ES2162078T3 - Compuestos terapeuticos. - Google Patents
Compuestos terapeuticos.Info
- Publication number
- ES2162078T3 ES2162078T3 ES96920967T ES96920967T ES2162078T3 ES 2162078 T3 ES2162078 T3 ES 2162078T3 ES 96920967 T ES96920967 T ES 96920967T ES 96920967 T ES96920967 T ES 96920967T ES 2162078 T3 ES2162078 T3 ES 2162078T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- oac
- compounds
- therapeutic compounds
- nhac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 230000001225 therapeutic effect Effects 0.000 title 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- GOWMBYUZXIZENX-CAUSLRQDSA-N 1-[(2r,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-(hexadecylamino)pyrimidin-2-one Chemical compound O=C1N=C(NCCCCCCCCCCCCCCCC)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 GOWMBYUZXIZENX-CAUSLRQDSA-N 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Abstract
SE REVELAN COMPUESTOS DE FORMULA (I), EN DONDE R ES HALOGENO; Y ES HIDROGENO, NH 2 , SH U OH; X ES (II), EN DONDE R 1 O R 2 SON UN ENLACE, SIENDO EL OTRO UN HIDROGENO; R 3 O R 4 SON UN HIDROGENO, SIENDO EL OTRO HIDROGENO, OH, OAC O NHAC, R 5 ES OH U OAC; R 7 O R 8 SON UN HIDROGENO, SIENDO EL OTRO OH U OAC; R9 ES HIDROGENO, CH SUB,2 OH O CH 2 OAC; CON LA ESTIPULACION DE QUE CUANDO R 4 ES OH, OAC O NHAC, ENTONCES R 8 ES HIDROGENO; Y ENANTIOMEROS DE TALES COMPUESTOS. TAMBIEN SE PROPORCIONAN FORMULAS FARMACEUTICAS QUE COMPRENDEN TALES COMPUESTOS, SU USO EN EL TRATAMIENTO DE DIVERSAS ENFERMEDADES, Y METODOS DE TRATAMIENTO EN LOS QUE SE EMPLEAN ESOS COMPUESTOS.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9512868.2A GB9512868D0 (en) | 1995-06-23 | 1995-06-23 | Therapeutic compounds |
GBGB9608372.0A GB9608372D0 (en) | 1996-04-23 | 1996-04-23 | Therapeutic compounds |
GBGB9608547.7A GB9608547D0 (en) | 1996-04-25 | 1996-04-25 | Therapeutic compounds |
US1676296P | 1996-05-03 | 1996-05-03 | |
US1697396P | 1996-05-07 | 1996-05-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2162078T3 true ES2162078T3 (es) | 2001-12-16 |
Family
ID=27517294
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96920967T Expired - Lifetime ES2162078T3 (es) | 1995-06-23 | 1996-06-24 | Compuestos terapeuticos. |
Country Status (16)
Country | Link |
---|---|
US (1) | US5945406A (es) |
EP (1) | EP0851866B1 (es) |
JP (1) | JPH11507942A (es) |
KR (1) | KR19990028344A (es) |
CN (1) | CN1196059A (es) |
AT (1) | ATE204878T1 (es) |
AU (1) | AU6234296A (es) |
CA (1) | CA2225247A1 (es) |
DE (1) | DE69614867T2 (es) |
ES (1) | ES2162078T3 (es) |
HU (1) | HUP9901438A3 (es) |
ID (1) | ID16479A (es) |
IL (1) | IL122700A0 (es) |
NO (1) | NO976043L (es) |
PL (1) | PL328266A1 (es) |
WO (1) | WO1997000882A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1196059A (zh) * | 1995-06-23 | 1998-10-14 | 牛津糖科学(英国)有限公司 | 治疗化合物 |
DE19741738A1 (de) * | 1997-09-22 | 1999-03-25 | Hoechst Ag | Linker-Nucleosid, seine Herstellung und Verwendung |
DE19741715A1 (de) | 1997-09-22 | 1999-03-25 | Hoechst Ag | Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung |
DE19837387A1 (de) | 1998-08-18 | 2000-02-24 | Aventis Res & Tech Gmbh & Co | 3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung |
US6344460B1 (en) * | 1999-03-19 | 2002-02-05 | Lonza Inc. | Propynyl uracils |
US20050143300A1 (en) * | 2003-10-10 | 2005-06-30 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
ES2628180T3 (es) | 2008-07-11 | 2017-08-02 | Board Of Regents, The University Of Texas System | Nuevos acetatos de 2-desoxi monosacáridos con actividad anticancerosa |
ES2897699T3 (es) | 2013-04-05 | 2022-03-02 | Univ Texas | Esteres de 2-desoxi-monosacáridos con actividad antiproliferativa |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3354160A (en) * | 1965-07-22 | 1967-11-21 | Hoffmann La Roche | Tri-lower alkyl-silyl-5-fluoropyrimidines |
DK149818C (da) * | 1976-10-28 | 1987-04-06 | Sankyo Co | Analogifremgangsmaade til fremstilling af 5-fluoruracil-derivater |
US4248999A (en) * | 1976-10-28 | 1981-02-03 | Sankyo Company Limited | 5-Fluorouracil derivatives and process for preparing thereof |
JPS55153796A (en) * | 1979-05-21 | 1980-11-29 | Meiji Seika Kaisha Ltd | 5-fluorouracil nucleoside and its preparation |
JPS5829798A (ja) * | 1981-08-15 | 1983-02-22 | Tetsuo Suami | ヌクレオシド類似体 |
JPS5872599A (ja) * | 1981-10-27 | 1983-04-30 | Kanto Ishi Pharma Co Ltd | 複合糖質誘導体 |
EP0119650A3 (en) * | 1983-03-21 | 1987-09-30 | THE PROCTER & GAMBLE COMPANY | Galactosyl-insulin conjugates useful in treating diabetics |
JP2696393B2 (ja) * | 1989-05-09 | 1998-01-14 | 株式会社日本抗体研究所 | チミン誘導体及びこれを含有する抗hiv剤 |
JPH0517494A (ja) * | 1991-07-10 | 1993-01-26 | Nippon Shoji Kk | グルコサミン誘導体 |
ATE284894T1 (de) * | 1994-10-24 | 2005-01-15 | Genencor Int | L-pyranosyl-nukleoside |
CN1196059A (zh) * | 1995-06-23 | 1998-10-14 | 牛津糖科学(英国)有限公司 | 治疗化合物 |
GB9626450D0 (en) * | 1996-12-20 | 1997-02-05 | Oxford Glycosciences Uk Ltd | Therapeutic compounds |
-
1996
- 1996-06-24 CN CN96196248A patent/CN1196059A/zh active Pending
- 1996-06-24 HU HU9901438A patent/HUP9901438A3/hu unknown
- 1996-06-24 JP JP9503686A patent/JPH11507942A/ja not_active Ceased
- 1996-06-24 ID IDP961794A patent/ID16479A/id unknown
- 1996-06-24 KR KR1019970709659A patent/KR19990028344A/ko not_active Application Discontinuation
- 1996-06-24 PL PL96328266A patent/PL328266A1/xx unknown
- 1996-06-24 ES ES96920967T patent/ES2162078T3/es not_active Expired - Lifetime
- 1996-06-24 IL IL12270096A patent/IL122700A0/xx unknown
- 1996-06-24 AU AU62342/96A patent/AU6234296A/en not_active Abandoned
- 1996-06-24 EP EP96920967A patent/EP0851866B1/en not_active Expired - Lifetime
- 1996-06-24 DE DE69614867T patent/DE69614867T2/de not_active Expired - Fee Related
- 1996-06-24 AT AT96920967T patent/ATE204878T1/de active
- 1996-06-24 CA CA002225247A patent/CA2225247A1/en not_active Abandoned
- 1996-06-24 WO PCT/GB1996/001519 patent/WO1997000882A1/en not_active Application Discontinuation
-
1997
- 1997-12-22 NO NO976043A patent/NO976043L/no not_active Application Discontinuation
- 1997-12-23 US US08/997,309 patent/US5945406A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE69614867T2 (de) | 2002-04-11 |
US5945406A (en) | 1999-08-31 |
NO976043L (no) | 1998-02-20 |
EP0851866A1 (en) | 1998-07-08 |
CA2225247A1 (en) | 1997-01-09 |
ATE204878T1 (de) | 2001-09-15 |
IL122700A0 (en) | 1998-12-06 |
HUP9901438A2 (hu) | 1999-08-30 |
AU6234296A (en) | 1997-01-22 |
JPH11507942A (ja) | 1999-07-13 |
NO976043D0 (no) | 1997-12-22 |
KR19990028344A (ko) | 1999-04-15 |
CN1196059A (zh) | 1998-10-14 |
ID16479A (id) | 1997-10-02 |
HUP9901438A3 (en) | 2000-07-28 |
MX9710529A (es) | 1998-08-30 |
DE69614867D1 (de) | 2001-10-04 |
PL328266A1 (en) | 1999-01-18 |
WO1997000882A1 (en) | 1997-01-09 |
EP0851866B1 (en) | 2001-08-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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