EE04060B1 - Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised - Google Patents
Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostisedInfo
- Publication number
- EE04060B1 EE04060B1 EEP200000315A EEP200000315A EE04060B1 EE 04060 B1 EE04060 B1 EE 04060B1 EE P200000315 A EEP200000315 A EE P200000315A EE P200000315 A EEP200000315 A EE P200000315A EE 04060 B1 EE04060 B1 EE 04060B1
- Authority
- EE
- Estonia
- Prior art keywords
- preparation
- pharmaceutical compositions
- heterocyclic compounds
- gastric acid
- acid secretion
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9704404A SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | New compounds |
PCT/SE1998/002091 WO1999028322A1 (en) | 1997-11-28 | 1998-11-18 | Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EE200000315A EE200000315A (et) | 2001-10-15 |
EE04060B1 true EE04060B1 (et) | 2003-06-16 |
Family
ID=20409181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EEP200000315A EE04060B1 (et) | 1997-11-28 | 1998-11-18 | Heterotsüklilised ühendid maohappesekretsiooni inhibeerimiseks, protsess nende valmistamiseks ja ravimkoostised |
Country Status (33)
Country | Link |
---|---|
US (1) | US6518270B1 (et) |
EP (1) | EP1042324B1 (et) |
JP (1) | JP2001525322A (et) |
KR (1) | KR20010032559A (et) |
CN (1) | CN1142933C (et) |
AR (1) | AR016972A1 (et) |
AT (1) | ATE233263T1 (et) |
AU (1) | AU752187C (et) |
BR (1) | BR9814755A (et) |
CA (1) | CA2311798A1 (et) |
CZ (1) | CZ292349B6 (et) |
DE (1) | DE69811735T2 (et) |
DK (1) | DK1042324T3 (et) |
EE (1) | EE04060B1 (et) |
ES (1) | ES2191356T3 (et) |
HK (1) | HK1030216A1 (et) |
HU (1) | HUP0100601A3 (et) |
ID (1) | ID24730A (et) |
IL (1) | IL136145A0 (et) |
IS (1) | IS5486A (et) |
MY (1) | MY121032A (et) |
NO (1) | NO315704B1 (et) |
NZ (1) | NZ504355A (et) |
PL (1) | PL340920A1 (et) |
PT (1) | PT1042324E (et) |
RU (1) | RU2241000C2 (et) |
SE (1) | SE9704404D0 (et) |
SK (1) | SK283904B6 (et) |
TR (1) | TR200001530T2 (et) |
TW (1) | TW515798B (et) |
UA (1) | UA70932C2 (et) |
WO (1) | WO1999028322A1 (et) |
ZA (1) | ZA9810468B (et) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997025429A1 (en) | 1996-01-04 | 1997-07-17 | Rican Limited | Helicobacter pylori bacterioferritin |
SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
AR025976A1 (es) * | 1999-10-08 | 2002-12-26 | Affinium Pharm Inc | Inhibidores de fab i. |
DE60230934D1 (de) * | 2001-04-06 | 2009-03-05 | Affinium Pharm Inc | Fab-i-inhibitoren |
JP2003119140A (ja) * | 2001-08-08 | 2003-04-23 | Sankyo Co Ltd | ピロロピリダジン化合物を含有する医薬 |
CN100537571C (zh) * | 2002-04-19 | 2009-09-09 | 细胞基因组公司 | 咪唑并[1,2-а]吡嗪-8-基胺,其制备方法及使用方法 |
US7312341B2 (en) | 2002-09-09 | 2007-12-25 | Cgi Pharmaceuticals, Inc. | 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof |
TW200420293A (en) * | 2002-09-25 | 2004-10-16 | Sankyo Co | Pharmaceutical compositions for the reduction of gastric acid concentration in blood |
AU2003266621A1 (en) * | 2002-09-25 | 2004-04-19 | Sankyo Company, Limited | Medicinal composition for treatment for or prevention of visceral pain |
DK1575951T3 (da) | 2002-12-06 | 2014-09-15 | Debiopharm Int Sa | Heterocykliske forbindelser, fremgangsmåder til fremstilling deraf og deres anvendelse i terapi |
US7189723B2 (en) | 2003-02-10 | 2007-03-13 | Cgi Pharmaceuticals, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity |
AR043002A1 (es) * | 2003-02-18 | 2005-07-13 | Altana Pharma Ag | Imidazopirazinas 6-substituidos |
JP4880448B2 (ja) * | 2003-03-17 | 2012-02-22 | アフィナム ファーマシューティカルズ,インコーポレーテッド | 複数の抗生物質を含む組成物、及びそれを用いる方法 |
WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
US7393848B2 (en) | 2003-06-30 | 2008-07-01 | Cgi Pharmaceuticals, Inc. | Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds |
WO2005019220A2 (en) | 2003-08-11 | 2005-03-03 | Cellular Genomics Inc. | Substituted imidazo[1,2-a]pyrazines as modulators of kinase activity |
AU2004285394B2 (en) | 2003-11-03 | 2009-01-08 | Astrazeneca Ab | Imidazo (1,2-A) pyridine derivatives for the treatment of silent gastro-esophageal reflux |
CA2568914C (en) | 2004-06-04 | 2013-09-24 | Affinium Pharmaceuticals, Inc. | Therapeutic agents, and methods of making and using the same |
KR20070053231A (ko) * | 2004-07-28 | 2007-05-23 | 다케다 야쿠힌 고교 가부시키가이샤 | 피롤로[2,3-c]피리딘 화합물, 그 제조 방법 및 용도 |
EP1776361A1 (en) * | 2004-08-02 | 2007-04-25 | Altana Pharma AG | 5-substituted 1h-pyrroloý3,2-b¨pyridines |
ES2426920T3 (es) * | 2004-09-03 | 2013-10-25 | Yuhan Corporation | Derivados de pirrolo[3,2-B]piridina y procesos para su preparación |
ATE466013T1 (de) * | 2004-09-03 | 2010-05-15 | Yuhan Corp | Pyrroloä3,2-cüpyridinderivate und verfahren zu deren herstellung |
PL1784404T3 (pl) * | 2004-09-03 | 2012-04-30 | Yuhan Corp | Pochodne pirolo[2,3-c]pirydyny i sposoby ich wytwarzania |
DK1784402T3 (da) | 2004-09-03 | 2011-11-14 | Yuhan Corp | Pyrrolo[3,2-c]pyridinderivater samt fremgangsmåder til deres fremstilling |
WO2007024294A2 (en) | 2005-05-03 | 2007-03-01 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
US7709468B2 (en) | 2005-09-02 | 2010-05-04 | Abbott Laboratories | Imidazo based heterocycles |
KR20080075027A (ko) * | 2005-12-05 | 2008-08-13 | 아피늄 파마슈티컬스, 인크. | Fabi 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물 |
CA2654202A1 (en) | 2006-06-06 | 2007-12-21 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
JP5468899B2 (ja) | 2006-07-20 | 2014-04-09 | アフィニウム ファーマシューティカルズ, インク. | Fabiインヒビターとしてのアクリルアミド誘導体 |
US8263613B2 (en) * | 2007-02-16 | 2012-09-11 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab I inhibitors |
AU2009215191A1 (en) | 2008-02-13 | 2009-08-20 | Gilead Connecticut, Inc. | 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof |
US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
US8440667B2 (en) | 2008-12-08 | 2013-05-14 | Gilead Connecticut, Inc. | Imidazopyrazine Syk inhibitors |
PT2373169E (pt) | 2008-12-08 | 2015-10-05 | Gilead Connecticut Inc | Inibidores de imidazopirazina da syk |
PT2545052E (pt) | 2010-03-11 | 2015-02-18 | Gilead Connecticut Inc | Inibidores da syk à base de imidazopiridinas |
EP2861608B8 (en) | 2012-06-19 | 2019-06-19 | Debiopharm International SA | Prodrug derivatives of (e)-n-methyl-n-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide |
KR20170116203A (ko) | 2013-07-30 | 2017-10-18 | 질레드 코네티컷 인코포레이티드 | Syk 억제제의 제제 |
KR101810798B1 (ko) | 2013-07-30 | 2017-12-19 | 질레드 코네티컷 인코포레이티드 | Syk 억제제의 다형체 |
NZ718825A (en) | 2013-12-04 | 2017-10-27 | Gilead Sciences Inc | Uses of a compound of formula i for treating cancer in a subject |
GB201321738D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
UY35898A (es) | 2013-12-23 | 2015-07-31 | Gilead Sciences Inc | ?compuestos inhibidores de syk y composiciones que los comprenden?. |
US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
JP6310144B2 (ja) | 2014-07-14 | 2018-04-18 | ギリアード サイエンシーズ, インコーポレイテッド | がんを処置するための組み合わせ |
JP6998881B2 (ja) | 2016-02-26 | 2022-02-10 | デビオファーム・インターナショナル・エス・アー | 糖尿病性足感染症の処置のための医薬 |
EP3672974A1 (en) | 2017-08-25 | 2020-07-01 | Gilead Sciences, Inc. | Polymorphs of syk inhibitors |
CN113950479A (zh) | 2019-02-22 | 2022-01-18 | 克洛诺斯生物股份有限公司 | 作为syk抑制剂的缩合吡嗪的固体形式 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507294A (en) * | 1982-03-08 | 1985-03-26 | Schering Corp. | Imidazo[1,2-a]pyrazines |
EP0068378B1 (en) | 1981-06-26 | 1986-03-05 | Schering Corporation | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
US4725601A (en) * | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
PT97467A (pt) * | 1990-04-27 | 1992-01-31 | Byk Gulden Lomberg Chem Fab | Processo para preparacao de novas piridazinas e de composicoes farmaceuticas que as contem |
US5041442A (en) * | 1990-07-31 | 1991-08-20 | Syntex (U.S.A.) Inc. | Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion |
WO1992006979A1 (de) * | 1990-10-15 | 1992-04-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue diazine |
ES2133331T3 (es) * | 1991-10-25 | 1999-09-16 | Byk Gulden Lomberg Chem Fab | Pirrolo-piridazinas con efectos protectores del estomago y de los intestinos. |
HU225920B1 (en) * | 1994-01-19 | 2008-01-28 | Sankyo Co | Pyrrolo[2,3-d]pyridazine derivatives, process for their preparation and pharmaceutical compositions containing them |
SE9602286D0 (sv) | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
SE9700661D0 (sv) | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
-
1997
- 1997-11-28 SE SE9704404A patent/SE9704404D0/xx unknown
-
1998
- 1998-11-16 AR ARP980105799A patent/AR016972A1/es unknown
- 1998-11-16 TW TW087118942A patent/TW515798B/zh active
- 1998-11-16 ZA ZA9810468A patent/ZA9810468B/xx unknown
- 1998-11-17 MY MYPI98005216A patent/MY121032A/en unknown
- 1998-11-18 HU HU0100601A patent/HUP0100601A3/hu unknown
- 1998-11-18 KR KR1020007005804A patent/KR20010032559A/ko not_active Application Discontinuation
- 1998-11-18 EE EEP200000315A patent/EE04060B1/et not_active IP Right Cessation
- 1998-11-18 IL IL13614598A patent/IL136145A0/xx unknown
- 1998-11-18 AT AT98957270T patent/ATE233263T1/de not_active IP Right Cessation
- 1998-11-18 CZ CZ20001947A patent/CZ292349B6/cs not_active IP Right Cessation
- 1998-11-18 SK SK674-2000A patent/SK283904B6/sk unknown
- 1998-11-18 DE DE69811735T patent/DE69811735T2/de not_active Expired - Fee Related
- 1998-11-18 JP JP2000523214A patent/JP2001525322A/ja active Pending
- 1998-11-18 RU RU2000113729/04A patent/RU2241000C2/ru not_active IP Right Cessation
- 1998-11-18 DK DK98957270T patent/DK1042324T3/da active
- 1998-11-18 UA UA2000052801A patent/UA70932C2/uk unknown
- 1998-11-18 NZ NZ504355A patent/NZ504355A/en unknown
- 1998-11-18 ID IDW20000987A patent/ID24730A/id unknown
- 1998-11-18 CA CA002311798A patent/CA2311798A1/en not_active Abandoned
- 1998-11-18 EP EP98957270A patent/EP1042324B1/en not_active Expired - Lifetime
- 1998-11-18 WO PCT/SE1998/002091 patent/WO1999028322A1/en not_active Application Discontinuation
- 1998-11-18 ES ES98957270T patent/ES2191356T3/es not_active Expired - Lifetime
- 1998-11-18 CN CNB98813344XA patent/CN1142933C/zh not_active Expired - Fee Related
- 1998-11-18 US US09/194,823 patent/US6518270B1/en not_active Expired - Lifetime
- 1998-11-18 AU AU13565/99A patent/AU752187C/en not_active Ceased
- 1998-11-18 PL PL98340920A patent/PL340920A1/xx not_active Application Discontinuation
- 1998-11-18 BR BR9814755-2A patent/BR9814755A/pt not_active Application Discontinuation
- 1998-11-18 TR TR2000/01530T patent/TR200001530T2/xx unknown
- 1998-11-18 PT PT98957270T patent/PT1042324E/pt unknown
-
2000
- 2000-05-10 IS IS5486A patent/IS5486A/is unknown
- 2000-05-26 NO NO20002721A patent/NO315704B1/no unknown
-
2001
- 2001-02-16 HK HK01101145A patent/HK1030216A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
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KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
|
KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
MM4A | Lapsed by not paying the annual fees |
Effective date: 20061118 |