CN107849096B - 去免疫化的志贺毒素a亚基支架和包含它们的细胞靶向分子 - Google Patents

去免疫化的志贺毒素a亚基支架和包含它们的细胞靶向分子 Download PDF

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CN107849096B
CN107849096B CN201680038854.6A CN201680038854A CN107849096B CN 107849096 B CN107849096 B CN 107849096B CN 201680038854 A CN201680038854 A CN 201680038854A CN 107849096 B CN107849096 B CN 107849096B
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cell
shiga toxin
targeting molecule
polypeptide
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CN107849096A (zh
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埃里克·波马
埃林·威勒特
加勒特·李·鲁滨逊
桑吉萨·拉贾戈帕兰
布丽吉特·布里斯克
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Molecular Templates Inc
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
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    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
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    • C07—ORGANIC CHEMISTRY
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    • C07K2319/00—Fusion polypeptide
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CN201680038854.6A 2015-05-30 2016-05-27 去免疫化的志贺毒素a亚基支架和包含它们的细胞靶向分子 Active CN107849096B (zh)

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US201562168758P 2015-05-30 2015-05-30
US201562168761P 2015-05-30 2015-05-30
US201562168760P 2015-05-30 2015-05-30
US201562168763P 2015-05-30 2015-05-30
US201562168762P 2015-05-30 2015-05-30
US201562168759P 2015-05-30 2015-05-30
US62/168,761 2015-05-30
US62/168,759 2015-05-30
US62/168,758 2015-05-30
US62/168,763 2015-05-30
US62/168,762 2015-05-30
US62/168,760 2015-05-30
PCT/US2016/034778 WO2016196344A1 (en) 2015-05-30 2016-05-27 De-immunized, shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same

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