ES2133331T3 - Pirrolo-piridazinas con efectos protectores del estomago y de los intestinos. - Google Patents

Pirrolo-piridazinas con efectos protectores del estomago y de los intestinos.

Info

Publication number
ES2133331T3
ES2133331T3 ES92922034T ES92922034T ES2133331T3 ES 2133331 T3 ES2133331 T3 ES 2133331T3 ES 92922034 T ES92922034 T ES 92922034T ES 92922034 T ES92922034 T ES 92922034T ES 2133331 T3 ES2133331 T3 ES 2133331T3
Authority
ES
Spain
Prior art keywords
stands
alkyl
pct
halogen
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92922034T
Other languages
English (en)
Inventor
Gerhard Grundler
Georg Rainer
Hartmann Schaefer
Jorg Senn-Bilfinger
Wolfgang-Alexander Simon
Richard Riedel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Application granted granted Critical
Publication of ES2133331T3 publication Critical patent/ES2133331T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

COMPUESTOS DE FORMULA (I), DONDE R1 ALQUILO O ALQUILENO SUSTITUIDO A TRAVES DE R5; R2 ALQUILO; R3 HIDROGENO, HALOGENO, CHO(FORMILO), HIDROXIMETILO, NITRO, AMINO O EL SUSTITUYENTE -CH2O-COR7; R4 HALOGENO O EL SUSTITUYENTE -A-B-R6; R5 FURILO, TIENILO, TETRAHIDROFURILO, FENILO O FENILO SUSTITUIDO A TRAVES DE UNO O DOS SUSTITUYENTES IGUALES O DIFERENTES DEL GRUPO HALOGENO, ALQUILO O ALCOXI; R6 HIDROGENO, TIENILO, FURILO, FENILO O FENILO SUSTITUIDO A TRAVES DE UNO O DOS SUSTITUYENTES IGUALES O DIFERENTES DEL GRUPO HALOGENO, ALQUILO, ALCOXI, NITRO, UREIDO, AMINO, ALQUILCARBONILOAMINO Y ALCOXI CARBONILOAMINO; R7 ALQUILO, ALCOXI LQUILO; A OXIGENO O NH; B UN ENLACE LINEAL, -CH2(METILENO) O -CH2-CH2-(1,2-ETILENO) Y N EL NUMERO 0 A 1, SON NUEVOS COMPUESTOS QUE SE EMPLEAN PARA LA PREVENCION Y EL TRATAMIENTO DE ENFERMEDADES GASTROINTESTINALES.
ES92922034T 1991-10-25 1992-10-21 Pirrolo-piridazinas con efectos protectores del estomago y de los intestinos. Expired - Lifetime ES2133331T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH311991 1991-10-25
CH312391 1991-10-25
CH312091 1991-10-25

Publications (1)

Publication Number Publication Date
ES2133331T3 true ES2133331T3 (es) 1999-09-16

Family

ID=27174142

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92922034T Expired - Lifetime ES2133331T3 (es) 1991-10-25 1992-10-21 Pirrolo-piridazinas con efectos protectores del estomago y de los intestinos.

Country Status (10)

Country Link
US (1) US5534515A (es)
EP (1) EP0609328B1 (es)
JP (1) JPH07500329A (es)
AT (1) ATE179419T1 (es)
AU (1) AU2870492A (es)
DE (1) DE59209687D1 (es)
DK (1) DK0609328T3 (es)
ES (1) ES2133331T3 (es)
GR (1) GR3030486T3 (es)
WO (1) WO1993008190A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU213105B (en) * 1992-12-23 1997-05-28 Richter Gedeon Vegyeszet Process for producing pyrroline derivatives and pharmaceutical compositions containing them
NZ278675A (en) * 1994-01-19 1997-07-27 Sankyo Co Pyrrolopyridazine derivatives; medicaments
US6316429B1 (en) * 1997-05-07 2001-11-13 Sugen, Inc. Bicyclic protein kinase inhibitors
SE9704404D0 (sv) * 1997-11-28 1997-11-28 Astra Ab New compounds
TWI287014B (en) 1999-06-15 2007-09-21 Sankyo Co Optically active pyrrolopyridazine compound
WO2001058901A1 (fr) * 2000-02-10 2001-08-16 Sankyo Company, Limited Compose de pyrrolopyridazine
UA80393C2 (uk) 2000-12-07 2007-09-25 Алтана Фарма Аг Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці
JP2003119140A (ja) * 2001-08-08 2003-04-23 Sankyo Co Ltd ピロロピリダジン化合物を含有する医薬
MY140561A (en) * 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
TW200418479A (en) * 2002-09-25 2004-10-01 Sankyo Co Pharmaceutical compositions for the treatment or prevention of visceral pains
WO2004029058A1 (ja) * 2002-09-25 2004-04-08 Sankyo Company, Limited 血中ガストリン濃度上昇の抑制のための医薬組成物
ME00524B (me) 2003-03-10 2011-10-10 Astrazeneca Ab Novi postupak za dobijanje roflumilasta
TW200509936A (en) * 2003-03-24 2005-03-16 Sankyo Co Pharmaceutical composition comprising a pyrrolopyridazine compound
JP5383183B2 (ja) * 2005-03-16 2014-01-08 タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング ロフルミラストを含有する矯味された剤形

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8901430D0 (en) * 1989-01-23 1989-03-15 Smithkline Beckman Intercredit Compounds
IL97931A0 (en) * 1990-04-27 1992-06-21 Byk Gulden Lomberg Chem Fab Pyridazine derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
WO1992006979A1 (de) * 1990-10-15 1992-04-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue diazine

Also Published As

Publication number Publication date
DE59209687D1 (de) 1999-06-02
DK0609328T3 (da) 1999-10-25
JPH07500329A (ja) 1995-01-12
ATE179419T1 (de) 1999-05-15
WO1993008190A1 (de) 1993-04-29
EP0609328B1 (de) 1999-04-28
US5534515A (en) 1996-07-09
EP0609328A1 (de) 1994-08-10
AU2870492A (en) 1993-05-21
GR3030486T3 (en) 1999-10-29

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