JP7219218B2 - 新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体 - Google Patents

新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体 Download PDF

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JP7219218B2
JP7219218B2 JP2019534303A JP2019534303A JP7219218B2 JP 7219218 B2 JP7219218 B2 JP 7219218B2 JP 2019534303 A JP2019534303 A JP 2019534303A JP 2019534303 A JP2019534303 A JP 2019534303A JP 7219218 B2 JP7219218 B2 JP 7219218B2
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JP2020504742A5 (https=
JP2020504742A (ja
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ミヒャエル グマッシュ
ミヒャエル サンダーソン
ディルク ケスラー
クリスティアーネ コフィンク
マシュー ラッセル ネザートン
ユルゲン ラムハーター
トビアス ヴンベルク
マルコ ホフマン
ファビオ サバリース
アンケ バウム
ドロテーア ルドルフ
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ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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JP2019534303A 2016-12-22 2017-12-21 新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体 Active JP7219218B2 (ja)

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EP16206422 2016-12-22
EP16206422.4 2016-12-22
PCT/EP2017/084265 WO2018115380A1 (en) 2016-12-22 2017-12-21 Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors

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JP2020504742A JP2020504742A (ja) 2020-02-13
JP2020504742A5 JP2020504742A5 (https=) 2021-02-04
JP7219218B2 true JP7219218B2 (ja) 2023-02-07

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US (2) US10898487B2 (https=)
EP (2) EP3878850A1 (https=)
JP (1) JP7219218B2 (https=)
CN (1) CN110167928A (https=)
WO (1) WO2018115380A1 (https=)

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JP7039489B2 (ja) 2016-05-18 2022-03-22 ミラティ セラピューティクス， インコーポレイテッド Ｋｒａｓ ｇ１２ｃ阻害剤
JP7219218B2 (ja) 2016-12-22 2023-02-07 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規のベンジルアミノ置換キナゾリンおよびｓｏｓ１阻害剤としての誘導体
WO2018126192A1 (en) * 2016-12-30 2018-07-05 Children's Medical Center Corporation Map2k1 (mek1) as a therapeutic target for arteriovenous malformations and associated disorders
CA3056970A1 (en) * 2017-03-21 2018-09-27 Bayer Pharma Aktiengesellschaft 2-methyl-quinazolines
US10647715B2 (en) 2017-11-15 2020-05-12 Mirati Therapeutics, Inc. KRas G12C inhibitors
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