DK1042324T3 - Heterocykliske forbindelser til inhibering af mavesyresekretion, fremgangsmåder til deres fremstilling og farmaceutiske præparater deraf - Google Patents

Heterocykliske forbindelser til inhibering af mavesyresekretion, fremgangsmåder til deres fremstilling og farmaceutiske præparater deraf

Info

Publication number
DK1042324T3
DK1042324T3 DK98957270T DK98957270T DK1042324T3 DK 1042324 T3 DK1042324 T3 DK 1042324T3 DK 98957270 T DK98957270 T DK 98957270T DK 98957270 T DK98957270 T DK 98957270T DK 1042324 T3 DK1042324 T3 DK 1042324T3
Authority
DK
Denmark
Prior art keywords
inhibition
preparation
methods
pharmaceutical preparations
heterocyclic compounds
Prior art date
Application number
DK98957270T
Other languages
Danish (da)
English (en)
Inventor
Kosrat Amin
Mikael Dahlstroem
Peter Nordberg
Ingemar Starke
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of DK1042324T3 publication Critical patent/DK1042324T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK98957270T 1997-11-28 1998-11-18 Heterocykliske forbindelser til inhibering af mavesyresekretion, fremgangsmåder til deres fremstilling og farmaceutiske præparater deraf DK1042324T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704404A SE9704404D0 (sv) 1997-11-28 1997-11-28 New compounds
PCT/SE1998/002091 WO1999028322A1 (en) 1997-11-28 1998-11-18 Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof

Publications (1)

Publication Number Publication Date
DK1042324T3 true DK1042324T3 (da) 2003-05-05

Family

ID=20409181

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98957270T DK1042324T3 (da) 1997-11-28 1998-11-18 Heterocykliske forbindelser til inhibering af mavesyresekretion, fremgangsmåder til deres fremstilling og farmaceutiske præparater deraf

Country Status (32)

Country Link
US (1) US6518270B1 (https=)
EP (1) EP1042324B1 (https=)
JP (1) JP2001525322A (https=)
KR (1) KR20010032559A (https=)
CN (1) CN1142933C (https=)
AR (1) AR016972A1 (https=)
AT (1) ATE233263T1 (https=)
AU (1) AU752187C (https=)
BR (1) BR9814755A (https=)
CA (1) CA2311798A1 (https=)
CZ (1) CZ292349B6 (https=)
DE (1) DE69811735T2 (https=)
DK (1) DK1042324T3 (https=)
EE (1) EE04060B1 (https=)
ES (1) ES2191356T3 (https=)
HU (1) HUP0100601A3 (https=)
ID (1) ID24730A (https=)
IL (1) IL136145A0 (https=)
IS (1) IS5486A (https=)
MY (1) MY121032A (https=)
NO (1) NO315704B1 (https=)
NZ (1) NZ504355A (https=)
PL (1) PL340920A1 (https=)
PT (1) PT1042324E (https=)
RU (1) RU2241000C2 (https=)
SE (1) SE9704404D0 (https=)
SK (1) SK283904B6 (https=)
TR (1) TR200001530T2 (https=)
TW (1) TW515798B (https=)
UA (1) UA70932C2 (https=)
WO (1) WO1999028322A1 (https=)
ZA (1) ZA9810468B (https=)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2324093A (en) 1996-01-04 1998-10-14 Rican Limited Helicobacter pylori bacterioferritin
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds
HU230030B1 (hu) 1999-10-08 2015-05-28 Debiopharm International Sa Fab I inhibitorok
EP1560584B1 (en) * 2001-04-06 2009-01-14 Affinium Pharmaceuticals, Inc. Fab i inhibitors
JP2003119140A (ja) * 2001-08-08 2003-04-23 Sankyo Co Ltd ピロロピリダジン化合物を含有する医薬
KR20050008691A (ko) * 2002-04-19 2005-01-21 셀룰러 지노믹스 아이엔씨 이미다조[1,2-a]피라진-8-일 아민, 그의 제조방법 및사용방법
AU2003270489A1 (en) 2002-09-09 2004-03-29 Cellular Genomics, Inc. 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
WO2004029058A1 (ja) * 2002-09-25 2004-04-08 Sankyo Company, Limited 血中ガストリン濃度上昇の抑制のための医薬組成物
TW200418479A (en) * 2002-09-25 2004-10-01 Sankyo Co Pharmaceutical compositions for the treatment or prevention of visceral pains
EP1575951B1 (en) * 2002-12-06 2014-06-25 Debiopharm International SA Heterocyclic compounds, methods of making them and their use in therapy
WO2004072080A1 (en) 2003-02-10 2004-08-26 Cellular Genomics, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of hsp90 complex activity
AR043002A1 (es) * 2003-02-18 2005-07-13 Altana Pharma Ag Imidazopirazinas 6-substituidos
WO2004082586A2 (en) * 2003-03-17 2004-09-30 Affinium Pharmaceuticals, Inc. Phamaceutical compositions comprising inhibitors of fab i and further antibiotics
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
WO2005005429A1 (en) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
KR20060099524A (ko) 2003-11-03 2006-09-19 아스트라제네카 아베 무증상 위식도 역류의 치료를 위한 이미다조[1,2-a]피리딘유도체
DK1828167T3 (da) * 2004-06-04 2014-10-20 Debiopharm Int Sa Acrylamidderivater som antibiotiske midler
KR101764575B1 (ko) * 2004-07-28 2017-08-03 다케다 야쿠힌 고교 가부시키가이샤 피롤로〔2,3-c〕피리딘 화합물, 그 제조 방법 및 용도
CA2575345A1 (en) * 2004-08-02 2006-02-09 Altana Pharma Ag 5-substituted 1h-pyrrolo[3,2-b]pyridines
ATE518858T1 (de) 2004-09-03 2011-08-15 Yuhan Corp Pyrroloä3,2-cüpyridinderivate und herstellungsverfahren dafür
CA2579083C (en) * 2004-09-03 2011-06-14 Yuhan Corporation Pyrrolo[3,2-c]pyridine derivatives and processes for the preparation thereof
CA2579127C (en) 2004-09-03 2011-08-02 Yuhan Corporation Pyrrolo[3,2-b]pyridine derivatives and processes for the preparation thereof
KR100958829B1 (ko) 2004-09-03 2010-05-25 주식회사유한양행 피롤로[2,3-c]피리딘 유도체 및 그의 제조방법
WO2007024294A2 (en) 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
JP2009507032A (ja) 2005-09-02 2009-02-19 アボット・ラボラトリーズ 新規なイミダゾ系複素環
KR20080075027A (ko) * 2005-12-05 2008-08-13 아피늄 파마슈티컬스, 인크. Fabi 억제제 및 항박테리아제로서의헤테로시클릴아크릴아미드 화합물
EP2029605A1 (en) * 2006-06-06 2009-03-04 Schering Corporation Imidazopyrazines as protein kinase inhibitors
JP5468899B2 (ja) 2006-07-20 2014-04-09 アフィニウム ファーマシューティカルズ, インク. Fabiインヒビターとしてのアクリルアミド誘導体
EP2125802A4 (en) 2007-02-16 2014-08-20 Debiopharm Int Sa SALTS, PRODRUGS AND POLYMORPHES OF FAB I INHIBITORS
WO2009102468A1 (en) 2008-02-13 2009-08-20 Cgi Pharmaceuticals, Inc. 6-aryl-imidaz0[l, 2-a] pyrazine derivatives, method of making, and method of use thereof
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
PE20120121A1 (es) 2008-12-08 2012-02-20 Gilead Connecticut Inc Derivados de imidazopirazina como inhibidores de syk
PL2716157T3 (pl) 2008-12-08 2017-06-30 Gilead Connecticut, Inc. Imidazopirazynowe inhibitory Syk
AU2011226689B2 (en) 2010-03-11 2016-09-01 Kronos Bio, Inc. Imidazopyridines Syk inhibitors
AU2013279021C1 (en) 2012-06-19 2017-03-16 Debiopharm International Sa Prodrug derivatives of (E)-N-methyl-N-((3-methylbenzofuran-2-yl)methyl)-3-(7-oxo-5,6,7,8-tetrahydro-1,8-naphthyridin-3-yl)acrylamide
PE20160605A1 (es) 2013-07-30 2016-07-20 Gilead Connecticut Inc Formulaciones de inhibidores de la syk
KR101810798B1 (ko) 2013-07-30 2017-12-19 질레드 코네티컷 인코포레이티드 Syk 억제제의 다형체
KR20160090903A (ko) 2013-12-04 2016-08-01 길리애드 사이언시즈, 인코포레이티드 암을 치료하는 방법
GB201321738D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic Agents
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
SG11201610551TA (en) 2014-07-14 2017-01-27 Gilead Sciences Inc Combinations for treating cancers
RS61312B1 (sr) 2016-02-26 2021-02-26 Debiopharm Int Sa Lek za lečenje infekcija dijabetskog stopala
EP3672974A1 (en) 2017-08-25 2020-07-01 Gilead Sciences, Inc. Polymorphs of syk inhibitors
TN2021000159A1 (en) 2019-02-14 2023-04-04 Debiopharm Int Sa Afabicin formulation, method for making the same and uses thereof
US11339168B2 (en) 2019-02-22 2022-05-24 Kronos Bio, Inc. Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors
SG11202113174SA (en) 2019-06-14 2021-12-30 Debiopharm Int Sa Medicament and use thereof for treating bacterial infections involving biofilm

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4507294A (en) * 1982-03-08 1985-03-26 Schering Corp. Imidazo[1,2-a]pyrazines
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
US4725601A (en) * 1985-06-04 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Certain imidazo[1,2-a]pyridines useful in the treatment of ulcers
WO1991017164A1 (de) * 1990-04-27 1991-11-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue pyridazine
US5041442A (en) 1990-07-31 1991-08-20 Syntex (U.S.A.) Inc. Pyrrolo(1,2-a)pyrazines as inhibitors of gastric acid secretion
WO1992006979A1 (de) * 1990-10-15 1992-04-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue diazine
JPH07500329A (ja) * 1991-10-25 1995-01-12 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング ピロロ−ピリダジン
ATE229020T1 (de) * 1994-01-19 2002-12-15 Sankyo Co Pyrrolopyridazin-derivate
SE9602286D0 (sv) 1996-06-10 1996-06-10 Astra Ab New compounds
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9704404D0 (sv) 1997-11-28 1997-11-28 Astra Ab New compounds

Also Published As

Publication number Publication date
ATE233263T1 (de) 2003-03-15
WO1999028322A1 (en) 1999-06-10
AU1356599A (en) 1999-06-16
HUP0100601A2 (hu) 2001-09-28
MY121032A (en) 2005-12-30
NO315704B1 (no) 2003-10-13
PT1042324E (pt) 2003-06-30
NZ504355A (en) 2001-12-21
RU2241000C2 (ru) 2004-11-27
SK283904B6 (sk) 2004-04-06
ZA9810468B (en) 1999-05-21
ES2191356T3 (es) 2003-09-01
CZ20001947A3 (cs) 2000-11-15
AR016972A1 (es) 2001-08-01
CN1142933C (zh) 2004-03-24
NO20002721L (no) 2000-07-28
EE200000315A (et) 2001-10-15
CZ292349B6 (cs) 2003-09-17
UA70932C2 (uk) 2004-11-15
CN1284078A (zh) 2001-02-14
BR9814755A (pt) 2000-10-03
EP1042324B1 (en) 2003-02-26
TW515798B (en) 2003-01-01
JP2001525322A (ja) 2001-12-11
NO20002721D0 (no) 2000-05-26
AU752187C (en) 2003-09-18
SE9704404D0 (sv) 1997-11-28
IS5486A (is) 2000-05-10
IL136145A0 (en) 2001-05-20
TR200001530T2 (tr) 2000-11-21
CA2311798A1 (en) 1999-06-10
ID24730A (id) 2000-08-03
SK6742000A3 (en) 2001-03-12
DE69811735T2 (de) 2003-12-18
US6518270B1 (en) 2003-02-11
HUP0100601A3 (en) 2002-10-28
PL340920A1 (en) 2001-03-12
EE04060B1 (et) 2003-06-16
EP1042324A1 (en) 2000-10-11
DE69811735D1 (de) 2003-04-03
KR20010032559A (ko) 2001-04-25
AU752187B2 (en) 2002-09-12
HK1030216A1 (en) 2001-04-27

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