IL122700A0 - Pyranosyl conjugates for delivery of active moieties - Google Patents

Pyranosyl conjugates for delivery of active moieties

Info

Publication number
IL122700A0
IL122700A0 IL12270096A IL12270096A IL122700A0 IL 122700 A0 IL122700 A0 IL 122700A0 IL 12270096 A IL12270096 A IL 12270096A IL 12270096 A IL12270096 A IL 12270096A IL 122700 A0 IL122700 A0 IL 122700A0
Authority
IL
Israel
Prior art keywords
hydrogen
pyranosyl
conjugates
delivery
oac
Prior art date
Application number
IL12270096A
Other languages
English (en)
Original Assignee
Oxford Glycosciences Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9512868.2A external-priority patent/GB9512868D0/en
Priority claimed from GBGB9608372.0A external-priority patent/GB9608372D0/en
Priority claimed from GBGB9608547.7A external-priority patent/GB9608547D0/en
Application filed by Oxford Glycosciences Uk Ltd filed Critical Oxford Glycosciences Uk Ltd
Publication of IL122700A0 publication Critical patent/IL122700A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Percussion Or Vibration Massage (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
IL12270096A 1995-06-23 1996-06-24 Pyranosyl conjugates for delivery of active moieties IL122700A0 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9512868.2A GB9512868D0 (en) 1995-06-23 1995-06-23 Therapeutic compounds
GBGB9608372.0A GB9608372D0 (en) 1996-04-23 1996-04-23 Therapeutic compounds
GBGB9608547.7A GB9608547D0 (en) 1996-04-25 1996-04-25 Therapeutic compounds
US1676296P 1996-05-03 1996-05-03
US1697396P 1996-05-07 1996-05-07
PCT/GB1996/001519 WO1997000882A1 (en) 1995-06-23 1996-06-24 Therapeutic compounds

Publications (1)

Publication Number Publication Date
IL122700A0 true IL122700A0 (en) 1998-12-06

Family

ID=27517294

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12270096A IL122700A0 (en) 1995-06-23 1996-06-24 Pyranosyl conjugates for delivery of active moieties

Country Status (16)

Country Link
US (1) US5945406A (de)
EP (1) EP0851866B1 (de)
JP (1) JPH11507942A (de)
KR (1) KR19990028344A (de)
CN (1) CN1196059A (de)
AT (1) ATE204878T1 (de)
AU (1) AU6234296A (de)
CA (1) CA2225247A1 (de)
DE (1) DE69614867T2 (de)
ES (1) ES2162078T3 (de)
HU (1) HUP9901438A3 (de)
ID (1) ID16479A (de)
IL (1) IL122700A0 (de)
NO (1) NO976043L (de)
PL (1) PL328266A1 (de)
WO (1) WO1997000882A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11507942A (ja) * 1995-06-23 1999-07-13 オックスフォード グリコサイエンセス（ユーケー） リミテッド 治療用化合物
DE19741738A1 (de) * 1997-09-22 1999-03-25 Hoechst Ag Linker-Nucleosid, seine Herstellung und Verwendung
DE19741715A1 (de) 1997-09-22 1999-03-25 Hoechst Ag Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19837387A1 (de) 1998-08-18 2000-02-24 Aventis Res & Tech Gmbh & Co 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
US6344460B1 (en) * 1999-03-19 2002-02-05 Lonza Inc. Propynyl uracils
US20050143300A1 (en) * 2003-10-10 2005-06-30 Ma Jian-Xing Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
HUE033210T2 (hu) * 2008-07-11 2017-11-28 Univ Texas Rákellenes aktivitású 2-dezoxi-monoszacharidok új acetátjai
EP3939595A1 (de) 2013-04-05 2022-01-19 Board of Regents, The University of Texas System Ester von 2-deoxymonosacchariden mit antiproliferativer wirkung

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3354160A (en) * 1965-07-22 1967-11-21 Hoffmann La Roche Tri-lower alkyl-silyl-5-fluoropyrimidines
US4248999A (en) * 1976-10-28 1981-02-03 Sankyo Company Limited 5-Fluorouracil derivatives and process for preparing thereof
DK149818C (da) * 1976-10-28 1987-04-06 Sankyo Co Analogifremgangsmaade til fremstilling af 5-fluoruracil-derivater
JPS55153796A (en) * 1979-05-21 1980-11-29 Meiji Seika Kaisha Ltd 5-fluorouracil nucleoside and its preparation
JPS5829798A (ja) * 1981-08-15 1983-02-22 Tetsuo Suami ヌクレオシド類似体
JPS5872599A (ja) * 1981-10-27 1983-04-30 Kanto Ishi Pharma Co Ltd 複合糖質誘導体
EP0119650A3 (de) * 1983-03-21 1987-09-30 THE PROCTER & GAMBLE COMPANY Galactosyl-Insulin-Konjugate für die Behandlung von Zuckerkranken
JP2696393B2 (ja) * 1989-05-09 1998-01-14 株式会社日本抗体研究所 チミン誘導体及びこれを含有する抗ｈｉｖ剤
JPH0517494A (ja) * 1991-07-10 1993-01-26 Nippon Shoji Kk グルコサミン誘導体
DE69533856T2 (de) * 1994-10-24 2005-12-08 Genencor International, Inc., Palo Alto L-pyranosyl-nukleoside
JPH11507942A (ja) * 1995-06-23 1999-07-13 オックスフォード グリコサイエンセス（ユーケー） リミテッド 治療用化合物
GB9626450D0 (en) * 1996-12-20 1997-02-05 Oxford Glycosciences Uk Ltd Therapeutic compounds

Also Published As

Publication number Publication date
JPH11507942A (ja) 1999-07-13
MX9710529A (es) 1998-08-30
HUP9901438A2 (hu) 1999-08-30
EP0851866B1 (de) 2001-08-29
CA2225247A1 (en) 1997-01-09
WO1997000882A1 (en) 1997-01-09
ID16479A (id) 1997-10-02
DE69614867D1 (de) 2001-10-04
AU6234296A (en) 1997-01-22
NO976043L (no) 1998-02-20
US5945406A (en) 1999-08-31
ATE204878T1 (de) 2001-09-15
HUP9901438A3 (en) 2000-07-28
EP0851866A1 (de) 1998-07-08
DE69614867T2 (de) 2002-04-11
NO976043D0 (no) 1997-12-22
CN1196059A (zh) 1998-10-14
PL328266A1 (en) 1999-01-18
KR19990028344A (ko) 1999-04-15
ES2162078T3 (es) 2001-12-16

Similar Documents

Publication Publication Date Title
TW282456B (de)
DE69214712D1 (de) Glykosylierte Arzneimittel-Vorstufen, Verfahren zu ihrer Herstellung und ihre Verwendungen
BG106586A (en) Pyrazolopyramidines as therapeutic agents
DE69520880D1 (de) 9-deoxotaxan verbindungen
MX9708621A (es) AGONISTAS beta-ADRENERGICOS, COMPOSICIONES QUE LOS CONTIENEN Y USO DE LOS MISMOS.
CA2108903A1 (en) Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use
ZA922297B (en) Crystalline tiababine monohydrate,its preparation and use
GB9418912D0 (en) Pharmaceutically active compounds
IL122700A0 (en) Pyranosyl conjugates for delivery of active moieties
NZ505103A (en) Phenylaminoalkylcarboxylic acid derivatives useful as beta 3 adrenoceptor stimulants
EP0793497A4 (de) Neue endiyn-chinonimine und verfahren zu deren herstellung und verwendung
CA2116829A1 (en) Use of a pregnane derivative
MY132057A (en) Quinoxalinones, a process for their preparation and their use
ZA957525B (en) Anthracycline derivatives
CA2168193A1 (en) Aryalkyl-thiadiazinones
MX9800049A (es) Antraquinonas mono- y disulfo-substituidas y su uso para el tratamiento de trastornos de la matriz del hueso.
ATE63921T1 (de) 6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
GEP20043225B (en) 1-Trifluoromethyl-4-Hydroxy-7- Piperidinyl-Aminomethylchroman Derivatives
ATE247955T1 (de) Selenophen-antitumormittel
ES2006488A6 (es) Un procedimiento para la preparacion de un glicosido de antraciclina.
AP9901637A0 (en) Crystalline hydrated sodium salt of (E)-4,6-dichloro-3-(2-oxo-1-phenylpyrrolidin-3-ylidene methyl)-1H-indole-2-carboxylic acid.
NZ238909A (en) Pyrimidine or triazine derivatives, preparation and medicaments thereof
MX9710093A (es) Uso de aminas alilicas.
AU4700993A (en) Diphosphates of catecholamines and pharmaceutical compositions containing them
MX9600165A (es) 3-alcoxicarbonil-tiadiazinonas, proceso para su preparacion y composiciones farmaceuticas que las contienen.