CN115605479A - 吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用 - Google Patents

吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用 Download PDF

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Publication number
CN115605479A
CN115605479A CN202180034576.8A CN202180034576A CN115605479A CN 115605479 A CN115605479 A CN 115605479A CN 202180034576 A CN202180034576 A CN 202180034576A CN 115605479 A CN115605479 A CN 115605479A
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CN
China
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group
compound
alkyl
cycloalkyl
cancer
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CN202180034576.8A
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English (en)
Inventor
李心
冯斌强
白东栋
贺峰
陶维康
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Application filed by Jiangsu Hengrui Medicine Co Ltd, Shanghai Hengrui Pharmaceutical Co Ltd filed Critical Jiangsu Hengrui Medicine Co Ltd
Publication of CN115605479A publication Critical patent/CN115605479A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

一种吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用。具体而言，涉及一种通式(I)所示的吡啶酮并嘧啶类衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂的用途，特别是作为SOS1抑制剂的用途和在制备用于治疗通过对SOS1的抑制而改善的疾病、病况或病症的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (21)

  1. PCT国内申请，权利要求书已公开。
CN202180034576.8A 2020-06-11 2021-06-11 吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用 Pending CN115605479A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CN202010529071 2020-06-11
CN2020105290716 2020-06-11
CN202011042186 2020-09-28
CN2020110421869 2020-09-28
CN202011400233 2020-12-02
CN2020114002332 2020-12-02
CN2021105095690 2021-05-11
CN202110509569 2021-05-11
PCT/CN2021/099552 WO2021249519A1 (zh) 2020-06-11 2021-06-11 吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用

Publications (1)

Publication Number Publication Date
CN115605479A true CN115605479A (zh) 2023-01-13

Family

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CN202180034576.8A Pending CN115605479A (zh) 2020-06-11 2021-06-11 吡啶酮并嘧啶类衍生物、其制备方法及其在医药上的应用

Country Status (11)

Country Link
US (1) US20230219951A1 (zh)
EP (1) EP4166555A1 (zh)
JP (1) JP2023528925A (zh)
KR (1) KR20230023672A (zh)
CN (1) CN115605479A (zh)
AU (1) AU2021287927A1 (zh)
BR (1) BR112022024120A2 (zh)
CA (1) CA3180615A1 (zh)
MX (1) MX2022015531A (zh)
TW (1) TW202214639A (zh)
WO (1) WO2021249519A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022135590A1 (zh) * 2020-12-27 2022-06-30 上海凌达生物医药有限公司 一类嘧啶并杂环类化合物、制备方法和用途
WO2022187411A1 (en) 2021-03-02 2022-09-09 Kumquat Biosciences Inc. Heterocycles and uses thereof
CN117479942A (zh) 2021-04-09 2024-01-30 勃林格殷格翰国际有限公司 抗癌疗法
US11912708B2 (en) 2022-04-20 2024-02-27 Kumquat Biosciences Inc. Macrocyclic heterocycles and uses thereof
WO2024027762A1 (zh) * 2022-08-05 2024-02-08 上海艾力斯医药科技股份有限公司 一种稠环化合物、其制备方法及其应用
WO2024074827A1 (en) 2022-10-05 2024-04-11 Sevenless Therapeutics Limited New treatments for pain

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019122129A1 (en) * 2017-12-21 2019-06-27 Boehringer Ingelheim International Gmbh Novel benzylamino substituted pyridopyrimidinones and derivatives as sos1 inhibitors
CN110167928A (zh) * 2016-12-22 2019-08-23 勃林格殷格翰国际有限公司 作为sos1抑制剂的新型经苄基氨基取代的喹唑啉和衍生物
CN114901662A (zh) * 2019-11-08 2022-08-12 锐新医药公司 双环杂芳基化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10501421B1 (en) 2017-01-27 2019-12-10 Vanderbilt University Substituted benzimidazoles as modulators of Ras signaling
US20220235013A1 (en) 2017-03-21 2022-07-28 Bayer Pharma Aktiengesellschaft 2-methyl-quinazolines
WO2019055540A1 (en) 2017-09-13 2019-03-21 D.E. Shaw Research, Llc COMPOUNDS AS INHIBITORS OF RAS AND THEIR USE
US20220274979A1 (en) 2018-04-18 2022-09-01 Bayer Pharma Aktiengesellschaft 2-methyl-aza-quinazolines

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110167928A (zh) * 2016-12-22 2019-08-23 勃林格殷格翰国际有限公司 作为sos1抑制剂的新型经苄基氨基取代的喹唑啉和衍生物
WO2019122129A1 (en) * 2017-12-21 2019-06-27 Boehringer Ingelheim International Gmbh Novel benzylamino substituted pyridopyrimidinones and derivatives as sos1 inhibitors
CN114901662A (zh) * 2019-11-08 2022-08-12 锐新医药公司 双环杂芳基化合物及其用途

Also Published As

Publication number Publication date
KR20230023672A (ko) 2023-02-17
TW202214639A (zh) 2022-04-16
JP2023528925A (ja) 2023-07-06
BR112022024120A2 (pt) 2022-12-27
WO2021249519A1 (zh) 2021-12-16
AU2021287927A1 (en) 2023-01-19
MX2022015531A (es) 2023-01-16
EP4166555A1 (en) 2023-04-19
CA3180615A1 (en) 2021-12-16
US20230219951A1 (en) 2023-07-13

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