IL123220A0 - Ibogamine congeners - Google Patents

Ibogamine congeners

Info

Publication number
IL123220A0
IL123220A0 IL12322096A IL12322096A IL123220A0 IL 123220 A0 IL123220 A0 IL 123220A0 IL 12322096 A IL12322096 A IL 12322096A IL 12322096 A IL12322096 A IL 12322096A IL 123220 A0 IL123220 A0 IL 123220A0
Authority
IL
Israel
Prior art keywords
substituted alkyl
unsubstituted
group
alkyl
nhr8
Prior art date
Application number
IL12322096A
Other languages
English (en)
Original Assignee
Albany Medical College
Univ Vermont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albany Medical College, Univ Vermont filed Critical Albany Medical College
Publication of IL123220A0 publication Critical patent/IL123220A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Glass Compositions (AREA)
  • Executing Machine-Instructions (AREA)
  • Oscillators With Electromechanical Resonators (AREA)
IL12322096A 1995-08-08 1996-08-02 Ibogamine congeners IL123220A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US204895P 1995-08-08 1995-08-08
PCT/US1996/012627 WO1997005869A1 (en) 1995-08-08 1996-08-02 Ibogamine congeners

Publications (1)

Publication Number Publication Date
IL123220A0 true IL123220A0 (en) 1998-09-24

Family

ID=21699020

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12322096A IL123220A0 (en) 1995-08-08 1996-08-02 Ibogamine congeners

Country Status (6)

Country Link
US (1) US6211360B1 (xx)
EP (1) EP0859610B1 (xx)
AT (1) ATE315389T1 (xx)
DE (1) DE69635737D1 (xx)
IL (1) IL123220A0 (xx)
WO (1) WO1997005869A1 (xx)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6780871B2 (en) 2001-01-29 2004-08-24 Albany Medical College Methods and compositions for treating addiction disorders
BR0106261A (pt) * 2001-12-26 2003-09-02 Fundacao Oswaldo Cruz Composições medicamentosas contendo alcalóides indólicos para o tratamento da aids
US20030199496A1 (en) * 2002-04-22 2003-10-23 Simon David Lew Pharmaceutical compositions containing alpha3beta4 nicotinic receptor antagonists and methods of their use
US20050251442A1 (en) * 2004-05-07 2005-11-10 Joseph Ficalora Consumer incentive system and business method
AU2009209276B2 (en) * 2008-01-28 2014-06-05 Albany Medical College Use of ibogamine congeners for treating obesity
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US9358237B2 (en) 2010-07-23 2016-06-07 Demerx, Inc. Noribogaine compositions
EP2481740B1 (en) * 2011-01-26 2015-11-04 DemeRx, Inc. Methods and compositions for preparing noribogaine from voacangine
US8742096B2 (en) * 2011-03-28 2014-06-03 Demerx, Inc. Methods and compositions for preparing noribogaine from voacangine
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
WO2013085922A1 (en) 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
WO2013085849A2 (en) * 2011-12-09 2013-06-13 Demerx, Inc. Sulfate esters of noribogaine
US20130178618A1 (en) 2012-01-10 2013-07-11 William Allen Boulanger Novel pharmaceutical intermediates and methods for preparing the same
US8877921B2 (en) 2012-01-25 2014-11-04 Demerx, Inc. Synthetic voacangine
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
CA2908240A1 (en) * 2012-03-27 2013-10-03 Albany Medical College Blocking of cue-induced drug reinstatement
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
JP2016508979A (ja) * 2012-12-20 2016-03-24 デメレックス， インコーポレイテッド 置換ノルイボガイン
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
AU2014208382A1 (en) 2013-01-24 2015-07-23 Tylerton International Holdings Inc. Body structure imaging
US20150366523A1 (en) 2013-01-24 2015-12-24 Shlomo Ben-Haim Neuronal imaging and treatment
WO2015033319A2 (en) 2013-09-08 2015-03-12 Shlomo Ben-Haim Apparatus and methods for diagnosis and treatment of patterns of nervous system activity affecting disease
WO2015104672A2 (en) 2014-01-10 2015-07-16 Tylerton International Holdings Inc. Detection of scar and fibrous cardiac zones
WO2015195673A2 (en) 2014-06-18 2015-12-23 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
CN105491951B (zh) 2014-07-30 2020-11-20 纳维斯国际有限公司 配准核医学数据
WO2021178691A1 (en) * 2020-03-05 2021-09-10 The Trustees Of Columbia University In The City Of New York Ibogaine analogs as therapeutics for neurological and psychiatric disorders
US11680066B2 (en) * 2020-05-18 2023-06-20 Jeffrey Alan McKinney Ibogaine-related compounds and corresponding methods
US12116372B1 (en) 2023-12-14 2024-10-15 William Allen Boulanger Process for preparing methyl 3-bromo-2-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)propanoate

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH434281A (de) * 1964-03-04 1967-04-30 Geigy Ag J R Verfahren zur Herstellung von polycyclischen Indolderivaten
US3681362A (en) * 1968-06-29 1972-08-01 Shionogi & Co Process for the preparation of isoquinuclidine alkaloids
GB1445287A (en) * 1973-10-24 1976-08-11 Omnium Chimique Sa Derivatives of iboga type alkaloids
FR2296418B1 (xx) * 1974-12-30 1978-07-21 Anvar
US4499096A (en) * 1983-11-18 1985-02-12 Lotsof Howard S Rapid method for interrupting the narcotic addiction syndrome
US4587243A (en) * 1985-07-15 1986-05-06 Lotsof Howard S Rapid method for interrupting the cocaine and amphetamine abuse syndrome
JPH0341081A (ja) * 1989-07-10 1991-02-21 Mitsui Petrochem Ind Ltd 二量体アルカロイド類の製造方法
US5152994A (en) 1990-05-31 1992-10-06 Lotsof Howard S Rapid method for interrupting or attenuating poly-drug dependency syndromes
JPH0559053A (ja) * 1991-02-28 1993-03-09 Mikio Yamazaki インドールアルカロイド化合物

Also Published As

Publication number Publication date
EP0859610A1 (en) 1998-08-26
WO1997005869A1 (en) 1997-02-20
ATE315389T1 (de) 2006-02-15
EP0859610B1 (en) 2006-01-11
EP0859610A4 (en) 2002-05-15
US6211360B1 (en) 2001-04-03
DE69635737D1 (de) 2006-04-06

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