CN106488910B - Kras g12c的抑制剂 - Google Patents

Kras g12c的抑制剂 Download PDF

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CN106488910B
CN106488910B CN201480055783.1A CN201480055783A CN106488910B CN 106488910 B CN106488910 B CN 106488910B CN 201480055783 A CN201480055783 A CN 201480055783A CN 106488910 B CN106488910 B CN 106488910B
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hydrocarbyl
group
cancer
compounds
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CN106488910A (zh
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李连升
冯军
吴涛
任平达
刘毅
刘源
龙筠
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Araxes Pharma LLC
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201480055783.1A 2013-10-10 2014-10-10 Kras g12c的抑制剂 Active CN106488910B (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201361889460P 2013-10-10 2013-10-10
US61/889,460 2013-10-10
US201462034619P 2014-08-07 2014-08-07
US62/034,619 2014-08-07
US201462052366P 2014-09-18 2014-09-18
US62/052,366 2014-09-18
JO289/2014 2014-10-09
TW103135318 2014-10-09
TW103135318A TWI659021B (zh) 2013-10-10 2014-10-09 Ｋｒａｓ ｇ１２ｃ之抑制劑
JOP/2014/0289A JO3805B1 (ar) 2013-10-10 2014-10-09 مثبطات كراس جي12سي
PCT/US2014/060036 WO2015054572A1 (en) 2013-10-10 2014-10-10 Inhibitors of kras g12c

Publications (2)

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CN106488910A CN106488910A (zh) 2017-03-08
CN106488910B true CN106488910B (zh) 2020-07-31

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JP (1) JP6559123B2 (enExample)
KR (1) KR20160076519A (enExample)
CN (1) CN106488910B (enExample)
AU (1) AU2014331794C1 (enExample)
BR (1) BR112016008016B8 (enExample)
CA (1) CA2926328C (enExample)
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UY35464A (es) 2013-03-15 2014-10-31 Araxes Pharma Llc Inhibidores covalentes de kras g12c.
US9745319B2 (en) 2013-03-15 2017-08-29 Araxes Pharma Llc Irreversible covalent inhibitors of the GTPase K-Ras G12C
TWI659021B (zh) 2013-10-10 2019-05-11 亞瑞克西斯製藥公司 Ｋｒａｓ ｇ１２ｃ之抑制劑
JO3556B1 (ar) 2014-09-18 2020-07-05 Araxes Pharma Llc علاجات مدمجة لمعالجة السرطان
US9862701B2 (en) 2014-09-25 2018-01-09 Araxes Pharma Llc Inhibitors of KRAS G12C mutant proteins
WO2016049568A1 (en) 2014-09-25 2016-03-31 Araxes Pharma Llc Methods and compositions for inhibition of ras
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ES2856880T3 (es) 2015-04-15 2021-09-28 Araxes Pharma Llc Inhibidores tricíclicos condensados de KRAS y métodos de uso de los mismos
EP3325447A1 (en) * 2015-07-22 2018-05-30 Araxes Pharma LLC Substituted quinazoline compounds and their use as inhibitors of g12c mutant kras, hras and/or nras proteins
US10144724B2 (en) 2015-07-22 2018-12-04 Araxes Pharma Llc Substituted quinazoline compounds and methods of use thereof
CN108026046B (zh) * 2015-07-22 2021-12-21 亚瑞克西斯制药公司 取代的喹唑啉化合物及其作为g12c突变体kras、hras和/或nras蛋白质的抑制剂的用途
PL3330271T3 (pl) * 2015-07-31 2022-12-19 Taiho Pharmaceutical Co., Ltd. Związek pirolo[2,3-d]pirymidyny lub jego sól
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WO2017058902A1 (en) * 2015-09-28 2017-04-06 Araxes Pharma Llc Inhibitors of kras g12c mutant proteins
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