CN110167928A - 作为sos1抑制剂的新型经苄基氨基取代的喹唑啉和衍生物 - Google Patents

作为sos1抑制剂的新型经苄基氨基取代的喹唑啉和衍生物 Download PDF

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Publication number
CN110167928A
CN110167928A CN201780083358.7A CN201780083358A CN110167928A CN 110167928 A CN110167928 A CN 110167928A CN 201780083358 A CN201780083358 A CN 201780083358A CN 110167928 A CN110167928 A CN 110167928A
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alkyl
aryl
base
independently selected
heteroaryl
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Chinese (zh)
Inventor
M·格马其
M·山德森
D·凯斯勒
C·科芬克
M·R·内瑟顿
J·莱姆哈特
T·温伯格
M·霍夫曼
F·萨瓦雷斯
A·鲍姆
D·鲁道夫
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Boehringer Ingelheim International GmbH
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Boehringer Ingelheim International GmbH
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CN201780083358.7A 2016-12-22 2017-12-21 作为sos1抑制剂的新型经苄基氨基取代的喹唑啉和衍生物 Pending CN110167928A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16206422 2016-12-22
EP16206422.4 2016-12-22
PCT/EP2017/084265 WO2018115380A1 (en) 2016-12-22 2017-12-21 Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors

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CN110167928A true CN110167928A (zh) 2019-08-23

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CN201780083358.7A Pending CN110167928A (zh) 2016-12-22 2017-12-21 作为sos1抑制剂的新型经苄基氨基取代的喹唑啉和衍生物

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US (2) US10898487B2 (https=)
EP (2) EP3558979B1 (https=)
JP (1) JP7219218B2 (https=)
CN (1) CN110167928A (https=)
WO (1) WO2018115380A1 (https=)

Cited By (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112174891A (zh) * 2020-11-02 2021-01-05 浙江省农业科学院 一种氟唑菌苯胺代谢物的制备方法
WO2021203768A1 (zh) * 2020-04-08 2021-10-14 江苏恒瑞医药股份有限公司 嘧啶并二环类衍生物、其制备方法及其在医药上的应用
WO2021228028A1 (zh) * 2020-05-09 2021-11-18 正大天晴药业集团股份有限公司 含磷的sos1抑制剂
CN113767100A (zh) * 2019-03-01 2021-12-07 锐新医药公司 双环杂芳基化合物及其用途
WO2021249519A1 (zh) * 2020-06-11 2021-12-16 江苏恒瑞医药股份有限公司 吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用
CN113801114A (zh) * 2020-06-11 2021-12-17 江苏恒瑞医药股份有限公司 稠合二环杂芳基类衍生物、其制备方法及其在医药上的应用
CN113912608A (zh) * 2020-07-10 2022-01-11 江苏恒瑞医药股份有限公司 嘧啶并嘧啶酮类衍生物、其制备方法及其在医药上的应用
WO2022017519A1 (zh) * 2020-07-24 2022-01-27 南京明德新药研发有限公司 喹唑啉类化合物
WO2022017339A1 (zh) * 2020-07-20 2022-01-27 江苏恒瑞医药股份有限公司 稠合哒嗪类衍生物、其制备方法及其在医药上的应用
WO2022028506A1 (zh) * 2020-08-06 2022-02-10 北京泰德制药股份有限公司 Sos1抑制剂、包含其的药物组合物及其用途
WO2022083657A1 (zh) * 2020-10-20 2022-04-28 苏州泽璟生物制药股份有限公司 取代苯并或吡啶并嘧啶胺类抑制剂及其制备方法和应用
CN114436976A (zh) * 2021-01-29 2022-05-06 石药集团中奇制药技术（石家庄）有限公司 一种新型喹唑啉类衍生物及其制备和应用
CN114524810A (zh) * 2020-11-21 2022-05-24 上海凌达生物医药有限公司 一类嘧啶并杂环类化合物、制备方法和用途
CN114621231A (zh) * 2020-12-14 2022-06-14 杭州中美华东制药有限公司 一种靶向降解/抑制活性的嵌合化合物及其制备方法和用途
WO2022121813A1 (zh) * 2020-12-07 2022-06-16 北京泰德制药股份有限公司 Sos1抑制剂、包含其的药物组合物及其用途
WO2022135610A1 (zh) * 2020-12-25 2022-06-30 武汉誉祥医药科技有限公司 四并环化合物及其药物组合物和应用
CN114685487A (zh) * 2020-12-27 2022-07-01 上海凌达生物医药有限公司 一类嘧啶并杂环类化合物、制备方法和用途
CN114685488A (zh) * 2020-12-31 2022-07-01 南京圣和药业股份有限公司 作为sos1抑制剂的化合物及其应用
WO2022143533A1 (zh) * 2020-12-30 2022-07-07 成都百裕制药股份有限公司 喹唑啉衍生物及其在医药上的应用
CN114746411A (zh) * 2019-11-29 2022-07-12 印度鲁宾有限公司 取代的三环化合物
WO2022148442A1 (zh) * 2021-01-07 2022-07-14 武汉人福创新药物研发中心有限公司 6-取代磷酰基喹唑啉类衍生物及其制备方法和用途
CN114835703A (zh) * 2021-02-02 2022-08-02 苏州泽璟生物制药股份有限公司 取代嘧啶并吡啶酮类抑制剂及其制备方法和应用
WO2022161461A1 (zh) * 2021-01-29 2022-08-04 江苏先声药业有限公司 Sos1抑制剂及其制备方法和应用
CN114853812A (zh) * 2021-02-04 2022-08-05 四川科伦博泰生物医药股份有限公司 含氧化膦基团的化合物、其制备方法及其在医药上的应用
WO2022166974A1 (zh) * 2021-02-08 2022-08-11 武汉人福创新药物研发中心有限公司 吡啶并嘧啶酮类衍生物及其制备方法和用途
CN114907284A (zh) * 2021-02-10 2022-08-16 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的化合物及其用途
CN114907324A (zh) * 2021-02-09 2022-08-16 苏州泽璟生物制药股份有限公司 取代苯并或吡啶并嘧啶胺类抑制剂及其制备方法和应用
WO2022170917A1 (zh) * 2021-02-09 2022-08-18 苏州阿尔脉生物科技有限公司 一种作为sos1抑制剂的多环嘧啶类衍生物、其制备方法及用途
WO2022171018A1 (zh) * 2021-02-09 2022-08-18 苏州泽璟生物制药股份有限公司 取代苯并或吡啶并嘧啶胺类抑制剂及其制备方法和应用
WO2022170802A1 (zh) * 2021-02-09 2022-08-18 苏州阿尔脉生物科技有限公司 一种作为sos1抑制剂的嘧啶并吡啶酮类衍生物、其制备方法及用途
WO2022171184A1 (zh) * 2021-02-10 2022-08-18 杭州英创医药科技有限公司 作为sos1抑制剂的杂环化合物
WO2022184116A1 (zh) * 2021-03-05 2022-09-09 江苏先声药业有限公司 新型sos1抑制剂及其制备方法和应用
CN115028644A (zh) * 2021-03-08 2022-09-09 首药控股(北京)股份有限公司 Sos1抑制剂杂环化合物
CN115043817A (zh) * 2021-03-09 2022-09-13 苏州泽璟生物制药股份有限公司 Sos1蛋白水解调节剂及其制备方法和应用
WO2022199635A1 (zh) * 2021-03-25 2022-09-29 南京明德新药研发有限公司 苄氨基喹唑啉类衍生物
WO2022199670A1 (zh) * 2021-03-26 2022-09-29 南京明德新药研发有限公司 6-氨基甲酸酯取代的杂芳环衍生物
CN115215884A (zh) * 2021-04-19 2022-10-21 昆药集团股份有限公司 苯并嘧啶三环类衍生物及其制备方法和应用
CN115215847A (zh) * 2021-04-16 2022-10-21 中国科学院上海药物研究所 一类kras-sos1抑制剂、其制备方法及其应用
CN115232108A (zh) * 2021-04-23 2022-10-25 上海领泰生物医药科技有限公司 Sos1降解剂及其制备方法和应用
WO2022222875A1 (zh) * 2021-04-19 2022-10-27 昆药集团股份有限公司 一种苯并嘧啶三环衍生物及其制备方法和应用
CN115246841A (zh) * 2021-09-14 2022-10-28 北京福元医药股份有限公司 苄氨基取代的嘧啶并吡喃酮衍生物及其组合物、制剂和用途
CN115417868A (zh) * 2021-09-13 2022-12-02 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的杂环化合物及其用途
WO2022258057A1 (en) * 2021-06-11 2022-12-15 Jingrui Biopharma Co., Ltd. Compounds as anticancer agents
WO2022262691A1 (en) * 2021-06-17 2022-12-22 Beijing Innocare Pharma Tech Co., Ltd. Heterocyclic compounds as sos1 inhibitors
WO2022268209A1 (zh) * 2021-06-24 2022-12-29 四川汇宇制药股份有限公司 一种嘧啶并环结构衍生物及其用途
CN115536660A (zh) * 2021-11-04 2022-12-30 北京福元医药股份有限公司 苄氨基取代的杂多环化合物及其组合物、制剂和用途
CN115605476A (zh) * 2019-12-27 2023-01-13 鲁宾有限公司（In） 取代的三环化合物
WO2023001229A1 (zh) * 2021-07-23 2023-01-26 浙江海正药业股份有限公司 嘧啶并环类衍生物及其制备方法和用途
CN115677824A (zh) * 2021-07-26 2023-02-03 中国科学院上海药物研究所 可诱导sos1蛋白质降解的化合物、制备方法和用途
CN115697994A (zh) * 2020-06-10 2023-02-03 江苏恒瑞医药股份有限公司 稠合喹唑啉类衍生物、其制备方法及其在医药上的应用
CN115677699A (zh) * 2021-07-23 2023-02-03 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用
CN115677601A (zh) * 2021-07-29 2023-02-03 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的化合物及其用途
WO2023030216A1 (zh) * 2021-08-30 2023-03-09 浙江海正药业股份有限公司 喹唑啉类衍生物、或其制备方法和用途
CN115942936A (zh) * 2020-06-24 2023-04-07 勃林格殷格翰国际有限公司 包含sos1抑制剂和kras g12c抑制剂的抗癌组合疗法
CN116143708A (zh) * 2021-11-21 2023-05-23 四川汇宇制药股份有限公司 一种多取代苯并氮杂芳基衍生物及其用途
WO2023109929A1 (zh) 2021-12-17 2023-06-22 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的杂环化合物及其用途
CN116425742A (zh) * 2019-11-08 2023-07-14 锐新医药公司 双环杂芳基化合物及其用途
CN116444447A (zh) * 2023-06-19 2023-07-18 中国药科大学 一种sos1和hdac双靶点喹唑啉羟肟酸化合物及其制法和应用
WO2023138526A1 (zh) * 2022-01-21 2023-07-27 南京明德新药研发有限公司 含烯丙基的甲基吡啶并嘧啶化合物的晶型
WO2023143147A1 (zh) * 2022-01-28 2023-08-03 上海优理惠生医药有限公司 一种哒嗪并吡啶酮类化合物、其药物组合物及应用
CN116546985A (zh) * 2021-01-28 2023-08-04 浙江海正药业股份有限公司 吡啶并嘧啶类衍生物及其制备方法和用途
CN116648250A (zh) * 2020-12-22 2023-08-25 韩美药品株式会社 作为sos1抑制剂的新型喹唑啉衍生物及其用途
CN116768858A (zh) * 2022-03-15 2023-09-19 杭州中美华东制药有限公司 具有kras-sos1抑制或降解活性的嵌合化合物及其用途
CN117024404A (zh) * 2022-05-10 2023-11-10 四川汇宇制药股份有限公司 苯并吡啶衍生物及其用途
WO2023241414A1 (zh) * 2022-06-13 2023-12-21 上海优理惠生医药有限公司 一种哒嗪类化合物、其药物组合物及应用
WO2024008185A1 (zh) * 2022-07-07 2024-01-11 武汉人福创新药物研发中心有限公司 包含sos1抑制剂的药物组合物
CN117651701A (zh) * 2021-03-02 2024-03-05 唯久生物技术(苏州)有限公司 作为sos1抑制剂的新型取代的二环氮杂杂环
WO2024061353A1 (zh) * 2022-09-23 2024-03-28 南京明德新药研发有限公司 喹唑啉类化合物的晶型及其制备方法
CN119907792A (zh) * 2022-10-21 2025-04-29 领泰生物医药(绍兴)有限公司 苄基或噻吩亚甲基取代的氨基喹唑啉衍生物及其作为sos1降解剂的用途

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102444509B1 (ko) 2016-05-18 2022-09-19 미라티 테라퓨틱스, 인크. Kras g12c 억제제
EP3558979B1 (en) 2016-12-22 2021-02-17 Boehringer Ingelheim International GmbH Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors
US11104955B2 (en) * 2016-12-30 2021-08-31 Children's Medical Center Corporation MAP2K1 (MEK1) as a therapeutic target for arteriovenous malformations and associated disorders
WO2018172250A1 (en) * 2017-03-21 2018-09-27 Bayer Pharma Aktiengesellschaft 2-methyl-quinazolines
US10647715B2 (en) 2017-11-15 2020-05-12 Mirati Therapeutics, Inc. KRas G12C inhibitors
LT3710439T (lt) 2017-11-15 2023-05-10 Mirati Therapeutics, Inc. Kras g12c inhibitoriai
HRP20230400T1 (hr) 2017-12-21 2023-06-23 Boehringer Ingelheim International Gmbh Benzilamino supstituirani piridopirimidinoni i derivati kao inhibitori sos1
US11472802B2 (en) 2018-01-18 2022-10-18 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
JP7060694B2 (ja) 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物
US20220274979A1 (en) * 2018-04-18 2022-09-01 Bayer Pharma Aktiengesellschaft 2-methyl-aza-quinazolines
WO2019217307A1 (en) 2018-05-07 2019-11-14 Mirati Therapeutics, Inc. Kras g12c inhibitors
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
EP3849537B1 (en) 2018-09-10 2024-10-23 Mirati Therapeutics, Inc. Combination therapies
EA202190749A1 (ru) 2018-09-10 2021-07-09 Мирати Терапьютикс, Инк. Способы комбинированной терапии
EP3849535A4 (en) 2018-09-10 2022-06-29 Mirati Therapeutics, Inc. Combination therapies
JP2022500385A (ja) 2018-09-10 2022-01-04 ミラティ セラピューティクス， インコーポレイテッド 組み合わせ療法
MX2021002804A (es) 2018-12-05 2021-07-15 Mirati Therapeutics Inc Terapias de combinacion.
EP3908283A4 (en) 2019-01-10 2022-10-12 Mirati Therapeutics, Inc. KRAS G12C INHIBITORS
MX2021010323A (es) * 2019-03-01 2021-12-10 Revolution Medicines Inc Compuestos bicíclicos de heterociclilo y usos de este.
CA3139018A1 (en) 2019-05-31 2020-12-03 Chiesi Farmaceutici S.P.A. Amino quinazoline derivatives as p2x3 inhibitors
EP3986408A1 (en) * 2019-06-19 2022-04-27 Boehringer Ingelheim International GmbH Anticancer combination therapy
TWI817018B (zh) 2019-06-28 2023-10-01 美商艾瑞生藥股份有限公司 用於治療ｂｒａｆ相關的疾病和失調症之化合物
MX2022002465A (es) 2019-08-29 2022-05-19 Mirati Therapeutics Inc Inhibidores de kras g12d.
WO2021061749A1 (en) 2019-09-24 2021-04-01 Mirati Therapeutics, Inc. Combination therapies
KR20220086628A (ko) * 2019-10-22 2022-06-23 루핀 리미티드 Prmt5 저해제의 약학적 조합물
EP4062914A4 (en) 2019-11-18 2024-01-17 Inxmed (Nanjing) Co., Ltd. USE OF AN FAK INHIBITOR IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF TUMORS PRESENTING AN NRAS MUTATION
PH12022551513A1 (en) 2019-12-20 2023-04-24 Mirati Therapeutics Inc Sos1 inhibitors
WO2023205701A1 (en) * 2022-04-20 2023-10-26 Kumquat Biosciences Inc. Macrocyclic heterocycles and uses thereof
PL4142495T3 (pl) 2020-04-28 2025-11-24 Basf Se Zastosowanie związków typu strobiluryny do zwalczania grzybów fitopatogennych zawierających podstawienie aminokwasowe f129l w mitochondrialnym białku cytochromu b nadające odporność na inhibitory qo (iii)
US20230172205A1 (en) 2020-04-28 2023-06-08 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors iv
EP3903582A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors ii
PL4142494T3 (pl) 2020-04-28 2025-11-24 Basf Se Zastosowanie związków typu strobiluryny do zwalczania grzybów fitopatogennych zawierających podstawienie aminokwasowe f129l w mitochondrialnym białku cytochromu b nadające odporność na inhibitory qo (ii)
JP7751594B2 (ja) 2020-04-28 2025-10-08 ビーエーエスエフ ソシエタス・ヨーロピア ミトコンドリアチトクロムｂタンパク質中にＱｏ阻害剤Ｉに対して耐性を付与するアミノ酸置換Ｆ１２９Ｌを含む植物病原性菌類を駆除するためのストロビルリン型化合物の使用
EP3903584A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors iv
EP3903583A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors iii
EP3903581A1 (en) 2020-04-28 2021-11-03 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors i
JP7808058B2 (ja) 2020-06-02 2026-01-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング がんを治療するための縮合環化２－アミノ－３－シアノチオフェン及び誘導体
TW202426436A (zh) 2020-06-09 2024-07-01 美商艾瑞生藥股份有限公司 用於治療ｂｒａｆ相關的疾病和病症之化合物
BR112023002312A2 (pt) 2020-08-11 2023-03-21 Basf Se Uso de compostos, métodos para combater fungos fitopatogênicos, compostos, composições agroquímicas e uso de pelo menos um composto de fórmula i
EP3970494A1 (en) 2020-09-21 2022-03-23 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors viii
US20250195521A1 (en) 2020-09-03 2025-06-19 Revolution Medicines, Inc. Use of sos1 inhibitors to treat malignancies with shp2 mutations
EP4210833A4 (en) 2020-09-11 2024-09-11 Mirati Therapeutics, Inc. CRYSTALLINE FORMS OF A KRAS G12C INHIBITOR
CA3194067A1 (en) 2020-09-15 2022-03-24 Revolution Medicines, Inc. Ras inhibitors
US20240025863A1 (en) * 2020-09-16 2024-01-25 Biotheryx, Inc. Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
US20230357239A1 (en) 2020-09-18 2023-11-09 Bayer Aktiengesellschaft Pyrido[2,3-d]pyrimidin-4-amines as sos1 inhibitors
CA3202531A1 (en) * 2020-11-18 2022-05-27 Modernatx, Inc. Ribonucleic acid purification
CN114539245A (zh) * 2020-11-26 2022-05-27 上海翰森生物医药科技有限公司 含嘧啶并环类衍生物调节剂、其制备方法和应用
JP2023553492A (ja) 2020-12-15 2023-12-21 ミラティ セラピューティクス， インコーポレイテッド アザキナゾリン汎ＫＲａｓ阻害剤
EP4262803A4 (en) 2020-12-16 2025-03-12 Mirati Therapeutics, Inc. Tetrahydropyridopyrimidine pan-kras inhibitors
JP7849366B2 (ja) 2020-12-22 2026-04-21 キル・レガー・セラピューティクス・インコーポレーテッド Ｓｏｓ１阻害剤およびその使用
CR20230402A (es) 2021-01-19 2023-11-21 Lupin Ltd Combinaciones farmacéuticas de inhibidores de sos1 para tratar o prevenir cancer
WO2022156792A1 (en) * 2021-01-25 2022-07-28 Guangdong Newopp Biopharmaceuticals Co., Ltd. Heterocyclic compounds as sos1 inhibitors
CN114835719A (zh) * 2021-02-01 2022-08-02 苏州泽璟生物制药股份有限公司 取代双环并芳杂环胺类抑制剂及其制备方法和应用
WO2022187411A1 (en) 2021-03-02 2022-09-09 Kumquat Biosciences Inc. Heterocycles and uses thereof
US20240197888A1 (en) * 2021-03-17 2024-06-20 Biotheryx, Inc. Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
GB202104609D0 (en) 2021-03-31 2021-05-12 Sevenless Therapeutics Ltd New Treatments for Pain
EP4313151A1 (en) 2021-03-31 2024-02-07 Sevenless Therapeutics Limited Sos1 inhibitors and ras inhibitors for use in the treatment of pain
WO2022212546A1 (en) * 2021-03-31 2022-10-06 Acerand Therapeutics (Usa) Limited Pyridopyrimidinone compounds
JP2024514127A (ja) 2021-04-09 2024-03-28 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗がん剤療法
WO2022217053A1 (en) * 2021-04-09 2022-10-13 Revolution Medicines, Inc. Use of sos1 inhibitors with ras inhibitors to treat cancers
TW202309022A (zh) 2021-04-13 2023-03-01 美商努法倫特公司 用於治療具egfr突變之癌症之胺基取代雜環
EP4074317A1 (en) * 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
US12280055B2 (en) 2021-05-27 2025-04-22 Mirati Therapeutics, Inc. Combination therapies
WO2022266248A1 (en) * 2021-06-16 2022-12-22 Biotheryx, Inc. Sos1 protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
WO2022271679A1 (en) 2021-06-21 2022-12-29 Mirati Therapeutics, Inc. Sos1 inhibitors
CA3227026A1 (en) * 2021-08-03 2023-02-09 Evopoint Biosciences Co., Ltd. Fused ring compound, pharmaceutical composition, and application thereof
EP4417607A4 (en) 2021-09-17 2025-08-06 Nanjing Zaiming Pharmaceutical Co Ltd HETEROCYCLIC COMPOUND USED AS AN SOS1 INHIBITOR AND USES THEREOF
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
US20240425501A1 (en) * 2021-10-21 2024-12-26 Sanjita Sasmal Novel bicyclic heteroaryl derivatives as sos1:kras proteinprotein interaction inhibitors
WO2023072671A1 (en) 2021-10-28 2023-05-04 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors ix
WO2023072670A1 (en) 2021-10-28 2023-05-04 Basf Se Use of strobilurin type compounds for combating phytopathogenic fungi containing an amino acid substitution f129l in the mitochondrial cytochrome b protein conferring resistance to qo inhibitors x
WO2023099624A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
JP2024542692A (ja) 2021-12-01 2024-11-15 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 環化２－アミノ－３－シアノチオフェンを含むｋｒａ分解化合物
JP2024543976A (ja) 2021-12-01 2024-11-26 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 癌の処置のための環化２－アミノ－３－シアノチオフェン及び誘導体
TW202340208A (zh) 2021-12-01 2023-10-16 德商百靈佳殷格翰國際股份有限公司 用於治療癌症之環狀2-胺基-3-氰基噻吩及衍生物
WO2023099608A1 (en) 2021-12-01 2023-06-08 Boehringer Ingelheim International Gmbh Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2023098825A1 (zh) * 2021-12-02 2023-06-08 勤浩医药（苏州）有限公司 Sos1抑制剂、包含其的药物组合物及其用途
US20250011304A1 (en) 2021-12-08 2025-01-09 Array Biopharma Inc. Crystalline form of n-(2-chloro-3-((5-chloro-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)-4-fluorophenyl)-3-fluoroazetidine-1-sulfonamide
CN119212994A (zh) 2021-12-17 2024-12-27 建新公司 作为shp2抑制剂的吡唑并吡嗪化合物
US20250154147A1 (en) 2022-01-14 2025-05-15 Jazz Pharmaceuticals Ireland Limited Novel amine-substituted phthalazines and derivatives as sos1 inhibitors
KR20230121208A (ko) 2022-02-10 2023-08-18 (주)파로스아이바이오 Sos1 억제제 및 이의 유도체
EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
US12419962B2 (en) 2022-03-16 2025-09-23 Biotheryx, Inc. Quinazolines, pharmaceutical compositions, and therapeutic applications
GB202203976D0 (en) 2022-03-22 2022-05-04 Jazz Pharmaceuticals Ireland Ltd Tricyclic phthalazines and derivatives as sos1 inhibitors
EP4473970A4 (en) 2022-03-31 2026-01-21 Eisai R&D Man Co Ltd PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF TUMORS
CN119031916A (zh) * 2022-04-08 2024-11-26 米拉蒂治疗股份有限公司 包含sos1抑制剂和egfr抑制剂的组合疗法
AU2023250314A1 (en) * 2022-04-08 2024-10-03 Mirati Therapeutics, Inc. Combination therapies comprising a sos1 inhibitor and a mek inhibitor
AU2023255692A1 (en) 2022-04-20 2024-10-03 Kumquat Biosciences Inc. Macrocyclic heterocycles and uses thereof
WO2023240263A1 (en) 2022-06-10 2023-12-14 Revolution Medicines, Inc. Macrocyclic ras inhibitors
EP4573095A1 (en) 2022-08-17 2025-06-25 Treeline Biosciences, Inc. Pyridopyrimidine kras inhibitors
WO2024056782A1 (en) 2022-09-16 2024-03-21 Bayer Aktiengesellschaft Sulfone-substituted pyrido[3,4-d]pyrimidine derivatives for the treatment of cancer
EP4598538A1 (en) 2022-10-05 2025-08-13 Sevenless Therapeutics Limited New treatments for pain
WO2024075070A2 (ko) * 2022-10-07 2024-04-11 제일약품주식회사 신규한 바이사이클릭 헤테로사이클릴 화합물 및 이의 용도
EP4602049A1 (en) 2022-10-13 2025-08-20 Bayer Aktiengesellschaft Sos1 inhibitors
US20240208909A1 (en) * 2022-12-02 2024-06-27 Accutar Biotechnology Inc. Substituted quinoline derivatives having sos1 inhibition activities and uses thereof
DE102024102431A1 (de) 2023-02-01 2024-08-01 Deutsche Institute für Textil- und Faserforschung Denkendorf Stiftung des öffentlichen Rechts Amin-funktionalisiertes Cellulosematerial, Verfahren zu dessen Herstellung und Verwendung als CO2-Adsorber
AU2023439518A1 (en) 2023-04-06 2025-08-28 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating tumors
AR132338A1 (es) 2023-04-07 2025-06-18 Revolution Medicines Inc Inhibidores de ras
CR20250420A (es) 2023-04-07 2025-11-20 Revolution Medicines Inc Inhibidores macrocíclicos de ras
CN121100123A (zh) 2023-04-14 2025-12-09 锐新医药公司 Ras抑制剂的结晶形式
CN121464140A (zh) 2023-04-14 2026-02-03 锐新医药公司 Ras抑制剂的结晶形式、含有其的组合物及其使用方法
PE20252789A1 (es) 2023-05-24 2025-12-22 Kumquat Biosciences Inc Compuestos heterociclicos y usos de estos
WO2024246099A1 (en) 2023-05-30 2024-12-05 Boehringer Ingelheim International Gmbh Spirocyclic annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer
WO2024245326A1 (zh) 2023-05-31 2024-12-05 四川汇宇制药股份有限公司 含氮官能团取代的哒嗪并吡啶酮衍生物及其用途
GB2631397A (en) 2023-06-28 2025-01-08 Sevenless Therapeutics Ltd New treatments for pain
CN121263417A (zh) 2023-06-30 2026-01-02 金橘生物科技公司 取代的稠合三环胺化合物及其作为ras抑制剂的用途
WO2025059046A1 (en) 2023-09-11 2025-03-20 Kumquat Biosciences Inc. Sos1 inhibitors for use in the treatment of philadelphia chromosome positive blood cancers
GB2633813A (en) 2023-09-21 2025-03-26 Sevenless Therapeutics Ltd New treatments for pain
TW202528315A (zh) 2023-09-21 2025-07-16 美商樹線生物科學公司 螺環二氫哌喃并吡啶ＫＲａｓ抑制劑
WO2025083426A1 (en) 2023-10-20 2025-04-24 Sevenless Therapeutics Limited New treatments for pain
WO2025090808A1 (en) 2023-10-25 2025-05-01 Kumquat Biosciences Inc. Combinations of sos-1 inhibitors with osimertinib and/or met inhibitors to treat cancer
WO2025090812A1 (en) * 2023-10-25 2025-05-01 Kumquat Biosciences Inc. Methods of modulating cell proliferation
WO2025090810A1 (en) 2023-10-25 2025-05-01 Kumquat Biosciences Inc. Use of sos1 inhibitors and amivantamab to treat cancer
TW202542151A (zh) 2023-12-22 2025-11-01 美商銳格醫藥有限公司 Ｓｏｓ１抑制劑及其用途
WO2025146548A1 (en) 2024-01-04 2025-07-10 Sevenless Therapeutics Limited Sos1 inhibitors useful to treat pain and cancer
WO2025171055A1 (en) 2024-02-06 2025-08-14 Kumquat Biosciences Inc. Heterocyclic conjugates and uses thereof
WO2025202022A1 (en) 2024-03-27 2025-10-02 Bayer Aktiengesellschaft Anticancer macrocyclic quinazoline-based inhibitors of the ineraction between ras and sos1
WO2025210042A1 (en) 2024-04-03 2025-10-09 Boehringer Ingelheim International Gmbh Combination of zongertinib with a sos1 inhibitor for use in the treatment of cancer
WO2025230971A1 (en) 2024-04-30 2025-11-06 Kumquat Biosciences Inc. Macrocyclic heterocycles as anticancer agents
WO2025245127A1 (en) 2024-05-21 2025-11-27 Treeline Biosciences, Inc. Spirocyclic dihydropyranopyrimidine kras inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008150118A2 (en) * 2007-06-05 2008-12-11 Hanmi Pharm. Co., Ltd. Novel amide derivative for inhibiting the growth of cancer cells
WO2016077793A1 (en) * 2014-11-14 2016-05-19 Children's Hospital Medical Center Sos1 inhibitors for cancer treatment

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5654307A (en) 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
US6174899B1 (en) 1998-05-14 2001-01-16 Morton Shulman Orally administered analgesic composition comprising myfadol
AU2003256323A1 (en) * 2002-06-26 2004-01-19 Chiron Corporation Sos1 inhibitors
MX2009010218A (es) 2007-03-23 2009-10-19 Hoffmann La Roche Derivados de aza-piridopirimidinona.
JP5634995B2 (ja) 2008-08-12 2014-12-03 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ 化学化合物
BRPI0924107A2 (pt) 2008-11-28 2019-09-24 Novartis Ag inibidores de hsp90 para tratamento terapêutico
NZ597692A (en) 2008-12-12 2013-08-30 Boehringer Ingelheim Int Anti-IGF antibodies
MX2012004846A (es) 2009-10-29 2012-10-05 Genosco Inhibidores de cinasa.
JP2013544524A (ja) 2010-12-06 2013-12-19 ターポン バイオシステムズ，インコーポレイテッド 生物学的生成物の連続プロセス法
US8846656B2 (en) 2011-07-22 2014-09-30 Novartis Ag Tetrahydropyrido-pyridine and tetrahydropyrido-pyrimidine compounds and use thereof as C5a receptor modulators
AR090151A1 (es) 2012-03-07 2014-10-22 Lilly Co Eli Compuestos inhibidores de raf
NZ629432A (en) 2012-03-14 2017-01-27 Lupin Ltd Heterocyclyl compounds as mek inhibitors
US9242969B2 (en) 2013-03-14 2016-01-26 Novartis Ag Biaryl amide compounds as kinase inhibitors
CA2904393A1 (en) 2013-03-15 2014-09-25 Araxes Pharma Llc Covalent inhibitors of kras g12c
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
EP3328418A1 (en) 2015-07-29 2018-06-06 Novartis AG Combination therapies comprising antibody molecules to pd-1
EP3558979B1 (en) * 2016-12-22 2021-02-17 Boehringer Ingelheim International GmbH Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors
WO2018172250A1 (en) 2017-03-21 2018-09-27 Bayer Pharma Aktiengesellschaft 2-methyl-quinazolines
EP3986408A1 (en) 2019-06-19 2022-04-27 Boehringer Ingelheim International GmbH Anticancer combination therapy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008150118A2 (en) * 2007-06-05 2008-12-11 Hanmi Pharm. Co., Ltd. Novel amide derivative for inhibiting the growth of cancer cells
WO2016077793A1 (en) * 2014-11-14 2016-05-19 Children's Hospital Medical Center Sos1 inhibitors for cancer treatment

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JU HOU: "Design, synthesis, anti-tumor activity, and molecular modeling of", 《EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY》 *

Cited By (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113767100A (zh) * 2019-03-01 2021-12-07 锐新医药公司 双环杂芳基化合物及其用途
CN116425742A (zh) * 2019-11-08 2023-07-14 锐新医药公司 双环杂芳基化合物及其用途
CN114746411B (zh) * 2019-11-29 2024-06-25 印度鲁宾有限公司 取代的三环化合物
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CN115605476A (zh) * 2019-12-27 2023-01-13 鲁宾有限公司（In） 取代的三环化合物
WO2021203768A1 (zh) * 2020-04-08 2021-10-14 江苏恒瑞医药股份有限公司 嘧啶并二环类衍生物、其制备方法及其在医药上的应用
CN115244058A (zh) * 2020-04-08 2022-10-25 江苏恒瑞医药股份有限公司 嘧啶并二环类衍生物、其制备方法及其在医药上的应用
WO2021228028A1 (zh) * 2020-05-09 2021-11-18 正大天晴药业集团股份有限公司 含磷的sos1抑制剂
CN115461342A (zh) * 2020-05-09 2022-12-09 正大天晴药业集团股份有限公司 含磷的sos1抑制剂
US12565511B2 (en) 2020-05-09 2026-03-03 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. SOS1 inhibitor containing phosphorus
CN115697994A (zh) * 2020-06-10 2023-02-03 江苏恒瑞医药股份有限公司 稠合喹唑啉类衍生物、其制备方法及其在医药上的应用
WO2021249519A1 (zh) * 2020-06-11 2021-12-16 江苏恒瑞医药股份有限公司 吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用
CN115605479A (zh) * 2020-06-11 2023-01-13 江苏恒瑞医药股份有限公司（Cn） 吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用
CN113801114A (zh) * 2020-06-11 2021-12-17 江苏恒瑞医药股份有限公司 稠合二环杂芳基类衍生物、其制备方法及其在医药上的应用
CN113801114B (zh) * 2020-06-11 2022-11-18 江苏恒瑞医药股份有限公司 稠合二环杂芳基类衍生物、其制备方法及其在医药上的应用
CN115605479B (zh) * 2020-06-11 2024-05-14 江苏恒瑞医药股份有限公司 吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用
CN115942936A (zh) * 2020-06-24 2023-04-07 勃林格殷格翰国际有限公司 包含sos1抑制剂和kras g12c抑制剂的抗癌组合疗法
CN113912608A (zh) * 2020-07-10 2022-01-11 江苏恒瑞医药股份有限公司 嘧啶并嘧啶酮类衍生物、其制备方法及其在医药上的应用
WO2022017339A1 (zh) * 2020-07-20 2022-01-27 江苏恒瑞医药股份有限公司 稠合哒嗪类衍生物、其制备方法及其在医药上的应用
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US12552787B2 (en) 2020-07-24 2026-02-17 Medshine Discovery Inc. Quinazoline compound
WO2022017519A1 (zh) * 2020-07-24 2022-01-27 南京明德新药研发有限公司 喹唑啉类化合物
CN116194446A (zh) * 2020-08-06 2023-05-30 北京泰德制药股份有限公司 Sos1抑制剂、包含其的药物组合物及其用途
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WO2022170802A1 (zh) * 2021-02-09 2022-08-18 苏州阿尔脉生物科技有限公司 一种作为sos1抑制剂的嘧啶并吡啶酮类衍生物、其制备方法及用途
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CN114907284A (zh) * 2021-02-10 2022-08-16 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的化合物及其用途
CN117295732A (zh) * 2021-02-10 2023-12-26 杭州英创医药科技有限公司 作为sos1抑制剂的杂环化合物
WO2022171184A1 (zh) * 2021-02-10 2022-08-18 杭州英创医药科技有限公司 作为sos1抑制剂的杂环化合物
WO2022171118A1 (zh) * 2021-02-10 2022-08-18 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的化合物及其用途
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WO2022184116A1 (zh) * 2021-03-05 2022-09-09 江苏先声药业有限公司 新型sos1抑制剂及其制备方法和应用
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WO2022188819A1 (zh) * 2021-03-09 2022-09-15 苏州泽璟生物制药股份有限公司 Sos1蛋白水解调节剂及其制备方法和应用
WO2022199635A1 (zh) * 2021-03-25 2022-09-29 南京明德新药研发有限公司 苄氨基喹唑啉类衍生物
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WO2022199670A1 (zh) * 2021-03-26 2022-09-29 南京明德新药研发有限公司 6-氨基甲酸酯取代的杂芳环衍生物
CN115215847B (zh) * 2021-04-16 2025-05-13 中国科学院上海药物研究所 一类kras-sos1抑制剂、其制备方法及其应用
CN115215847A (zh) * 2021-04-16 2022-10-21 中国科学院上海药物研究所 一类kras-sos1抑制剂、其制备方法及其应用
CN115215884A (zh) * 2021-04-19 2022-10-21 昆药集团股份有限公司 苯并嘧啶三环类衍生物及其制备方法和应用
WO2022222875A1 (zh) * 2021-04-19 2022-10-27 昆药集团股份有限公司 一种苯并嘧啶三环衍生物及其制备方法和应用
CN115232108A (zh) * 2021-04-23 2022-10-25 上海领泰生物医药科技有限公司 Sos1降解剂及其制备方法和应用
CN115232108B (zh) * 2021-04-23 2025-04-18 领泰生物医药(绍兴)有限公司 Sos1降解剂及其制备方法和应用
WO2022258057A1 (en) * 2021-06-11 2022-12-15 Jingrui Biopharma Co., Ltd. Compounds as anticancer agents
WO2022262691A1 (en) * 2021-06-17 2022-12-22 Beijing Innocare Pharma Tech Co., Ltd. Heterocyclic compounds as sos1 inhibitors
WO2022268209A1 (zh) * 2021-06-24 2022-12-29 四川汇宇制药股份有限公司 一种嘧啶并环结构衍生物及其用途
CN117580836A (zh) * 2021-06-24 2024-02-20 四川汇宇制药股份有限公司 一种嘧啶并环结构衍生物及其用途
CN115677699A (zh) * 2021-07-23 2023-02-03 武汉誉祥医药科技有限公司 三并环化合物及其药物组合物和应用
CN117769556A (zh) * 2021-07-23 2024-03-26 浙江海正药业股份有限公司 嘧啶并环类衍生物及其制备方法和用途
WO2023001229A1 (zh) * 2021-07-23 2023-01-26 浙江海正药业股份有限公司 嘧啶并环类衍生物及其制备方法和用途
CN115677824A (zh) * 2021-07-26 2023-02-03 中国科学院上海药物研究所 可诱导sos1蛋白质降解的化合物、制备方法和用途
CN115677824B (zh) * 2021-07-26 2026-02-03 中国科学院上海药物研究所 可诱导sos1蛋白质降解的化合物、制备方法和用途
CN115677601B (zh) * 2021-07-29 2025-06-03 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的化合物及其用途
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WO2023030216A1 (zh) * 2021-08-30 2023-03-09 浙江海正药业股份有限公司 喹唑啉类衍生物、或其制备方法和用途
CN115417868A (zh) * 2021-09-13 2022-12-02 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的杂环化合物及其用途
CN115417868B (zh) * 2021-09-13 2024-04-02 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的杂环化合物及其用途
CN115246841A (zh) * 2021-09-14 2022-10-28 北京福元医药股份有限公司 苄氨基取代的嘧啶并吡喃酮衍生物及其组合物、制剂和用途
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CN116143708A (zh) * 2021-11-21 2023-05-23 四川汇宇制药股份有限公司 一种多取代苯并氮杂芳基衍生物及其用途
WO2023109929A1 (zh) 2021-12-17 2023-06-22 石药集团中奇制药技术（石家庄）有限公司 一种具有抗肿瘤活性的杂环化合物及其用途
WO2023138526A1 (zh) * 2022-01-21 2023-07-27 南京明德新药研发有限公司 含烯丙基的甲基吡啶并嘧啶化合物的晶型
WO2023143147A1 (zh) * 2022-01-28 2023-08-03 上海优理惠生医药有限公司 一种哒嗪并吡啶酮类化合物、其药物组合物及应用
CN116768858A (zh) * 2022-03-15 2023-09-19 杭州中美华东制药有限公司 具有kras-sos1抑制或降解活性的嵌合化合物及其用途
CN117024404A (zh) * 2022-05-10 2023-11-10 四川汇宇制药股份有限公司 苯并吡啶衍生物及其用途
WO2023241414A1 (zh) * 2022-06-13 2023-12-21 上海优理惠生医药有限公司 一种哒嗪类化合物、其药物组合物及应用
WO2024008185A1 (zh) * 2022-07-07 2024-01-11 武汉人福创新药物研发中心有限公司 包含sos1抑制剂的药物组合物
WO2024061353A1 (zh) * 2022-09-23 2024-03-28 南京明德新药研发有限公司 喹唑啉类化合物的晶型及其制备方法
CN119894894B (zh) * 2022-09-23 2025-12-05 无锡瓴方生物医药科技有限公司 喹唑啉类化合物的晶型及其制备方法
CN119894894A (zh) * 2022-09-23 2025-04-25 无锡瓴方生物医药科技有限公司 喹唑啉类化合物的晶型及其制备方法
CN119907792A (zh) * 2022-10-21 2025-04-29 领泰生物医药(绍兴)有限公司 苄基或噻吩亚甲基取代的氨基喹唑啉衍生物及其作为sos1降解剂的用途
CN119907792B (zh) * 2022-10-21 2025-12-09 领泰生物医药(绍兴)有限公司 苄基或噻吩亚甲基取代的氨基喹唑啉衍生物及其作为sos1降解剂的用途
CN116444447A (zh) * 2023-06-19 2023-07-18 中国药科大学 一种sos1和hdac双靶点喹唑啉羟肟酸化合物及其制法和应用
CN116444447B (zh) * 2023-06-19 2023-09-22 中国药科大学 一种sos1和hdac双靶点喹唑啉羟肟酸化合物及其制法和应用

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