CN105307672B - 用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂 - Google Patents

用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂 Download PDF

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CN105307672B
CN105307672B CN201480034914.8A CN201480034914A CN105307672B CN 105307672 B CN105307672 B CN 105307672B CN 201480034914 A CN201480034914 A CN 201480034914A CN 105307672 B CN105307672 B CN 105307672B
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amino
carboxy
butyryl
ethoxy
glucagon
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CN105307672A (zh
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U.森斯富斯
T.克鲁塞
J.F.劳
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Novo Nordisk AS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201480034914.8A 2013-04-18 2014-04-22 用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂 Active CN105307672B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP13164272.0 2013-04-18
EP13164272 2013-04-18
US201361814969P 2013-04-23 2013-04-23
US61/814969 2013-04-23
EP13196656 2013-12-11
EP13196656.6 2013-12-11
PCT/EP2014/058084 WO2014170496A1 (en) 2013-04-18 2014-04-22 Stable, protracted glp-1/glucagon receptor co-agonists for medical use

Publications (2)

Publication Number Publication Date
CN105307672A CN105307672A (zh) 2016-02-03
CN105307672B true CN105307672B (zh) 2021-01-05

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CN201480034914.8A Active CN105307672B (zh) 2013-04-18 2014-04-22 用于医学用途的稳定、延长的glp-1/胰高血糖素受体共激动剂

Country Status (16)

Country Link
US (3) US9474790B2 (enExample)
EP (1) EP2986313B1 (enExample)
JP (1) JP6594856B2 (enExample)
KR (1) KR20160021758A (enExample)
CN (1) CN105307672B (enExample)
AU (1) AU2014255608B2 (enExample)
BR (1) BR112015025464A2 (enExample)
CA (1) CA2909581A1 (enExample)
MX (1) MX362275B (enExample)
MY (1) MY174727A (enExample)
PL (1) PL2986313T3 (enExample)
RS (1) RS59124B1 (enExample)
RU (1) RU2683039C2 (enExample)
SI (1) SI2986313T1 (enExample)
WO (1) WO2014170496A1 (enExample)
ZA (1) ZA201507010B (enExample)

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KR102291020B1 (ko) * 2014-12-30 2021-08-20 한미약품 주식회사 안정성이 증가된 글루카곤 유도체
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