CN113041432A - 包括视觉指示物的药剂输送装置 - Google Patents
包括视觉指示物的药剂输送装置 Download PDFInfo
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- CN113041432A CN113041432A CN202110156703.3A CN202110156703A CN113041432A CN 113041432 A CN113041432 A CN 113041432A CN 202110156703 A CN202110156703 A CN 202110156703A CN 113041432 A CN113041432 A CN 113041432A
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Abstract
在此公开一种药物输送装置,其包括:装容流体的药筒,所述药筒包括:用作具有输入部位的光管的光管区部和光联接到所述光管的光漫射区部;和光源,其在所述光管的所述输入部位光联接到所述药筒,使得来自所述光源在所述输入部位处进入的至少一些光在所述光漫射区部漫射。
Description
本申请是于2016年10月10日递交的、申请号为201680083809.2、发明名称为“包括视觉指示物的药剂传输装置”的中国专利申请的分案申请。
技术领域
本发明在其一些实施例中涉及一种视觉用户指示物,更特别地但非排斥性地涉及一种用作用户指示光的药剂输送装置。
背景技术
美国专利US8784378公开“描述一种用于药物输送装置的药筒或药筒固持器的视觉识别编码。视觉识别编码包括包含药物的药筒和位于药筒上的光源,以可视地指示正确药筒已被插入药物输送装置中。光源可为发光二极管(LED),表面安装二极管(SMD)、或有机发光二极管(OLED)。也可包括药筒固持器以接纳药筒。在另一实施例中,光源可位于药筒固持器或剂量设定构件上”。
Eggert的美国专利申请公开No.2014/0228768公开“一种手持式医疗装置具有壳体,至少一个操作者能够启动的钮安装到壳体表面上;和光源,其安装到壳体内处于钮下方并被布置成将光朝向钮引导。大致整个钮和邻近于钮的壳体表面是不透明的,除了邻近于钮周界的窄条是非不透明的”。
另外的背景技术包括本发明人的国际专利申请公开No.WO2013173092。
发明内容
示例1:一种医药输送装置,具有用于装容药筒的空隙和至少一个窗,该医药输送装置包括:药筒,其装容流体材料,所述药筒包括:光管区部,其用作具有输入部位的光管;和光漫射区部,其光联接到所述光管并当所述药筒位于所述空隙中时对准所述窗;光源,其在所述光管的所述输入部位处光联接到所述药筒,使得来自所述光源在所述输入部位处进入的至少一些光在所述光漫射区部处漫射。
示例2:一种医药输送装置,包括:壳体,该壳体在其中限定用于药筒的空隙,并具有与空隙的至少一部分重叠的窗;药筒,其装容流体材料并位于所述空隙内,所述药筒包括:光管区部,其用作具有输入部位的光管;和光漫射区部,其光联接到所述光管并当所述药筒位于所述空隙中时对准所述窗;光源,其位于所述壳体内,并在所述光管的所述输入部位处光联接到所述药筒,使得来自所述光源在所述输入部位处进入的至少一些光在所述光漫射区部处漫射,并通过所述窗离开壳体。
示例3:根据示例1-2中任一项所述的装置,还包括:壳体,该壳体在其中限定用于所述药筒的空隙,并具有窗,所述窗与所述空隙的至少一部分重叠;其中,所述药筒位于所述空隙内,并且所述光源位于所述壳体内,使得在所述光漫射区部漫射的光通过所述窗离开所述壳体。
示例4:根据示例1-3中任一项所述的装置,还包括:控制电路,其具有根据所述医药输送装置的状态操作所述光源的指令。
示例5:根据示例1-2中任一项所述的装置,其中,所述光漫射区部包括至少一个突出元件。
示例6:根据示例5所述的装置,其中,所述突出元件至少部分地包围所述药筒的周边。
示例7:根据示例5所述的装置,其中,所述突出元件以超出所述药筒的壁的切线的一定角度延伸。
示例8:根据示例1所述的装置,其中,所述光漫射区部包括具有增加的表面粗糙部的表面区域。
示例9:根据示例8所述的装置,其中,所述表面区域以均匀分散方式漫射所述光。
示例10:根据示例8所述的装置,其中,所述表面区域的尺寸设计成设置为在是由所述光源的表面区域所限定区域的至少两倍的区域上分散所述光。
示例11:根据示例1所述的装置,其中,光漫射区部包括至少一个隆起。
示例12:根据示例1所述的装置,其中,光漫射区部包括至少一个狭槽。
示例13:根据示例1所述的装置,其中,所述药筒还包括标志。
示例14:根据示例13所述的装置,其中,所述光漫射区部位于所述标志的近处,使得所述光管和所述标志从单个观看方向是可见的。
示例15:根据示例1所述的装置,其中,所述光源以具有2至7个光源的范围的数量被设置。
示例16:根据示例1所述的装置,其中,所述光源以具有3至6个光源的范围的数量被设置。
示例17:根据示例16所述的装置,具有多个输入部位和多个光漫射区部,光漫射区部的每个联接到输入部位的每个。
示例18:根据示例17所述的装置,其中,输入部位的每个及其相关联的光漫射区部光联接到光源中的单个光源。
示例19:一种用于指示用户关于医药输送装置的状态方法,包括:将至少一个光源与药筒光联接,所述药筒装容流体材料并具有光输入部位;通过所述药筒将光漫射区部光联接到所述光输入部位;将所述至少一个光源和所述药筒定位在具有窗的壳体中,使得所述光漫射区部对准所述窗;根据所述医药输送装置的状态操作所述至少一个光源。
示例20:根据示例19所述的方法,其中,医药输送装置的状态包括正在输送状态。
示例21:根据示例19所述的方法,其中,医药输送装置的状态包括停止输送状态。
示例22:根据示例19所述的方法,其中,医药输送装置的状态包括开启或关闭状态。
示例23:根据示例19所述的方法,其中,医药输送装置的状态包括装置故障状态。
示例24:根据示例19所述的方法,其中,医药输送装置的状态包括流体材料的存量状态。
示例25:根据示例19所述的方法,其中,所述至少一个光源的所述操作包括以连续方式开启所述光源。
示例26:根据示例19所述的方法,其中,所述操作所述至少一个光源包括以间歇方式开启所述光源。
示例27:根据示例26所述的方法,其中,所述操作所述至少一个光源包括改变所述间歇方式的频率。
示例28:根据示例19所述的方法,其中,所述操作所述至少一个光源包括关闭光源。
示例29:根据示例19所述的方法,其中,所述操作所述至少一个光源包括改变光源的颜色。
示例30:一种制造医药输送装置的工艺,包括:模制药筒,该药筒包括:透明区部,其用作具有输入部位的光管;和光漫射区部,其光联接到所述光管;用流体材料填充所述药筒;提供壳体,所述壳体在其中限定用于所述药筒的空隙并具有与所述空隙的至少一部分重叠的窗;将所述药筒定位在所述空隙内,使得所述光漫射区部对准所述窗;将至少一个光源定位在所述壳体内并且通过所述输入部位将所述至少一个光源光联接到所述光管,使得来自所述光源在所述光管输入处进入的至少一些光在所述光漫射区部处漫射并通过所述窗离开所述壳体。
示例31:根据示例30所述的工艺,其中,所述模制包括使用水晶齐尼思(CrystalZenith)。
示例32:根据示例30-31中任一项所述的工艺,还包括:操作性地将所述至少一个光源与控制电路联接。
示例33:根据示例32所述的工艺,还包括对所述控制电路编程以根据所述装置的操作状态开启或关闭所述至少一个光源。
示例34:根据示例32所述的工艺,还包括:对所述控制电路编程以根据所述流体材料的存量状态调节由所述至少一个光源生成的光。
示例35:根据示例30-34中任一项所述的工艺,还包括在允许看到所述流体材料的存量状态的物理指示物的位置中模制所述光漫射区部。
示例36:根据示例35所述的工艺,其中,所述物理指示物包括流体材料的流体水平。
示例37:根据示例35所述的工艺,其中,所述物理指示物包括标志标记。
示例38:根据示例35所述的工艺,其中,所述物理指示物包括药筒柱塞位置。
示例39:一种制造医药输送装置的工艺,包括:模制药筒,该药筒包括:透明区部,其用作具有输入部位的光管;和光漫射区部,其光联接到所述光管;用流体材料填充所述药筒。
示例40:根据示例30所述的工艺,还包括:提供壳体,所述壳体在其中限定用于药筒的空隙并具有与所述空隙的至少一部分重叠的窗;将所述药筒定位在所述空隙内,使得所述光漫射区部对准所述窗;将至少一个光源定位在所述壳体内并且通过所述输入部位将所述至少一个光源光联接到所述光管,使得来自所述光源在所述光管输入处进入的至少一些光在所述光漫射区部处漫射并通过所述窗离开所述壳体。
示例41:根据示例1所述的装置,还包括:壳体,该壳体在其中限定用于所述药筒的空隙,并具有与所述空隙的至少一部分重叠的窗;其中,所述药筒位于所述空隙内,并且所述光源位于所述壳体内,使得在所述光漫射区部处漫射的所述光通过所述窗离开所述壳体。
示例42:根据示例1所述的装置,还包括:控制电路,其具有根据所述医药输送装置的状态操作所述光源的指令。
示例43:根据示例1所述的装置,其中,所述光漫射区部包括具有增加的表面粗糙部的表面区域,所述表面区域的尺寸设计成在是由所述光源的表面区域所限定区域的至少两倍的区域上分散所述光。
示例44:根据示例1所述的装置,其中,所述药筒还包括标志,并且其中所述光漫射区部位于所述标志的近处,使得所述光管和所述标志从单个观看方向(可对于两个或更多个窗)是可见的。
示例45:根据示例19所述的方法,其中,所述医药输送装置的所述状态包括正在输送状态、停止输送状态、开启或关闭状态、装置故障状态中的至少一种,和它们的任意组合。
示例46:根据示例19所述的方法,其中,所述操作所述至少一个光源包括以连续方式或者以间歇方式开启所述光源。
示例47:根据示例30所述的工艺,还包括:将所述至少一个光源与控制电路操作性地联接,并对所述控制电路编程以根据所述装置的状态操作所述至少一个光源。
示例48:根据示例30所述的工艺,还包括:对所述控制电路编程以根据所述流体材料的存量状态调节由所述至少一个光源生成的光。
示例49:根据示例30所述的工艺,还包括:在允许看到所述流体材料的存量状态的物理指示物的位置中模制所述光漫射区部。
示例50:一种医药输送装置,其具有用于装容药筒的空隙和至少一个窗,该医药输送装置包括:
(a)药筒,其装容流体材料,其中所述药筒的至少一部分以层结构形成衬里,所述层结构用作具有光输入部位的光管,且所述层结构还包括光漫射区部,所述光漫射区部光联接到所述光管并当所述药筒位于所述空隙中时对准所述窗;和
(b)光源,其在所述光管的所述输入部位处光联接到所述层结构,使得来自所述光源在所述输入部位处进入的至少一些光在所述光漫射区部漫射。
示例51:根据示例50所述的装置,其中,所述层结构的至少一部分包括用于附接到所述药筒的表面上的粘接表面。
示例52:根据示例50所述的装置,其中,所述层结构至少部分地透明。
示例53:根据示例52所述的装置,其中,所述光漫射区部包括至少一个标记,所述标记漫射有限范围的波长。
示例54:根据示例53所述的装置,其中,所述标记是文字,其指向所述装置的用户指示。
示例55:根据示例50所述的装置,其中,所述层结构被构造为漫射具有根据所述流体的至少一个视觉感知特性来选择的波长的光。
示例56:一种药物输送装置,包括:包含流体的药筒,该药筒包括:光管区部,其用作具有输入部位的光管;和光漫射区部,其光联接到所述光管;和光源,其在所述光管的所述输入部位处光联接到所述药筒,使得来自所述光源在所述输入部位进入的至少一些光在所述光漫射区部漫射。
示例57:根据示例1所述的装置,还包括:壳体,该壳体在其中限定用于所述药筒的空隙,并具有至少一个窗,至少一个所述窗与所述空隙的至少一部分重叠;其中,所述药筒位于所述空隙内,并且所述光源位于所述壳体内,使得在所述光漫射区部处漫射的所述至少一些光通过所述窗离开所述壳体。
示例58:根据示例1、19、30、50、56和57中任一项所述的装置,其中,所述流体是生物活性材料。
示例59:根据示例56-58中任一项所述的装置,还包括控制电路,其具有根据所述药物输送装置的状态操作所述光源的指令。
示例60:根据示例56-59中任一项所述的装置,其中,所述光漫射区部包括至少一个突出元件。
示例61:根据示例60所述的装置,其中,所述突出元件至少部分地包围所述药筒的周边。
示例62:根据示例60所述的装置,其中,所述突出元件以超出所述药筒的壁的切线的一定角度延伸。
示例63:根据示例56-62中任一项所述的装置,其中,所述光漫射区部包括具有增加的表面粗糙部的表面区域,所述表面区域的尺寸设计成在是由所述光源的表面区域所限定区域的至少两倍的区域上分散所述光。
示例64:根据示例56-63中任一项所述的装置,其中,所述药筒还包括标志,并且其中所述光漫射区部位于所述标志的近处,使得所述光管和所述标志从单个观看方向是可见的。
示例65:根据示例56-64中任一项所述的装置,其中,所述光源以具有2至7个光源的范围的数量被设置。
示例66:根据示例56-65中任一项所述的装置,其中,所述光漫射区部是所述药筒的壁。
示例67:根据示例56-11中任一项所述的装置,其中,所述光漫射区部传送来自所述光源的所述光的80%。
示例68:根据示例56-57中任一项所述的装置,其中,所述光漫射区部是设置在所述药筒中的柱塞。
示例69:一种用于指示用户关于药物输送装置的状态方法,包括:将至少一个光源与药筒光联接,所述药筒装容流体并具有光输入部位;通过所述药筒将光漫射区部光联接到所述光输入部位;将所述至少一个光源和所述药筒定位在具有至少一个窗的壳体中,使所述光漫射区部对准所述至少一个窗;和根据所述药物输送装置的状态操作所述至少一个光源。
示例70:根据示例69所述的方法,其中,所述药物输送装置的所述状态包括正在输送状态、停止输送状态、开启或关闭状态、装置故障状态中的至少一种,和它们的任意组合。
示例71:根据示例69所述的方法,其中,所述药物输送装置的所述状态包括所述流体的存量状态。
示例72:根据示例69-71中任一项所述的方法,其中,所述操作所述至少一个光源包括以连续方式或者以间歇方式开启所述光源。
示例73:根据示例69-72中任一项所述的方法,其中,所述操作所述至少一个光源包括改变所述光源的颜色。
示例74:一种制造药物输送装置的工艺,包括:形成药筒,该药筒包括:透明区部,其用作具有输入部位的光管;和光漫射区部,其光联接到所述光管;以及用流体填充所述药筒。
示例75:根据示例19所述的工艺,还包括:提供壳体,所述壳体在其中限定用于所述药筒的空隙并具有与所述空隙的至少一部分重叠的窗;将所述药筒定位在所述空隙内,使得所述光漫射区部对准所述窗;将至少一个光源定位在所述壳体内并且通过所述输入部位将所述至少一个光源光联接到所述光管,使得来自所述光源在所述光管输入处进入的至少一些光在所述光漫射区部处漫射并通过所述窗离开所述壳体。
示例76:根据示例74所述的工艺,其中,所述形成包括模制。
示例77:根据示例76所述的工艺,其中,所述模制包括使用Crystal Zenith。
示例78:根据示例74-77中任一项所述的工艺,还包括:将所述至少一个光源与控制电路操作性地联接,并对所述控制电路编程以根据所述装置的状态操作所述至少一个光源。
示例79:根据示例78所述的工艺,还包括:对所述控制电路编程以根据所述流体的存量状态调节由所述至少一个光源生成的光。
示例80:根据示例74-79中任一项所述的工艺,还包括:在允许看到所述流体的存量状态的物理指示物的位置中形成所述光漫射区部。
示例81:一种药物输送装置,其具有用于装容药筒的空隙和至少一个窗,该药物输送装置包括:药筒,其装容流体,其中所述药筒的至少一部分以层结构形成衬里,所述层结构用作具有光输入部位的光管,所述层结构还包括光漫射区部,所述光漫射区部光联接到所述光管并当所述药筒位于所述空隙中时对准所述窗;和光源,其在所述光管的所述输入部位处光联接到所述层结构,使得来自所述光源在所述输入部位处进入的至少一些光在所述光漫射区部漫射。
示例82:根据示例81所述的装置,其中,所述层结构的至少一部分包括用于附接到所述药筒的表面上的粘接表面。
示例83:根据示例81-82中任一项所述的装置,其中,所述层结构至少部分地透明。
示例84:根据示例83所述的装置,其中,所述光漫射区部包括至少一个标记,所述标记漫射有限范围的波长。
示例85:根据示例84所述的方法,其中,所述标记是文字,其指向所述装置的用户指示。
示例86:根据示例81-85中任一项所述的装置,其中,所述层结构被构造为漫射具有根据所述流体的至少一个视觉感知特性来选择的波长的光。
示例87:一种用于定位在具有壳体的药物输送装置内的药筒,所述药筒包括:光管区部,其用作具有输入部位的光管;和光漫射区部,其光联接到所述光管;其中,所述光漫射区部延伸超出由所述壳体限定的平面。
示例88:根据示例87所述的药筒,其中,当所述输入部位光联接到光源时,来自所述光源在所述输入部位处进入的至少一些光在所述光漫射区部漫射。
示例89:根据示例87-88中任一项所述的药筒,其中,所述药筒和所述光漫射区部由相同材料制成。
除非另行限定,否则在此使用的所有技术和/或科学用词具有与本发明所属技术领域的普通技术人员通常理解相同的含义。虽然与在此所述方法和材料相似或等同的方法和材料可用于本发明的实施例的实践中或检测中,但是示例性的方法和/或材料描述如下。在冲突情况下,将以专利申请文件(包括限定)为准。此外,材料、方法和示例仅为例示性的,并非意在必要性限制。
本发明的实施例的方法和/或系统的实施可涉及:人工地、自动地、或以其组合方式执行或完成所选任务。另外,根据本发明的方法和/或系统的实施例的实际设施和设备,多个所选任务可通过硬件、通过软件、或通过固件、或通过它们的组合使用操作系统实施。
例如,根据本发明的实施例用于执行所选任务的硬件可实现为芯片或电路。对于软件,根据本发明的实施例的所选任务可实现为使用任意适合操作系统由计算机执行的多个软件指令。在本发明的示例性实施例中,根据如本文中所述的方法和/或系统的示例性实施例的一个或多个任务通过数据处理器(例如用于执行多个指令的计算平台)执行。可选地,数据处理器包括:非永久性存储器,以用于存储指令和/或数据,和/或永久性存储器,例如硬磁盘,和/或可移除的介质,以用于存储指令和/或数据。可选地,还提供网络连接。可选地还提供显示器和/或用户输入装置,例如键盘或鼠标。
附图说明
本发明的一些实施例在此仅通过示例参照附图描述。现在详细地具体参照附图,应注意,所示细节是示例性的并且用于例示性论述本发明的实施例。对此,通过附图进行的描述对于本领域技术人员可如何实践本发明的实施例是显见的。
在附图中:
图1是例示出根据本发明的一些实施例的具有用户指示光的示例性装置的框图;
图2示意性例示出根据本发明一些实施例的具有用户指示光的示例性药物输送装置;
图3A-B示意性例示出根据本发明一些实施例的示例性药物输送装置壳体,其中,图3A例示出壳体截面的立体图,而图3B例示出根据本发明一些实施例的壳体截面和可选的药筒的立体图;
图4示意性例示出根据本发明一些实施例的具有可选的延伸光漫射区部的示例性药筒的立体图;
图5A-B示意性例示出根据本发明一些实施例的具有可选的光漫射表面和/或粘贴物的示例性药筒的立体图,其中,图5A例示出光漫射表面,而图5B例示出光漫射粘贴物;
图6A-B示意性例示出根据本发明一些实施例的具有可选的光漫射突出部的示例性药筒的立体图,其中,图6A例示出等距布置的突出部,图6B例示出以非等距方式布置的突出部;
图7示意性例示出根据本发明一些实施例的具有可选的光漫射隆起的示例性药筒的立体图;
图8示意性例示出根据本发明一些实施例的具有可选的光漫射狭槽的示例性药筒的立体图;
图9示意性例示出根据本发明一些实施例的具有能够通过光漫射表面识别的柱塞的示例性药筒的立体图;
图10是例示出根据本发明一些实施例的示例性制造工艺的流程图;
图11是例示出根据本发明一些实施例的示例性光指示算法的流程图;
图12是例示出根据本发明一些实施例的用于将药剂药筒用作用户指示光的示例性方法的流程图。
具体实施方式
本发明在其一些实施例中涉及一种视觉用户指示物,更特别地但非排斥性地涉及一种用作用户指示光的药剂输送装置。
概述
本发明的多个实施例的方案涉及:将药筒用作光管以用于指示药物输送装置的状态。在一些实施例中,光管涉及在药筒壁的至少一部分体积中行进和/或漫射和/或传送和/或引导的光,可选地装容药剂、例如生物活性材料的药筒。例如,生物活性材料是对患者的身体具有治疗效果的任意成分。可替代地,药剂是非生物活性材料,例如安慰剂。在一些实施例中,药筒包括:光漫射区部,例如光联接到光管并用于将光漫射到药筒壁外的元件。可替代地或另外地,光漫射区部用作光输入部,收集来自光源并进入药筒光管的光。可选地,这样的药筒用于药物输送装置(诸如例如注射装置)中的用户指示模块。
如在此使用的,药筒是装容流体并具有针的腔室。在一些实施例中,所述针相对于药筒的纵向轴线平行。可替代地,所述针相对于药筒的纵向轴线弯曲,可选地大致垂直于纵向轴线。如在此使用的流体是指:用于医疗目的的液体和/或气体。在一些实施例中,流体包括药剂,可选地为例如药物的生物活性材料或者为例如安慰剂的非生物活性材料。在一些实施例中,流体包括悬浮液、和/或溶液、和/或混溶或不混溶液体的混合物。
在一些实施例中,光源光联接到药筒,其中至少一些由光源产生的光传送和/或引导和/或漫射和/或行进通过药筒壁的至少一部分体积。在一些实施例中,光源通过位于药筒上的光漫射区部光联接到药筒,使得其嵌入注射装置内;可选地,光漫射区部从装容药筒的壳体外不可见且仅用作光输入部位。可替代地或另外地,光联接到药筒中行进的光的光漫射区部位于药筒上处于从装容药筒的壳体外可看到的位置。
例如,由光源产生的光行进到嵌入到注射装置中且用作光输入部的光漫射区部,并且光输入部引导光行进通过药筒的至少一部分体积。可选地,第二光漫射区部(可选地位于与光输入部的大致相反处)引导光行进通过从药筒相反方向可看到的药筒体积。可替代地或另外地,光漫射通过药筒中装容的流体。
在一些实施例中,至少两个窗设置在注射器壳体中,可选地用于允许用户观看所述药筒的多于一个的部分。可选地,至少一个窗允许观看药剂和/或柱塞。可替代地或另外地,至少一个窗允许观看光漫射区部。在一些实施例中,相同窗允许观看药剂(和/或柱塞)和光漫射区部两者。具有窗观看药剂(光也通过所述窗传送)的可能的优点在于,注射器内产生的光有助于改进注射器中药剂状态的监察。
在一些实施例中,光根据输送药筒装置的状态由光源产生。在一些实施例中,状态是装置操作状态,例如正在输送状态和/或停止输送状态和/或输送结束状态和/或马达开启/关闭状态和/或电源可用性和/或装置故障。可替代地或另外地,状态是流体被输送和/或留在药筒中的量的存量状态。
使用药剂药筒传送用户指示光的可能的优点在于减少以下需要:将分立的指示光模块添加到输送装置。减少装置中模块的数量有可能减少可能的装置故障。此外,另一可能的优点是:呈现指示光的表面区域放大,指示光有可能从宽视角范围可看到。通常,可由用户看到的输送药筒表面大于分立模块中设置的典型指示光,因此,用户可更容易并通过从多种不同角度观看探测到指示光。在一些实施例中,装置内产生的大多数光到药筒之外,例如至少90%、或至少80%、或至少70%,或至少60%。
在一些实施例中,位于装容药剂的药筒的近处的光源具有双重作用:第一作用包括:形成状态指示光,其被构造成行进通过药筒壁的至少一部分并且沿用户观看路径。第二作用包括:照亮药筒内容物,使能够观看药筒中的药剂状态,和/或观看在药筒壁上设置的标志,和/或观看柱塞位置。在一些实施例中,使用相同的窗时,用户可在观察药剂状态(例如,药剂流体水平和/或柱塞位置和/或标志标记)的同时看到装置操作的状态的指示光。具有用于上述指示的相同的观察窗的可能的优点是:其给予用户对两个指示物更多的观看,可减少误解的可能性,和/或为用户在指示物之一中提供何时存在故障的指示物。在一些实施例中,设置至少两个窗,至少一个用于至少观看药剂,至少一个用于至少观看药筒光引导。可选地,两个窗定位而能够同时观看。
在一些实施例中,相同的光源照射药筒(可能有利于读取药剂的刻度和/或水平)和/或包括编码状态指示物(例如颜色和/或闪烁)。在一些实施例中,光性能适合于药剂的光行进特性,例如,如果药剂是不透明的、或透明的、或半透明的,则使用不同的光特征。在一些实施例中,光源的颜色根据药剂的颜色而确定。在一些实施例中,药剂可为具有任意颜色的材料。可替代地或另外地,药剂可具有乳状的和/或不透明的外观。
在一些实施例中,被构造成利于药剂的柱塞提供行进通过药筒壁的光的全反射变化,可选地使光在柱塞边缘接触药筒壁之处向用户方向漫射到药筒壁外,从而提供柱塞位置的光指示。可替代地或另外地,光学元件(例如漫射器和/或反射器)可添加到柱塞,例如在柱塞的基底(例如近端)处。可替代地或另外地,柱塞的与药筒接触的壁可用作光引导部。
在一些实施例中,设置壳体,其具有观察窗,能够使用户观看用作光管且嵌入壳体中的输送药筒。可选地,观察窗是装容输送药筒的壳体中并且能够使用户视觉观看药筒的任意孔。在一些实施例中,观察窗被设置用于用户视觉探测指示光,其嵌入壳体内并具有朝向药筒的光路。可选地,观察窗用作在壳体内产生且行进通过药筒体积的光的视觉指示物。可能地,观察窗具有双重用途,用于探测指示光和用于使用户视觉监察药筒内容物。可替代地或另外地,药筒设置有具有光传送和/或散射性能的附加物。可选地,观察窗可包括窗玻璃和/或可包括开放空间。
在一些实施例中,操作状态通过使用多个光波性能(例如,频率和/或幅度和/或持续时间)指示。在一些实施例中,光连续传送。可替代地或另外地,光例如通过闪烁间歇传送。在一些实施例中,光性能包括闪烁频率,其可随时间增大或减小。例如,闪烁频率在一些实施例中关联于输送速度和/或关联于已被输送的药剂量。
在一些实施例中,药筒通过具有至少一部分透明区段而用作光管。如在此所用的,透明涉及允许至少一些光行进穿过其中的材料。在一些实施例中,药筒包括采用附加视觉特征的形式的光漫射区部。在一些实施例中,视觉特征被构造成通过其引导(即传送)光路。可替代地或另外地,视觉特征被构造成通过其漫射光。在一些实施例中,视觉特征从药筒表面突出,可选地由与药筒相同的材料制成,可选地由药筒外表面模制而成。可替代地,视觉特征在成分上不同于药筒,并被设计成引导和/或漫射药筒的至少一部分周边周围的光。
在一些实施例中,视觉特征包括多个突出部,例如周向突出肋和/或周向突出肋的区段,可选地正交于药筒的纵向轴线。可替代地或另外地,视觉特征包括多个分开的隆起。在其上具有突出部的表面的可能的优点在于:突出元件相对于平滑表面而言有可能传送和/或漫射更大量的光。在一些实施例中,突出部是等距的,可能能够实现大致均匀的光传送。可替代地,突出部非对称地分布,可能使更多光能够传送到预定表面区域。
可替代地或另外地,视觉特征包括多个狭槽和/或槽。可替代地或另外地,视觉特征包括至少一个突出部和至少一个狭槽。可能地,突出部和/或狭槽被构造成使光行进穿过药筒壁的体积以漫射到药筒壁外。可替代地或另外地,药筒壁的至少一部分包括增加的粗糙部,使得光漫射到药筒壁外。在一些实施例中,表面纹理(例如隆起和/或狭槽和/或粗糙部)设置在药筒壁的外表面上。可替代地或另外地,表面纹理设置在药筒壁的内表面上。
在一些实施例中,突出部成组布置,引导来自独立操作光源的光路。可选地,设置多个这样的组,每个组联接到独立操作光源。多个独立操作组的可能的优点在于,通过为每组突出部指定不同的解释,增加同时为用户提供的视觉信息。例如,第一组突出部与第一光源关联,指示例如装置的输送操作状态,而第二组突出部与第二光源关联,指示例如药剂量的状态。
在一些实施例中,视觉特征包括:突起元件,其具有光引导和/或漫射性能。在一些实施例中,所述元件突起超出由药筒和/或壳体限定的平面。光传送突起元件的可能的优点在于,其有可能通过其更好地引导光传播。此外,突出元件有可能从各种观察角度被更方便地看到和/或注意到。
在一些实施例中,突起元件所包括光漫射区部,其被构造成延伸超出由药筒壳体限定的平面和/或由窗的内边缘限定的平面和/或由窗的外边缘限定的平面。延伸超出壳体和/或窗的边缘的可能的优点在于,增大光漫射区部的用户可用视角。在一些实施例中,设置多于一个的光漫射区部,可选地每一个光漫射区部联接到不同的光源。
在一些实施例中,药筒包括至少一个对准引导部,其限定药筒相对于嵌入的注射装置的取向。在一些实施例中,对准引导部突起穿过药筒的外表面。可替代地,对准引导部包括:药筒外表面中的凹部。可选地,对准引导部与注射器装置内的互补几何特征互锁,可选地防止药筒相对于装置旋转。可能地,对准引导部能够使药筒以预定取向定位,例如相对于装置壳体的观察窗和/或光源而定位,可选地允许附加的视觉特征对用户可见。
本发明的多个实施例的方案涉及一种工艺,用于制造光传送和/或漫射药筒用于药剂输送以用作用户指示模块,例如用于注射器装置中。
在一些实施例中,通过将药筒嵌入壳体中而设置药物输送装置,壳体具有至少部分地对准药筒位置的窗。可选地,窗沿着药筒的纵向轴线或者药剂喷出所通过的任意轴线设置。
在一些实施例中,至少一个光源位于所述壳体内,使得其光联接到药筒。在一些实施例中,设置范围在1至10个的光源。可替代地,设置范围在2至7个的光源。可替代地,设置范围在3至6个的光源。可替代地,设置4个光源。
在一些实施例中,药筒由允许可见光频率范围内的电磁波行进的材料制成。可选地,所述材料至少部分地透明,可选地允许观看被输送成分。可替代地,药筒在内部涂覆有不透明材料,例如在光敏药剂的情况下,但是,药筒壁能够使可见光漫射通过其体积。在一些实施例中,药筒的至少一部分使用Crystal Zenith制造,可选地通过模制而成。可替代地或另外地,药筒的至少一部分使用玻璃制成。可替代地或另外地,药筒的至少一部分使用现有技术中公知的用于药筒的标准材料制成。
在一些实施例中,药筒被非对称地模制而成,可选地具有传送/漫射元件,在传送/漫射元件处观察窗被设计成相对于药筒装配。可替代地或另外地,药筒被模制为具有传送/漫射元件,传送/漫射元件被嵌入注射器壳体内,可选地从外侧不可见。可替代地或另外地,药筒被模制为具有:相对于观察窗和壳体平面的限定的角度。
在一些实施例中,药筒通过具有至少两种材料的层结构制成。可选地,层结果材料中的至少一种是不透明的。可替代地或另外地,层结构材料中的至少一种是透明的,可选地是部分透明的。在一些实施例中,在至少一个所述层结构中,可见光行进和/或漫射通过其体积。
本发明的一些实施例的方案涉及光引导衬里和/或粘贴物,其尺寸和形状设计成对药剂药筒的至少一部分形成衬里。在一些实施例中,粘贴物包括具有光漫射性能的材料,即,光可通过粘贴物的体积的至少一部分行进和/或漫射和/或传送。可选地,粘贴物表面的至少一部分包括粘接材料,用于粘接到药筒的内和/或外表面上。在一些实施例中,粘贴物包括在其表面上的文字和/或标记,可选地仅当暴露于特别是在特定波长范围内的光时可见。
可选地,粘贴物仅当与一定波长的光共用视觉路径时可见,所述波长范围在400-450、和/或450-480、和/或480-490、和/或490-500、和/或500-560、和/或560-580、和/或580-600、和/或600-650、和/或650-750、和/或任意范围更大、更小或中间的范围。
在一些实施例中,文字和/或标记包括光漫射材料并当光从光输入部位行进到它们时被照亮。可选地,粘贴物包括光输入部,光输入部位于注射器壳体内并与嵌入壳体内的至少一个光源共用视觉路径。可替代地或另外地,文字和/或标记仅通过具有作为光引导材料的轮廓而可见。可替代地或另外地,文字和/或标记通过被光引导粘贴物包围而可见,而非自身引导光可见,例如通过从粘贴物中对文字和/或标记穿孔并形成形状为文字和/或标记的无材料空间而实现。
在一些实施例中,药筒和/或注射筒按照区别于流体储存器填充的工艺制造。相应地,可选地,一些光引导类型在第一工艺中提供,并且其它光引导类型在第二工艺中提供。例如,模制的光引导特征部可通过药筒模制工艺提供,而衬里可由不同制造者组装到药筒上,在填充和/或以柱塞密封之前或之后进行。在一些实施例中,通过第一工艺提供的光引导特征被构造成与各种光源和/或流体兼容。可替代地或另外地,通过第二工艺提供的光引导特征针对特定的流体类型和/或用于填充的流体的光性能而专门定制。可选地,第一工艺中的特征独立于第二工艺中的特征提供。
在详细解释本发明的至少一个实施例之前,应理解,本发明不必使其应用局限于在以下描述中所述和/或在附图和/或示例中所示的部件的结构和布置和/或方法的细节。本发明能够实现其它实施例或者以各种方式实践或执行。
用于药物输送装置中的示例性用户指示光路
现在参见附图,图1例示出框图,例示出根据本发明一些实施例的具有用户指示光的示例性装置。在一些实施例中,药物输送装置设置有壳体106,壳体106具有窗162并具有空隙164。在一些实施例中,装容药剂(例如生物活性材料)的药筒102位于空隙164内。在一些实施例中,光源104也位于壳体内,可选地在药筒近处。
在一些实施例中,药筒102被构造用作光管,将由光源104产生的光渡送到窗162。可选地,药筒102包括光输入部位122,其与光源104共用光路。在一些实施例中,药筒102由具有光传播性能的材料制成。可选地,药筒102的壁的至少一部分用作光管124以传送光至少通过其体积的一部分。
在一些实施例中,药筒102包括光漫射区部126。可选地,光漫射区部126包括延伸元件。可选地,延伸元件大致垂直于药筒102的纵向轴线,如图4中的示例所示。可替代地或另外地,光漫射区部126包括多个突出元件,如图6中的示例所示。可替代地或另外地,光漫射区部126包括至少一个隆起,如图7中的示例所示。可替代地或另外地,光漫射区部126包括至少一个狭槽,如图8中的示例所示。可替代地或另外地,光漫射区部126包括至少一个表面区域,其相对于药筒102的其它部分具有增加的粗糙部,如图5中的示例所示。在一些实施例中,药筒的远端部分包括用作光漫射区部126的凸缘,如图4中所示。
在一些实施例中,光漫射区部126包括沿药筒纵向轴线的布置。可替代地或另外地,光漫射区部126包括沿药筒周边的至少一部分的布置。在一些实施例中,光管124包括沿药筒102周边的至少一部分延伸的材料,用作在位于光管的一部分的附近处的光源和位于光管的第二部分的附近处的光漫射区部之间的光管。
在一些实施例中,光源104生成的光行进通过光路110。可选地,光源104生成的光行进到药筒102中设置的光输入部122。在一些实施例中,光从光输入部122行进到药筒102的光管124。可选地,光管124包括药筒102的透明区部。在一些实施例中,光管124包括药筒102的壁的整个体积。可替代地,药筒102的仅一部分由能够使光行进的材料制成。在一些实施例中,药筒102包括多层材料,其中至少一层材料允许光行进通过该层材料。
在一些实施例中,行进通过光路110的光内反射,除非当遇到光漫射区部126时。在一些实施例中,光漫射区部126的形状设计为允许行进通过光路110的光漫射到药筒102的内部容积外。
在一些实施例中,窗162对准药筒102,使得光漫射区部126通过窗162可见。这样,在一些实施例中,行进通过光路110的光漫射到光漫射区部126外并漫射到壳体106的外部112。
在一些实施例中,窗162位于壳体106的顶盖中,可选地接近于操作钮的位置。可替代地或另外地,窗162位于壳体162的底座中,可选地接近于可移除的安全衬里的位置。
在一些实施例中,窗162成形为圆形。可替代地或另外地,窗162成形为椭圆形或细长多边形,可选地与药筒102的纵向轴线对准。可替代地或另外地,窗162成形为狭槽。
在一些实施例中,壳体106包括:多个窗162,其可选地对准药筒102的不同区段。可替代地或另外地,窗162包括在多个壳体隔室之间的观看区部。例如,如果壳体106设置为多部件构造,则多个壳体部件可选地组装成使得:药筒102的至少一部分可在壳体部件之间被看到。可选地,药筒102用作多个壳体部件之间的连接器,例如,通过使至少一个壳体用于药筒近端并且使分立的至少一个壳体用于药筒远端,而药筒的中间区部的至少一部分可用于在近端和远端壳体隔室之间观看。
具有用作光管的药筒的示例性药物输送装置
现在参见图2,其示意性例示出根据本发明一些实施例的具有用户指示光的示例性药物输送装置的俯视图。在一些实施例中,药筒102用作药物输送装置(例如注射器201)的用户指示物。根据一些实施例,注射器201包括具有窗162的壳体106,窗162对准药筒102。药筒102在一些实施例中被定位成使得:光漫射区部126通过窗162可见。在一些实施例中,光漫射区部126漫射初始从药筒102传送的光,该药筒102用作来自光源104的光管。
在一些实施例中,光漫射区部126设置在药筒的背侧上,即,在面向窗162的一侧上。在这样的实施例中,光漫射区部126可选地用于传送漫射通过药筒102的壁的光。可替代地或另外地,光漫射区部设置在药筒的腹侧上,即,在面向注射器201的内部分的一侧上。在这样的实施例中,光漫射区部126可选地用作光输入部,收集由光源104在注射器201内产生的光,并将光传送到药筒壁,光于是通过窗162可见。在一些实施例中,窗162包括拱顶,例如曲形材料和/或圆柱形盖,用于覆盖和/或保护药筒。提供曲形盖的可能的优点是,如果光漫射区部126延伸超出壳体106的表面,则保护光漫射区部126。典型地,当药筒和/或光漫射区部126由玻璃制成并在受到冲击时易于破裂时,可使用保护盖。在一些实施例中,拱顶从壳体表面所限定的平面突起至少0.5mm、和/或至少1mm、和/或至少2mm、和/或至少5mm。
在一些实施例中,窗162实现第二作用,此时允许观看位于部位208处的柱塞202,柱塞202被构造成通过流体出口将药剂推出药筒102。可选地,柱塞202由马达206推动。可替代地或另外地,窗162允许观看药筒102中设置的药剂流体水平。可替代地,药筒102包括不透明的内层用于保护光敏药剂。
在一些实施例中,提供控制电路204,其可选地具有操作光源104的指令。例如,控制电路204在一些实施例中可从马达206获取关于装置的操作状态的输入,且可选地相应提供用于由光源104产生光的指令。可替代地或另外地,控制电路204在一些实施例中可获取关于柱塞202位置的输入,且可选地相应提供用于由光源104产生光的指令。
可选地,壳体106包括至少两个窗162、164。在一些实施例中,窗164允许观看药筒102的远端部分302。可选地,药筒102的远部分302包括采用凸缘210形式的光漫射区部,其在图3中进一步详细例示。在一些实施例中,窗164的尺寸和形状设计成允许观看凸缘,所述窗可选地采取狭槽的形状。示例性药物输送装置壳体和药筒
现在参见图3,示意性例示出根据本发明一些实施例的示例性药物输送装置壳体,其中,图3A例示出壳体截面的立体图,而图3B例示出根据本发明一些实施例的壳体截面和容纳药筒的立体图。
在一些实施例中,药物输送装置(例如注射器)包括具有窗162的壳体106。在一些实施例中,壳体106包括空隙164,空隙164的尺寸和形状设计成适于容纳药筒102。可选地,窗162根据空隙164设置,使药筒102从所述窗至少部分地可见。在一些实施例中,药筒的从所述窗可见的部分被构造可选地通过在可见部分中包括光漫射区部126而用作用户指示光。
在一些实施例中,药筒102包括:近端304,其被限定为具有针容纳构件208;远端302,其被限定为具有孔310用以容纳柱塞。在一些实施例中,柱塞被构造为沿药筒102的纵向轴线被推动,且可选地对准窗164的纵向轴线。在一些实施例中,药筒的非对称取向特征使药筒定位而使得:远端302、近端304和光漫射区部126正确对准壳体106和/或窗162。例如,互锁构件可设置在药筒102和壳体106中。在一些实施例中,这样的非对称取向对准特征避免药筒102在壳体106内移位和/或旋转。可替代地或另外地,药筒的远端和/或近端包括:连接器,诸如例如隔板和/或物理连接特征,例如卡合部和/或周向唇。
在一些实施例中,光源104位于壳体106中,使其与药筒102至少一部分、可选地与包括允许光行进通过药筒102体积(可选地通过其壁)的透明区部的部分共用光路。在一些实施例中,提供多于一个光源,可选地提供多于2个。可替代地,提供多于3个光源。可替代地,提供多于4个光源。在一些实施例中,每个光源光联接到药筒102中设置的不同光管,和/或光联接到不同光漫射区部。在一些实施例中,提供多个光源以增强指示光的观看区域,可选地所有光源以相同方式操作。可替代地,提供多个光源以允许同时操作不同的指示,例如,绿光指示装置马达的操作状态,且其与指示输送的闪烁的红光一起开启。在一些实施例中,光源104包括发光二极管。
具有延伸光漫射区部的示例性药筒
现在参见图4,其示意性例示出根据本发明一些实施例的具有至少一个延伸光漫射区部的示例性药筒的立体图。
在一些实施例中,设置光漫射表面462以漫射可选地为药筒102的壁的光管402中行进的光。在一些实施例中,光管402包括药筒102的从远端部分302延伸到近端部分304的整个壁。可替代地,光管402被设置为仅在药筒102的一部分中具有透明区部,可选地仅纵向轴线的一部分。可替代地,光管402设置为仅在药筒102的一部分中具有透明区部,可选地仅药筒102的周边的一部分。
在一些实施例中,光漫射区部462以一角度延伸而超出与药筒102的周边相切的平面。可替代地或另外地,光漫射区部462朝向垂直于药筒102的纵向轴线的方向延伸。在一些实施例中,光漫射区部462包括大致与药筒102的纵向轴线对准的纵向轴线。可替代地,光漫射区部462包括与药筒102的纵向轴线大致垂直的纵向轴线。
在一些实施例中,区部462在模制工艺中与药筒模制。可替代地或另外地,区部462可选地通过使区部462的尺寸和形状设计成匹配于药筒至少一部分而添加到药筒。在一些实施例中,区部462压靠药筒的光传送壁/层。
可选地,药筒102的远端302包括凸缘210。在一些实施例中,除了或者替代光漫射区部462凸缘210用作光漫射区部。在一些实施例中,凸缘210包括至少部分地包围远端302的周界的边缘,可选地具有沿远离药筒102的中心轴线的方向延伸超出远端302的周界的至少一个边沿特征317。可能地,边沿特征317可引导由壳体中所包括的光源所产生的光,可选地将光传输通过凸缘210。在一些实施例中,凸缘210的传输光的至少一部分从壳体外可见。可替代地或另外地,凸缘210和/或边沿317的尺寸和形状设计成与壳体中包括的至少一个特征互补,该至少一个特征可能将药筒的位置的取向固定到壳体内。
引导光通过药筒102的远端302中设置的光漫射区部的可能的优点在于,远端区域在柱塞之后可能没有药剂,药剂可能位于药筒的更近端的位置。没有药剂的环境可能允许光在没有干涉或改变影响(可由于药剂存在导致)的情况下漫射。
具有光漫射表面区域的示例性药筒
现在参见图5A,其示意性例示出根据本发明一些实施例的具有至少一个光漫射表面区域的示例性药筒的立体图。
在一些实施例中,光漫射表面区域562设置在药筒102中。在一些实施例中,表面区域562被构造成通过粗糙表面而漫射行进通过由药筒102所提供的光管502的光。在一些实施例中,粗糙表面被限定为与药筒周边不相切的表面和/或以各种角度延伸(可选地无序延伸)的表面。在一些实施例中,不相切的表面的角度越大,则限定越大的粗糙度水平。可能地,行进通过光管502的光当遇到平滑表面时内反射和/或当遇到粗糙表面562时漫射到光管外。
在一些实施例中,多于一个粗糙表面区域562被设置。在一些实施例中,表面区域562被构造为以均匀方式漫射光,即,每单位面积漫射等量的光。可替代地,表面区域562被构造为每单位面积提供漫射不等量的光,例如通过具有粗糙度水平梯度和/或更大/更小粗糙度水平的区域。
现在参见图5B,示意性例示出本发明的一些实施例的方案,其中为药筒502设置衬里和/或粘贴物564。在一些实施例中,药筒502在其内表面上用粘贴物564作衬里。可替代地或另外地,粘贴物564在药筒564外表面上形成衬里。在一些实施例中,粘贴物564包括具有光引导性能的材料,并且可选地,在注射器壳体内产生的光与粘贴物564共用视觉路径。
在一些实施例中,粘贴物564包括至少一个标记566,标记566可选地为文字和/或标志和/或符号和/或任何其它视觉标记。可选地,标记566仅当共用路径的光在注射器壳体内产生时可见。在一些实施例中,标记566仅当在内部产生的光具有特定波长范围,例如在400-450、和/或450-480、和/或480-490、和/或490-500、和/或500-560、和/或560-580、和/或580-600、和/或600-650、和/或650-750的范围内、和/或任意范围更大、更小或中间的范围时可见。在一些实施例中,粘接层和/或粘贴物具有在约0.05mm至约1mm的范围内的厚度。可替代地,厚度在0.25mm至约0.75mm的范围内。
可选地,标记566可见,与内部光源共用视觉路径,而周围的粘贴物564不引导光通过其中。可替代地或另外地,标记566和周围的粘贴物564引导具有不同波长范围的光。可替代地或另外地,仅周围粘贴物564引导光,而标记566例如通过对标记566所占据区域和/或包围标记566的轮廓穿孔不引导光。在一些实施例中,标记566印刷在粘贴物上,然后安置到药筒上。在一些实施例中,标记566包括文字,可选地指向装置的用户指示,例如指示“OK”和/或“Error”(若装置故障)、和/或“Cold”。用户指示文字可选地针对每个用户指示文字使用不同颜色或者不同波长范围提供给用户。例如,“Error”可由红光指示和/或设置有红色滤光器,“OK”可呈现为绿色,“Cold”可由蓝色呈现。
在一些实施例中,粘贴物564是柔性的。可选地,粘贴物564可在任意的市场销售药筒上形成衬里。在一些实施例中,粘贴物564在已通过模制而制成的药筒的至少一部分上形成衬里,晚于模制工艺进行,可选地早于药筒被填充药剂。可替代地,在药筒填充之后,粘贴物564在药筒502上形成衬里。在一些实施例中,粘贴物564的至少一部分是透明的。可替代地或另外地,粘贴物564的至少一部分是半透明的。可替代地或另外地,粘贴物564的至少一部分是不透明的。
在一些实施例中,粘贴物564被构造成传输具有特定波长范围的光。通过粘贴物564传输的波长可选地根据药筒中包括的药剂的至少一个视觉感知特性而选择。在一些实施例中,视觉感知特性包括药剂的颜色。可替代地或另外地,视觉感知特性包括药剂的反射性。可替代地或另外地,视觉感知特性包括药剂的吸光度。
具有光漫射突出元件的示例性药筒
现在参见图6,示意性例示出根据本发明一些实施例的具有多个光漫射突出部的示例性药筒的立体图,其中,图6A例示出等距布置的突出部,图6B例示出以非等距方式布置的突出部。
在一些实施例中,设置至少一个突出元件662,其沿药筒102的周边的至少一部分延伸。在一些实施例中,设置多个突出元件662。可选地,突出元件662可选地沿药筒102的纵向轴线等距布置。等距元件662的可能的优点是,从各种视角统一观看。可替代地,突出元件662可选地相对于药筒102的纵向轴线非等距地布置。非等距元件662的可能的优点是,例如允许观看在元件662相互更远的部分处输送的药剂。
具有光漫射隆起的示例性药筒
现在参见图7,示意性例示出根据本发明一些实施例的具有至少一个光漫射隆起的示例性药筒的立体图。
在一些实施例中,药筒102的光漫射区部包括至少一个隆起762。在一些实施例中,隆起762包括被限制到相对较小表面区域的突出表面。在一些实施例中,隆起762从药筒102的整个表面区域的约1%至约5%的范围内的区部区域突出。可替代地或另外地,隆起762从药筒102的整个表面区域的约10%至约20%的范围内的区部区域突出。可替代地或另外地,隆起762从药筒102的整个表面区域的20%至约30%的范围内的区部区域突出。
在一些实施例中,隆起762延伸到不超过0.2mm的高度。可替代地或另外地,隆起762延伸到不超过0.5mm的高度。可替代地或另外地,隆起762延伸到不超过1mm的高度。
具有光漫射狭槽的示例性药筒
现在参见图8,示意性例示出根据本发明一些实施例的具有至少一个光漫射狭槽的示例性药筒的立体图。
在一些实施例中,光漫射区部包括在药筒102中的至少一个狭槽862。在一些实施例中,狭槽862设置为药筒102中的刻蚀元件。可选地,狭槽862沿药筒102的整个周边设置。可替代地或另外地,狭槽862沿药筒102的周边的一部分设置。可替代地或另外地,狭槽862平行于药筒102的纵向轴线设置。可选地,纵向对准的狭槽862增强观看药剂流体存量状态的光路。可选地,狭槽的内表面可为平滑的和/或粗糙的和/或具有不同的粗糙度。
具有光漫射柱塞接触的示例性药筒
现在参见图9,示意性例示出根据本发明一些实施例的具有通过漫射和/或反射光能够识别的柱塞的示例性药筒的立体图。
在一些实施例中,柱塞202限定与药筒102的内壁的接触壁962。在一些实施例中,接触壁962通过使光在与柱塞202的接触壁处漫射用作光漫射区部。在一些实施例中,通过接触壁962发射的光有助于识别柱塞的位置,可能有助于随后输送药剂。在一些实施例中,光漫射壁处于柱塞的近端部分处(在此,柱塞接触药剂)。光漫射区部位于柱塞的近端处具有的可能的优点在于:显示出药剂与柱塞的接触部位。可替代地或另外地,光漫射壁处于柱塞的远端处。可替代地或另外地,光漫射壁位于柱塞的远端和近端之间。在一些实施例中,提供标志以基于柱塞的光漫射壁的位置估计剩余药剂量。
示例性制造工艺
现在参见图10,其示出流程图,该流程图例示出根据本发明一些实施例的示例性制造工艺。
在一些实施例中,工艺通过模制药筒1002开始,药筒被构造用作光管并具有光漫射区部。可选地,整个药筒使用透明材料(可选地为聚合物,可选地为Crystal Zenith和/或玻璃)模制。可替代地或另外地,药筒仅一部分使用透明材料模制,可选地所述部分限定光输入部位。可选地,模制的药筒被内涂覆以第二材料层,其可选地具有不同于模制材料的光传播特性。
在一些实施例中,在模制药筒之后,例如通过以粘贴物(可选地为用作光漫射体的粘贴物)在药筒表面至少一部分(可选地在药筒的内表面形成衬里)形成衬里提供药筒表面的衬里1003。可替代地或另外地,粘贴物在药筒的外表面形成衬里。在一些实施例中,粘贴物防止至少一部分光到达药剂,这当所用药剂具有光敏性时可能有用。在一些实施例中,粘贴物包括反射材料。可替代地或另外地,粘贴物设置有书写文字。可替代地或另外地,药筒可选地通过以化学方式联结而设置有一层光引导元件。
在一些实施例中,在药筒的至少一部分上形成衬里的粘贴物包含光敏图示和/或文字。可替代地或另外地,粘贴物包含荧光特征,其仅当暴露于特定波长范围时能够探测到。例如,粘贴物包含文字和/或标志,其仅当被嵌入的光源开启时和/或当特定的波长发射时可见。可选地,粘贴物是透明的、或半透明的、或不透明的。
在一些实施例中,一旦模制而成,则药筒被填充以药剂1004。可选地,光输入部位和/或透明光管、和/或光漫射区部根据被填充药剂的性能制造。例如,如果药剂是透明的,则可选地使药筒的非透明部分避免光以不受控的设置行进。可替代地,当药剂是光敏性的时,药筒可选地被涂覆以不透明材料。
在一些实施例中,设置带窗的壳体1006。在一些实施例中,药筒位于壳体中1008,使得光漫射区部对准窗。可选地,壳体包括尺寸和形状设计为匹配于药筒的空隙。在一些实施例中,壳体还包括尺寸和形状设计为与模制药筒的各部分互锁的构件,使得提供药筒相对于壳体的预定取向。在一些实施例中,执行药筒的定位,使得药筒的至少一部分从窗可见。可选地,药筒的从窗可见的部分包括光漫射区部。
在一些实施例中,至少一个光源位于壳体中1010。在一些实施例中,光源定位成具有药筒至少一部分(可选地为光输入部位)的光路。
示例性制造光指示算法
现在参见图11,其示出流程图,该流程图例示出根据本发明一些实施例的示例性光指示算法。
在一些实施例中,一旦装置开启1120,则光源开启1102,诸如例如当电力通过控制电路传感时。可选地,用户可以开始药物输送。在一些实施例中,当药剂输送进行时1140,光以闪烁频率A闪烁1104。在一些实施例中,当输送停止时1160,光源停止闪烁1106,可选地返回初始操作状态。可替代地,光源发射具有不同颜色的光。
在一些实施例中,一旦识别出故障1180,则光以频率B闪烁1108。在一些实施例中,一旦输送结束1100,则光闪烁停止,且可选地光改变颜色1110。在一些实施例中,当装置关闭和/或从用户身体移除时1111,光关闭1112。
在一些实施例中,不正确使用也通过光通知,例如当装置输送药剂时用户无意中移除装置时。
可选地,还提供非视觉指示物,用于任意装置状态指示。例如,提供振动(可选地通过马达产生)。可替代地或另外地,可提供声音指示,用于任意装置状态指示。
在药物输送装置中提供用户指示光的示例性方法
现在参见图12,其示出了流程图,该流程图例示出根据本发明一些实施例的使用药剂药筒作为用户指示光的示例性方法。
在一些实施例中,包含药剂的药筒通过以下方式用作用户指示光:使光源与药筒光联接1202,该药筒被构造用作光管以用于由光源产生的光。在一些实施例中,药筒还包括至少一个光漫射区部,其可选地光联接到药筒的光管1204,从而使例如由光源产生的光行进通过光管(为药筒)并通过光漫射元件漫射到药筒壁外。
在一些实施例中,药筒和光源位于药物输送装置的具有窗的壳体中1206。可选地,药筒和/或光源相对于窗对准1208,使得光源产生的光行进通过光漫射区部并到窗外。
在一些实施例中,根据如在此提供的装置状态,根据药物输送装置的状态操作光1210。
如在此所用,用词“约”是指±25%。
用词“包括(comprises)”及其变体(comprising)、“包含(includes)”及其变体(including)、“具有”及它们的同源词意味着:“包括但不限于”。
用词“构成”意味着“包括且限于”。
用词“主要构成”意味着:组分、方法或结构可包括另外的成分、步骤和/或部件,但仅当所述另外的成分、步骤和/或部件不实质改变所请求保护的组分、方法或结构的基本和新颖特性时。
如在此所用,单数形式“一”、“一个”、“所述”包括表示多个,除非上下文中另外明确指明。
在本申请全文中,本发明的各个实施例可按照范围形式呈现。应理解,按范围形式的描述仅为了方便和简要,不应被认为是在本发明范围内的严格限制。相应地,范围描述应被认为已具体公开所有可能的子范围以及此范围内的个体数值。例如,如1至6的范围描述应被认为已具体公开各子范围(例如,1至3、1至4、1至5、2至4、2至6、3至6,等等)、以及此范围内的个体数(例如,1、2、3、4、5、6)。这适用于任意范围宽度。
无论何时在此指出数字范围,则其是指:包括所指范围内的任意所述数字(分数或整数)。表述第一指示数字与第二指示数字“之间的范围”和“从”第一指示数字“到”第二指示数字的范围在此能够互换使用,并且是指包括第一指示数字和第二指示数字以及它们之间的所有分数和整数数字。
如在此所用,用词“方法”是指用于实现给定的任务的方式、手段、技术和过程,包括但不限于:由化学、药理、生物、生化和药剂领域的从业人员所公知的方式、手段、技术和过程,或者易于由化学、药理、生物、生化和药剂领域的从业人员从公知的方式、手段、技术和过程中开发出的方式、手段、技术和过程。
如在此所用,用词“治疗”包括:废除、实质禁止、减缓或逆转状况进程、实质减轻临床或美学状况症状、或者实质防止临床或美学状况症状出现。
应认识到,本发明的特定特征(其为了清楚起见在其它实施例的上下文中描述)也可与单个实施例组合提供。相反地,本发明的各个特征(其为了简要起见在单个实施例的上下文中描述)也可单独地或以任意适合子组合方式提供,或者提供为适用于本发明的任意其它所述实施例。各个实施例的上下文中所述的特定特征被认为不是这些实施例的关键特征,除非该实施例在没有这些元件的情况下无法操作。
虽然本发明已经结合其特定实施例描述,但是显然多种可替代方案、修改方案和变化方案对于本领域技术人员而言将是显见的。因此,意在包含所有处于所附权利要求书的精神和广义范围内的这种可替代方案、修改方案和变化方案。
在此说明书中提及的所有公开物、专利和专利申请在此以全文通过引用并入本说明书中,其程度等同于每个独立公开物、专利或专利申请通过引用具体独立描述并入本文。此外,在此申请中任何文献的引用或识别不应被理解为承认这些文献可用作本发明的现有技术。在使用章节标题的范围内,它们不应被解释为必然限制。
Claims (15)
1.一种药物输送装置,包括:
(a)药筒,其装容流体,所述药筒包括:
(i)光管区部,其用作具有输入部位的光管;和
(ii)光漫射区部,其光联接到所述光管;以及
(b)光源,其在所述光管的所述输入部位处光联接到所述药筒,使得来自所述光源在所述输入部位处进入的至少一些光在所述光漫射区部处漫射。
2.根据权利要求1所述的药物输送装置,其中,所述光漫射区部在模制工艺中与所述药筒一起模制。
3.根据权利要求1所述的药物输送装置,其中,所述药筒的远端包括凸缘,所述凸缘用作所述光漫射区部。
4.根据权利要求1所述的药物输送装置,其中,所述光漫射区部是光漫射表面区域,所述光漫射表面区域被构造成通过具有粗糙表面而漫射行进通过由所述药筒所提供的所述光管的光。
5.根据权利要求1所述的药物输送装置,其中,所述光漫射区部包括至少一个突出元件。
6.根据权利要求5所述的药物输送装置,其中,所述突出元件至少部分地包围所述药筒的周边。
7.根据权利要求5所述的药物输送装置,其中,所述至少一个突出元件包括沿所述药筒的纵向轴线等距地间隔布置的多个突出元件。
8.根据权利要求5所述的药物输送装置,其中,所述至少一个突出元件包括沿所述药筒的纵向轴线非等距地间隔布置的多个突出元件。
9.根据权利要求1所述的药物输送装置,其中,所述光漫射区部包括至少一个圆形隆起。
10.根据权利要求1所述的药物输送装置,其中,所述光漫射区部包括至少一个光漫射狭槽。
11.根据权利要求10所述的药物输送装置,其中,所述至少一个光漫射狭槽沿所述药筒的整个周边设置。
12.根据权利要求1所述的药物输送装置,其中,所述光漫射区部为粘贴物。
13.根据权利要求12所述的药物输送装置,其中,所述药筒利用所述粘贴物在所述药筒的内表面上形成衬里。
14.根据权利要求12所述的药物输送装置,其中,所述药筒利用所述粘贴物在所述药筒的外表面上形成衬里。
15.根据权利要求12所述的药物输送装置,其中,所述粘贴物包括至少一个标记,所述标记包括文字和/或标志和/或符号。
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US201662281536P | 2016-01-21 | 2016-01-21 | |
US62/281,536 | 2016-01-21 | ||
US15/204,542 | 2016-07-07 | ||
US15/204,542 US10576207B2 (en) | 2015-10-09 | 2016-07-07 | Angled syringe patch injector |
US15/269,248 US10086145B2 (en) | 2015-09-22 | 2016-09-19 | Rotation resistant friction adapter for plunger driver of drug delivery device |
US15/269,248 | 2016-09-19 | ||
CN201680083809.2A CN109219458B (zh) | 2016-01-21 | 2016-10-10 | 包括视觉指示物的药剂传输装置 |
PCT/US2016/056258 WO2017127141A1 (en) | 2016-01-21 | 2016-10-10 | Medicament delivery device comprising a visual indicator |
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US20220054754A1 (en) | 2022-02-24 |
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US20190022323A1 (en) | 2019-01-24 |
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US11311674B2 (en) | 2022-04-26 |
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