CN108771681B - 作为dna-pk抑制剂的化合物及其氘化衍生物的共晶 - Google Patents

作为dna-pk抑制剂的化合物及其氘化衍生物的共晶 Download PDF

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CN108771681B
CN108771681B CN201811084734.7A CN201811084734A CN108771681B CN 108771681 B CN108771681 B CN 108771681B CN 201811084734 A CN201811084734 A CN 201811084734A CN 108771681 B CN108771681 B CN 108771681B
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compound
cancer
crystal
adipic acid
formula
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CN108771681A (zh
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K·W·恩蒂-阿达
S·A·奥尼尔
张越刚
I·N·卡迪亚拉
K·斯塔夫罗普洛斯
M·纳瓦莫尔
P·穆杜努里
宋彬
J·G·范阿尔斯坦
M·沃尔多
M·斯特罗迈耶
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Vertex Pharmaceuticals Inc
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CN201811084734.7A 2013-10-17 2014-10-17 作为dna-pk抑制剂的化合物及其氘化衍生物的共晶 Active CN108771681B (zh)

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BR112016028119A2 (pt) 2014-06-06 2017-08-22 Res Triangle Inst Agonistas receptores de apelina (apj) e usos dos mesmos
KR20180008594A (ko) 2015-05-18 2018-01-24 신-낫 프로덕츠 엔터프라이즈 엘엘씨 약제학적 공-결정 및 그의 용도
WO2016205785A1 (en) * 2015-06-19 2016-12-22 Syn-Nat Products Enterprise LLC Pharmaceutical composition of carboplatin based co-crystals and use thereof
WO2016205782A1 (en) 2015-06-19 2016-12-22 Syn-Nat Products Enterprise LLC Composition containing carboplatin and use
AU2016284816B2 (en) 2015-06-25 2021-10-07 Syn-Nat Products Enterprise LLC Pharmaceutical co-crystal composition and use thereof
CR20180323A (es) 2015-11-20 2018-08-06 Idorsia Pharmaceuticals Ltd Derivados de indol n-sustituídos como moduladores de los receptores de pge2
CN108602806B (zh) 2015-12-09 2022-07-12 研究三角协会 改进的爱帕琳肽受体(apj)激动剂及其用途
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MX394860B (es) 2016-09-27 2025-03-24 Vertex Pharma Metodo para tratar cancer usando una combinacion de agentes que dañan adn e inhibidores de proteina cinasa dependiente de adn (adn-pk).
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ES3040063T3 (en) * 2016-12-19 2025-10-28 Merck Patent Gmbh Combination of a protein kinase inhibitor and an additional chemotherapeutic agent
JP7071342B6 (ja) 2016-12-21 2023-12-20 リサーチ トライアングル インスティテュート 改善されたバイオアベイラビリティを有するジアリールプリン誘導体
TW201900180A (zh) 2017-05-18 2019-01-01 瑞士商愛杜西亞製藥有限公司 嘧啶衍生物
HRP20211380T1 (hr) 2017-05-18 2021-11-26 Idorsia Pharmaceuticals Ltd Derivati pirimidina kao modulatori receptora pge2
AR111807A1 (es) 2017-05-18 2019-08-21 Idorsia Pharmaceuticals Ltd Derivados de benzofurano y benzotiofeno como moduladores del receptor pge2
AR111941A1 (es) 2017-05-18 2019-09-04 Idorsia Pharmaceuticals Ltd Derivados de pirimidina como moduladores del receptor de pge2
JP7466448B2 (ja) 2018-01-17 2024-04-12 バーテックス ファーマシューティカルズ インコーポレイテッド Ｄｎａ－ｐｋ阻害剤
ES2980444T3 (es) 2018-01-17 2024-10-01 Vertex Pharma Inhibidores de ADN-PK
KR20200110687A (ko) 2018-01-17 2020-09-24 버텍스 파마슈티칼스 인코포레이티드 유전체 편집 효율을 증가시키기 위한 퀴녹살리논 화합물, 조성물, 방법 및 키트
US12221447B2 (en) 2018-08-20 2025-02-11 Duke University Methods and compositions for drugs to treat ophthalmic diseases
CA3100035A1 (en) 2018-08-27 2020-03-05 Regeneron Pharmaceuticals, Inc. Use of raman spectroscopy in downstream purification
CN112300126A (zh) * 2019-07-31 2021-02-02 山东轩竹医药科技有限公司 杂环类dna-pk抑制剂
CN112574179B (zh) * 2019-09-29 2022-05-10 山东轩竹医药科技有限公司 Dna-pk抑制剂
CN114478399B (zh) * 2020-10-27 2024-10-29 华东理工大学 嘧菌酯低共熔混合物及其制备方法和应用
CN120555509B (zh) * 2025-07-30 2025-11-04 之江实验室 氨磷汀在提高基因组定点插入效率中的应用

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