AR016001A1 - Uso de polimeros de amina alifatica para la fabricacion de medicamentos para la reduccion de niveles de oxalato en un paciente - Google Patents
Uso de polimeros de amina alifatica para la fabricacion de medicamentos para la reduccion de niveles de oxalato en un pacienteInfo
- Publication number
- AR016001A1 AR016001A1 ARP980105513A ARP980105513A AR016001A1 AR 016001 A1 AR016001 A1 AR 016001A1 AR P980105513 A ARP980105513 A AR P980105513A AR P980105513 A ARP980105513 A AR P980105513A AR 016001 A1 AR016001 A1 AR 016001A1
- Authority
- AR
- Argentina
- Prior art keywords
- patient
- integer
- manufacture
- amine polymers
- alifatic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
- A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/51—Lyases (4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/04—Drugs for disorders of the urinary system for urolithiasis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/03—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
- C12Y102/03004—Oxalate oxidase (1.2.3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01002—Oxalate decarboxylase (4.1.1.2)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Uso de polímeros de amina alifática para la fabricacion de un medicamento para reduccion de los niveles de oxalato en un paciente que lo necesiteconsistente en administrar a dicho paciente una cantidad terapéuticamente efectiva de uno o más polímerosde amina alifática. En una realizacion elpolímero posee una unidad repetitiva que tiene la formula seleccionada de: formulas (I) y sus sales y copolímeros, donde n es un numero enteropositivo y x es cero o un numero entero entre 1 y 4, y y z son numeros enteros de uno o más y R, R1, R2 y R3, independientemente, son H o un grupo alquilo,alquilamino o arilo substituido o no substituido. Más en particular el polímero es un polímero entrecruzado que tiene una unidad repetitiva de formula(II) y sussales, donde n es un numero entero positivo y x es cero o un numero entero entre 1 y 4. Los polímeros son particularmente utiles en el tratamientode cálculos urinarios.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/964,956 US5985938A (en) | 1997-11-05 | 1997-11-05 | Method for reducing oxalate |
Publications (1)
Publication Number | Publication Date |
---|---|
AR016001A1 true AR016001A1 (es) | 2001-05-30 |
Family
ID=25509224
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP980105513A AR016001A1 (es) | 1997-11-05 | 1998-11-03 | Uso de polimeros de amina alifatica para la fabricacion de medicamentos para la reduccion de niveles de oxalato en un paciente |
Country Status (10)
Country | Link |
---|---|
US (3) | US5985938A (es) |
EP (2) | EP1645278A3 (es) |
JP (1) | JP4452402B2 (es) |
AR (1) | AR016001A1 (es) |
AU (1) | AU1364799A (es) |
CA (1) | CA2349620C (es) |
DE (1) | DE69833134T2 (es) |
TW (1) | TW585772B (es) |
WO (1) | WO1999022744A1 (es) |
ZA (1) | ZA989671B (es) |
Families Citing this family (62)
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US5667775A (en) * | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
US8486389B2 (en) | 1997-05-23 | 2013-07-16 | Oxthera, Inc. | Compositions and methods for treating or preventing oxalate-related disease |
US5985938A (en) * | 1997-11-05 | 1999-11-16 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
US6566407B2 (en) | 1997-11-05 | 2003-05-20 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
US6733780B1 (en) * | 1999-10-19 | 2004-05-11 | Genzyme Corporation | Direct compression polymer tablet core |
US20020054903A1 (en) * | 1999-10-19 | 2002-05-09 | Joseph Tyler | Direct compression polymer tablet core |
GB9927088D0 (en) * | 1999-11-17 | 2000-01-12 | Secr Defence | Use of poly(diallylamine) polymers |
DE10028167B4 (de) * | 2000-06-09 | 2004-02-19 | Storch, Rüdiger, Dr. | Verwendung von Calciumsalzen zur Entgegenwirkung der Bildung von Oxalatharnsteinen |
MXPA03009571A (es) * | 2001-04-18 | 2004-02-12 | Genzyme Corp | Metodo para tratar la gota y unir el acido urico. |
AU2002257147B9 (en) * | 2001-04-18 | 2005-08-18 | Genzyme Corporation | Methods of treating syndrome X with aliphatic polyamines |
WO2002085380A1 (en) * | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for treating gout and reducing serum uric acid |
DK1923064T3 (en) * | 2001-04-18 | 2017-10-02 | Genzyme Corp | Use of amine polymer for lowering serum glucose |
EP1923064B1 (en) | 2001-04-18 | 2017-06-28 | Genzyme Corporation | Use of amine polymer for lowering serum glucose |
WO2002085379A1 (en) * | 2001-04-18 | 2002-10-31 | Geltex Pharmaceuticals, Inc. | Method for improving vascular access in patients with vascular shunts |
EP1379258B1 (en) * | 2001-04-18 | 2006-06-28 | Genzyme Corporation | Low salt forms of polyallylamine |
CA2442414C (en) | 2001-04-23 | 2011-02-01 | Anormed, Inc. | Use of rare earth compounds for the prevention of kidney stone disease |
US7041280B2 (en) * | 2001-06-29 | 2006-05-09 | Genzyme Corporation | Aryl boronate functionalized polymers for treating obesity |
AU2002363783A1 (en) * | 2001-10-05 | 2003-05-26 | Ixion Biotechnology, Inc. | Materials and methods for reducing oxalate concentrations in fluids |
US6600011B2 (en) * | 2001-10-09 | 2003-07-29 | Genzyme Corporation | Process for purification and drying of polymer hydrogels |
AU2002362735B2 (en) * | 2001-10-09 | 2005-10-13 | Genzyme Corporation | Process for purification and drying of polymer hydrogels |
AU2003282867A1 (en) * | 2002-10-22 | 2004-05-13 | Genzyme Corporation | Amine polymers for promoting bone formation |
US7385012B2 (en) * | 2003-11-03 | 2008-06-10 | Ilypsa, Inc. | Polyamine polymers |
US7459502B2 (en) * | 2003-11-03 | 2008-12-02 | Ilypsa, Inc. | Pharmaceutical compositions comprising crosslinked polyamine polymers |
US7449605B2 (en) * | 2003-11-03 | 2008-11-11 | Ilypsa, Inc. | Crosslinked amine polymers |
US7767768B2 (en) * | 2003-11-03 | 2010-08-03 | Ilypsa, Inc. | Crosslinked amine polymers |
US7608674B2 (en) * | 2003-11-03 | 2009-10-27 | Ilypsa, Inc. | Pharmaceutical compositions comprising cross-linked small molecule amine polymers |
US7335795B2 (en) * | 2004-03-22 | 2008-02-26 | Ilypsa, Inc. | Crosslinked amine polymers |
PT2269589E (pt) | 2004-03-30 | 2014-02-26 | Relypsa Inc | Polímeros de ligação a ião e seus usos |
EP1755655A4 (en) * | 2004-05-07 | 2011-03-30 | Oxthera Inc | METHOD AND COMPOSITIONS FOR REDUCING OXALATE CONCENTRATIONS |
US7985418B2 (en) | 2004-11-01 | 2011-07-26 | Genzyme Corporation | Aliphatic amine polymer salts for tableting |
US20060177415A1 (en) * | 2004-11-01 | 2006-08-10 | Burke Steven K | Once a day formulation for phosphate binders |
JP2008526771A (ja) * | 2004-12-30 | 2008-07-24 | ジェンザイム コーポレーション | 高リン酸血症のための亜鉛含有処置 |
CA2620406A1 (en) | 2005-09-02 | 2007-03-08 | Genzyme Corporation | Method for removing phosphate and polymer used therefore |
HUE026628T2 (en) | 2005-09-15 | 2016-06-28 | Genzyme Corp | Pouches for amine polymers |
US20090162314A1 (en) * | 2005-11-08 | 2009-06-25 | Huval Chad C | Magnesium-Containing Polymers for the Treatment of Hyperphosphatemia |
PT1962873E (pt) * | 2005-12-14 | 2013-08-29 | Oxthera Inc | Composições farmacêuticas compreendendo bactérias redutoras de oxalato |
CN104013581A (zh) | 2005-12-16 | 2014-09-03 | 奥克斯赛拉公司 | 用于减少草酸和/或其盐的组合物和方法 |
US20080085259A1 (en) * | 2006-05-05 | 2008-04-10 | Huval Chad C | Amine condensation polymers as phosphate sequestrants |
JP2009542653A (ja) * | 2006-07-05 | 2009-12-03 | ジェンザイム コーポレーション | リン酸塩過剰血症のための鉄(ii)含有治療剤 |
EP2043767B1 (en) | 2006-07-14 | 2020-03-25 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
CA2658338A1 (en) * | 2006-07-18 | 2008-01-24 | Genzyme Corporation | Amine dendrimers |
RU2009107184A (ru) | 2006-08-02 | 2010-09-10 | Элтус Фармасьютикалз Инк. (Us) | Кристаллизованная оксалатдекарбоксилаза и способы применения |
JP2010504975A (ja) | 2006-09-29 | 2010-02-18 | ゲンズイメ コーポレーション | アミドデンドリマー組成物 |
US8802094B2 (en) * | 2006-10-25 | 2014-08-12 | Wisconsin Alumni Research Foundation | Method of reducing phosphate absorption by administering orally an IgY anti-intestinal sodium phosphate cotransporter type 2B antibody |
AU2007309026B2 (en) | 2006-10-26 | 2013-09-12 | Aovatechnologies, Inc. | Methods of reducing phosphate absorption |
BRPI0720234A2 (pt) | 2006-12-14 | 2013-12-24 | Genzyme Corp | Composição farmacêutica |
EP2114376A1 (en) * | 2007-02-23 | 2009-11-11 | Genzyme Corporation | Amine polymer compositions |
US20100196305A1 (en) * | 2007-03-08 | 2010-08-05 | Dhal Pradeep K | Sulfone polymer compositions |
WO2008113364A2 (en) * | 2007-03-20 | 2008-09-25 | Recepticon Aps | Amino derivatives to prevent nephrotoxicity and cancer |
EP2152277A1 (en) * | 2007-04-27 | 2010-02-17 | Genzyme Corporation | Amido-amine dendrimer compositions |
US20100316589A1 (en) * | 2007-12-14 | 2010-12-16 | Hitesh Bhagat | Coated Pharmaceutical Compositions |
FR2928373B1 (fr) | 2008-03-05 | 2010-12-31 | Centre Nat Rech Scient | Polymere derive de la polyethylenimine lineaire pour le transfert de gene. |
US20110142952A1 (en) * | 2008-06-20 | 2011-06-16 | Harris David J | Pharmaceutical Compositions |
WO2010123039A1 (ja) * | 2009-04-21 | 2010-10-28 | 株式会社医学生物学研究所 | 生物学的材料の不動化を行うための組成物 |
WO2014113648A1 (en) | 2013-01-18 | 2014-07-24 | Allena Pharmaceuticals, Inc. | Crystallized oxalate decarboxylase and methods of use |
CA2906501A1 (en) * | 2013-03-15 | 2014-09-25 | Genzyme Corporation | Sequestrants of advanced glycation end product (age) precursors |
JP6574414B2 (ja) | 2013-06-07 | 2019-09-11 | アレナ ファーマシューティカルズ, インコーポレイテッド | 透析のための組成物、方法、および器具 |
US10435528B2 (en) | 2013-09-17 | 2019-10-08 | Aquanano Llc | High-capacity anion exchange materials |
MA41202A (fr) | 2014-12-18 | 2017-10-24 | Genzyme Corp | Copolymères polydiallymine réticulé pour le traitement du diabète de type 2 |
US11603524B2 (en) | 2015-04-02 | 2023-03-14 | Oxidien Pharmaceuticals, Llc | High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate |
GB201718803D0 (en) * | 2017-11-14 | 2017-12-27 | Phoenix Molecular Pte Ltd | Method for isolation of nucleic acids |
WO2019236858A1 (en) * | 2018-06-06 | 2019-12-12 | The Board Of Trustees Of The University Of Illinois | Zwitterionic biocompatible polymers, methods, and uses thereof |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
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US4198396A (en) * | 1974-07-03 | 1980-04-15 | Warren-Teed Laboratories, Inc. | Dissolution of gallstones |
US4143130A (en) * | 1977-08-29 | 1979-03-06 | Warren-Teed Laboratories, Inc. | Method for treating kidney stones |
JPS60202869A (ja) * | 1984-03-26 | 1985-10-14 | Ajinomoto Co Inc | 大環状ポリアミン誘導体及びその用途 |
DE3727082A1 (de) * | 1987-08-14 | 1989-02-23 | Goedecke Ag | Pharmazeutische zubereitungen zur behandlung der urolithiasis |
US5244913A (en) * | 1991-11-19 | 1993-09-14 | Baxter International Inc. | Compositions and methods for dissolving body calculi |
US5487888A (en) * | 1993-05-20 | 1996-01-30 | Geltex, Inc. | Iron-binding polymers for oral administration |
US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
US5624963A (en) * | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
US5667775A (en) * | 1993-08-11 | 1997-09-16 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
US5496545A (en) * | 1993-08-11 | 1996-03-05 | Geltex Pharmaceuticals, Inc. | Phosphate-binding polymers for oral administration |
TW474813B (en) * | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
TR199901613T2 (xx) * | 1996-10-23 | 1999-10-21 | The Dow Chemical Company | Diyet ile al�nan fosfat veya oksalat emilimini azaltmaya ili�kin suda ��z�nen polimerler |
US5985938A (en) * | 1997-11-05 | 1999-11-16 | Geltex Pharmaceuticals, Inc. | Method for reducing oxalate |
-
1997
- 1997-11-05 US US08/964,956 patent/US5985938A/en not_active Expired - Lifetime
-
1998
- 1998-10-23 ZA ZA989671A patent/ZA989671B/xx unknown
- 1998-10-26 AU AU13647/99A patent/AU1364799A/en not_active Abandoned
- 1998-10-26 EP EP05076677A patent/EP1645278A3/en not_active Withdrawn
- 1998-10-26 DE DE69833134T patent/DE69833134T2/de not_active Expired - Lifetime
- 1998-10-26 JP JP2000518676A patent/JP4452402B2/ja not_active Expired - Lifetime
- 1998-10-26 CA CA002349620A patent/CA2349620C/en not_active Expired - Fee Related
- 1998-10-26 EP EP98957371A patent/EP1044008B1/en not_active Expired - Lifetime
- 1998-10-26 WO PCT/US1998/022606 patent/WO1999022744A1/en active IP Right Grant
- 1998-11-03 TW TW087118238A patent/TW585772B/zh not_active IP Right Cessation
- 1998-11-03 AR ARP980105513A patent/AR016001A1/es unknown
-
1999
- 1999-07-22 US US09/359,226 patent/US6177478B1/en not_active Expired - Lifetime
-
2000
- 2000-09-25 US US09/668,874 patent/US6281252B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU1364799A (en) | 1999-05-24 |
US5985938A (en) | 1999-11-16 |
ZA989671B (en) | 1999-04-28 |
EP1645278A3 (en) | 2007-11-14 |
JP4452402B2 (ja) | 2010-04-21 |
WO1999022744A1 (en) | 1999-05-14 |
EP1645278A2 (en) | 2006-04-12 |
DE69833134D1 (de) | 2006-03-30 |
EP1044008B1 (en) | 2006-01-04 |
CA2349620C (en) | 2008-04-08 |
TW585772B (en) | 2004-05-01 |
EP1044008A1 (en) | 2000-10-18 |
US6281252B1 (en) | 2001-08-28 |
JP2001521902A (ja) | 2001-11-13 |
CA2349620A1 (en) | 1999-05-14 |
DE69833134T2 (de) | 2006-08-10 |
US6177478B1 (en) | 2001-01-23 |
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Legal Events
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