DE60011269D1 - Azaidole mit serotonin rezeptor affinität - Google Patents

Azaidole mit serotonin rezeptor affinität

Info

Publication number
DE60011269D1
DE60011269D1 DE60011269T DE60011269T DE60011269D1 DE 60011269 D1 DE60011269 D1 DE 60011269D1 DE 60011269 T DE60011269 T DE 60011269T DE 60011269 T DE60011269 T DE 60011269T DE 60011269 D1 DE60011269 D1 DE 60011269D1
Authority
DE
Germany
Prior art keywords
group
formula
azaidole
double bond
serotonin receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60011269T
Other languages
English (en)
Other versions
DE60011269T2 (de
Inventor
Louise Edwards
Abdelmalik Slassi
Ashok Tehim
Tao Xin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire NPS Pharmaceuticals Inc
Original Assignee
NPS Allelix Corp Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS Allelix Corp Canada filed Critical NPS Allelix Corp Canada
Application granted granted Critical
Publication of DE60011269D1 publication Critical patent/DE60011269D1/de
Publication of DE60011269T2 publication Critical patent/DE60011269T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE60011269T 1999-08-12 2000-08-14 Azaidole mit serotonin rezeptor affinität Expired - Lifetime DE60011269T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14834399P 1999-08-12 1999-08-12
US148343P 1999-08-12
PCT/IB2000/001122 WO2001012629A1 (en) 1999-08-12 2000-08-14 Azaindoles having serotonin receptor affinity

Publications (2)

Publication Number Publication Date
DE60011269D1 true DE60011269D1 (de) 2004-07-08
DE60011269T2 DE60011269T2 (de) 2005-06-23

Family

ID=22525363

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60011269T Expired - Lifetime DE60011269T2 (de) 1999-08-12 2000-08-14 Azaidole mit serotonin rezeptor affinität

Country Status (10)

Country Link
EP (1) EP1204662B1 (de)
JP (1) JP4969004B2 (de)
AT (1) ATE268330T1 (de)
AU (1) AU779832B2 (de)
CA (1) CA2382247C (de)
DE (1) DE60011269T2 (de)
DK (1) DK1204662T3 (de)
ES (1) ES2222219T3 (de)
MX (1) MXPA02001473A (de)
WO (1) WO2001012629A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10030037A1 (de) 2000-06-17 2001-12-20 Mann & Hummel Filter Zylindrische Filterpatrone mit Stützrohr
ITRM20010356A1 (it) 2001-06-21 2002-12-23 Sigma Tau Ind Farmaceuti "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina.
CA2470863C (en) * 2001-12-20 2012-05-15 Wyeth Indolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
TW200301251A (en) 2001-12-20 2003-07-01 Wyeth Corp Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands
GB0202679D0 (en) * 2002-02-05 2002-03-20 Glaxo Group Ltd Novel compounds
AU2003226724A1 (en) * 2002-03-27 2003-10-08 Glaxo Group Limited Quinoline and aza-indole derivatives and their use as 5-ht6 ligands
UA78999C2 (en) * 2002-06-04 2007-05-10 Wyeth Corp 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6
EP1897876A3 (de) 2002-06-20 2009-03-18 Biovitrum AB (publ) Zur Behandlung von Obesitas, Typ II-Diabetes und ZNS-Erkrankungen geeignete Verbindungen
TW200403243A (en) 2002-07-18 2004-03-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
EP1592772A2 (de) * 2003-01-31 2005-11-09 Pfizer Products Incorporated 5ht7 antagonisten und umgekehrten agonisten
BRPI0407493A (pt) * 2003-02-14 2006-02-14 Wyeth Corp derivados heterociclil-3-sulfinilazaindol ou -azaindazol como ligantes de 5-hidroxitriptamina-6
BRPI0412809A (pt) * 2003-07-23 2006-09-26 Wyeth Corp compostos de sulfonildihidrobenzimidazolona como ligantes a 5-hidróxitriptamina-6
ES2222828B1 (es) 2003-07-30 2006-04-16 Laboratorios Del Dr. Esteve, S.A. Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos.
US7696229B2 (en) 2006-02-17 2010-04-13 Memory Pharmaceuticals Corporation Compounds having 5-HT6 receptor affinity
ES2398299T3 (es) * 2006-07-03 2013-03-15 Proximagen Ltd. Indoles como moduladores de 5-HT6
JP2014515368A (ja) * 2011-05-26 2014-06-30 第一三共株式会社 プロテインキナーゼ阻害剤としての複素環化合物
JP6454346B2 (ja) 2013-12-20 2019-01-16 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 芳香族複素環式化合物及び医薬におけるその応用
CA2953004C (en) 2014-07-08 2023-02-21 Sunshine Lake Pharma Co., Ltd. Aromatic heterocyclic derivatives and pharmaceutical applications thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL310443A1 (en) * 1993-03-01 1995-12-11 Merck Sharp & Dohme Derivatives of pyrolo-pyridine
US5846982A (en) * 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake
EP0875513A1 (de) * 1997-04-14 1998-11-04 Eli Lilly And Company Substituierte heteroaromatische 5-HT1F Agoniste
US5905084A (en) * 1997-11-14 1999-05-18 Eli Lilly And Company 5-HTIF -agonists effective in treating migraine
US6562809B1 (en) * 1998-09-18 2003-05-13 Nps Allelix Corp. 3-bicycloindole compounds

Also Published As

Publication number Publication date
JP2003507380A (ja) 2003-02-25
AU779832B2 (en) 2005-02-10
ATE268330T1 (de) 2004-06-15
DE60011269T2 (de) 2005-06-23
DK1204662T3 (da) 2004-10-04
WO2001012629A1 (en) 2001-02-22
EP1204662B1 (de) 2004-06-02
CA2382247A1 (en) 2001-02-22
JP4969004B2 (ja) 2012-07-04
ES2222219T3 (es) 2005-02-01
EP1204662A1 (de) 2002-05-15
AU6310300A (en) 2001-03-13
CA2382247C (en) 2010-09-28
MXPA02001473A (es) 2003-07-21

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NPS PHARMACEUTICALS,INC., BEDMINSTER, N.J., US