CN108055865B - 用于治疗的新的TNFα结构 - Google Patents

用于治疗的新的TNFα结构

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Publication number
CN108055865B
CN108055865B CN201580081000.1A CN201580081000A CN108055865B CN 108055865 B CN108055865 B CN 108055865B CN 201580081000 A CN201580081000 A CN 201580081000A CN 108055865 B CN108055865 B CN 108055865B
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Prior art keywords
tnf
trimer
compound
binding
tnfr1
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CN108055865A (zh
Inventor
J·P·奥康奈尔
J·R·波特
A·劳森
B·克罗普里安
S·E·拉佩琦
T·J·诺曼
G·J·瓦里楼
T·L·阿拉卡基
A·B·伯金
W·R·皮特
M·D·凯尔米阿诺
D·A·舒伯特
D·J·莱特伍德
R·J·伍顿
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UCB Biopharma SRL
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UCB Biopharma SRL
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CN201580081000.1A 2015-06-18 2015-10-22 用于治疗的新的TNFα结构 Active CN108055865B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1510758.4 2015-06-18
GBGB1510758.4A GB201510758D0 (en) 2015-06-18 2015-06-18 Novel TNFa structure for use in therapy
PCT/EP2015/074491 WO2016202412A1 (en) 2015-06-18 2015-10-22 NOVEL TNFα STRUCTURE FOR USE IN THERAPY

Publications (2)

Publication Number Publication Date
CN108055865A CN108055865A (zh) 2018-05-18
CN108055865B true CN108055865B (zh) 2021-06-15

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CN201580081000.1A Active CN108055865B (zh) 2015-06-18 2015-10-22 用于治疗的新的TNFα结构
CN201580080984.1A Active CN107771286B (zh) 2015-06-18 2015-10-22 作用机制
CN202010405385.5A Active CN111574517B (zh) 2015-06-18 2015-10-22 作用机制
CN201580081026.6A Active CN107810419B (zh) 2015-06-18 2015-10-22 调节剂测定
CN201580080985.6A Active CN108290945B (zh) 2015-06-18 2015-10-22 抗体
CN201580080990.7A Active CN108139407B (zh) 2015-06-18 2015-10-22 抗体表位

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CN201580080984.1A Active CN107771286B (zh) 2015-06-18 2015-10-22 作用机制
CN202010405385.5A Active CN111574517B (zh) 2015-06-18 2015-10-22 作用机制
CN201580081026.6A Active CN107810419B (zh) 2015-06-18 2015-10-22 调节剂测定
CN201580080985.6A Active CN108290945B (zh) 2015-06-18 2015-10-22 抗体
CN201580080990.7A Active CN108139407B (zh) 2015-06-18 2015-10-22 抗体表位

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US (12) US11022614B2 (enExample)
EP (8) EP3311169B1 (enExample)
JP (12) JP6659030B2 (enExample)
KR (2) KR102599907B1 (enExample)
CN (6) CN108055865B (enExample)
AU (2) AU2015398985A1 (enExample)
CA (5) CA2987698C (enExample)
CL (2) CL2017003189A1 (enExample)
EA (4) EA201890081A1 (enExample)
ES (5) ES2902415T3 (enExample)
GB (1) GB201510758D0 (enExample)
IL (2) IL256099B2 (enExample)
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PL (4) PL3311168T3 (enExample)
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CN107438620A (zh) 2015-03-31 2017-12-05 韦斯夸尔德有限公司 多肽
EP3294726A1 (en) 2015-04-17 2018-03-21 AbbVie Inc. Indazolones as modulators of tnf signaling
AR104293A1 (es) 2015-04-17 2017-07-12 Abbvie Inc Indazolonas como moduladores de la señalización de tnf
WO2016168641A1 (en) 2015-04-17 2016-10-20 Abbvie Inc. Tricyclic modulators of tnf signaling
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
WO2018060453A1 (en) 2016-09-30 2018-04-05 Vhsquared Limited Compositions
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope
WO2018119142A1 (en) 2016-12-21 2018-06-28 Amgen Inc. Anti-tnf alpha antibody formulations
US11628159B2 (en) * 2017-01-10 2023-04-18 Eth Zurich Cell-protective compounds and their use
CN114514243B (zh) 2019-06-21 2025-01-24 索瑞索制药公司 多肽
WO2020254827A1 (en) 2019-06-21 2020-12-24 Vhsquared Limited Polypeptides
JP7561364B2 (ja) * 2020-04-30 2024-10-04 国立大学法人東北大学 蛍光偏光免疫分析法

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