CN1106701A - 药用组合物 - Google Patents

药用组合物 Download PDF

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CN1106701A
CN1106701A CN94109091A CN94109091A CN1106701A CN 1106701 A CN1106701 A CN 1106701A CN 94109091 A CN94109091 A CN 94109091A CN 94109091 A CN94109091 A CN 94109091A CN 1106701 A CN1106701 A CN 1106701A
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gluconase
inhibitor
acarbose
preparation
tetrahydrolipstatin
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CN1076196C (zh
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K·-D·布雷默
P·肖卢维兹
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F Hoffmann La Roche AG
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Abstract

一种含有葡萄糖甙酶和/或淀粉酶抑制剂和脂 肪酶抑制剂作为活性物质和常规药用载体的药物制 剂。

Description

本发明涉及含有葡萄糖甙酶和/或淀粉酶抑制剂和脂肪酶抑制剂作为活性物质和常规药用载体的药物制剂。
据发现这种制剂可以用于治疗肥胖症。
因此，本发明还涉及葡萄糖甙酶和/或淀粉酶抑制剂与脂肪酶抑制剂同时合用、单独使用或按时间顺序隔开使用在治疗肥胖方面的用途。
根据本发明所能应用的葡萄糖甙酶和/或淀粉酶抑制剂有例如acarbose，adiposine，voglibose（AO-128），miglitol（Bay-m-1099），emiglitate（Bay-o-1248），MDL-25637，camiglibose（MDL-73945），tendamistate，Al-3688，trestatin，pradimicin-Q和salbostatin。
脂肪酶抑制剂有：例如Tetrahydrolipstatin，lipstatin，FL-386，WAY-121898，Bay-N-3176，valilactone，esterastin，ebelactone    A，ebelactone    B和RHC    80267。
能够进行发酵制备脂肪酶抑制剂例如lipstatin或esterastin的生物量或发酵块，也可以用作为脂肪酶抑制剂。后者在例如欧洲专利EP-A    129748和美国专利USP    4189438中都有叙述。
已经知道，葡萄糖甙酶和/或淀粉酶抑制剂，例如acarbose，可以阻滞碳水化合物的消化。
也已经知道，脂肪酶抑制剂，例如tetrahydrolipstatin（orlistat），可以在肠道内对脂肪酶产生部份抑制作用。
但是，在单种药物治疗中，脂肪酶抑制剂本身结合以节食一般只能起到适度的体重减轻，而葡萄糖甙酶和/或淀粉酶抑制剂基本上起不到使体重减轻的作用。现在惊奇地发现葡萄糖甙酶和/或淀粉酶抑制剂与脂肪酶抑制剂合用却能比单种药物治疗的情况造成大得多的体重减轻。这在下述的试验中得到证明。
该试验是在两个自愿者（A和B）中分两个试验期进行的。在七天的预试期内规定A的平均日热量为2560千卡而B为1850千卡，在这期间不服任何药物。在随后的十四天主试验期中，两个自愿者每餐各给以120mg的orlistat和100mg的acarbose。并没有规定特殊的膳食，而将体力活动减至最少。这里，如在预试期中那样也规定，A的平均日热量为2185千卡，而B为2050千卡。从下表中可以看出，两个自愿者的体重减轻是很明显的。
Figure 941090914_IMG1
与此作比较，在一个安慰剂对照的十二个星期的试验期中，用orlistat（3×120mg/天）单独治疗的情况下，患者的体重减轻平均为1.8kg（即0.3kg/14天）（Int.J.Obesity    1992;16（增刊1）：16，摘要063）。
根据本发明，葡萄糖甙酶和/或淀粉酶抑制剂可以以药物制剂的形式来使用，其中也含有脂肪酶抑制剂，或者与含有脂肪酶抑制剂的制剂混合作为一种特定组合来使用。
优选使用acarbose和orlistat。
为治疗肥胖症，这些活性成份口服使用。
它们可以以每公斤体重每日约0.003mg至约20mg优选0.015mg至10mg葡萄糖甙酶和/或淀粉酶抑制剂和大约0.15mg至20mg优选0.5mg至10mg脂肪酶抑制剂的剂量服用。
用于口服的本发明制剂可以采用片剂、胶囊、溶液或乳剂的形式。
固体剂型例如片剂和胶囊剂，每一剂量单位宜包含大约0.2mg至约100mg的葡萄糖甙酶和/或淀粉酶抑制剂和10mg至200mg的脂肪酶抑制剂。
除了治疗肥胖症之外，本发明的制剂或活性物质的组合可以用于对常与肥胖相联系发生的疾病如糖尿病、高血压、高脂血症以及耐胰岛素综合症等的治疗与预防。
对于所有这些适应症，所述活性物质都可以按上述的剂量范围来使用，个别的剂量可根据所治疗的疾病的性质以及患者的年龄和情况而定，可以在医学专家所认可的范围内来确定。
本发明通过下列的实施例详述。
具下列组成的药物制剂以本身已知的方法制备：
实施例A
软明胶胶囊：每一胶囊的用量
Orlistat        60mg
中链甘油三酯        450μl
Acarbose        50mg
实施例B
硬明胶胶囊：
Acarbose        25.0mg
Orlistat        30.0mg
晶状乳糖        37.0mg
微晶纤维素        20.0mg
聚乙烯聚吡咯烷酮        8.5mg
羧甲基淀粉钠        8.5mg
滑石粉        4.5mg
硬脂酸镁        1.5mg
胶囊内充物重量        135.0mg
实施例C
片剂：
Acarbose        25.0mg
Orlistat        30.0mg
无水乳糖            118.8mg
微晶纤维素        30.0mg
聚乙烯聚吡咯烷酮        10.0mg
羧甲基纤维素        10.0mg
硬脂酸镁        1.2mg
片剂重量        225.0mg
实施例D
具有控制的活性物质释放和在胃中存留时间增长的片剂：
Acarbose        50.0mg
Orlistat        60.0mg
粉末状乳糖        70.0mg
羟丙基甲基纤维素        52.5mg
聚乙烯聚吡咯烷酮        7.5mg
滑石粉        8.0mg
硬脂酸镁        1.0mg
胶体硅酸        1.0mg
芯重        250.0mg
羟丙基甲基纤维素        2.5mg
滑石粉        1.25mg
二氧化钛        1.25mg
薄膜包衣重量        5.0mg
实施例E
用于再制的粉末：
Acarbose        100.0mg
Orlistat        120.0mg
乙基香兰素        10.0mg
天冬酰苯丙氨酸甲酯        30.0mg
喷雾法制的脱脂奶粉        4740.0mg
总计        5000.0mg

Claims (10)

1、一种含有葡萄糖甙酶和/或淀粉酶抑制剂和脂肪酶抑制剂作为活性物质和常规药用载体的药物制剂。
2、一种如权利要求1的制剂，其特征在于其中的葡萄糖甙酶和/或淀粉酶抑制剂是acarbose，adiposine，voglibose（AO-128），miglitol（Bay-m-1099），emiglitate（Bay-o-1248），MDL-25637，camiglibose（MDL-73945），tendamistate，Al-3688，trestatin，pradimicin-Q或salbostatin。
3、一种如权利要求1的制剂，其特征在于其中的脂肪酶抑制剂是tetrahydrolipstatin，lipstatin，FL-386，WAY-121898，Bay-N-3176，valilactone，esterastin，ebelactone    A，ebelactone    B或RHC80267。
4、一种如权利要求1，2或3的制剂，其特征在于它含有acarbose和tetrahydrolipstatin作为活性物质。
5、一种含有葡萄糖甙酶和/或淀粉酶抑制剂和脂肪酶抑制剂的产品，它作为一种组合制剂用于在肥胖的治疗中同时、单独或按时间顺序隔开使用。
6、一种如权利要求5的产品，其特征在于它含有在权利要求2中提出的葡萄糖甙酶和/或淀粉酶抑制剂和在权利要求3中提出的脂肪酶抑制剂，特别是acarbose和tetrahydrolipstatin。
7、一种商业包装，它含有作为药用活性物质的葡萄糖甙酶和/或淀粉酶抑制剂连同说明该药物与脂肪酶抑制剂在治疗肥胖症中如何同时、单独或按时间顺序隔开使用的联合使用说明书。
8、一种如权利要求7的商业包装，它含有acarbose连同它与tetrahydrolipstatin联合应用的说明书。
9、葡萄糖甙酶和/或淀粉酶抑制剂在制造用于治疗肥胖的与脂肪酶合用的药物制剂中的用途。
10、根据权利要求9的将acarbose与tetrahydrolipstatin联合使用。
CN94109091A 1993-08-05 1994-08-04 药用组合物 Expired - Lifetime CN1076196C (zh)

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CN100349614C (zh) * 2005-10-21 2007-11-21 南京工业大学 一种含α－淀粉酶抑制剂的固体混合物及其制备工艺和在制药中的应用
CN100352504C (zh) * 2002-11-07 2007-12-05 爱克斯国际商务集团公司 含有α－葡糖苷酶抑制剂和α－淀粉酶抑制剂的营养补充剂
CN102805744A (zh) * 2011-06-02 2012-12-05 鲁南制药集团股份有限公司 一种治疗或预防肥胖症以及代谢综合症的药物组合物
CN102872062A (zh) * 2011-07-13 2013-01-16 鲁南制药集团股份有限公司 一种治疗或预防肥胖症以及代谢综合症的药物组合物
CN107308154A (zh) * 2017-07-19 2017-11-03 重庆植恩药业有限公司 治疗或预防肥胖症以及代谢综合征的药物组合物及其应用
CN107405309A (zh) * 2014-12-17 2017-11-28 安普洛德制药公司 用于治疗肥胖症和相关代谢紊乱的奥利司他和阿卡波糖的调释组合物

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KR950005319A (ko) 1995-03-20
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