DE69833134D1 - Verwendung aliphatischer amine zur verminderung von oxalat - Google Patents

Verwendung aliphatischer amine zur verminderung von oxalat

Info

Publication number
DE69833134D1
DE69833134D1 DE69833134T DE69833134T DE69833134D1 DE 69833134 D1 DE69833134 D1 DE 69833134D1 DE 69833134 T DE69833134 T DE 69833134T DE 69833134 T DE69833134 T DE 69833134T DE 69833134 D1 DE69833134 D1 DE 69833134D1
Authority
DE
Germany
Prior art keywords
oxalate
reduction
aliphatic amine
aliphatic
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69833134T
Other languages
English (en)
Other versions
DE69833134T2 (de
Inventor
Randall Holmes-Farley
Harry Mandeville
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of DE69833134D1 publication Critical patent/DE69833134D1/de
Application granted granted Critical
Publication of DE69833134T2 publication Critical patent/DE69833134T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/51—Lyases (4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/03—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with oxygen as acceptor (1.2.3)
    • C12Y102/03004—Oxalate oxidase (1.2.3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01002—Oxalate decarboxylase (4.1.1.2)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69833134T 1997-11-05 1998-10-26 Verwendung aliphatischer amine zur verminderung von oxalat Expired - Lifetime DE69833134T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/964,956 US5985938A (en) 1997-11-05 1997-11-05 Method for reducing oxalate
PCT/US1998/022606 WO1999022744A1 (en) 1997-11-05 1998-10-26 Use of aliphatic polyamines for reducing oxalate
US964956 2001-09-26

Publications (2)

Publication Number Publication Date
DE69833134D1 true DE69833134D1 (de) 2006-03-30
DE69833134T2 DE69833134T2 (de) 2006-08-10

Family

ID=25509224

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69833134T Expired - Lifetime DE69833134T2 (de) 1997-11-05 1998-10-26 Verwendung aliphatischer amine zur verminderung von oxalat

Country Status (10)

Country Link
US (3) US5985938A (de)
EP (2) EP1044008B1 (de)
JP (1) JP4452402B2 (de)
AR (1) AR016001A1 (de)
AU (1) AU1364799A (de)
CA (1) CA2349620C (de)
DE (1) DE69833134T2 (de)
TW (1) TW585772B (de)
WO (1) WO1999022744A1 (de)
ZA (1) ZA989671B (de)

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US6566407B2 (en) 1997-11-05 2003-05-20 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US5985938A (en) * 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
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US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
GB9927088D0 (en) * 1999-11-17 2000-01-12 Secr Defence Use of poly(diallylamine) polymers
DE10028167B4 (de) * 2000-06-09 2004-02-19 Storch, Rüdiger, Dr. Verwendung von Calciumsalzen zur Entgegenwirkung der Bildung von Oxalatharnsteinen
BR0209133A (pt) * 2001-04-18 2004-06-15 Genzyme Corp Método para tratar gota e para reduzir os nìveis de ácido úrico n0 sangue
EP1923064B1 (de) 2001-04-18 2017-06-28 Genzyme Corporation Verwendung von Aminpolymeren zur Minderung des Serumglukosegehaltes
WO2002085380A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for treating gout and reducing serum uric acid
CA2444028A1 (en) 2001-04-18 2002-10-31 Genzyme Corporation Methods of treating syndrome x with aliphatic polyamines
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
CA2444046C (en) * 2001-04-18 2011-06-07 Steven K. Burke Use of colesevelam in reducing serum glucose
EP1379258B1 (de) * 2001-04-18 2006-06-28 Genzyme Corporation Salzformarme polyallylamine
JP4515030B2 (ja) 2001-04-23 2010-07-28 アノーメッド インコーポレイティド 腎臓結石疾患の予防のための希土類化合物の使用
US7041280B2 (en) * 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
WO2003042380A2 (en) * 2001-10-05 2003-05-22 Ixion Biotechnology, Inc. Materials and methods for reducing oxalate concentrations in fluids
WO2003031501A1 (en) * 2001-10-09 2003-04-17 Genzyme Corporation Process for purification and drying of polymer hydrogels
US6600011B2 (en) * 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
WO2004037274A1 (en) * 2002-10-22 2004-05-06 Genzyme Corporation Amine polymers for promoting bone formation
US7459502B2 (en) 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
EP3574896A1 (de) 2004-03-30 2019-12-04 Relypsa, Inc. Ionenbindende polymere und verwendungen davon
US20080317810A1 (en) * 2004-05-07 2008-12-25 Harmeet Sidhu Methods and Compositions for Reducing Oxalate Concentrations
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
US7985418B2 (en) 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
EP1830832A1 (de) * 2004-12-30 2007-09-12 Genzyme Corporation Zinkhaltige behandlungen für hyperphosphatämie
CA2620406A1 (en) 2005-09-02 2007-03-08 Genzyme Corporation Method for removing phosphate and polymer used therefore
EP1924246B1 (de) * 2005-09-15 2015-10-21 Genzyme Corporation Beutelformulierung für aminpolymere
WO2007056405A2 (en) * 2005-11-08 2007-05-18 Genzyme Corporation Magnesium-containing polymers for the treatment of hyperphosphatemia
PT1962873E (pt) * 2005-12-14 2013-08-29 Oxthera Inc Composições farmacêuticas compreendendo bactérias redutoras de oxalato
ES2362897T3 (es) 2005-12-16 2011-07-14 Oxthera, Inc. Composiciones y métodos para reducción del oxalato.
JP2009536246A (ja) * 2006-05-05 2009-10-08 ゲンズイメ コーポレーション ホスフェート捕捉剤としてのアミン縮合重合体
JP2009542653A (ja) * 2006-07-05 2009-12-03 ジェンザイム コーポレーション リン酸塩過剰血症のための鉄（ｉｉ）含有治療剤
US9375499B2 (en) * 2006-07-14 2016-06-28 Wisconsin Alumni Research Foundation Adsorptive membranes for trapping viruses
MX2009000611A (es) * 2006-07-18 2009-04-16 Genzyme Corp Dendrimeros de amina.
WO2008105911A2 (en) * 2006-08-02 2008-09-04 Altus Pharmaceuticals Inc. Crystallized oxalate decarboxylase and methods of use
BRPI0717545A2 (pt) 2006-09-29 2013-10-22 Gezyme Corp Composição farmacêutica, método para tratar uma doença, polímero de amida, rede de polímero, e, método para preparar um polímero de amida
ES2573636T3 (es) * 2006-10-25 2016-06-09 Wisconsin Alumni Research Foundation Métodos para reducir la absorción de fosfato empleando un anticuerpo anti-Npt2B
BRPI0716317A8 (pt) * 2006-10-26 2019-02-05 Aovatechnologies Inc método para reduzir a absorção de fosfato em um indivíduo animal humano ou não-humano e método para reduzir a absorção de fosfato em um indivíduo humano
JP2010513271A (ja) 2006-12-14 2010-04-30 ゲンズイメ コーポレーション アミド−アミンポリマー組成物
WO2008103368A1 (en) * 2007-02-23 2008-08-28 Genzyme Corporation Amine polymer compositions
US20100196305A1 (en) * 2007-03-08 2010-08-05 Dhal Pradeep K Sulfone polymer compositions
WO2008113364A2 (en) * 2007-03-20 2008-09-25 Recepticon Aps Amino derivatives to prevent nephrotoxicity and cancer
JP2010525061A (ja) * 2007-04-27 2010-07-22 ゲンズイメ コーポレーション アミドアミンデンドリマー組成物
EP2217215A1 (de) * 2007-12-14 2010-08-18 Genzyme Corporation Beschichtete pharmazeutische zusammensetzungen
FR2928373B1 (fr) 2008-03-05 2010-12-31 Centre Nat Rech Scient Polymere derive de la polyethylenimine lineaire pour le transfert de gene.
US20110142952A1 (en) * 2008-06-20 2011-06-16 Harris David J Pharmaceutical Compositions
JPWO2010123039A1 (ja) * 2009-04-21 2012-10-25 株式会社医学生物学研究所 生物学的材料の不動化を行うための組成物
US9714456B2 (en) 2013-01-18 2017-07-25 Allena Pharmaceuticals, Inc. Crystallized oxalate decarboxylase and methods of use
AU2014235500A1 (en) * 2013-03-15 2015-11-05 Genzyme Corporation Sequestrants of advanced glycation end product (AGE) precursors
EP3003358B1 (de) 2013-06-07 2021-03-24 Allena Pharmaceuticals Inc. Dialysezusammensetzungen und -vorrichtungen
US10435528B2 (en) 2013-09-17 2019-10-08 Aquanano Llc High-capacity anion exchange materials
MA41202A (fr) 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
US11603524B2 (en) 2015-04-02 2023-03-14 Oxidien Pharmaceuticals, Llc High efficiency oxalate-degrading enzymes for degradation of insoluble and soluble oxalate
GB201718803D0 (en) * 2017-11-14 2017-12-27 Phoenix Molecular Pte Ltd Method for isolation of nucleic acids
WO2019236858A1 (en) * 2018-06-06 2019-12-12 The Board Of Trustees Of The University Of Illinois Zwitterionic biocompatible polymers, methods, and uses thereof

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Also Published As

Publication number Publication date
JP4452402B2 (ja) 2010-04-21
CA2349620C (en) 2008-04-08
AR016001A1 (es) 2001-05-30
US6177478B1 (en) 2001-01-23
DE69833134T2 (de) 2006-08-10
EP1645278A3 (de) 2007-11-14
WO1999022744A1 (en) 1999-05-14
US6281252B1 (en) 2001-08-28
ZA989671B (en) 1999-04-28
TW585772B (en) 2004-05-01
AU1364799A (en) 1999-05-24
EP1044008B1 (de) 2006-01-04
CA2349620A1 (en) 1999-05-14
EP1645278A2 (de) 2006-04-12
EP1044008A1 (de) 2000-10-18
US5985938A (en) 1999-11-16
JP2001521902A (ja) 2001-11-13

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