
DE69811735T2 (de) 2003-12-18
CA2311798A1 (en) 1999-06-10
IL136145A0 (en) 2001-05-20
CN1284078A (zh) 2001-02-14
NO20002721D0 (no) 2000-05-26
EE200000315A (et) 2001-10-15
SK283904B6 (sk) 2004-04-06
HUP0100601A2 (hu) 2001-09-28
NZ504355A (en) 2001-12-21
EP1042324B1 (de) 2003-02-26
AU1356599A (en) 1999-06-16
CZ292349B6 (cs) 2003-09-17
US6518270B1 (en) 2003-02-11
AU752187B2 (en) 2002-09-12
HK1030216A1 (en) 2001-04-27
ID24730A (id) 2000-08-03
SE9704404D0 (sv) 1997-11-28
PT1042324E (pt) 2003-06-30
NO315704B1 (no) 2003-10-13
WO1999028322A1 (en) 1999-06-10
UA70932C2 (uk) 2004-11-15
DK1042324T3 (da) 2003-05-05
EP1042324A1 (de) 2000-10-11
IS5486A (is) 2000-05-10
DE69811735D1 (de) 2003-04-03
HUP0100601A3 (en) 2002-10-28
TR200001530T2 (tr) 2000-11-21
AU752187C (en) 2003-09-18
MY121032A (en) 2005-12-30
BR9814755A (pt) 2000-10-03
TW515798B (en) 2003-01-01
AR016972A1 (es) 2001-08-01
CN1142933C (zh) 2004-03-24
EE04060B1 (et) 2003-06-16
PL340920A1 (en) 2001-03-12
ZA9810468B (en) 1999-05-21
KR20010032559A (ko) 2001-04-25
ES2191356T3 (es) 2003-09-01
RU2241000C2 (ru) 2004-11-27
NO20002721L (no) 2000-07-28
SK6742000A3 (en) 2001-03-12
JP2001525322A (ja) 2001-12-11
CZ20001947A3 (cs) 2000-11-15

Similar Documents

Publication Publication Date Title
ATE233263T1 (de) Heterocyclische verbindungen zur hemmung der magensäureproduktion, verfahren zu ihrer herstellung und pharmazeutische zubereitungen davon
ATE252562T1 (de) Pyrazolcarbonsäurederivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen
ATE234291T1 (de) Metallproteinasehemmer, diesen enthaltende pharmazeutische zusammensetzung und dessen pharmazeutische verwendung und verfahren zu ihrer herstellung
DE59610280D1 (de) Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
ATE370946T1 (de) 16-halogen-epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung
ATE222251T1 (de) Substituierte heterocyclische verbindungen, verfahren zu deren herstellung und sie enthaltende pharmazeutische zusammensetzungen
DE60036294D1 (de) Umgossener transponder und verfahren zu dessen herstellung
DE50113328D1 (de) Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
ATE248811T1 (de) Indanylsubstituierte benzolcarbonamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen
DE3880515D1 (de) Granuliertes mittel fuer wiederkaeuer und verfahren zu dessen herstellung.
DE50114874D1 (de) Chinazolinderivate, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
DE69902535D1 (de) Phenoxypropanolamin-derivate, verfahren zu ihrer herstellung und diese enthaltenden pharmazeutischen zusammensetzungen
ATE215951T1 (de) Tetracyclische campothecineanalogue, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und diese enthaltende pharmazeutische zubereitungen
DE50111799D1 (de) Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung
ATE228144T1 (de) Phosphonsäure-substituierte benzazepinon-n- essigsäurederivate sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3785507D1 (de) Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
DE60017552D1 (de) Geschaeumte schokolade und verfahren zu dessen herstellung
DE59707503D1 (de) Neue arylglycinamidderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
DE50013167D1 (de) 2'-substituierte 1,1'-biphenyl-2-carboxamide, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltende pharmazeutische zubereitungen
DE3782107D1 (de) Azabicyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
DE69909209D1 (de) Pyrimidinon-derivate, diese verbindungen enthaltenden pharmazeutische zubereitungen und verfharen zu ihrer herstellung
ATE264837T1 (de) N-guanidinalkylamide, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate
ATE294175T1 (de) 4-sulfonamid-piperidin-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen
ATE544448T1 (de) Morphinsulfat enthaltende mikrogranulate, verfahren zu deren herstellung und pharmazeutische zusammensetzungen
DE69808793D1 (de) Pharmazeutische zusammensetzungen aus dalfopristine und quinupristine und verfahren zu ihrer herstellung

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1042324

Country of ref document: EP

REN Ceased due to non-payment of the annual fee