HUP0100601A3 - Bicyclic compounds containing nitrogen, processes for their preparation and pharmaceutical compositions thereof - Google Patents
Bicyclic compounds containing nitrogen, processes for their preparation and pharmaceutical compositions thereofInfo
- Publication number
- HUP0100601A3 HUP0100601A3 HU0100601A HUP0100601A HUP0100601A3 HU P0100601 A3 HUP0100601 A3 HU P0100601A3 HU 0100601 A HU0100601 A HU 0100601A HU P0100601 A HUP0100601 A HU P0100601A HU P0100601 A3 HUP0100601 A3 HU P0100601A3
- Authority
- HU
- Hungary
- Prior art keywords
- processes
- preparation
- pharmaceutical compositions
- compounds containing
- containing nitrogen
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title 2
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 229910052757 nitrogen Inorganic materials 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9704404A SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | New compounds |
PCT/SE1998/002091 WO1999028322A1 (en) | 1997-11-28 | 1998-11-18 | Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0100601A2 HUP0100601A2 (hu) | 2001-09-28 |
HUP0100601A3 true HUP0100601A3 (en) | 2002-10-28 |
Family
ID=20409181
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0100601A HUP0100601A3 (en) | 1997-11-28 | 1998-11-18 | Bicyclic compounds containing nitrogen, processes for their preparation and pharmaceutical compositions thereof |
Country Status (33)
Country | Link |
---|---|
US (1) | US6518270B1 (hu) |
EP (1) | EP1042324B1 (hu) |
JP (1) | JP2001525322A (hu) |
KR (1) | KR20010032559A (hu) |
CN (1) | CN1142933C (hu) |
AR (1) | AR016972A1 (hu) |
AT (1) | ATE233263T1 (hu) |
AU (1) | AU752187C (hu) |
BR (1) | BR9814755A (hu) |
CA (1) | CA2311798A1 (hu) |
CZ (1) | CZ292349B6 (hu) |
DE (1) | DE69811735T2 (hu) |
DK (1) | DK1042324T3 (hu) |
EE (1) | EE04060B1 (hu) |
ES (1) | ES2191356T3 (hu) |
HK (1) | HK1030216A1 (hu) |
HU (1) | HUP0100601A3 (hu) |
ID (1) | ID24730A (hu) |
IL (1) | IL136145A0 (hu) |
IS (1) | IS5486A (hu) |
MY (1) | MY121032A (hu) |
NO (1) | NO315704B1 (hu) |
NZ (1) | NZ504355A (hu) |
PL (1) | PL340920A1 (hu) |
PT (1) | PT1042324E (hu) |
RU (1) | RU2241000C2 (hu) |
SE (1) | SE9704404D0 (hu) |
SK (1) | SK283904B6 (hu) |
TR (1) | TR200001530T2 (hu) |
TW (1) | TW515798B (hu) |
UA (1) | UA70932C2 (hu) |
WO (1) | WO1999028322A1 (hu) |
ZA (1) | ZA9810468B (hu) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE355375T1 (de) | 1996-01-04 | 2006-03-15 | Novartis Vaccines & Diagnostic | Bakterioferritin aus helicobacter pylori |
SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
PE20010635A1 (es) * | 1999-10-08 | 2001-08-15 | Smithkline Beecham Corp | Inhibidores de fab i utiles para el tratamiento de infecciones bacterianas |
DE60230934D1 (de) * | 2001-04-06 | 2009-03-05 | Affinium Pharm Inc | Fab-i-inhibitoren |
JP2003119140A (ja) * | 2001-08-08 | 2003-04-23 | Sankyo Co Ltd | ピロロピリダジン化合物を含有する医薬 |
WO2003089434A2 (en) * | 2002-04-19 | 2003-10-30 | Cellular Genomics, Inc. | IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES METHOD OF MAKING AND METHOD OF USE THEREOF |
US7312341B2 (en) | 2002-09-09 | 2007-12-25 | Cgi Pharmaceuticals, Inc. | 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof |
TW200418479A (en) * | 2002-09-25 | 2004-10-01 | Sankyo Co | Pharmaceutical compositions for the treatment or prevention of visceral pains |
TW200420293A (en) * | 2002-09-25 | 2004-10-16 | Sankyo Co | Pharmaceutical compositions for the reduction of gastric acid concentration in blood |
ES2518316T3 (es) * | 2002-12-06 | 2014-11-05 | Debiopharm International Sa | Compuestos heterocíclicos, métodos de fabricación de los mismos y su uso en terapia |
WO2004072080A1 (en) | 2003-02-10 | 2004-08-26 | Cellular Genomics, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity |
AR043002A1 (es) * | 2003-02-18 | 2005-07-13 | Altana Pharma Ag | Imidazopirazinas 6-substituidos |
DE602004016831D1 (de) * | 2003-03-17 | 2008-11-13 | Affinium Pharm Inc | Pharmazeutische zusammensetzungen inhibitoren von fab i und weitere antibiotika enthaltend |
WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
WO2005005429A1 (en) | 2003-06-30 | 2005-01-20 | Cellular Genomics, Inc. | Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds |
US7259164B2 (en) | 2003-08-11 | 2007-08-21 | Cgi Pharmaceuticals, Inc. | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity |
AU2004285394B2 (en) | 2003-11-03 | 2009-01-08 | Astrazeneca Ab | Imidazo (1,2-A) pyridine derivatives for the treatment of silent gastro-esophageal reflux |
CA2568914C (en) * | 2004-06-04 | 2013-09-24 | Affinium Pharmaceuticals, Inc. | Therapeutic agents, and methods of making and using the same |
US20070293532A1 (en) * | 2004-07-28 | 2007-12-20 | Takeda Pharmaceutical Compan6Y Limited | Pyrrolo [2,3-C] Pyridine Compound, Process for Producing the Same, and Use |
JP2008508347A (ja) * | 2004-08-02 | 2008-03-21 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 5置換された1H−ピロロ[3,2−b]ピリジン |
MX2007002219A (es) * | 2004-09-03 | 2007-05-04 | Yuhan Corp | Derivados de pirrolo [3,2-b ] piridina y procesos para su preparacion. |
DK1784402T3 (da) * | 2004-09-03 | 2011-11-14 | Yuhan Corp | Pyrrolo[3,2-c]pyridinderivater samt fremgangsmåder til deres fremstilling |
CN101018789B (zh) | 2004-09-03 | 2010-09-08 | 株式会社柳韩洋行 | 吡咯并[2,3-c]吡啶衍生物及其制备方法 |
JP4989477B2 (ja) * | 2004-09-03 | 2012-08-01 | ユーハン・コーポレイション | ピロロ[3,2−c]ピリジン誘導体及びその製造方法 |
US7777040B2 (en) | 2005-05-03 | 2010-08-17 | Cgi Pharmaceuticals, Inc. | Certain substituted ureas, as modulators of kinase activity |
CA2620223A1 (en) | 2005-09-02 | 2007-03-08 | Abbott Laboratories | Novel imidazo based heterocycles |
US20090156578A1 (en) * | 2005-12-05 | 2009-06-18 | PAULS Henry | 3-Heterocyclylacrylamide Compounds as Fab I Inhibitors and Antibacterial Agents |
US7557104B2 (en) | 2006-06-06 | 2009-07-07 | Schering Corporation | Imidazopyrazines as protein kinase inhibitors |
EP2687533B1 (en) | 2006-07-20 | 2017-07-19 | Debiopharm International SA | Acrylamide derivatives as FAB I inhibitors |
EP2125802A4 (en) | 2007-02-16 | 2014-08-20 | Debiopharm Int Sa | SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS |
AU2009215191A1 (en) | 2008-02-13 | 2009-08-20 | Gilead Connecticut, Inc. | 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof |
US8450321B2 (en) | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
KR20170013414A (ko) | 2008-12-08 | 2017-02-06 | 질레드 코네티컷 인코포레이티드 | 이미다조피라진 syk 억제제 |
CA2745871C (en) | 2008-12-08 | 2018-02-20 | Gilead Connecticut, Inc. | Imidazopyrazine syk inhibitors |
US9562056B2 (en) | 2010-03-11 | 2017-02-07 | Gilead Connecticut, Inc. | Imidazopyridines Syk inhibitors |
PL2861608T3 (pl) | 2012-06-19 | 2019-09-30 | Debiopharm International Sa | Pochodne prolekowe (e)-n-metylo-n-((3-metylobenzofuran-2-ylo)metylo)-3-(7-okso-5,6,7,8-tetrahydro-1,8-naftyrydyn-3-ylo)akryloamidu |
MD4684B1 (ro) | 2013-07-30 | 2020-03-31 | Gilead Connecticut INc. | Formulări pe bază de imidazopirazine în calitate de inhibitori SYK |
US9657023B2 (en) | 2013-07-30 | 2017-05-23 | Gilead Connecticut, Inc. | Polymorph of Syk inhibitors |
EA201690608A1 (ru) | 2013-12-04 | 2016-12-30 | Джилид Сайэнс, Инк. | Способы лечения раковых заболеваний |
GB201321738D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
TWI662037B (zh) | 2013-12-23 | 2019-06-11 | 美商基利科學股份有限公司 | 脾酪胺酸激酶抑制劑 |
US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
NZ726365A (en) | 2014-07-14 | 2018-06-29 | Gilead Sciences Inc | Combinations for treating cancers |
US10751351B2 (en) | 2016-02-26 | 2020-08-25 | Debiopharm International S.A. | Medicament for treatment of diabetic foot infections |
KR102399996B1 (ko) | 2017-08-25 | 2022-05-20 | 길리애드 사이언시즈, 인코포레이티드 | Syk 억제제의 다형체 |
WO2020172431A1 (en) | 2019-02-22 | 2020-08-27 | Gilead Sciences, Inc. | Solid forms of condensed pyrazines as syk inhibitors |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4507294A (en) * | 1982-03-08 | 1985-03-26 | Schering Corp. | Imidazo[1,2-a]pyrazines |
DE3269604D1 (en) * | 1981-06-26 | 1986-04-10 | Schering Corp | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them |
US4725601A (en) | 1985-06-04 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers |
AU7754691A (en) | 1990-04-27 | 1991-11-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel pyridazines |
US5041442A (en) * | 1990-07-31 | 1991-08-20 | Syntex (U.S.A.) Inc. | Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion |
WO1992006979A1 (de) * | 1990-10-15 | 1992-04-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue diazine |
EP0609328B1 (de) | 1991-10-25 | 1999-04-28 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrrolo-pyridazine mit magen- und darmschutzwirkungen |
AU680998B2 (en) | 1994-01-19 | 1997-08-14 | Sankyo Company Limited | Pyrrolopyridazine derivative |
SE9602286D0 (sv) | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
SE9700661D0 (sv) | 1997-02-25 | 1997-02-25 | Astra Ab | New compounds |
SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
-
1997
- 1997-11-28 SE SE9704404A patent/SE9704404D0/xx unknown
-
1998
- 1998-11-16 AR ARP980105799A patent/AR016972A1/es unknown
- 1998-11-16 ZA ZA9810468A patent/ZA9810468B/xx unknown
- 1998-11-16 TW TW087118942A patent/TW515798B/zh active
- 1998-11-17 MY MYPI98005216A patent/MY121032A/en unknown
- 1998-11-18 BR BR9814755-2A patent/BR9814755A/pt not_active Application Discontinuation
- 1998-11-18 AT AT98957270T patent/ATE233263T1/de not_active IP Right Cessation
- 1998-11-18 CN CNB98813344XA patent/CN1142933C/zh not_active Expired - Fee Related
- 1998-11-18 TR TR2000/01530T patent/TR200001530T2/xx unknown
- 1998-11-18 IL IL13614598A patent/IL136145A0/xx unknown
- 1998-11-18 ES ES98957270T patent/ES2191356T3/es not_active Expired - Lifetime
- 1998-11-18 US US09/194,823 patent/US6518270B1/en not_active Expired - Lifetime
- 1998-11-18 EE EEP200000315A patent/EE04060B1/xx not_active IP Right Cessation
- 1998-11-18 NZ NZ504355A patent/NZ504355A/en unknown
- 1998-11-18 PT PT98957270T patent/PT1042324E/pt unknown
- 1998-11-18 EP EP98957270A patent/EP1042324B1/en not_active Expired - Lifetime
- 1998-11-18 RU RU2000113729/04A patent/RU2241000C2/ru not_active IP Right Cessation
- 1998-11-18 AU AU13565/99A patent/AU752187C/en not_active Ceased
- 1998-11-18 DK DK98957270T patent/DK1042324T3/da active
- 1998-11-18 SK SK674-2000A patent/SK283904B6/sk unknown
- 1998-11-18 ID IDW20000987A patent/ID24730A/id unknown
- 1998-11-18 CZ CZ20001947A patent/CZ292349B6/cs not_active IP Right Cessation
- 1998-11-18 HU HU0100601A patent/HUP0100601A3/hu unknown
- 1998-11-18 PL PL98340920A patent/PL340920A1/xx not_active Application Discontinuation
- 1998-11-18 WO PCT/SE1998/002091 patent/WO1999028322A1/en not_active Application Discontinuation
- 1998-11-18 DE DE69811735T patent/DE69811735T2/de not_active Expired - Fee Related
- 1998-11-18 CA CA002311798A patent/CA2311798A1/en not_active Abandoned
- 1998-11-18 JP JP2000523214A patent/JP2001525322A/ja active Pending
- 1998-11-18 KR KR1020007005804A patent/KR20010032559A/ko not_active Application Discontinuation
- 1998-11-18 UA UA2000052801A patent/UA70932C2/uk unknown
-
2000
- 2000-05-10 IS IS5486A patent/IS5486A/is unknown
- 2000-05-26 NO NO20002721A patent/NO315704B1/no unknown
-
2001
- 2001-02-16 HK HK01101145A patent/HK1030216A1/xx not_active IP Right Cessation
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