DE69614867T2 - Therapeutische verbindungen - Google Patents

Therapeutische verbindungen

Info

Publication number
DE69614867T2
DE69614867T2 DE69614867T DE69614867T DE69614867T2 DE 69614867 T2 DE69614867 T2 DE 69614867T2 DE 69614867 T DE69614867 T DE 69614867T DE 69614867 T DE69614867 T DE 69614867T DE 69614867 T2 DE69614867 T2 DE 69614867T2
Authority
DE
Germany
Prior art keywords
hydrogen
oac
compounds
nhac
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69614867T
Other languages
English (en)
Other versions
DE69614867D1 (de
Inventor
Stephen Martin Courtney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford Glycosciences UK Ltd
Original Assignee
Oxford Glycosciences UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9512868.2A external-priority patent/GB9512868D0/en
Priority claimed from GBGB9608372.0A external-priority patent/GB9608372D0/en
Priority claimed from GBGB9608547.7A external-priority patent/GB9608547D0/en
Application filed by Oxford Glycosciences UK Ltd filed Critical Oxford Glycosciences UK Ltd
Application granted granted Critical
Publication of DE69614867D1 publication Critical patent/DE69614867D1/de
Publication of DE69614867T2 publication Critical patent/DE69614867T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
DE69614867T 1995-06-23 1996-06-24 Therapeutische verbindungen Expired - Fee Related DE69614867T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9512868.2A GB9512868D0 (en) 1995-06-23 1995-06-23 Therapeutic compounds
GBGB9608372.0A GB9608372D0 (en) 1996-04-23 1996-04-23 Therapeutic compounds
GBGB9608547.7A GB9608547D0 (en) 1996-04-25 1996-04-25 Therapeutic compounds
US1676296P 1996-05-03 1996-05-03
US1697396P 1996-05-07 1996-05-07
PCT/GB1996/001519 WO1997000882A1 (en) 1995-06-23 1996-06-24 Therapeutic compounds

Publications (2)

Publication Number Publication Date
DE69614867D1 DE69614867D1 (de) 2001-10-04
DE69614867T2 true DE69614867T2 (de) 2002-04-11

Family

ID=27517294

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69614867T Expired - Fee Related DE69614867T2 (de) 1995-06-23 1996-06-24 Therapeutische verbindungen

Country Status (16)

Country Link
US (1) US5945406A (de)
EP (1) EP0851866B1 (de)
JP (1) JPH11507942A (de)
KR (1) KR19990028344A (de)
CN (1) CN1196059A (de)
AT (1) ATE204878T1 (de)
AU (1) AU6234296A (de)
CA (1) CA2225247A1 (de)
DE (1) DE69614867T2 (de)
ES (1) ES2162078T3 (de)
HU (1) HUP9901438A3 (de)
ID (1) ID16479A (de)
IL (1) IL122700A0 (de)
NO (1) NO976043L (de)
PL (1) PL328266A1 (de)
WO (1) WO1997000882A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997000882A1 (en) * 1995-06-23 1997-01-09 Oxford Glycosciences (Uk) Limited Therapeutic compounds
DE19741738A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Linker-Nucleosid, seine Herstellung und Verwendung
DE19741715A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19837387A1 (de) 1998-08-18 2000-02-24 Aventis Res & Tech Gmbh & Co 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
US6344460B1 (en) * 1999-03-19 2002-02-05 Lonza Inc. Propynyl uracils
US20050143300A1 (en) * 2003-10-10 2005-06-30 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
US8927506B2 (en) 2008-07-11 2015-01-06 Board Of Regents, The University Of Texas System Acetates of 2-deoxy monosaccharides with anticancer activity
ES2897699T3 (es) 2013-04-05 2022-03-02 Univ Texas Esteres de 2-desoxi-monosacáridos con actividad antiproliferativa

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US4248999A (en) * 1976-10-28 1981-02-03 Sankyo Company Limited 5-Fluorouracil derivatives and process for preparing thereof
DK149818C (da) * 1976-10-28 1987-04-06 Sankyo Co Analogifremgangsmaade til fremstilling af 5-fluoruracil-derivater
JPS55153796A (en) * 1979-05-21 1980-11-29 Meiji Seika Kaisha Ltd 5-fluorouracil nucleoside and its preparation
JPS5829798A (ja) * 1981-08-15 1983-02-22 Tetsuo Suami ヌクレオシド類似体
JPS5872599A (ja) * 1981-10-27 1983-04-30 Kanto Ishi Pharma Co Ltd 複合糖質誘導体
EP0119650A3 (de) * 1983-03-21 1987-09-30 THE PROCTER & GAMBLE COMPANY Galactosyl-Insulin-Konjugate für die Behandlung von Zuckerkranken
JP2696393B2 (ja) * 1989-05-09 1998-01-14 株式会社日本抗体研究所 チミン誘導体及びこれを含有する抗ｈｉｖ剤
JPH0517494A (ja) * 1991-07-10 1993-01-26 Nippon Shoji Kk グルコサミン誘導体
DE69533856T2 (de) * 1994-10-24 2005-12-08 Genencor International, Inc., Palo Alto L-pyranosyl-nukleoside
WO1997000882A1 (en) * 1995-06-23 1997-01-09 Oxford Glycosciences (Uk) Limited Therapeutic compounds
GB9626450D0 (en) * 1996-12-20 1997-02-05 Oxford Glycosciences Uk Ltd Therapeutic compounds

Also Published As

Publication number Publication date
ID16479A (id) 1997-10-02
HUP9901438A3 (en) 2000-07-28
PL328266A1 (en) 1999-01-18
KR19990028344A (ko) 1999-04-15
NO976043D0 (no) 1997-12-22
HUP9901438A2 (hu) 1999-08-30
CA2225247A1 (en) 1997-01-09
IL122700A0 (en) 1998-12-06
JPH11507942A (ja) 1999-07-13
ES2162078T3 (es) 2001-12-16
EP0851866A1 (de) 1998-07-08
CN1196059A (zh) 1998-10-14
ATE204878T1 (de) 2001-09-15
MX9710529A (es) 1998-08-30
DE69614867D1 (de) 2001-10-04
US5945406A (en) 1999-08-31
AU6234296A (en) 1997-01-22
EP0851866B1 (de) 2001-08-29
WO1997000882A1 (en) 1997-01-09
NO976043L (no) 1998-02-20

Similar Documents

Publication Publication Date Title
CY1107391T1 (el) Αρυλσυμπυκνωμενες αζαπολυκυκλικες ενωσεις
PA8432901A1 (es) Compuestos de piridilpirrol
SE9904505D0 (sv) Novel compounds
DE69520880T2 (de) 9-deoxotaxan verbindungen
DK0765327T3 (da) Pyrazolo- og pyrrolopyridiner
GB9514473D0 (en) Chemical compounds
MY108885A (en) Heterocyclic-cyclic amine derivatives.
SE9504661D0 (sv) New compounds
TNSN06032A1 (en) Pyridazine derivatives and their use as therapeutic agents
DE60030741D1 (de) Chinazoline verbindungen als heilmittel
NO996108L (no) 9-oksinerytromycinderivater
ATE260658T1 (de) Pharmazeutische zubereitungen zur verminderung von atmungsdepressionen
FR2712591B1 (fr) Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
DE69614867D1 (de) Therapeutische verbindungen
SE8801845L (sv) Farmakologiskt aktiva substituerade bensa mider
MX9700959A (es) Derivados de becimidazol que tienen actividad dopaminergica.
ATE275143T1 (de) Verbindungen
AP9801377A0 (en) Tricyclic erythromycin derivatives.
ES2173195T3 (es) Derivados de antraciclina.
NO175097C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive hydrazoner
ATE330958T1 (de) Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
ATE247955T1 (de) Selenophen-antitumormittel
GEP20043225B (en) 1-Trifluoromethyl-4-Hydroxy-7- Piperidinyl-Aminomethylchroman Derivatives
ATE171181T1 (de) Katecholamine-diphosphate und diese enthaltende arzneimittel
DE69104286D1 (de) Disubstituierte Polymethylenimine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel.

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee