ATE233263T1 - Heterocyclische verbindungen zur hemmung der magensäureproduktion, verfahren zu ihrer herstellung und pharmazeutische zubereitungen davon - Google Patents
Heterocyclische verbindungen zur hemmung der magensäureproduktion, verfahren zu ihrer herstellung und pharmazeutische zubereitungen davonInfo
- Publication number
- ATE233263T1 ATE233263T1 AT98957270T AT98957270T ATE233263T1 AT E233263 T1 ATE233263 T1 AT E233263T1 AT 98957270 T AT98957270 T AT 98957270T AT 98957270 T AT98957270 T AT 98957270T AT E233263 T1 ATE233263 T1 AT E233263T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- stomachic
- inhibiting
- pharmaceutical preparations
- heterocyclic compounds
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 2
- 239000002253 acid Substances 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9704404A SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | New compounds |
| PCT/SE1998/002091 WO1999028322A1 (en) | 1997-11-28 | 1998-11-18 | Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE233263T1 true ATE233263T1 (de) | 2003-03-15 |
Family
ID=20409181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98957270T ATE233263T1 (de) | 1997-11-28 | 1998-11-18 | Heterocyclische verbindungen zur hemmung der magensäureproduktion, verfahren zu ihrer herstellung und pharmazeutische zubereitungen davon |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6518270B1 (de) |
| EP (1) | EP1042324B1 (de) |
| JP (1) | JP2001525322A (de) |
| KR (1) | KR20010032559A (de) |
| CN (1) | CN1142933C (de) |
| AR (1) | AR016972A1 (de) |
| AT (1) | ATE233263T1 (de) |
| AU (1) | AU752187C (de) |
| BR (1) | BR9814755A (de) |
| CA (1) | CA2311798A1 (de) |
| CZ (1) | CZ292349B6 (de) |
| DE (1) | DE69811735T2 (de) |
| DK (1) | DK1042324T3 (de) |
| EE (1) | EE04060B1 (de) |
| ES (1) | ES2191356T3 (de) |
| HU (1) | HUP0100601A3 (de) |
| ID (1) | ID24730A (de) |
| IL (1) | IL136145A0 (de) |
| IS (1) | IS5486A (de) |
| MY (1) | MY121032A (de) |
| NO (1) | NO315704B1 (de) |
| NZ (1) | NZ504355A (de) |
| PL (1) | PL340920A1 (de) |
| PT (1) | PT1042324E (de) |
| RU (1) | RU2241000C2 (de) |
| SE (1) | SE9704404D0 (de) |
| SK (1) | SK283904B6 (de) |
| TR (1) | TR200001530T2 (de) |
| TW (1) | TW515798B (de) |
| UA (1) | UA70932C2 (de) |
| WO (1) | WO1999028322A1 (de) |
| ZA (1) | ZA9810468B (de) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1463097A (en) | 1996-01-04 | 1997-08-01 | Rican Limited | Helicobacter pylori bacterioferritin |
| SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
| CZ302015B6 (cs) * | 1999-10-08 | 2010-09-08 | Affinium Pharmaceuticals, Inc. | Inhibitory Fab I |
| JP4387804B2 (ja) * | 2001-04-06 | 2009-12-24 | アフィニアム・ファーマシューティカルズ・インコーポレイテッド | FabI阻害剤 |
| JP2003119140A (ja) * | 2001-08-08 | 2003-04-23 | Sankyo Co Ltd | ピロロピリダジン化合物を含有する医薬 |
| MXPA04010288A (es) | 2002-04-19 | 2005-05-17 | Cellular Genomics Inc | Imidazo[1,2-a]pirazin-8-ilaminas, y metodos para su fabricacion y usos. |
| AU2003270489A1 (en) | 2002-09-09 | 2004-03-29 | Cellular Genomics, Inc. | 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF |
| TW200420293A (en) * | 2002-09-25 | 2004-10-16 | Sankyo Co | Pharmaceutical compositions for the reduction of gastric acid concentration in blood |
| AU2003266621A1 (en) * | 2002-09-25 | 2004-04-19 | Sankyo Company, Limited | Medicinal composition for treatment for or prevention of visceral pain |
| PT1575951E (pt) * | 2002-12-06 | 2014-09-15 | Debiopharm Int Sa | Compostos heterocíclicos, métodos para os preparar e sua utilização em terapia |
| US7189723B2 (en) | 2003-02-10 | 2007-03-13 | Cgi Pharmaceuticals, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity |
| AR043002A1 (es) * | 2003-02-18 | 2005-07-13 | Altana Pharma Ag | Imidazopirazinas 6-substituidos |
| CA2519429C (en) * | 2003-03-17 | 2013-08-06 | Affinium Pharmaceuticals, Inc. | Pharmaceutical compositions comprising inhibitors of fab i and further antibiotics |
| WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
| WO2005005429A1 (en) | 2003-06-30 | 2005-01-20 | Cellular Genomics, Inc. | Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds |
| US7259164B2 (en) | 2003-08-11 | 2007-08-21 | Cgi Pharmaceuticals, Inc. | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity |
| AU2004285394B2 (en) | 2003-11-03 | 2009-01-08 | Astrazeneca Ab | Imidazo (1,2-A) pyridine derivatives for the treatment of silent gastro-esophageal reflux |
| WO2007053131A2 (en) | 2004-06-04 | 2007-05-10 | Affinium Pharmaceuticals, Inc. | Acrylamide derivatives as antibiotic agents |
| ATE527258T1 (de) * | 2004-07-28 | 2011-10-15 | Takeda Pharmaceutical | Pyrroloä2,3-cüpyridinverbindung, verfahren zu deren herstellung und anwendung |
| EP1776361A1 (de) * | 2004-08-02 | 2007-04-25 | Altana Pharma AG | 5-substituierte 1h-pyrrolo[3,2-b]pyridine |
| ATE518858T1 (de) * | 2004-09-03 | 2011-08-15 | Yuhan Corp | Pyrroloä3,2-cüpyridinderivate und herstellungsverfahren dafür |
| US7642269B2 (en) | 2004-09-03 | 2010-01-05 | Yuhan Corporation | Pyrrolo[3,2-B]pyridine derivatives and processes for the preparation thereof |
| KR100946220B1 (ko) * | 2004-09-03 | 2010-03-08 | 주식회사유한양행 | 피롤로[3,2-c]피리딘 유도체 및 그의 제조방법 |
| BRPI0514925A (pt) * | 2004-09-03 | 2008-07-01 | Yuhan Corp | derivados de pirrol[2,3-c]piridina e processos para a preparação destes |
| US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
| WO2007028051A2 (en) | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
| JP2009518399A (ja) * | 2005-12-05 | 2009-05-07 | アフィニウム ファーマシューティカルズ, インク. | Fabi阻害剤および抗菌剤としてのヘテロ環アクリルアミド化合物 |
| CN101516883A (zh) * | 2006-06-06 | 2009-08-26 | 先灵公司 | 作为蛋白激酶抑制剂的咪唑并吡嗪化合物 |
| EP2687533B1 (de) | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamidderivate als FAB-I-Hemmer |
| WO2008098374A1 (en) * | 2007-02-16 | 2008-08-21 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab i inhibitors |
| JP5496915B2 (ja) | 2008-02-13 | 2014-05-21 | シージーアイ ファーマシューティカルズ,インコーポレーテッド | 6−アリール−イミダゾ[1,2−a]ピラジン誘導体、その製造方法、及びその使用方法 |
| CA2745871C (en) | 2008-12-08 | 2018-02-20 | Gilead Connecticut, Inc. | Imidazopyrazine syk inhibitors |
| US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
| KR101748925B1 (ko) | 2008-12-08 | 2017-06-19 | 질레드 코네티컷 인코포레이티드 | 이미다조피라진 syk 억제제 |
| EP2545052B1 (de) | 2010-03-11 | 2014-11-12 | Gilead Connecticut, Inc. | Imidazopyridine als syk-inhibitoren |
| HRP20190980T1 (hr) | 2012-06-19 | 2019-08-23 | Debiopharm International Sa | Derivati predlijeka (e)-n-metil-n((3-metilbenzofuran-2 il)metil)-3-(7-okso-5,6,7,8-tetrahidro-1,8-naftiridin-3-il)akrilamida |
| NZ715745A (en) | 2013-07-30 | 2017-06-30 | Gilead Connecticut Inc | Formulation of syk inhibitors |
| TW201602108A (zh) | 2013-07-30 | 2016-01-16 | 吉李德康乃狄克公司 | 脾酪胺酸激酶(Syk)抑制劑之多晶型 |
| PT3076976T (pt) | 2013-12-04 | 2020-12-07 | Kronos Bio Inc | Métodos para tratar cancros |
| GB201321738D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
| TWI662037B (zh) | 2013-12-23 | 2019-06-11 | 美商基利科學股份有限公司 | 脾酪胺酸激酶抑制劑 |
| US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
| EP3169366A1 (de) | 2014-07-14 | 2017-05-24 | Gilead Sciences, Inc. | Kombinationen zur behandlung von krebs |
| AU2017223037B2 (en) | 2016-02-26 | 2022-04-14 | Debiopharm International S.A. | Medicament for treatment of diabetic foot infections |
| EP3672974A1 (de) | 2017-08-25 | 2020-07-01 | Gilead Sciences, Inc. | Polymorphe von syk-hemmern |
| US12403131B2 (en) | 2019-02-14 | 2025-09-02 | Debiopharm International S.A. | Afabicin formulation, method for making the same and uses thereof |
| JP2022521413A (ja) | 2019-02-22 | 2022-04-07 | クロノス バイオ インコーポレイテッド | Syk阻害剤としての縮合ピラジンの固体形態 |
| MX2021015513A (es) | 2019-06-14 | 2022-04-20 | Debiopharm Int Sa | Medicamento y uso del mismo para tratar infecciones bacterianas que involucran una biopelicula. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4507294A (en) * | 1982-03-08 | 1985-03-26 | Schering Corp. | Imidazo[1,2-a]pyrazines |
| EP0068378B1 (de) | 1981-06-26 | 1986-03-05 | Schering Corporation | Imidazo(1,2-a)pyridine und -pyrazine, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
| US4725601A (en) | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
| PT97467A (pt) | 1990-04-27 | 1992-01-31 | Byk Gulden Lomberg Chem Fab | Processo para preparacao de novas piridazinas e de composicoes farmaceuticas que as contem |
| US5041442A (en) | 1990-07-31 | 1991-08-20 | Syntex (U.S.A.) Inc. | Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion |
| AU8712191A (en) | 1990-10-15 | 1992-05-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New diazines |
| DK0609328T3 (da) * | 1991-10-25 | 1999-10-25 | Byk Gulden Lomberg Chem Fab | Pyrrolo-pyridaziner med gastro-intestinal beskyttelsesvirkning |
| KR100361199B1 (ko) * | 1994-01-19 | 2003-04-16 | 상꾜 가부시키가이샤 | 피롤로피리다진유도체 |
| SE9602286D0 (sv) | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
| SE9700661D0 (sv) | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
| SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
-
1997
- 1997-11-28 SE SE9704404A patent/SE9704404D0/xx unknown
-
1998
- 1998-11-16 TW TW087118942A patent/TW515798B/zh active
- 1998-11-16 ZA ZA9810468A patent/ZA9810468B/xx unknown
- 1998-11-16 AR ARP980105799A patent/AR016972A1/es unknown
- 1998-11-17 MY MYPI98005216A patent/MY121032A/en unknown
- 1998-11-18 ES ES98957270T patent/ES2191356T3/es not_active Expired - Lifetime
- 1998-11-18 RU RU2000113729/04A patent/RU2241000C2/ru not_active IP Right Cessation
- 1998-11-18 SK SK674-2000A patent/SK283904B6/sk unknown
- 1998-11-18 BR BR9814755-2A patent/BR9814755A/pt not_active Application Discontinuation
- 1998-11-18 WO PCT/SE1998/002091 patent/WO1999028322A1/en not_active Ceased
- 1998-11-18 DK DK98957270T patent/DK1042324T3/da active
- 1998-11-18 IL IL13614598A patent/IL136145A0/xx unknown
- 1998-11-18 DE DE69811735T patent/DE69811735T2/de not_active Expired - Fee Related
- 1998-11-18 ID IDW20000987A patent/ID24730A/id unknown
- 1998-11-18 EP EP98957270A patent/EP1042324B1/de not_active Expired - Lifetime
- 1998-11-18 CN CNB98813344XA patent/CN1142933C/zh not_active Expired - Fee Related
- 1998-11-18 AT AT98957270T patent/ATE233263T1/de not_active IP Right Cessation
- 1998-11-18 AU AU13565/99A patent/AU752187C/en not_active Ceased
- 1998-11-18 KR KR1020007005804A patent/KR20010032559A/ko not_active Ceased
- 1998-11-18 TR TR2000/01530T patent/TR200001530T2/xx unknown
- 1998-11-18 UA UA2000052801A patent/UA70932C2/uk unknown
- 1998-11-18 NZ NZ504355A patent/NZ504355A/en unknown
- 1998-11-18 US US09/194,823 patent/US6518270B1/en not_active Expired - Lifetime
- 1998-11-18 JP JP2000523214A patent/JP2001525322A/ja active Pending
- 1998-11-18 PL PL98340920A patent/PL340920A1/xx not_active Application Discontinuation
- 1998-11-18 EE EEP200000315A patent/EE04060B1/xx not_active IP Right Cessation
- 1998-11-18 HU HU0100601A patent/HUP0100601A3/hu unknown
- 1998-11-18 CA CA002311798A patent/CA2311798A1/en not_active Abandoned
- 1998-11-18 PT PT98957270T patent/PT1042324E/pt unknown
- 1998-11-18 CZ CZ20001947A patent/CZ292349B6/cs not_active IP Right Cessation
-
2000
- 2000-05-10 IS IS5486A patent/IS5486A/is unknown
- 2000-05-26 NO NO20002721A patent/NO315704B1/no unknown
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Legal Events
| Date | Code | Title | Description |
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| UEP | Publication of translation of european patent specification |
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| REN | Ceased due to non-payment of the annual fee |