ATE315389T1 - Ibogamin verwandte verbindungen - Google Patents

Ibogamin verwandte verbindungen

Info

Publication number
ATE315389T1
ATE315389T1 AT96928041T AT96928041T ATE315389T1 AT E315389 T1 ATE315389 T1 AT E315389T1 AT 96928041 T AT96928041 T AT 96928041T AT 96928041 T AT96928041 T AT 96928041T AT E315389 T1 ATE315389 T1 AT E315389T1
Authority
AT
Austria
Prior art keywords
substituted alkyl
unsubstituted
group
alkyl
ibogamine
Prior art date
Application number
AT96928041T
Other languages
English (en)
Inventor
Stanley D Glick
Martin E Kuehne
Original Assignee
Albany Medical College
Univ Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albany Medical College, Univ Vermont filed Critical Albany Medical College
Application granted granted Critical
Publication of ATE315389T1 publication Critical patent/ATE315389T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Glass Compositions (AREA)
  • Executing Machine-Instructions (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
AT96928041T 1995-08-08 1996-08-02 Ibogamin verwandte verbindungen ATE315389T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US204895P 1995-08-08 1995-08-08

Publications (1)

Publication Number Publication Date
ATE315389T1 true ATE315389T1 (de) 2006-02-15

Family

ID=21699020

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96928041T ATE315389T1 (de) 1995-08-08 1996-08-02 Ibogamin verwandte verbindungen

Country Status (6)

Country Link
US (1) US6211360B1 (de)
EP (1) EP0859610B1 (de)
AT (1) ATE315389T1 (de)
DE (1) DE69635737D1 (de)
IL (1) IL123220A0 (de)
WO (1) WO1997005869A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780871B2 (en) 2001-01-29 2004-08-24 Albany Medical College Methods and compositions for treating addiction disorders
BR0106261A (pt) * 2001-12-26 2003-09-02 Fundacao Oswaldo Cruz Composições medicamentosas contendo alcalóides indólicos para o tratamento da aids
US20030199496A1 (en) * 2002-04-22 2003-10-23 Simon David Lew Pharmaceutical compositions containing alpha3beta4 nicotinic receptor antagonists and methods of their use
US20050251442A1 (en) * 2004-05-07 2005-11-10 Joseph Ficalora Consumer incentive system and business method
EP2244572B1 (de) * 2008-01-28 2016-04-27 Albany Medical College Verwendung von ibogamin-kongeneren zur behandlung von adipositas
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
CA2806232A1 (en) * 2010-07-23 2012-01-26 Demerx, Inc. Noribogaine compositions
EP2481740B1 (de) * 2011-01-26 2015-11-04 DemeRx, Inc. Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin
US8742096B2 (en) 2011-03-28 2014-06-03 Demerx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
CA2855990A1 (en) 2011-12-09 2013-06-13 Demerx, Inc. Sulfate esters of noribogaine
JP2015500833A (ja) 2011-12-09 2015-01-08 デメレックス， インコーポレイテッド ノルイボガインのリン酸エステル
US20130178618A1 (en) 2012-01-10 2013-07-11 William Allen Boulanger Novel pharmaceutical intermediates and methods for preparing the same
CA2858820C (en) 2012-01-25 2021-08-17 Demerx, Inc. Synthetic voacangine
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
WO2013148572A1 (en) * 2012-03-27 2013-10-03 Albany Medical College Blocking of cue-induced drug reinstatement
EP2934541A4 (de) * 2012-12-20 2016-08-03 Demerx Inc Substituiertes noribogain
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
AU2014208382A1 (en) 2013-01-24 2015-07-23 Tylerton International Holdings Inc. Body structure imaging
CN104936623A (zh) 2013-01-24 2015-09-23 泰勒顿国际控股公司 神经元成像与治疗
US10052495B2 (en) 2013-09-08 2018-08-21 Tylerton International Inc. Detection of reduced-control cardiac zones
US10646183B2 (en) 2014-01-10 2020-05-12 Tylerton International Inc. Detection of scar and fibrous cardiac zones
WO2015195673A2 (en) 2014-06-18 2015-12-23 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
CN105491952B (zh) 2014-07-30 2020-08-04 纳维斯国际有限公司 探头定位
US20230102206A1 (en) * 2020-03-05 2023-03-30 The Trustees Of Columbia University In The City Of New York Ibogaine analogs as therapeutics for neurological and psychiatric disorders
US11680066B2 (en) * 2020-05-18 2023-06-20 Jeffrey Alan McKinney Ibogaine-related compounds and corresponding methods

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH434281A (de) * 1964-03-04 1967-04-30 Geigy Ag J R Verfahren zur Herstellung von polycyclischen Indolderivaten
US3681362A (en) 1968-06-29 1972-08-01 Shionogi & Co Process for the preparation of isoquinuclidine alkaloids
GB1445287A (en) * 1973-10-24 1976-08-11 Omnium Chimique Sa Derivatives of iboga type alkaloids
FR2296418B1 (de) 1974-12-30 1978-07-21 Anvar
US4499096A (en) * 1983-11-18 1985-02-12 Lotsof Howard S Rapid method for interrupting the narcotic addiction syndrome
US4587243A (en) 1985-07-15 1986-05-06 Lotsof Howard S Rapid method for interrupting the cocaine and amphetamine abuse syndrome
JPH0341081A (ja) * 1989-07-10 1991-02-21 Mitsui Petrochem Ind Ltd 二量体アルカロイド類の製造方法
US5152994A (en) 1990-05-31 1992-10-06 Lotsof Howard S Rapid method for interrupting or attenuating poly-drug dependency syndromes
JPH0559053A (ja) * 1991-02-28 1993-03-09 Mikio Yamazaki インドールアルカロイド化合物

Also Published As

Publication number Publication date
US6211360B1 (en) 2001-04-03
EP0859610B1 (de) 2006-01-11
EP0859610A1 (de) 1998-08-26
WO1997005869A1 (en) 1997-02-20
DE69635737D1 (de) 2006-04-06
EP0859610A4 (de) 2002-05-15
IL123220A0 (en) 1998-09-24

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Legal Events

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